癫痫患者人格特征研究进展_Journal of Epilepsy

Authors：

王雪 , 马芮 , 邵娜 ,  孟红梅

吉林大学第一医院神经内科（长春 130021）;

Corresponding author：

孟红梅, Email: hongmeiyp@126.com

Keywords：

癫痫; 人格; 影响因素

DOI：

10.7507/2096-0247.20180069

Video：

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癫痫是中枢神经系统的常见疾病，越来越得到人们的关注。部分患者可出现人格改变，且发生率高达 5%～18%，不仅影响着癫痫患者的生活、工作、学习，也给社会带来了沉重的负担。因此，治疗癫痫发作的同时，也要关注癫痫患者的人格特征。目前，关于人格改变在癫痫患者中产生的原因尚不清楚，癫痫后的人格特征是有其独特的病理基础还是受多种因素的影响尚无定论。文章通过对癫痫患者的人格特点及其相关的影响因素进行探讨，提高临床对癫痫患者人格改变的重视，从而早期进行个性化的干预和康复。

Citation： 王雪, 马芮, 邵娜, 孟红梅. 癫痫患者人格特征研究进展. Journal of Epilepsy, 2018, 4(5): 415-420. doi: 10.7507/2096-0247.20180069 Copy

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2.	Matsuura M, Oana Y, Kato M, et al. A multicenter study on the prevalence of psychi- atric disorders among new referrals for epilepsy in Japan. Epilepsia, 2003, 44(1): 107-114.
3.	王焕林, 高柏良. 癫痫性精神障碍的诊断分类及治疗现状. 中华神经科杂志, 1995, 28(1): 48-50.
4.	陈思媛, 秦阳, 刘炳伦, 等. 成年癫痫患者个性特点研究. 中国临床研究, 2013, 26(11): 1177-1178.
5.	Irle E, Lange C, Sachsse U. Reduced size and abnormal asymmetry of parietalcortex in women with borderline personality disorder. Biol Psychiatry, 2005, 57(2): 173-182.
6.	Krishnamoorthy ES, Trimble MR, Blumer D. The classification of neuropsychiatric disorders in epilepsy: a proposal by the ILAE Commission on Psychobiology of Epilepsy. Epilepsy Behav, 2007, 10(3): 349-353.
7.	Phillips ML, Drevets WC, Rauch SL, et al. Neurobiology of emotion perception: the neural basis of normal emotion perception. Biol Psychiatry, 2003, 54(5): 504-514.
8.	Hariri AR, Drabant EM, Weinberger DR. Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry, 2006, 59(10): 888-897.
9.	Taylor SF, Liberzon I. Neural correlates of emotion regulation in psychopathology. TrendsCognSci, 2007, 11(10): 413-418.
10.	Gong XY. The revision of Eysenck personality questionnaire in China. Psychol Sci Newslett, 1984, 4: 11-18.
11.	Gibbs FA. Ictal and non-ictal psychiatric disorders in temporal lobe epilepsy. J Nerv Ment Dis, 1951, 113(6): 522-528.
12.	Kennedy SH, Javanmard M, Vaccarino FJ. A review of functional neuroimaging in mood disorders: positron emission tomography and depression. Can J Psychiatr, 1997, 42(5): 467-475.
13.	Geschwind N. Pathogenesis of behavior change in temporal lobe epilepsy. Res Publ Assoc Res Nerv Ment Dis, 1983, 61: 355-370.
14.	Meldolesi GN, Di Gennaro G, Quarato PP, et al. Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: A 2-year follow-up study. Epilepsy Res, 2007, 77(1): 22-30.
15.	Bechara A, Damasio H, Damasio AR. Emotion.decision making and the orbitofrontal cortex. Cereb Cortex, 2000, 10(3): 295-307.
16.	de Araujo FG, Lin K, Lin J, et al. Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study. Epilepsia, 2009, 50(5): 1201-1209.
17.	Mao LY, Ding J, Peng WF, et al. Disease duration and arcuate fasciculus abnormalities correlate with psychoticism in patients with epilepsy. Seizure, 2011, 20(10): 741-747.
18.	Wolf RC, Sambataro F, Vasic N, et al. Aberrant connectivity of resting-state networks in borderline personality disorder. J Psychiatry Neurosci, 2011, 36(6): 402-411.
19.	Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry, 1998, 44(3): 151-162.
20.	Moore TM, Scarpa A, Raine A. A meta-analysis of serotonin metabolite 5-HIAA and antisocial behavior. Aggressive Behav, 2002, 28(4): 299-316.
21.	Bagdy G, Kecskemeti V, Riba P, et al. Serotonin and epilepsy. Neurochem, 2007, 100(4): 857-873.
22.	Sperli F, Rentsch D, Despland PA, et al. Psychiatric comorbidity in patients evaluated for chronic epilepsy: a differential role of the right hemisphere? Eur Neurol, 2009, 61(6): 350-357.
23.	Kalinin VV, Polyanskiy DA. Focus laterality and interictal psychiatric disorder in temporal lobe epilepsy. Seizure, 2009, 18(3): 176-179.
24.	Locke DEC, Fakhoury TA, Berry DTR, et al. Objective evaluation of personality and psychopathology in temporal lobe versus extratemporal lobe epilepsy. Epilepsy Behav, 2010, 17(2): 172-177.
