迷走神经刺激术治疗药物难治性癫痫中影响治疗效果的相关因素分析_Journal of Epilepsy

Authors：

熊金彪 ¹ , 曹艺耀 ¹ , 陈旨娟 ¹ , 毓青 ² ,  杨卫东 ¹

1. ;
2. ;

Corresponding author：

杨卫东, Email: yangweidongshine@sina.com

Keywords：

迷走神经刺激术; 癫痫; 预后; 影响因素

DOI：

10.7507/2096-0247.20180040

Video：

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迷走神经刺激术（Vagus nerve stimulation，VNS）自 1997 年经美国食品药品监督局批准以来，应用越来越广泛，目前为止，全世界约有 80 000 多例药物难治性癫痫患者接受了 VNS 治疗。大量文献证实，VNS 不仅能减少药物难治性癫痫患者的发作频率，还能减轻癫痫发作严重程度、缩短发作的持续时间或发作后的恢复时间，改善患者生活质量。尽管如此，仍有一部分药物难治性癫痫患者 VNS 治疗效果不理想，甚至无效。为此，选择适合 VNS 治疗的患者，术前根据相关影响因素预测治疗效果尤为重要。文章以综述形式阐述可能影响 VNS 治疗癫痫效果的因素。

Citation： 熊金彪, 曹艺耀, 陈旨娟, 毓青, 杨卫东. 迷走神经刺激术治疗药物难治性癫痫中影响治疗效果的相关因素分析. Journal of Epilepsy, 2018, 4(3): 229-233. doi: 10.7507/2096-0247.20180040 Copy

