癫痫网络的定义：立体脑电图和信号分析的贡献_Journal of Epilepsy

Authors：

 BartolomeiF , LagardeS , WendlingF , 郑舒畅　译 , 秦兵　审

Corresponding author：

BartolomeiF, Email: fabrice.bartolomei@ap-hm.fr

Keywords：

立体脑电图; 信号处理; 脑网络; 局灶性癫痫; 功能连接

DOI：

10.7507/2096-0247.20180028

Video：

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致痫网络定义为癫痫放电产生和传播过程中累及的脑区。基于颅内电极电生理数据的分析，文章综述介绍了致痫网络的历史、方法和概念。在癫痫术前评估中，确定产生癫痫发作的脑区（如致痫区）是最重要的目标。较药物难治性局灶性癫痫传统的、局限性的视觉分析方法而言，致痫网络作为一个模型已逐渐得到公认。该模型能更好地描述发作动态演变的复杂性、更真实地描述大脑致痫性的异常分布。致痫网络概念在历史上与立体脑电图（SEEG）方法学的发展及随后脑电信号定量分析相关。SEEG 有明确的发作期、发作前及发作间期放电模式，可以用信号分析方法对上述模式进行分析，如高频振荡定量分析或分析功能连接的改变。我们可以在皮层和皮层下脑区癫痫发生和传播的过程中，依据 SEEG 数据分析得到大脑连接的显著变化，这些变化与不同的发作症状学模式相关。发作间期特征就是致痫网络产生异常电活动（发作间期棘波）及功能连接的改变。致痫网络大尺度建模新方法的引入为更好地预测手术预后提供了新方法。就明确致痫性脑区的分布而言，致痫网络的概念是一个关键的要素，这对癫痫手术尤为重要。

Citation： BartolomeiF, LagardeS, WendlingF, 郑舒畅　译, 秦兵　审. 癫痫网络的定义：立体脑电图和信号分析的贡献. Journal of Epilepsy, 2018, 4(2): 135-149. doi: 10.7507/2096-0247.20180028 Copy

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2. Wendling F, Chauvel P, Biraben A, et al. From intracerebral EEG signals to brain connectivity: identification of epileptogenic networks in partial epilepsy. Front Syst Neurosci, 2010, 4: 154.
3. Laufs H. Functional imaging of seizures and epilepsy: evolution from zones to networks. Curr Opin Neurol, 2012, 25(2): 194-200.
4. Guye M, Bartolomei F, Ranjeva JP. Imaging structural and functional connectivity: towards a unified definition of human brain organization? Curr Opin Neurol, 2008, 21(4): 393-403.
5. Stefan H, Lopes da Silva FH. Epileptic neuronal networks: methods of identification and clinical relevance. Front Neurol, 2013, 4: 8.
6. Bartolomei F, Guye M, Wendling F. Abnormal binding and disruption in large scale networks involved in human partial seizures. EPJ Nonlinear Biomed Phys, 2013, 1: 1-16.
7. Luders HO, Najm I, Nair D, et al. The epileptogenic zone: general principles. Epileptic Disord, 2006, 8(Suppl 2): S1-S9.
8. Panzica F, Varotto G, Rotondi F, et al. Identification of the epileptogenic zone from stereo-EEG signals: a connectivity-graph theory approach. Front Neurol, 2013, 4: 175.
9. Pittau F, Megevand P, Sheybani L, et al. Mapping epileptic activity: sources or networks for the clinicians? Front Neurol, 2014, 5: 218.
10. Bernhardt BC, Hong S, Bernasconi A, et al. Imaging structural and functional brain networks in temporal lobe epilepsy. Front Hum Neurosci, 2013, 7: 624.
11. Bettus G, Ranjeva JP, Wendling F, et al. Interictal functional connectivity of human epileptic networks assessed by intracerebral EEG and BOLD signal fluctuations. PLoS ONE, 2011, 6(5): e20071.
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14. Jehi L, Friedman D, Carlson C, et al. The evolution of epilepsy surgery between, 1991 and, 2011 in nine major epilepsy centers across the United States, Germany, and Australia. Epilepsia, 2015, 56(10): 1526-1533.
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癫痫网络的定义：立体脑电图和信号分析的贡献

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