25.	Liu RS, Lemieux L, Bell GS, et al. Cerebral damage in epilepsy: a population-based longitudinal quantitative MRI study. Epilepsia, 2005, 46(9): 1482-1494.
26.	毛玲艳, 丁晶, 彭伟, 等. 癫痫患者发作间歇期人格改变及相关因素分析. 中华神经科杂志, 2013, 45(4): 224-228.
27.	Moschetta S, Fiore LA, Fuentes D, et al. Personality traits in patients with juvenile myoclonic epilepsy. Epilepsy Behav, 2011, 21(4): 473-477.
28.	SwinkelsWA, Duijsens IJ, Spinhoven P. Personality disorder traits in patients with epilepsy. Seizure, 2003, 12(8): 587-594.
29.	Wilson SJ, Wrench JM, McIntosh AM, et al. Personality development in the context of intractable epilepsy. ArchNeurol, 2009, 66(1): 68-72.
30.	Brent DA, Crumrine PK, Varma RR, et al. Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics, 1987, 80(6): 909-917.
31.	Loring DW, Marino S, Meador KJ. Neuropsychological and behavioral effects of antiepilepsy drugs. Neuropsychol Rev, 2007, 17(4): 413-425.
32.	Mula M, Sander JW. Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug Safety, 2007, 30(7): 555-567.
33.	Nemets B, Bersudsky Y, Belmaker RH. Controlled double-blind trial of phenytoin vs. fluoxetine in major depressive disorder. J Clin Psychiatry, 2005, 66(5): 586-590.
34.	Stanford MS, Helfritz LE, Conklin SM, et al. A comparison of anticonvulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol, 2005, 13(1): 72-77.
35.	Roger J, Grangeon H, Gueyj J, et al. Psychiatric and psychologic effects ofethosuximide treatment of epileptics. Encéphale, 1968, 57(5): 407-438.
36.	Banu SH, Jahan M, Koli UK, et al. Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. BMJ, 2007, 334(7605): 1207-1207.
37.	Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet, 2007, 369(9566): 1000-1015.
38.	Grunze HC. Anticonvulsants in bipolar disorder. J Ment Health, 2010, 19(2): 127-141.
39.	Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassified epilepsy: an unblinded, randomised con-trolled trial. Lancet, 2007, 369(9566): 1016-1026.
40.	Lindenmayer JP, Kotsaftis A. Use of sodium valproate in violent and aggressive behaviors: a critical review. J Clin Psychiatry, 2000, 61(12): 123-128.
41.	Levinson DF, Devinsky O. Psychiatric adverse events during vigabatrin therapy. Neurology, 1999, 53(7): 1503-1511.
42.	Reich DB, ZanariniMC, Bieri KA. A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder. Int Clin Psychopharmacol, 2009, 24(5): 270-275.
43.	Beran RG, Gibson RJ. Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine. Epilepsia, 1998, 39(3): 280-282.
44.	Wolf SM, Shinnar S, Kang H, et al. Gabapentin toxicity in children manifesting as behavioral changes. Epilepsia, 1995, 36(12): 1203-1205.
45.	Lee DO, Steingard RJ, Cesena M, et al. Behavioral side effects of gabapentin in children. Epilepsia, 1996, 37(1): 87-90.
46.	Cooney C, Murphy S, Tessema H, et al. Use of low-dose gabapentin for aggressive behavior in vascular and mixed Vascular/Alzheimer dementia. J Neuropsychiatry Clin Neurosci, 2013, 25(2): 120-125.
47.	Pasini A, Pitzianti M, Baratta A, et al. Timing and clinical characteristics of topiramate-induced psychosis in a patient with epilepsy and tuberous sclerosis. Clin Neuropharmacol, 2014, 37(1): 38-39.
48.	Mula M, Trimble MR, Lhatoo SD, et al. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia, 2003, 44(5): 659-663.
49.	Nickel C, Lahmann C, Tritt K, et al. Topiramate in treatment of depressive andanger symptoms in female depressive patients: a randomized, double-blind, placebo-controlled study. J Affect Disord, 2005, 87(2-3): 243-252.
50.	Mula M, Monaco F. Antiepileptic drugs and psychopathology of epilepsy: an update. Epileptic Disord, 2009, 11(1): 1-9.
51.	Mattes JA. Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial. J Clin Psychopharmacol, 2005, 25(6): 575-579.
52.	Fujikawa M, Kishimoto Y, Kakisaka Y, et al. Obsessive-compulsive behavior induced by levetiracetam. J Child Neurol, 2015, 30(7): 942-944.
53.	Mula M, Trimble MR, Yuen A, et al. Psychiatric adverse events during levetiracetam therapy. Neurology, 2003, 61(15): 704-706.

