Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness_Journal of Epilepsy

Authors：

 ZHAO Yuhua ¹ , ZHAXI Cuomu ² , YU Hao ¹ , ZHANG Yalong ² , ZHANG Tao ¹ , YANG Li ² , CIDAN Zhuoga ¹ , MIMA Dunzhu ¹ , DING Zhijie ¹

1. Department of Neurology, the People's Hospital of TAR, Lhasa 850000, China;
2. Department of Internal Medicine, Tibet Frontier Defence General Team Hospital, Lhasa 850000, China;

Corresponding author：

ZHAO Yuhua, Email: drolyang@163.com

Keywords：

Electroencephalogram; Acute mountain sickness; Distribution characteristics; Early warning effect

DOI：

10.7507/2096-0247.20170044

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Objective The purpose of the research is to study the distribution and early warning of electroencephalogram (EEG) in acute mountain sickness (AMS). Methods A total of 280 healthy young men were recruited from September 2016 to October 2016. The basic data were collected by the centralized flow method, the general situation of the division of the investigators after the training, the Lewis Lake score, the computer self-rating anxiety scale and depression scale, and the collection of EEG. Follow up in three months. Results 94 of the patients with AMS, morbidity is 33%, 21 (22.34%) of the patients are moderate to severe, 73 (77.66%) are mild, morbidity is 26.67%. The abnormal detection rate of electrogram was 7.9% (22/280), which were mild EEG, normal EEG abnormal rate was 8.6% (16/186), abnormal detection rate of mild AMS was 4.1% (3/73), and the abnormal detection rate was 14.3% (3/21) in the medium / heavy AMS. The latter was significantly different from the previous (P < 0.05). Three months follow-up of this group of patients with 0 case of high altitude disease. Conclusions The EEG in AMS is mainly a rhythm irregular, unstable, poor amplitude modulation; or two hemisphere volatility difference of more than 50% or slightly increased activity. The result is statistically significant, suggesting that EEG distributions has possible early warning of AMS.

Citation： ZHAO Yuhua, ZHAXI Cuomu, YU Hao, ZHANG Yalong, ZHANG Tao, YANG Li, CIDAN Zhuoga, MIMA Dunzhu, DING Zhijie. Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness. Journal of Epilepsy, 2017, 3(4): 298-301. doi: 10.7507/2096-0247.20170044 Copy

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15.	李波, 戴维, 刘琨, 等.心理干预对新兵急行军后焦虑-抑郁情绪的影响.沈阳医学院学报, 2016, 18(1): 27-29.
16.	刘畅, 陈祉妍, 李丁川, 等.新兵焦虑-抑郁情绪测查及影响因素分析.中国临床心理学杂志, 2006, 14(4):371-372.
17.	杨金生, 石向群, 谷有权等.急进高原部队官兵抑郁和焦虑的评估.解放军预防医学杂志, 2006, 24(6): 355-356.
18.	赵瑾, 杨来启, 吴兴曲, 等.急进高原部队官兵抑郁和焦虑的评估及相关干预.山东医药, 2012, 52(32): 54-55.
19.	胡军, 李晓云, 王东红, 等.急进高原官兵抑郁-焦虑及其影响因素的研究.西北国防医学杂志. 2015, 36(6): 377-38.
20.	Sand T, Tygaard O. Quantitative EEG in acute mountain sickness. Acta Neurol Scand, 1998, 98(6):386-390.
21.	杨定周, 李素芝, 胡海燕, 等.脑电图在高原脑水肿早期的表现及诊断价值.华南国防医学杂志, 2010, 24(3): 171-173.
22.	Berend Feddersen, Horald Ausserer, Florian Thanbichler, et al.Right temproral cerebral dysfunction heralds symptoms of acute mountain sickness.J Neurol, 2007, 254(3): 359-363.
23.	Berend Feddersen, Pritam Neupane, Florian Thanbichler, et al. Reginal differences in the cerebral blood flow velocity response to hypobaric hypoxia at high altitudes. Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (11): 1846-1851.

