脑电图在新生儿惊厥诊断中的应用_Journal of Epilepsy

Authors：

韩烨 , 符娜 ,  秦炯

北京大学人民医院儿科（北京 100044）;

Corresponding author：

秦炯, Email: qinjiong@263.com

Keywords：

新生儿; 惊厥; 脑电图

DOI：

10.7507/2096-0247.20180041

Video：

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脑电图（EEG）是新生儿惊厥的重要检测手段。新生儿神经系统处于不断发育的过程，与之相应；EEG 表现为与受孕龄相关的动态变化。应避免将与发育成熟度相关的波形误认为痫性电活动。新生儿惊厥的 EEG 异常包括发作间期与发作期异常，发作间期背景活动是评价预后的可靠指标。确定某种波形是否为发作期放电时，应结合其出现的部位、频率、形态等特征综合判断。

Citation： 韩烨, 符娜, 秦炯. 脑电图在新生儿惊厥诊断中的应用. Journal of Epilepsy, 2018, 4(3): 234-237. doi: 10.7507/2096-0247.20180041 Copy

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2.	Selton D, Andre M, Hascoët JM. Normal EEG in very premature infants: reference criteria. Clin Neurophysiol, 2000, 111(12): 2116-2124.
3.	Tsuchida TN, Wusthoff CJ, Shellhaas RA, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the american clinical neurophysiology society critical care monitoring committee. J Clin Neurophysiol, 2013, 30(2): 161-173.
4.	André M, Lamblin MD, D’Allest AM, et al. Electroencephalography in premature and full-term infants. Developmental features and glossary. Neurophysiol Clin, 2010, 40(2): 59-124.
5.	Vasudevan C, Levene M. Epidemiology and aetiology of neonatal seizures. Semin Fetal Neonatal Med, 2013, 18(4): 185-191.
6.	Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
7.	Shah DK, Mackay MT, Lavery S, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics, 2008, 121(6): 1146-1154.
8.	Scher MS, Alvin J, Gaus L, et al. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol, 2003, 28(4): 277-280.
9.	Glass HC. Neonatal seizures: advances in mechanisms and management. Clin Perinatol, 2014, 41(1): 177-190.
10.	Volpe JJ. Neonatal seizures: current concepts and revised classification. Pediatrics, 1989, 84(3): 422-428.
11.	Kanhere S. Recent advances in neonatal seizures. Indian J Pediatr, 2014, 81(9): 917-925.
12.	Scher MS, Aso K, Beggarly ME, et al. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics, 1993, 91(1): 128-134.
13.	Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology, 1987, 37(12): 1837-1844.
14.	Lai YH, Ho CS, Chiu NC, et al. Prognostic factors of developmental outcome in neonatal seizures in term infants. Pediatr Neonatol, 2013, 54(3): 166-172.
15.	Laroia N, Guillet R, Burchfiel J, et al. EEG Background as predictor of electrographic seizures in high-risk neonates. Epilepsia, 2010, 39(5): 545-551.
16.	Garfinkle J, Shevell MI. Prognostic factors and development of a scoring system for outcome of neonatal seizures in term infants. Eur J Paediatr Neurol, 2011, 15(3): 222-229.
17.	Almubarak S, Wong PK. Long-term clinical outcome of neonatal EEG findings. J Clin Neurophysiol, 2011, 28(2): 185-189.
18.	Tsuchida TN. EEG background patterns and prognostication of neonatal encephalopathy in the era of hypothermia. J Clin Neurophysiol, 2013, 30(2): 122-125.
19.	Holmes GL, Lombroso CT. Prognostic value of background patterns in the neonatal EEG. J Clin Neurophysiol, 1993, 10(3): 323-352.
20.	Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia, 2010, 51(4): 676-685.
21.	Lee IC, Yang JJ, Li SY. AKCNQ2 E515D mutation associated with benign familial neonatal seizures and continuous spike and waves during slow-wave sleep syndrome in Taiwan. J Formos Med Assoc, 2017, 116(9): 711-719.
22.	Hart AR, Pilling EL, Alix JJ. Neonatal seizures-part 2: Aetiology of acute symptomatic seizures, treatments and the neonatal epilepsy syndromes. Arch Dis Child Educ Pract Ed, 2015, 100(5): 226-232.
23.	Cohen R, Baselvanagaite L, Goldbergstern H, et al. Two siblings with early infantile myoclonic encephalopathy due to mutation in the gene encoding mitochondrial glutamate/H+ symporter SLC25A22. Eur J Paediatr Neurol, 2014, 18(6): 801-805.
24.	Backx L, Ceulemans B, Vermeesch JR, et al. Early myoclonic encephalopathy caused by a disruption of the neuregulin-1 receptor ErbB4. Eur J Hum Genet, 2009, 17(3): 378-382.
25.	Kato M, Saitsu H, Murakami Y, et al. PIGA mutations cause early-onset epileptic encephalopathies and distinctive features. Neurology, 2014, 82(18): 1587-1596.
26.	张赟健, 周水珍. 早发性癫痫性脑病基因突变研究与诊治. 中国实用儿科杂志, 2015(7): 492-497.
27.	Beal JC, Cherian K, Moshe SL. Early-onset epileptic encephalopathies: ohtahara syndrome and early myoclonic encephalopathy. Pediatr Neurol, 2012, 47(5): 317-323.

