癫痫患者治疗经济评价的系统回顾_Journal of Epilepsy

Authors：

 WijnenBFM , van MastrigtGAPG , EversSMAA , 李思思　译 , 高慧　慕洁　审

Corresponding author：

WijnenBFM, Email: b.wijnen@maastrichtuniversity.nl

Keywords：

癫痫; 经济评价; 药物干预; 非药物干预; 研究质量

DOI：

10.7507/2096-0247.20180085

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

越来越多的治疗方案和与癫痫相关的高成本促进了癫痫疾病经济评价的发展。因此，检查这些经济评价的可用性、质量并找出潜在的研究差距非常重要。除了研究抗癫痫药物（AEDs）和非药物（例如癫痫手术、生酮饮食、迷走神经刺激）治疗外，本综述还考察了所有经济评价的方法学质量。我们使用 MEDLINE，EMBASE，NHS 经济评价数据库（NHS EED），Econlit，Web of Science 和 CEA Registry 进行了文献检索。此外，还使用了 Cochrane 评价，Cochrane DARE 和 Cochrane 健康技术评价数据库。为了识别相关研究，我们设计了将预定义的临床检索策略与检索过滤器结合的模式以识别健康经济学相关的研究。以下主题都使用了特别设计的特定检索策略：① AEDs；② 认知缺陷患者；③ 老年患者；④ 癫痫手术；⑤ 生酮饮食；⑥ 迷走神经刺激；⑦ 治疗（非）惊厥性癫痫持续状态。本综述共纳入 40 篇文献，其中 29 篇（73%）为有关药物干预的文章。以“健康经济学标准共识”（Consensus health economic criteria，CHEC）评价，所有文章的平均质量评分为 81.8%，最低质量评分为 21.05%，有五项研究评分为 100%。使用综合健康经济评价报告标准（Consolidated health economic evaluation reporting standards，CHEERS），平均质量得分为 77.0%，最低为 22.7%，有四项研究评定为 100%。所有纳入的文章在方法学上存在很大的差异，这阻碍了将信息进行有意义地合并。总的来说，方法学质量是可以接受的，尽管一些研究质量明显比其他研究差。研究之间的异质性强调需要确定一个参考案例（例如应该如何进行癫痫内的经济评价），并就什么为“最佳治疗标准”达成共识。

Citation： WijnenBFM, van MastrigtGAPG, EversSMAA, 李思思　译, 高慧　慕洁　审. 癫痫患者治疗经济评价的系统回顾. Journal of Epilepsy, 2018, 4(6): 526-544. doi: 10.7507/2096-0247.20180085 Copy