1. Hackett PH, Roach RC. High-altitude illness. N Engl J Med, 2001, 345(2): 107-114.
2. Roach RC, Bartsch P, Hackett PH, et al. The Lake Louise acute mountain sickness scoring system. Hypoxia and Molecular Medicine.In proceedings of the 8^th International Hypoxia symposium, Burlington, Canada, 1993: 272-274.https://www.researchgate.net/publication/277718910_The_Lake_Louise_Acute_Mountain_Sickness_Scoring_System.
3. 西藏自治区统计局, 国家统计局西藏调查总队. 2015西藏统计年鉴.中国统计出版社, 北京, 2015: 9.
4. Martin J Macinnis, Eric A Carter, Michael G Freeman, et al. A prospective epidemiological study of acute mountain sickness in nepalese pilgrims ascending to high altitude (4380). PloS One, 2013, 8(10): 1-6.
5. Wu YI. Mountain rescue: the highest earthquake in Yushu. High Alt Med Biol, 2011, 12(1): 93-95.
6. WU Tian-yi, DING Shou-quan, LIU Jin-liang, et al. Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula. Chinese Medical Journal, 2012, 125(8): 1393-1400.
7. 刘阳, 张继航, 武晓静, 等.平原动脉血压对急性高原病易感性的预测.军事医学, 2014, 38(4): 252-259.
8. 邱友竹, 余洁, 王连友等.急进高原环境对血管内皮功能的影响及其与急性高原病的关系.解放军医学杂志, 2015, 40(5):415-419.
9. 巩江, 倪士峰, 李文华, 等.高原疾病相关易感基因的研究进展.基础医学与临床, 2012, 32(6):719-723.
10. 耿倩雯, 张继航, 覃军, 等. Nrf2基因单核苷酸多态性与急性高原病相关性研究.军事医学, 2015, 39(2): 105-107.
11. 刘晓燕, 吴逊.临床脑电图学.人民卫生出版社, 北京, 2006:214-215.
12. 王慎旭、何伟华、张明德.平原籍战士急进高原后短期体质变化与急性高原病发病情况的调查.实用医学杂志, 2015, 12(5):392-393.
13. 董建伟, 石自福, 李宇, 等.不同海拔驻地人群进驻高原急性高原反应发病情况比较.西北国防医学杂志, 2015, 36(8):520-522.
14. 卢娟, 苟于强, 王涛, 等.高原驻训部队急性高原反应流行病学调查.西北国防医学杂志, 2016, 37(4): 253-255.
15. 李波, 戴维, 刘琨, 等.心理干预对新兵急行军后焦虑-抑郁情绪的影响.沈阳医学院学报, 2016, 18(1): 27-29.
16. 刘畅, 陈祉妍, 李丁川, 等.新兵焦虑-抑郁情绪测查及影响因素分析.中国临床心理学杂志, 2006, 14(4):371-372.
17. 杨金生, 石向群, 谷有权等.急进高原部队官兵抑郁和焦虑的评估.解放军预防医学杂志, 2006, 24(6): 355-356.
18. 赵瑾, 杨来启, 吴兴曲, 等.急进高原部队官兵抑郁和焦虑的评估及相关干预.山东医药, 2012, 52(32): 54-55.
19. 胡军, 李晓云, 王东红, 等.急进高原官兵抑郁-焦虑及其影响因素的研究.西北国防医学杂志. 2015, 36(6): 377-38.
20. Sand T, Tygaard O. Quantitative EEG in acute mountain sickness. Acta Neurol Scand, 1998, 98(6):386-390.
21. 杨定周, 李素芝, 胡海燕, 等.脑电图在高原脑水肿早期的表现及诊断价值.华南国防医学杂志, 2010, 24(3): 171-173.
22. Berend Feddersen, Horald Ausserer, Florian Thanbichler, et al.Right temproral cerebral dysfunction heralds symptoms of acute mountain sickness.J Neurol, 2007, 254(3): 359-363.
23. Berend Feddersen, Pritam Neupane, Florian Thanbichler, et al. Reginal differences in the cerebral blood flow velocity response to hypobaric hypoxia at high altitudes. Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (11): 1846-1851.

Journal of Epilepsy

Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness

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