- 重庆医科大学附属第一医院（周新雨）、复旦大学附属华山医院（洪震、虞培敏）、江西省儿童医院（钟建民）、吉林大学第一医院（林卫红）、山西医科大学第一医院（孙美珍）、上海市精神卫生中心（何燕玲、李冠军）、四川大学华西医院（李劲梅、周东）、温州医科大学附属第一医院（徐惠琴）、浙江大学医学院附属第二医院（丁美萍、郭谊）;
中国抗癫痫协会共患病专业委员会执笔（按单位拼音和姓氏笔画排列，排名不分先后）,
Email: yiguo@zju.edu.cn
Citation： 中国抗癫痫协会共患病专业委员会执笔（按单位拼音和姓氏笔画排列，排名不分先后）. 癫痫伴焦虑诊断治疗的中国专家共识. Journal of Epilepsy, 2018, 4(3): 185-191. doi: 10.7507/2096-0247.20180033 Copy
| 1. | 刘鸣, 刘俊峰. 中国脑血管病指南制定方法及应用. 中华神经科杂志, 2015, 48(4): 241-245. |
| 2. | Rai D, Kerr MP, McManus S, et al. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia, 2012, 53(6): 1095-1103. |
| 3. | Tellez-Zenteno JF, Patten SB, Jetté N, et al. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia, 2007, 48(12): 2336-2344. |
| 4. | Mensah SA, Beavis JM, Thapar AK, et al. A community study of the presence of anxiety disorder in people with epilepsy. Epilepsy Behav, 2007, 11(1): 118-124. |
| 5. | Stefanello S, Marín-Léon L, Fernandes PT et al. Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study. Epilepsia, 2010, 51(7): 1120-1125. |
| 6. | Swinkels WA, Kuyk J, de Graaf EH, et al. Prevalence of psychopathology in dutch epilepsy inpatients: a comparative study. Epilepsy Behav, 2001, 2(5): 441-447. |
| 7. | Jones JE, Hermann BP, Barry JJ, et al. Clinical assessment of axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci, 2005, 17(2): 172-179. |
| 8. | Scott AJ, Sharpe L, Hunt C, et al. Anxiety and depressive disorders in people with epilepsy: A meta-analysis. Epilepsia, 2017, 58(6): 973-982. |
| 9. | 付朝伟, 徐飚, 詹思延, 等. 中国四城市综合医院神经内科患者抑郁焦虑现况研究. 中华流行病学杂志, 2006, 27(9): 803-807. |
| 10. | Yu P, Zhou D, Liao W, et al. An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China. Epilepsy Behav, 2017, 69: 126-132. |
| 11. | Christensen J, Vestergaard M, Mortensen PB, et al. Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol, 2007, 6(8): 693-698. |
| 12. | Munger Clary HM. Anxiety and Epilepsy: what neurologists and epileptologists should know. Curr Neurol Neurosci Rep, 2014, 14(5): 445. |
| 13. | Kwon OY, Park SP. Depression and anxiety in people with epilepsy. J Clin Neurol, 2014, 10(3): 175-188. |
| 14. | Johnson EK, Jones JE, Seidenberg M, et al. The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia, 2004, 45(5): 544-550. |
| 15. | Stahl SM. Brainstorms: symptoms and circuits, part 2: anxiety disorders. J Clin Psychiatry, 2003, 64(12): 1408-1409. |
| 16. | Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med, 2004, 10(7): 685-692. |
| 17. | Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a c ritical review of the evidence. J Clin Psychopharmacol, 2007, 27(3): 263-272. |
| 18. | Savic I, Lindstrom P, Gulyas B, et al. Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy. Neurology, 2004, 62(8): 1343-1351. |
| 19. | Kerr MP, Mensah S, Besag F, et al. International consensus clinical practice statements for the treatment of neuropsychiatric conditions associated with epilepsy. Epilepsia, 2011, 52(11): 2133-2138. |
| 20. | Tong X, An D, McGonigal A, et al. Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy. Epilepsy Res, 2016, 120: 31-36. |
| 21. | 吴文源, 魏镜, 陶明. 综合医院焦虑抑郁诊断和治疗的专家共识. 中华医学杂志, 2012, 92(31): 2174-2181. |
| 22. | 吴冬燕, 虞培敏, 洪震. 癫痫合并焦虑. 中国临床神经科学, 2015, 23(1): 110-114. |
| 23. | Eddy CM, Rickards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol, 2012, 32(3): 362-375. |
| 24. | Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nat Rev Neurol, 2016, 12(2): 106-116. |
| 25. | Brandt C, Mula M. Anxiety disorders in people with epilepsy. Epilepsy Behav, 2016, 59: 87-91. |
| 26. | 吴文源. 焦虑障碍防治指南. 北京: 人民卫生出版社, 2010: 24-48. |
| 27. | Italiano D, Spina E, Leon JD. Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants. Expert Opin Drug Metab Toxicol, 2014, 10(11): 1457-1489. |
| 28. | 神经系统疾病伴发抑郁焦虑障碍的诊治专家共识组. 神经系统疾病伴发抑郁焦虑障碍的诊断治疗专家共识(更新版). 中华内科杂志., 2011, 50(9):799-805. |