1.	Liu H, Yang Z, Huang L, et al. Heart-rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug-resistant epilepsy. Epilepsia, 2017, 58(6): 1015-1022.
2.	Shahwan A, Bailey C, Maxiner W, et al. Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction. Epilepsia, 2009, 50(5): 1220-1228.
3.	Renfroe JB, Wheless JW. Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsy. Neurology, 2002, 59(6 Suppl 4): 26-30.
4.	Hallbook T, Lundgren J, Stjernqvist K, et al. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure, 2005, 14(7): 504-513.
5.	Helmers SL, Duh MS, Guerin A, et al. Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy. Eur J Paediatr Neurol, 2012, 16(5): 449-458.
6.	Majoie HJ, Berfelo MW, Aldenkamp AP, et al. Vagus nerve stimulation in patients with catastrophic childhood epilepsy, a 2-year follow-up study. Seizure, 2005, 14(1): 10-18.
7.	Casazza M, Avanzini G, Ferroli P, et al. Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern. Seizure, 2006, 15(3): 198-207.
8.	Holmes MD, Silbergeld DL, Drouhard D, et al. Effect of vagus nerve stimulation on adults with pharmacoresistant generalized epilepsy syndromes. Seizure, 2004, 13(5): 340-345.
9.	Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg, 2011, 115(6): 1248-1255.
10.	Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
11.	Ardesch JJ, Buschman HP, Wagener-Schimmel LJ, et al. Vagus nerve stimulation for medically refractory epilepsy: a long-term follow-up study. Seizure, 2007, 16(7): 579-585.
12.	Arhan E, Serdaroglu A, Kurt G, et al. The efficacy of vagal nerve stimulation in children with pharmacoresistant epilepsy: practical experience at a Turkish tertiary referral center. Eur J Paediatr Neurol, 2010, 14(4): 334-339.
13.	Choi SJ, Hong SC, Seo DW, et al. Long-Term outcome of vagus nerve stimulation for refractory epilepsy: A longitudinal 4 year follow-up study in korea. J Epilepsy Res, 2013, 3(1): 16-20.
14.	Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav, 2011, 20(1): 57-63.
15.	Kabir SM, Rajaraman C, Rittey C, et al. Vagus nerve stimulation in children with intractable epilepsy: indications, complications and outcome. Childs Nerv Syst, 2009, 25(9): 1097-1100.
16.	Kim MJ, Yum MS, Kim EH, et al. An interictal EEG can predict the outcome of vagus nerve stimulation therapy for children with intractable epilepsy. Childs Nerv Syst, 2017, 33(1): 145-151.
17.	Serdaroglu A, Arhan E, Kurt G, et al. Long term effect of vagus nerve stimulation in pediatric intractable epilepsy: an extended follow-up. Childs Nerv Syst, 2016, 32(4): 641-646.
18.	Siddiqui F, Herial NA, Ali, Ii. Cumulative effect of vagus nerve stimulators on intractable seizures observed over a period of 3years. Epilepsy Behav, 2010, 18(3): 299-302.
19.	Namgung WC, Ko TS, Lee SA, et al. Vagus nerve stimulation for intractable epilepsy: outcomes in children and adults. Neuromodulation, 2010, 13(1): 44-49.
20.	Wheeler M, De Herdt V, Vonck K, et al. Efficacy of vagus nerve stimulation for refractory epilepsy among patient subgroups: a re-analysis using the engel classification. Seizure, 2011, 20(4): 331-335.
21.	Murphy J, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: the first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560-564.
22.	Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2017, 79(2): 152-158.