1.	Van de Vel A, Cuppens K, Bonroy B, et al. Non-EEG seizure-detection systems and potential SUDEP prevention: state of the art. Seizure, 2013, 22(5): 345-355.
2.	Ngugi AK, Kariuki SM, Bottomley C, et al. Incidence of epilepsy: a systematic review and meta-analysis. Neurol Clin Pract, 2011, 77(10): 1005-1012.
3.	International Society for Pharmacoeconomics and Outcomes Research. Pharmacoeconomic Guidelines Around the World, 2016. Available at: http://www.ispor.org/peguidelines/index.asp. Accessed July 22, 2016.
4.	Glauser T, Ben-Menachem E, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2006, 47(7): 1094-1120.
5.	Duncan JS, Sander JW, Sisodiya SM, et al. Adult epilepsy. Lancet, 2006, 367(9516): 1087-1100.
6.	Drummond MF, Sculpher MJ, Claxton K, et al. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press, 2015.
7.	Brazier J. Measuring and valuing health benefits for economic evaluation. Oxford: Oxford University Press, 2007.
8.	Knies S, Severens JL, Ament AJHA, et al. The transferability of valuing lost productivity across jurisdictions. Differences between national pharmacoeconomic guidelines. Value Health, 2010, 13(5): 519-527.
9.	Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 2009, 6(7): e1000097.
10.	Evers S, Goossens M, De Vet H, et al. Criteria list for assessment of methodological quality of economic evaluations: Consensus on health economic criteria. Int J Technol Assess Health Care, 2005, 21(2): 240-245.
11.	Odnoletkova I, Goderis G, Pil L, et al. Cost-effectiveness of therapeutic education to prevent the development and progression of type 2 diabetes: systematic review. J Diabetes Res Clin Metab, 2014, 5: 438-445.
12.	Husereau D, Drummond M, Petrou S, et al. Consolidated health economic evaluation reporting standards (CHEERS) statement. Cost Eff Resour Alloc, 2013, 11(1): 6.
13.	International Monetary Fund. World Economic Outlook Database, 2015. Available at: http://www.imf.org/external/pubs/ft/weo/2013/02/weodata/index.aspx/;http://eppi.ioe.ac.uk/costconversion/default.aspx. Accessed July 22, 2016.
14.	Knoester PD, Deckers CL, Termeer EH, et al. A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients. Value Health, 2007, 10: 173-182.
15.	Van Hout BA, Gagnon DD, McNulty P, et al. The cost effectiveness of two new antiepileptic therapies in the absence of direct comparative data: a first approximation. Pharmacoeconomics, 2003, 21(5): 315-326.
16.	Remak E, Hutton J, Price M, et al. A Markov model of treatment of newly diagnosed epilepsy in the UK: an initial assessment of costeffectiveness of topiramate. Eur J Health Econ, 2003, 4(4): 271-278.
17.	Marson AG, Appleton R, Baker GA, et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs: the SANAD trial. Health Technol Assess, 2007, 11: 1-134.
18.	Balabanov PP, Zahariev ZI. A pharmacoeconomic comparison of monotherapy with Tegretol, Finlepsin and Trileptal (preliminary data). Folia Med (Plovdiv), 2006, 48(2): 37-43.
19.	Balabanov PP, Zahariev ZI, Mateva NG. Evaluation of the factors affecting the quality of life and total costs in epilepsy patients on monotherapy with carbamazepine and valproate. Folia Med (Plovdiv), 2008, 50(2): 18-23.
20.	Chisholm D. Cost-effectiveness of first-line antiepileptic drug treatments in the developing world: a population-level analysis. Epilepsia, 2005, 46(5): 751-759.
21.	Chisholm D, Saxena S. Cost effectiveness of strategies to combat neuropsychiatric conditions in sub-saharan africa and south east asia: mathematical modelling study. Br Med J, 2012, 344: e609.
22.	Gureje O, Chisholm D, Kola L, et al. Cost-effectiveness of an essential mental health intervention package in nigeria. World Psychiatry, 2007, 6(1): 42-48.
23.	Bolin K, Berggren F, Forsgren L. Lacosamide as treatment of epileptic seizures: cost utility results for sweden. Acta Neurol Scand, 2010, 121(6): 406-412.