| 29. | Aliyev NA, Aliyev ZN. Valproate (depakine-chrono) in the acute treatment of outpatients with generalized anxiety disorder without psychiatric comorbidity: randomized, double-blind placebo-controlled study. Eur Psychiatry, 2008, 23(2): 109-114. |
| 30. | Pande AC, Pollack MH, Crockatt J, et al. Placebo-controlled study of gabapentin treatment of panic disorder. J Clin Psychopharmacol, 2000, 20(4): 467-471. |
| 31. | Uhde TW, Stein MB, Post RM. Lack of efficacy of carbamazepine in the treatment of panic disorder. Am J Psychiatry, 1988, 145(9): 1104-1109. |
| 32. | Tondo L, Burrai C, Scamonatti L, et al. Carbamazepine in panic disorder. Am J Psychiatry, 1989, 146(4): 558-559. |
| 33. | Windhaber J, Maierhofer D, Dantendorfer K. Oxcarbazepine for panic disorder occurring after two grand mal seizures: a case report. J Clin Psychiatry, 1997, 58(9): 404-405. |
| 34. | Dantendorfer K, Frey R, Maierhofer D, et al. Sudden arousals from slow wave sleep and panic disorder: successful treatment with anticonvulsants: a case report. Sleep, 1996, 19(9): 744-746. |
| 35. | Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the british association for psychopharmacology. J Psychopharmacol, 2014, 28(5): 403-439. |
| 36. | Mula M. Treatment of anxiety disorders in epilepsy: an evidence-based approach. Epilepsia, 2013, 54(Suppl 1):13-18. |
| 37. | Pintor L, Baillés E, Matrai S, et al. Efficiency of venlafaxine in patients with psychogenic nonepileptic seizures and anxiety and/or depressive disorders. J Neuropsychiatry Clin Neurosci, 2010, 22(4): 401-408. |
| 38. | Baldwin DS, Waldman S, Allgulander C. Evidence-based pharmacological treatment of generalized anxiety disorder. Int J Neuropsychopharmacol, 2011, 14(4): 697-710. |
| 39. | Harrison CL, Ferrier N, Young AH. Tolerability of high-dose venlafaxine in depressed patients. J Psychopharmacol, 2004, 18(2): 200-204. |
| 40. | Thase ME. Effects of venlafaxine on blood pressure: A meta-analysis of original data from 3744 depressed patients. J Clin Psychiatry. 1998, 59(10): 502-508. |
| 41. | Martin JL, Sainz-Pardo M, Furukawa TA, et al. Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol, 2007, 21(7): 774-782. |
| 42. | Dell’Osso B, Lader M. Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? a critical reappraisal. Eur Psychiatry, 2012, 28(1): 7-20. |
| 43. | Gammans RE, Stringfellow JC, Hvizdos AJ, et al. Use of buspirone in patients with generalized anxiety disorder and coexisting depressive symptoms. Neuropsychobiology, 1992, 25(4): 193-201. |
| 44. | 陶明, 韩耀静, 高静芳, 等. 坦度螺酮治疗青少年焦虑障碍的开放性研究. 中华医学杂志. 2012, 92(13): 920-923. |
| 45. | Tolin D. Is cognitive-behavioral therapy more effective than other therapies? a meta-analytic review. Clin Psychol Revi, 2010, 30(6): 710-720. |
| 46. | Spence S, Donovan C, March S, et al. A randomized controlled trial of online versus clinic-based cbt for adolescent anxiety. J Consult Clin Psychol, 2011, 79(5): 629-642. |
| 47. | Keefe J, Mccarthy K, Dinger U, et al. A meta-analytic review of psychodynamic therapies for anxiety disorders. Clin Psychol Rev, 2014, 34(4): 309-323. |
| 48. | Markowitz J, Lipsitz J, Milrod B, et al. Critical review of outcome research on interpersonal psychotherapy for anxiety disorder. Depress Anxiety, 2014, 31(4): 316-325. |
| 49. | Dunn DW, Besag F, Caplan R, et al. Psychiatric and behavioural disorders in children with epilepsy (ILAE Task Force Report): Anxiety, depression and childhood epilepsy. Epileptic Disord, 2016, 18 (Suppl. 1): 24-30. |
| 50. | Beesdo K, Dipl-Psycha SK, Pine DS, et al. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatr Clin North Am, 2009, 32(3): 483-524. |
| 51. | 任颖, 苏林雁, 黄广文, 等. 儿童焦虑障碍的行为特征. 中国临床康复, 2005, 9(8): 94-95. |
| 52. | Katzman MA, Bleau P, Blier P, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry, 2014, 14(Suppl 1): 1-83. |
- 1. 刘鸣, 刘俊峰. 中国脑血管病指南制定方法及应用. 中华神经科杂志, 2015, 48(4): 241-245.