23.	Helmers SL, Griesemer DA, Dean JC, et al. Observations on the use of vagus nerve stimulation earlier in the course of pharmacoresistant epilepsy: patients with seizures for six years or less. Neurologist, 2003, 9(3): 160-164.
24.	Colicchio G, Policicchio D, Barbati G, et al. Vagal nerve stimulation for drug-resistant epilepsies in different age, aetiology and duration. Childs Nerv Syst, 2010, 26(6): 811-819.
25.	Klinkenberg S, Aalbers MW, Vles JS, et al. Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial. Dev Med Child Neurol, 2012, 54(9): 855-861.
26.	Thompson EM, Wozniak SE, Roberts CM, et al. Vagus nerve stimulation for partial and generalized epilepsy from infancy to adolescence. J Neurosurg Pediatr, 2012, 10(3): 200-205.
27.	Meng FG, Jia FM, Ren XH, et al. Vagus nerve stimulation for pediatric and adult patients with pharmaco-resistant epilepsy. Chin Med J (Engl), 2015, 128(19): 2599-2604.
28.	Lagae L, Verstrepen A, Nada A, et al. Vagus nerve stimulation in children with drug-resistant epilepsy: age at implantation and shorter duration of epilepsy as predictors of better efficacy?. Epileptic Disord, 2015, 17(3): 308-314.
29.	Amar AP, Apuzzo ML. Vagus nerve stimulation therapy for patients with persistent seizures after epilepsy surgery. Stereotact Funct Neurosurg, 2003, 80(1-4): 9-13.
30.	Elliott RE, Morsi A, Geller EB, et al. Impact of failed intracranial epilepsy surgery on the effectiveness of subsequent vagus nerve stimulation. Neurosurgery, 2011, 69(6): 1210-1217.
31.	Rychlicki F, Zamponi N, Trignani R, et al. Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients. Seizure, 2006, 15(7): 483-490.
32.	De Herdt V, Boon P, Ceulemans B, et al. Vagus nerve stimulation for refractory epilepsy: a belgian multicenter study. Eur J Paediatr Neurol, 2007, 11(5): 261-269.
33.	Arcos A, Romero L, Gelabert M, et al. Can we predict the response in the treatment of epilepsy with vagus nerve stimulation?. Neurosurg Rev, 2014, 37(4): 661-668.
34.	李世绰, 洪震. 临床诊疗指南·癫痫病分册. 2 版 (修订本). 北京: 人民卫生出版社, 2015: 6.
35.	王焕明, 胡飞, 陈俊. 迷走神经刺激术治疗一例顽固性癫痫. 癫痫杂志, 2017, 3(5): 452-454.
36.	Zamponi N, Passamonti C, Cesaroni E, et al. Effectiveness of vagal nerve stimulation (VNS) in patients with drop-attacks and different epileptic syndromes. Seizure, 2011, 20(6): 468-474.
37.	Janszky J, Hoppe M, Behne F, et al. Vagus nerve stimulation: predictors of seizure freedom. J Neurol Neurosurg Psychiatry, 2005, 76(3): 384-389.
38.	Ghaemi K, Elsharkawy AE, Schulz R, et al. Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up. Seizure-European Journal of Epilepsy, 2010, 19(5): 264-268.
39.	Abd-El-Barr MM, Joseph JR, Schultz R, et al. Vagus nerve stimulation for drop attacks in a pediatric population. Epilepsy Behav, 2010, 19(3): 394-399.
40.	Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for classification and terminology. Epilepsia, 2017, 58(4): 522-530.
41.	Englot DJ, Rolston JD, Wang DD, et al. Efficacy of vagus nerve stimulation in posttraumatic versus nontraumatic epilepsy. J Neurosurg, 2012, 117(5): 970-977.
42.	Arya R, Greiner HM, Lewis A, et al. Predictors of response to vagus nerve stimulation in childhood-onset medically refractory epilepsy. J Child Neurol, 2014, 29(12): 1652-1659.
43.	Fernandez L, Gedela S, Tamber M, et al. Vagus nerve stimulation in children less than 3 years with medically intractable epilepsy. Epilepsy Res, 2015, 112: 37-42.