24.	Simoens S, De Naeyer L, Dedeken P. Cost effectiveness of lacosamide in the adjunctive treatment of patients with refractory focal epilepsy in Belgium. CNS Drugs, 2012, 26(4): 337-350.
25.	Knoester PD, Boendermaker AJ, Egberts AC, et al. Cost-effectiveness of add-on lamotrigine therapy in clinical practice. Epilepsy Res, 2005, 67(3): 143-151.
26.	Vera-Llonch M, Brandenburg NA, Oster G. Cost-effectiveness of addon therapy with pregabalin in patients with refractory partial epilepsy. Epilepsia, 2008, 49(3): 431-437.
27.	Maltoni S, Messori A. Lifetime cost-utility analysis of patients with refractory epilepsy treated with adjunctive topiramate therapy: costeffectiveness in refractory epilepsy. Clin Drug Investig, 2003, 23(4): 225-232.
28.	Remak E, Hutton J, Selai CE, et al. A cost-utility analysis of adjunctive treatment with newer antiepileptic drugs in the UK. J Med Econ, 2004, 7: 29-40.
29.	Hawkins N, Epstein D, Drummond M, et al. Assessing the costeffectiveness of new pharmaceuticals in epilepsy in adults: the results of a probabilistic decision model. Med Decis Making, 2005, 25(5): 493-510.
30.	Spackman DE, Yeates A, Rentz AM, et al. The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy. J Med Econ, 2007, 10(4): 455-473.
31.	Kristian B, Wachtmeister K, Stefan F, et al. Retigabine as add-on treatment of refractory epilepsy: a cost-utility study in a Swedish setting. Acta Neurol Scand, 2013, 127(6): 419-426.
32.	Craig D, Rice S, Paton F, et al. Retigabine for the adjunctive treatment of adults with partial-onset seizures in epilepsy with and without secondary generalization: a NICE single technology appraisal. Pharmacoeconomics, 2013, 301(2): 101-110.
33.	Frew EJ, Sandercock J, Whitehouse WP, et al. The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies. Seizure, 2007, 16(2): 99-112.
34.	Gharibnaseri Z, Kebriaeezadeh A, Nikfar S, et al. Cost-effectiveness of adding-on new antiepileptic drugs to conventional regimens in controlling intractable seizures in children. Daru, 2012, 20(1): 17.
35.	Benedict A, Verdian L, Maclaine G. The cost effectiveness of rufinamide in the treatment of Lennox-Gastaut syndrome in the UK. Pharmacoeconomics, 2010, 28(3): 185-199.
36.	Blais L, Sheehy O, St-Hilaire JM, et al. Economic evaluation of levetiracetam as an add-on therapy in patients with refractory epilepsy. Pharmacoeconomics, 2005, 23(5): 493-503.
37.	Suh GH, Lee SK. Economic evaluation of add-on levetiracetam for the treatment of refractory partial epilepsy in korea. Psychiatry Investig, 2009, 6(3): 185-193.
38.	Verdian L, Yi Y. Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with lennox-gastaut syndrome in the United Kingdom. Seizure, 2010, 19(1): 1-11.
39.	Clements KM, Skornicki M, O’Sullivan AK. Cost-effectiveness analysis of antiepileptic drugs in the treatment of lennox-gastaut syndrome. Epilepsy Behav, 2013, 29(1): 184-189.
40.	Bowen JM, Snead OC, Chandra K, et al. Epilepsy care in ontario: an economic analysis of increasing access to epilepsy surgery. Ont Health Technol Assess Ser, 2012, 12(18): 1-41.
41.	Widjaja E, Li B, Schinkel CD, et al. Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy. Epilepsy Res, 2011, 94(1-2): 61-68.
42.	Oldham MS, Horn PS, Tsevat J, et al. Costs and clinical outcomes of epilepsy surgery in children with drug-resistant epilepsy. Pediatr Neurol, 2015, 53(3): 216-220.
43.	de Kinderen RJ, Lambrechts DA, Wijnen BF, et al. An economic evaluation of the ketogenic diet versus care as usual in children and adolescents with intractable epilepsy: an interim analysis. Epilepsia, 2016, 57(1): 41-50.
44.	De Kinderen RJ, Postulart D, Aldenkamp AP, et al. Cost-effectiveness of the ketogenic diet and vagus nerve stimulation for the treatment of children with intractable epilepsy. Epilepsy Res, 2015, 110: 119-131.
