Analysis on efficacy of busprione in treatment of anxiety in patients with epilepsy_Journal of Epilepsy

Authors：

Li Fanmin ¹ ,  Wu Mengdong ² , Li Zhiyuan ³

1. Department of Critical Intensive Care, Heze Municipal Hospital, Heze 274000, China;
2. Departmert of Pharmacy, Heze Municipal Hospital, Heze 274000, China;
3. Departhert of Neurology, Heze Municipal Hospital, Heze 274000, China;

Corresponding author：

Wu Mengdong, Email: 2501837752@qq.com

Keywords：

Busprione; Anxiety disorder; Epilepsy

DOI：

10.7507/2096-0247.20170046

Video：

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Objective To evaluate the efficacy and safety of busprione in treatment of anxiety in patients with epilepsy. Methods 122 patients with anxiety accompanied with epilepsy were collected from sep.15, 201 to June 30.2016 in the Department of Neurology in Heze Municipal Hospital, they were randomly divided into busprione group(61 cases)and alprazolam group(61 cases), and treated respectively for 6 weeks.Curative effect were evaluated by the Self-rating anxiety scale (SAS) and Hamilton anxiety scale (HAMA). Adverse reactions in two groups were recorded during the treatment. Results Busprione had same efficacy with alprazolam in anxiety accompanied with epilepsy, and its adverse reaction was milder. Conclusion Busprione is safe and effective for treating anxiety accompanied with epilepsy in short time.

Citation： Li Fanmin, Wu Mengdong, Li Zhiyuan. Analysis on efficacy of busprione in treatment of anxiety in patients with epilepsy. Journal of Epilepsy, 2017, 3(4): 307-309. doi: 10.7507/2096-0247.20170046 Copy

1.	神经系统疾病伴发抑郁焦虑障碍的诊治专家共识组.神经系统疾病伴发抑郁焦虑障碍的诊断治疗专家共识(更新版).中华内科杂志, 2011, 50(09): 799-805.
2.	Viteva EI, Zahariev ZI. Depressivity, anxiety and quality of life in patients with refractory epilepsy. Folia Med(Plovdiv), 2009, 51(3): 42-49.
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5.	常亮, 常靖, 冯石献, 等.癫痫患者伴发焦虑状况及其影响因素研究.中华流行病学杂志, 2012, 33(10): 1098-1099.
6.	陈湛愔, 陈文荣, 林海峰, 等.癫痫患者人格个性因素对情感障碍和认知障影响的研究.中华行为医学与脑科学杂志, 2009, 18(10): 876-879.
7.	周文竹, 董春波, 宋凡, 等.成年癫痫患者伴发焦虑抑郁情绪及相关因素研究.医学与哲学, 2010, 31(11): 56-58.
8.	白杨, 宋凡.癫痫患者共情能力与焦虑抑郁的相关性研究.癫痫杂志, 2017, 3(3): 204-212.
9.	佟晓燕, 王玉平.成年癫痫患者抑郁、焦虑状况及生活质量调查.脑与神经疾病杂志, 2009, 17(02): 123-126.
10.	张婧, 侯钢.丁螺环酮精神药理机制研究进展.临床精神医学杂志, 2012, 22(06): 423-424.

1. 神经系统疾病伴发抑郁焦虑障碍的诊治专家共识组.神经系统疾病伴发抑郁焦虑障碍的诊断治疗专家共识(更新版).中华内科杂志, 2011, 50(09): 799-805.
2. Viteva EI, Zahariev ZI. Depressivity, anxiety and quality of life in patients with refractory epilepsy. Folia Med(Plovdiv), 2009, 51(3): 42-49.
3. 洪震.丙戊酸钠——癫痫治疗一线用药.癫痫杂志, 2017, 3(3): 278-279.
4. 童馨.广泛性焦虑障碍量表(GAD-7) 在中国癫痫患者中的检验.癫痫杂志, 2016, 2(5): 469.
5. 常亮, 常靖, 冯石献, 等.癫痫患者伴发焦虑状况及其影响因素研究.中华流行病学杂志, 2012, 33(10): 1098-1099.
6. 陈湛愔, 陈文荣, 林海峰, 等.癫痫患者人格个性因素对情感障碍和认知障影响的研究.中华行为医学与脑科学杂志, 2009, 18(10): 876-879.
7. 周文竹, 董春波, 宋凡, 等.成年癫痫患者伴发焦虑抑郁情绪及相关因素研究.医学与哲学, 2010, 31(11): 56-58.
8. 白杨, 宋凡.癫痫患者共情能力与焦虑抑郁的相关性研究.癫痫杂志, 2017, 3(3): 204-212.
9. 佟晓燕, 王玉平.成年癫痫患者抑郁、焦虑状况及生活质量调查.脑与神经疾病杂志, 2009, 17(02): 123-126.
10. 张婧, 侯钢.丁螺环酮精神药理机制研究进展.临床精神医学杂志, 2012, 22(06): 423-424.

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