- 2. Rai D, Kerr MP, McManus S, et al. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia, 2012, 53(6): 1095-1103.
- 3. Tellez-Zenteno JF, Patten SB, Jetté N, et al. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia, 2007, 48(12): 2336-2344.
- 4. Mensah SA, Beavis JM, Thapar AK, et al. A community study of the presence of anxiety disorder in people with epilepsy. Epilepsy Behav, 2007, 11(1): 118-124.
- 5. Stefanello S, Marín-Léon L, Fernandes PT et al. Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study. Epilepsia, 2010, 51(7): 1120-1125.
- 6. Swinkels WA, Kuyk J, de Graaf EH, et al. Prevalence of psychopathology in dutch epilepsy inpatients: a comparative study. Epilepsy Behav, 2001, 2(5): 441-447.
- 7. Jones JE, Hermann BP, Barry JJ, et al. Clinical assessment of axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci, 2005, 17(2): 172-179.
- 8. Scott AJ, Sharpe L, Hunt C, et al. Anxiety and depressive disorders in people with epilepsy: A meta-analysis. Epilepsia, 2017, 58(6): 973-982.
- 9. 付朝伟, 徐飚, 詹思延, 等. 中国四城市综合医院神经内科患者抑郁焦虑现况研究. 中华流行病学杂志, 2006, 27(9): 803-807.
- 10. Yu P, Zhou D, Liao W, et al. An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China. Epilepsy Behav, 2017, 69: 126-132.
- 11. Christensen J, Vestergaard M, Mortensen PB, et al. Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol, 2007, 6(8): 693-698.
- 12. Munger Clary HM. Anxiety and Epilepsy: what neurologists and epileptologists should know. Curr Neurol Neurosci Rep, 2014, 14(5): 445.
- 13. Kwon OY, Park SP. Depression and anxiety in people with epilepsy. J Clin Neurol, 2014, 10(3): 175-188.
- 14. Johnson EK, Jones JE, Seidenberg M, et al. The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia, 2004, 45(5): 544-550.
- 15. Stahl SM. Brainstorms: symptoms and circuits, part 2: anxiety disorders. J Clin Psychiatry, 2003, 64(12): 1408-1409.
- 16. Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med, 2004, 10(7): 685-692.
- 17. Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a c ritical review of the evidence. J Clin Psychopharmacol, 2007, 27(3): 263-272.
- 18. Savic I, Lindstrom P, Gulyas B, et al. Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy. Neurology, 2004, 62(8): 1343-1351.
- 19. Kerr MP, Mensah S, Besag F, et al. International consensus clinical practice statements for the treatment of neuropsychiatric conditions associated with epilepsy. Epilepsia, 2011, 52(11): 2133-2138.
- 20. Tong X, An D, McGonigal A, et al. Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy. Epilepsy Res, 2016, 120: 31-36.
- 21. 吴文源, 魏镜, 陶明. 综合医院焦虑抑郁诊断和治疗的专家共识. 中华医学杂志, 2012, 92(31): 2174-2181.
- 22. 吴冬燕, 虞培敏, 洪震. 癫痫合并焦虑. 中国临床神经科学, 2015, 23(1): 110-114.
- 23. Eddy CM, Rickards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol, 2012, 32(3): 362-375.
- 24. Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nat Rev Neurol, 2016, 12(2): 106-116.
- 25. Brandt C, Mula M. Anxiety disorders in people with epilepsy. Epilepsy Behav, 2016, 59: 87-91.
- 26. 吴文源. 焦虑障碍防治指南. 北京: 人民卫生出版社, 2010: 24-48.
- 27. Italiano D, Spina E, Leon JD. Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants. Expert Opin Drug Metab Toxicol, 2014, 10(11): 1457-1489.
- 28. 神经系统疾病伴发抑郁焦虑障碍的诊治专家共识组. 神经系统疾病伴发抑郁焦虑障碍的诊断治疗专家共识(更新版). 中华内科杂志., 2011, 50(9):799-805.