45.	Helmers SL, Duh MS, Guerin A, et al. Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy. Eur J Paediatr Neurol, 2012, 16(5): 449-458.
46.	Majoie HJ, Berfelo MW, Aldenkamp AP, et al. Vagus nerve stimulation in children with therapy-resistant epilepsy diagnosed as lennox-gastaut syndrome: clinical results, neuropsychological effects, and cost-effectiveness. J Clin Neurophysiol, 2001, 18(5): 419-428.
47.	Beretta S, Beghi E, Messina P, et al. Comprehensive educational plan for patients with epilepsy and comorbidity (EDU-COM): a pragmatic randomised trial. J Neurol Neurosurg Psychiatry, 2014, 85(8): 889-894.
48.	Noble AJ, McCrone P, Seed PT, et al. Clinical-and cost-effectiveness of a nurse led self-management intervention to reduce emergency visits by people with epilepsy. PLoS ONE, 2014, 9(6): e90789.
49.	Plumpton CO, Brown I, Reuber M, et al. Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence. Epilepsy Behav, 2015, 45: 180-186.
50.	Rane CT, Dalvi SS, Gogtay NJ, et al. A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adult patients with generalized tonic-clonic epilepsy. Br J Clin Pharmacol, 2001, 52(2): 193-195.
51.	Lee D, Gladwell D, Batty AJ, et al. The cost effectiveness of licensed oromucosal midazolam (Buccolam) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited. Paediatr Drugs, 2013, 15(2): 151-162.
52.	Lee DC, Gladwell D, Hatswell AJ, et al. A comparison of the costeffectiveness of treatment of prolonged acute convulsive epileptic seizures in children across europe. Health Econ Rev, 2014, 4: 6.
53.	Zorg RvdVe. Zinnige en duurzame zorg. Zoetermeer, 2006.
54.	Wilby J, Kainth A, Hawkins N, et al. Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health Technol Assess, 2005, 9(15): 172.
55.	van Steenbergen-Weijenburg KM, van der Feltz-Cornelis CM, Horn EK, et al. Cost-effectiveness of collaborative care for the treatment of major depressive disorder in primary care. A systematic review. Bmc Health Serv Res, 2010, 10: 19.
56.	Udsen FW, Hejlesen O, Ehlers LH. A systematic review of the cost and cost-effectiveness of telehealth for patients suffering from chronic obstructive pulmonary disease. J Telemed Telecare, 2014, 20(4): 212-220.
57.	Claxton K, Sculpher M, Drummond M. A rational framework for decision making by the National Institute for Clinical Excellence (NICE). Lancet, 2002, 360: 711-715.
58.	Hiligsmann M, Cooper C, Guillemin F, et al. A reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Amsterdam: Elsevier, 2014, 44(3): 271-282.
59.	Hiligsmann M, Cooper C, Arden N, et al. Health economics in the field of osteoarthritis: an expert’s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Amsterdam: Elsevier, 2013, 43(3): 303-313.
60.	Bolin K, Forsgren L. The cost effectiveness of newer epilepsy treatments: a review of the literature on partial-onset seizures. Pharmacoeconomics, 2012, 30(10): 903-923.
61.	Knies S, Ament AJ, Evers SM, et al. The transferability of economic evaluations: testing the model of welte. Value Health, 2009, 12(5): 730-738.
62.	Kralj-Hans I, Goldstein LH, Noble AJ, et al. Self-management education for adults with poorly controlled epILEpsy (SMILE (UK)): a randomised controlled trial protocol. BMC Neurol, 2014, 14: 69.
63.	Leenen LA, Wijnen BF, de Kinderen RJ, et al. (Cost)-effectiveness of a multi-component intervention for adults with epilepsy: study protocol of a Dutch randomized controlled trial (ZMILE study. BMC Neurol, 2014, 14: 255.
64.	de Kinderen RJ, Lambrechts DA, Postulart D, et al. Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial. BMC Neurol, 2011, 11: 1-10.
65.	de Kinderen RJ, Wijnen BF, van Breukelen G, et al. From clinically relevant outcome measures to quality of life in epilepsy: a time tradeoff study. Epilepsy Res, 2016, 125: 24-31.
66.	Jentink J, Boersma C, de Jong-van den Berg LT, et al. Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. J Med Econ, 2012, 15(5): 862-868.