1. Jacoby A, Snape D, Baker GA. Epilepsy and social identity: the stigma of a chronic neurological disorder. Lancet Neurol, 2005, 4(3): 171-178.
2. Matsuura M, Oana Y, Kato M, et al. A multicenter study on the prevalence of psychi- atric disorders among new referrals for epilepsy in Japan. Epilepsia, 2003, 44(1): 107-114.
3. 王焕林, 高柏良. 癫痫性精神障碍的诊断分类及治疗现状. 中华神经科杂志, 1995, 28(1): 48-50.
4. 陈思媛, 秦阳, 刘炳伦, 等. 成年癫痫患者个性特点研究. 中国临床研究, 2013, 26(11): 1177-1178.
5. Irle E, Lange C, Sachsse U. Reduced size and abnormal asymmetry of parietalcortex in women with borderline personality disorder. Biol Psychiatry, 2005, 57(2): 173-182.
6. Krishnamoorthy ES, Trimble MR, Blumer D. The classification of neuropsychiatric disorders in epilepsy: a proposal by the ILAE Commission on Psychobiology of Epilepsy. Epilepsy Behav, 2007, 10(3): 349-353.
7. Phillips ML, Drevets WC, Rauch SL, et al. Neurobiology of emotion perception: the neural basis of normal emotion perception. Biol Psychiatry, 2003, 54(5): 504-514.
8. Hariri AR, Drabant EM, Weinberger DR. Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry, 2006, 59(10): 888-897.
9. Taylor SF, Liberzon I. Neural correlates of emotion regulation in psychopathology. TrendsCognSci, 2007, 11(10): 413-418.
10. Gong XY. The revision of Eysenck personality questionnaire in China. Psychol Sci Newslett, 1984, 4: 11-18.
11. Gibbs FA. Ictal and non-ictal psychiatric disorders in temporal lobe epilepsy. J Nerv Ment Dis, 1951, 113(6): 522-528.
12. Kennedy SH, Javanmard M, Vaccarino FJ. A review of functional neuroimaging in mood disorders: positron emission tomography and depression. Can J Psychiatr, 1997, 42(5): 467-475.
13. Geschwind N. Pathogenesis of behavior change in temporal lobe epilepsy. Res Publ Assoc Res Nerv Ment Dis, 1983, 61: 355-370.
14. Meldolesi GN, Di Gennaro G, Quarato PP, et al. Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: A 2-year follow-up study. Epilepsy Res, 2007, 77(1): 22-30.
15. Bechara A, Damasio H, Damasio AR. Emotion.decision making and the orbitofrontal cortex. Cereb Cortex, 2000, 10(3): 295-307.
16. de Araujo FG, Lin K, Lin J, et al. Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study. Epilepsia, 2009, 50(5): 1201-1209.
17. Mao LY, Ding J, Peng WF, et al. Disease duration and arcuate fasciculus abnormalities correlate with psychoticism in patients with epilepsy. Seizure, 2011, 20(10): 741-747.
18. Wolf RC, Sambataro F, Vasic N, et al. Aberrant connectivity of resting-state networks in borderline personality disorder. J Psychiatry Neurosci, 2011, 36(6): 402-411.
19. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry, 1998, 44(3): 151-162.
20. Moore TM, Scarpa A, Raine A. A meta-analysis of serotonin metabolite 5-HIAA and antisocial behavior. Aggressive Behav, 2002, 28(4): 299-316.
21. Bagdy G, Kecskemeti V, Riba P, et al. Serotonin and epilepsy. Neurochem, 2007, 100(4): 857-873.
22. Sperli F, Rentsch D, Despland PA, et al. Psychiatric comorbidity in patients evaluated for chronic epilepsy: a differential role of the right hemisphere? Eur Neurol, 2009, 61(6): 350-357.
23. Kalinin VV, Polyanskiy DA. Focus laterality and interictal psychiatric disorder in temporal lobe epilepsy. Seizure, 2009, 18(3): 176-179.
24. Locke DEC, Fakhoury TA, Berry DTR, et al. Objective evaluation of personality and psychopathology in temporal lobe versus extratemporal lobe epilepsy. Epilepsy Behav, 2010, 17(2): 172-177.
25. Liu RS, Lemieux L, Bell GS, et al. Cerebral damage in epilepsy: a population-based longitudinal quantitative MRI study. Epilepsia, 2005, 46(9): 1482-1494.
26. 毛玲艳, 丁晶, 彭伟, 等. 癫痫患者发作间歇期人格改变及相关因素分析. 中华神经科杂志, 2013, 45(4): 224-228.
27. Moschetta S, Fiore LA, Fuentes D, et al. Personality traits in patients with juvenile myoclonic epilepsy. Epilepsy Behav, 2011, 21(4): 473-477.