- 29. Aliyev NA, Aliyev ZN. Valproate (depakine-chrono) in the acute treatment of outpatients with generalized anxiety disorder without psychiatric comorbidity: randomized, double-blind placebo-controlled study. Eur Psychiatry, 2008, 23(2): 109-114.
- 30. Pande AC, Pollack MH, Crockatt J, et al. Placebo-controlled study of gabapentin treatment of panic disorder. J Clin Psychopharmacol, 2000, 20(4): 467-471.
- 31. Uhde TW, Stein MB, Post RM. Lack of efficacy of carbamazepine in the treatment of panic disorder. Am J Psychiatry, 1988, 145(9): 1104-1109.
- 32. Tondo L, Burrai C, Scamonatti L, et al. Carbamazepine in panic disorder. Am J Psychiatry, 1989, 146(4): 558-559.
- 33. Windhaber J, Maierhofer D, Dantendorfer K. Oxcarbazepine for panic disorder occurring after two grand mal seizures: a case report. J Clin Psychiatry, 1997, 58(9): 404-405.
- 34. Dantendorfer K, Frey R, Maierhofer D, et al. Sudden arousals from slow wave sleep and panic disorder: successful treatment with anticonvulsants: a case report. Sleep, 1996, 19(9): 744-746.
- 35. Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the british association for psychopharmacology. J Psychopharmacol, 2014, 28(5): 403-439.
- 36. Mula M. Treatment of anxiety disorders in epilepsy: an evidence-based approach. Epilepsia, 2013, 54(Suppl 1):13-18.
- 37. Pintor L, Baillés E, Matrai S, et al. Efficiency of venlafaxine in patients with psychogenic nonepileptic seizures and anxiety and/or depressive disorders. J Neuropsychiatry Clin Neurosci, 2010, 22(4): 401-408.
- 38. Baldwin DS, Waldman S, Allgulander C. Evidence-based pharmacological treatment of generalized anxiety disorder. Int J Neuropsychopharmacol, 2011, 14(4): 697-710.
- 39. Harrison CL, Ferrier N, Young AH. Tolerability of high-dose venlafaxine in depressed patients. J Psychopharmacol, 2004, 18(2): 200-204.
- 40. Thase ME. Effects of venlafaxine on blood pressure: A meta-analysis of original data from 3744 depressed patients. J Clin Psychiatry. 1998, 59(10): 502-508.
- 41. Martin JL, Sainz-Pardo M, Furukawa TA, et al. Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol, 2007, 21(7): 774-782.
- 42. Dell’Osso B, Lader M. Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? a critical reappraisal. Eur Psychiatry, 2012, 28(1): 7-20.
- 43. Gammans RE, Stringfellow JC, Hvizdos AJ, et al. Use of buspirone in patients with generalized anxiety disorder and coexisting depressive symptoms. Neuropsychobiology, 1992, 25(4): 193-201.
- 44. 陶明, 韩耀静, 高静芳, 等. 坦度螺酮治疗青少年焦虑障碍的开放性研究. 中华医学杂志. 2012, 92(13): 920-923.
- 45. Tolin D. Is cognitive-behavioral therapy more effective than other therapies? a meta-analytic review. Clin Psychol Revi, 2010, 30(6): 710-720.
- 46. Spence S, Donovan C, March S, et al. A randomized controlled trial of online versus clinic-based cbt for adolescent anxiety. J Consult Clin Psychol, 2011, 79(5): 629-642.
- 47. Keefe J, Mccarthy K, Dinger U, et al. A meta-analytic review of psychodynamic therapies for anxiety disorders. Clin Psychol Rev, 2014, 34(4): 309-323.
- 48. Markowitz J, Lipsitz J, Milrod B, et al. Critical review of outcome research on interpersonal psychotherapy for anxiety disorder. Depress Anxiety, 2014, 31(4): 316-325.
- 49. Dunn DW, Besag F, Caplan R, et al. Psychiatric and behavioural disorders in children with epilepsy (ILAE Task Force Report): Anxiety, depression and childhood epilepsy. Epileptic Disord, 2016, 18 (Suppl. 1): 24-30.
- 50. Beesdo K, Dipl-Psycha SK, Pine DS, et al. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatr Clin North Am, 2009, 32(3): 483-524.
- 51. 任颖, 苏林雁, 黄广文, 等. 儿童焦虑障碍的行为特征. 中国临床康复, 2005, 9(8): 94-95.
- 52. Katzman MA, Bleau P, Blier P, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry, 2014, 14(Suppl 1): 1-83.