1. Dereymaeker A, Pillay K, Vervisch J, et al. Review of sleep-EEG in preterm and term neonates. Early Hum Dev, 2017, 113: 87-103.
2. Selton D, Andre M, Hascoët JM. Normal EEG in very premature infants: reference criteria. Clin Neurophysiol, 2000, 111(12): 2116-2124.
3. Tsuchida TN, Wusthoff CJ, Shellhaas RA, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the american clinical neurophysiology society critical care monitoring committee. J Clin Neurophysiol, 2013, 30(2): 161-173.
4. André M, Lamblin MD, D’Allest AM, et al. Electroencephalography in premature and full-term infants. Developmental features and glossary. Neurophysiol Clin, 2010, 40(2): 59-124.
5. Vasudevan C, Levene M. Epidemiology and aetiology of neonatal seizures. Semin Fetal Neonatal Med, 2013, 18(4): 185-191.
6. Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
7. Shah DK, Mackay MT, Lavery S, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics, 2008, 121(6): 1146-1154.
8. Scher MS, Alvin J, Gaus L, et al. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol, 2003, 28(4): 277-280.
9. Glass HC. Neonatal seizures: advances in mechanisms and management. Clin Perinatol, 2014, 41(1): 177-190.
10. Volpe JJ. Neonatal seizures: current concepts and revised classification. Pediatrics, 1989, 84(3): 422-428.
11. Kanhere S. Recent advances in neonatal seizures. Indian J Pediatr, 2014, 81(9): 917-925.
12. Scher MS, Aso K, Beggarly ME, et al. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics, 1993, 91(1): 128-134.
13. Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology, 1987, 37(12): 1837-1844.
14. Lai YH, Ho CS, Chiu NC, et al. Prognostic factors of developmental outcome in neonatal seizures in term infants. Pediatr Neonatol, 2013, 54(3): 166-172.
15. Laroia N, Guillet R, Burchfiel J, et al. EEG Background as predictor of electrographic seizures in high-risk neonates. Epilepsia, 2010, 39(5): 545-551.
16. Garfinkle J, Shevell MI. Prognostic factors and development of a scoring system for outcome of neonatal seizures in term infants. Eur J Paediatr Neurol, 2011, 15(3): 222-229.
17. Almubarak S, Wong PK. Long-term clinical outcome of neonatal EEG findings. J Clin Neurophysiol, 2011, 28(2): 185-189.
18. Tsuchida TN. EEG background patterns and prognostication of neonatal encephalopathy in the era of hypothermia. J Clin Neurophysiol, 2013, 30(2): 122-125.
19. Holmes GL, Lombroso CT. Prognostic value of background patterns in the neonatal EEG. J Clin Neurophysiol, 1993, 10(3): 323-352.
20. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia, 2010, 51(4): 676-685.
21. Lee IC, Yang JJ, Li SY. AKCNQ2 E515D mutation associated with benign familial neonatal seizures and continuous spike and waves during slow-wave sleep syndrome in Taiwan. J Formos Med Assoc, 2017, 116(9): 711-719.
22. Hart AR, Pilling EL, Alix JJ. Neonatal seizures-part 2: Aetiology of acute symptomatic seizures, treatments and the neonatal epilepsy syndromes. Arch Dis Child Educ Pract Ed, 2015, 100(5): 226-232.
23. Cohen R, Baselvanagaite L, Goldbergstern H, et al. Two siblings with early infantile myoclonic encephalopathy due to mutation in the gene encoding mitochondrial glutamate/H+ symporter SLC25A22. Eur J Paediatr Neurol, 2014, 18(6): 801-805.
24. Backx L, Ceulemans B, Vermeesch JR, et al. Early myoclonic encephalopathy caused by a disruption of the neuregulin-1 receptor ErbB4. Eur J Hum Genet, 2009, 17(3): 378-382.
25. Kato M, Saitsu H, Murakami Y, et al. PIGA mutations cause early-onset epileptic encephalopathies and distinctive features. Neurology, 2014, 82(18): 1587-1596.
26. 张赟健, 周水珍. 早发性癫痫性脑病基因突变研究与诊治. 中国实用儿科杂志, 2015(7): 492-497.
27. Beal JC, Cherian K, Moshe SL. Early-onset epileptic encephalopathies: ohtahara syndrome and early myoclonic encephalopathy. Pediatr Neurol, 2012, 47(5): 317-323.

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