1. Liu H, Yang Z, Huang L, et al. Heart-rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug-resistant epilepsy. Epilepsia, 2017, 58(6): 1015-1022.
2. Shahwan A, Bailey C, Maxiner W, et al. Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction. Epilepsia, 2009, 50(5): 1220-1228.
3. Renfroe JB, Wheless JW. Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsy. Neurology, 2002, 59(6 Suppl 4): 26-30.
4. Hallbook T, Lundgren J, Stjernqvist K, et al. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure, 2005, 14(7): 504-513.
5. Helmers SL, Duh MS, Guerin A, et al. Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy. Eur J Paediatr Neurol, 2012, 16(5): 449-458.
6. Majoie HJ, Berfelo MW, Aldenkamp AP, et al. Vagus nerve stimulation in patients with catastrophic childhood epilepsy, a 2-year follow-up study. Seizure, 2005, 14(1): 10-18.
7. Casazza M, Avanzini G, Ferroli P, et al. Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern. Seizure, 2006, 15(3): 198-207.
8. Holmes MD, Silbergeld DL, Drouhard D, et al. Effect of vagus nerve stimulation on adults with pharmacoresistant generalized epilepsy syndromes. Seizure, 2004, 13(5): 340-345.
9. Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg, 2011, 115(6): 1248-1255.
10. Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
11. Ardesch JJ, Buschman HP, Wagener-Schimmel LJ, et al. Vagus nerve stimulation for medically refractory epilepsy: a long-term follow-up study. Seizure, 2007, 16(7): 579-585.
12. Arhan E, Serdaroglu A, Kurt G, et al. The efficacy of vagal nerve stimulation in children with pharmacoresistant epilepsy: practical experience at a Turkish tertiary referral center. Eur J Paediatr Neurol, 2010, 14(4): 334-339.
13. Choi SJ, Hong SC, Seo DW, et al. Long-Term outcome of vagus nerve stimulation for refractory epilepsy: A longitudinal 4 year follow-up study in korea. J Epilepsy Res, 2013, 3(1): 16-20.
14. Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav, 2011, 20(1): 57-63.
15. Kabir SM, Rajaraman C, Rittey C, et al. Vagus nerve stimulation in children with intractable epilepsy: indications, complications and outcome. Childs Nerv Syst, 2009, 25(9): 1097-1100.
16. Kim MJ, Yum MS, Kim EH, et al. An interictal EEG can predict the outcome of vagus nerve stimulation therapy for children with intractable epilepsy. Childs Nerv Syst, 2017, 33(1): 145-151.
17. Serdaroglu A, Arhan E, Kurt G, et al. Long term effect of vagus nerve stimulation in pediatric intractable epilepsy: an extended follow-up. Childs Nerv Syst, 2016, 32(4): 641-646.
18. Siddiqui F, Herial NA, Ali, Ii. Cumulative effect of vagus nerve stimulators on intractable seizures observed over a period of 3years. Epilepsy Behav, 2010, 18(3): 299-302.
19. Namgung WC, Ko TS, Lee SA, et al. Vagus nerve stimulation for intractable epilepsy: outcomes in children and adults. Neuromodulation, 2010, 13(1): 44-49.
20. Wheeler M, De Herdt V, Vonck K, et al. Efficacy of vagus nerve stimulation for refractory epilepsy among patient subgroups: a re-analysis using the engel classification. Seizure, 2011, 20(4): 331-335.
21. Murphy J, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: the first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560-564.
22. Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2017, 79(2): 152-158.
23. Helmers SL, Griesemer DA, Dean JC, et al. Observations on the use of vagus nerve stimulation earlier in the course of pharmacoresistant epilepsy: patients with seizures for six years or less. Neurologist, 2003, 9(3): 160-164.
24. Colicchio G, Policicchio D, Barbati G, et al. Vagal nerve stimulation for drug-resistant epilepsies in different age, aetiology and duration. Childs Nerv Syst, 2010, 26(6): 811-819.
25. Klinkenberg S, Aalbers MW, Vles JS, et al. Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial. Dev Med Child Neurol, 2012, 54(9): 855-861.
26. Thompson EM, Wozniak SE, Roberts CM, et al. Vagus nerve stimulation for partial and generalized epilepsy from infancy to adolescence. J Neurosurg Pediatr, 2012, 10(3): 200-205.
27. Meng FG, Jia FM, Ren XH, et al. Vagus nerve stimulation for pediatric and adult patients with pharmaco-resistant epilepsy. Chin Med J (Engl), 2015, 128(19): 2599-2604.
28. Lagae L, Verstrepen A, Nada A, et al. Vagus nerve stimulation in children with drug-resistant epilepsy: age at implantation and shorter duration of epilepsy as predictors of better efficacy?. Epileptic Disord, 2015, 17(3): 308-314.
29. Amar AP, Apuzzo ML. Vagus nerve stimulation therapy for patients with persistent seizures after epilepsy surgery. Stereotact Funct Neurosurg, 2003, 80(1-4): 9-13.
30. Elliott RE, Morsi A, Geller EB, et al. Impact of failed intracranial epilepsy surgery on the effectiveness of subsequent vagus nerve stimulation. Neurosurgery, 2011, 69(6): 1210-1217.
31. Rychlicki F, Zamponi N, Trignani R, et al. Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients. Seizure, 2006, 15(7): 483-490.
32. De Herdt V, Boon P, Ceulemans B, et al. Vagus nerve stimulation for refractory epilepsy: a belgian multicenter study. Eur J Paediatr Neurol, 2007, 11(5): 261-269.
33. Arcos A, Romero L, Gelabert M, et al. Can we predict the response in the treatment of epilepsy with vagus nerve stimulation?. Neurosurg Rev, 2014, 37(4): 661-668.
34. 李世绰, 洪震. 临床诊疗指南·癫痫病分册. 2 版 (修订本). 北京: 人民卫生出版社, 2015: 6.
35. 王焕明, 胡飞, 陈俊. 迷走神经刺激术治疗一例顽固性癫痫. 癫痫杂志, 2017, 3(5): 452-454.
36. Zamponi N, Passamonti C, Cesaroni E, et al. Effectiveness of vagal nerve stimulation (VNS) in patients with drop-attacks and different epileptic syndromes. Seizure, 2011, 20(6): 468-474.
37. Janszky J, Hoppe M, Behne F, et al. Vagus nerve stimulation: predictors of seizure freedom. J Neurol Neurosurg Psychiatry, 2005, 76(3): 384-389.
38. Ghaemi K, Elsharkawy AE, Schulz R, et al. Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up. Seizure-European Journal of Epilepsy, 2010, 19(5): 264-268.
39. Abd-El-Barr MM, Joseph JR, Schultz R, et al. Vagus nerve stimulation for drop attacks in a pediatric population. Epilepsy Behav, 2010, 19(3): 394-399.
40. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for classification and terminology. Epilepsia, 2017, 58(4): 522-530.
41. Englot DJ, Rolston JD, Wang DD, et al. Efficacy of vagus nerve stimulation in posttraumatic versus nontraumatic epilepsy. J Neurosurg, 2012, 117(5): 970-977.
42. Arya R, Greiner HM, Lewis A, et al. Predictors of response to vagus nerve stimulation in childhood-onset medically refractory epilepsy. J Child Neurol, 2014, 29(12): 1652-1659.
43. Fernandez L, Gedela S, Tamber M, et al. Vagus nerve stimulation in children less than 3 years with medically intractable epilepsy. Epilepsy Res, 2015, 112: 37-42.

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