• Department of Neurosurgery, Tangdu Hospital of Air Force Military Medical University, Xian 710038, China;
ZHANG Hua, Email: zhanghuadoc@126.com
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Objective To investigate the efficacy and safety of the phase Ⅰ corpus callosotomy in the treatment of adult refractory epilepsy. Methods We conducted a retrospective analysis of 56 adults with intractable epilepsy in Tangdu Hospital from January 2011 to July 2016.All patients were treated for the phase Ⅰ total corpus callosotomy, followed up 1~5 years after surgery. Results 14 cases (25.0%) patients achieved complete seizure free after surgery, 19 cases (33.9%) whose seizures reduced more than 90%, 10 cases (17.9%) reduced between 50%~90%, 7 cases (12.5%) between 30%~50%, 6 cases (10.7%) decreased below 30%; Drop attacks of 47 cases (83.9%) patients disappeared. Postoperative complications occurred in 13 cases(23.2%), and most of them recovered well. 5 cases(8.9%) had long-term sensory disassociation, no serious complications and death. The percentage of patients reporting improvement in quality of life was 67.9%. Conclusions For patients with intractable epilepsy who can not undergo focal resection, Ⅰ phase total corpus callosotomy has a certain effect on reducing seizure frequency, eliminating drop attacks, and improving the quality of life.

Citation: WANG Weiwen, LIU Bei, LIU Yong, LI Huanfa, JING Xiaorong, DONG Shan, ZHANG Wei, ZHANG Hua. Clinical analysis of phase Ⅰ total corpus callosotomy in adults with intractable epilepsy. Journal of Epilepsy, 2017, 3(6): 470-473. doi: 10.7507/2096-0247.20170074 Copy

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