28. SwinkelsWA, Duijsens IJ, Spinhoven P. Personality disorder traits in patients with epilepsy. Seizure, 2003, 12(8): 587-594.
29. Wilson SJ, Wrench JM, McIntosh AM, et al. Personality development in the context of intractable epilepsy. ArchNeurol, 2009, 66(1): 68-72.
30. Brent DA, Crumrine PK, Varma RR, et al. Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics, 1987, 80(6): 909-917.
31. Loring DW, Marino S, Meador KJ. Neuropsychological and behavioral effects of antiepilepsy drugs. Neuropsychol Rev, 2007, 17(4): 413-425.
32. Mula M, Sander JW. Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug Safety, 2007, 30(7): 555-567.
33. Nemets B, Bersudsky Y, Belmaker RH. Controlled double-blind trial of phenytoin vs. fluoxetine in major depressive disorder. J Clin Psychiatry, 2005, 66(5): 586-590.
34. Stanford MS, Helfritz LE, Conklin SM, et al. A comparison of anticonvulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol, 2005, 13(1): 72-77.
35. Roger J, Grangeon H, Gueyj J, et al. Psychiatric and psychologic effects ofethosuximide treatment of epileptics. Encéphale, 1968, 57(5): 407-438.
36. Banu SH, Jahan M, Koli UK, et al. Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. BMJ, 2007, 334(7605): 1207-1207.
37. Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet, 2007, 369(9566): 1000-1015.
38. Grunze HC. Anticonvulsants in bipolar disorder. J Ment Health, 2010, 19(2): 127-141.
39. Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassified epilepsy: an unblinded, randomised con-trolled trial. Lancet, 2007, 369(9566): 1016-1026.
40. Lindenmayer JP, Kotsaftis A. Use of sodium valproate in violent and aggressive behaviors: a critical review. J Clin Psychiatry, 2000, 61(12): 123-128.
41. Levinson DF, Devinsky O. Psychiatric adverse events during vigabatrin therapy. Neurology, 1999, 53(7): 1503-1511.
42. Reich DB, ZanariniMC, Bieri KA. A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder. Int Clin Psychopharmacol, 2009, 24(5): 270-275.
43. Beran RG, Gibson RJ. Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine. Epilepsia, 1998, 39(3): 280-282.
44. Wolf SM, Shinnar S, Kang H, et al. Gabapentin toxicity in children manifesting as behavioral changes. Epilepsia, 1995, 36(12): 1203-1205.
45. Lee DO, Steingard RJ, Cesena M, et al. Behavioral side effects of gabapentin in children. Epilepsia, 1996, 37(1): 87-90.
46. Cooney C, Murphy S, Tessema H, et al. Use of low-dose gabapentin for aggressive behavior in vascular and mixed Vascular/Alzheimer dementia. J Neuropsychiatry Clin Neurosci, 2013, 25(2): 120-125.
47. Pasini A, Pitzianti M, Baratta A, et al. Timing and clinical characteristics of topiramate-induced psychosis in a patient with epilepsy and tuberous sclerosis. Clin Neuropharmacol, 2014, 37(1): 38-39.
48. Mula M, Trimble MR, Lhatoo SD, et al. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia, 2003, 44(5): 659-663.
49. Nickel C, Lahmann C, Tritt K, et al. Topiramate in treatment of depressive andanger symptoms in female depressive patients: a randomized, double-blind, placebo-controlled study. J Affect Disord, 2005, 87(2-3): 243-252.
50. Mula M, Monaco F. Antiepileptic drugs and psychopathology of epilepsy: an update. Epileptic Disord, 2009, 11(1): 1-9.
51. Mattes JA. Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial. J Clin Psychopharmacol, 2005, 25(6): 575-579.
52. Fujikawa M, Kishimoto Y, Kakisaka Y, et al. Obsessive-compulsive behavior induced by levetiracetam. J Child Neurol, 2015, 30(7): 942-944.
53. Mula M, Trimble MR, Yuen A, et al. Psychiatric adverse events during levetiracetam therapy. Neurology, 2003, 61(15): 704-706.

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