1. Van de Vel A, Cuppens K, Bonroy B, et al. Non-EEG seizure-detection systems and potential SUDEP prevention: state of the art. Seizure, 2013, 22(5): 345-355.
2. Ngugi AK, Kariuki SM, Bottomley C, et al. Incidence of epilepsy: a systematic review and meta-analysis. Neurol Clin Pract, 2011, 77(10): 1005-1012.
3. International Society for Pharmacoeconomics and Outcomes Research. Pharmacoeconomic Guidelines Around the World, 2016. Available at: http://www.ispor.org/peguidelines/index.asp. Accessed July 22, 2016.
4. Glauser T, Ben-Menachem E, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2006, 47(7): 1094-1120.
5. Duncan JS, Sander JW, Sisodiya SM, et al. Adult epilepsy. Lancet, 2006, 367(9516): 1087-1100.
6. Drummond MF, Sculpher MJ, Claxton K, et al. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press, 2015.
7. Brazier J. Measuring and valuing health benefits for economic evaluation. Oxford: Oxford University Press, 2007.
8. Knies S, Severens JL, Ament AJHA, et al. The transferability of valuing lost productivity across jurisdictions. Differences between national pharmacoeconomic guidelines. Value Health, 2010, 13(5): 519-527.
9. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 2009, 6(7): e1000097.
10. Evers S, Goossens M, De Vet H, et al. Criteria list for assessment of methodological quality of economic evaluations: Consensus on health economic criteria. Int J Technol Assess Health Care, 2005, 21(2): 240-245.
11. Odnoletkova I, Goderis G, Pil L, et al. Cost-effectiveness of therapeutic education to prevent the development and progression of type 2 diabetes: systematic review. J Diabetes Res Clin Metab, 2014, 5: 438-445.
12. Husereau D, Drummond M, Petrou S, et al. Consolidated health economic evaluation reporting standards (CHEERS) statement. Cost Eff Resour Alloc, 2013, 11(1): 6.
13. International Monetary Fund. World Economic Outlook Database, 2015. Available at: http://www.imf.org/external/pubs/ft/weo/2013/02/weodata/index.aspx/;http://eppi.ioe.ac.uk/costconversion/default.aspx. Accessed July 22, 2016.
14. Knoester PD, Deckers CL, Termeer EH, et al. A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients. Value Health, 2007, 10: 173-182.
15. Van Hout BA, Gagnon DD, McNulty P, et al. The cost effectiveness of two new antiepileptic therapies in the absence of direct comparative data: a first approximation. Pharmacoeconomics, 2003, 21(5): 315-326.
16. Remak E, Hutton J, Price M, et al. A Markov model of treatment of newly diagnosed epilepsy in the UK: an initial assessment of costeffectiveness of topiramate. Eur J Health Econ, 2003, 4(4): 271-278.
17. Marson AG, Appleton R, Baker GA, et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs: the SANAD trial. Health Technol Assess, 2007, 11: 1-134.
18. Balabanov PP, Zahariev ZI. A pharmacoeconomic comparison of monotherapy with Tegretol, Finlepsin and Trileptal (preliminary data). Folia Med (Plovdiv), 2006, 48(2): 37-43.
19. Balabanov PP, Zahariev ZI, Mateva NG. Evaluation of the factors affecting the quality of life and total costs in epilepsy patients on monotherapy with carbamazepine and valproate. Folia Med (Plovdiv), 2008, 50(2): 18-23.
20. Chisholm D. Cost-effectiveness of first-line antiepileptic drug treatments in the developing world: a population-level analysis. Epilepsia, 2005, 46(5): 751-759.
21. Chisholm D, Saxena S. Cost effectiveness of strategies to combat neuropsychiatric conditions in sub-saharan africa and south east asia: mathematical modelling study. Br Med J, 2012, 344: e609.
22. Gureje O, Chisholm D, Kola L, et al. Cost-effectiveness of an essential mental health intervention package in nigeria. World Psychiatry, 2007, 6(1): 42-48.
23. Bolin K, Berggren F, Forsgren L. Lacosamide as treatment of epileptic seizures: cost utility results for sweden. Acta Neurol Scand, 2010, 121(6): 406-412.
24. Simoens S, De Naeyer L, Dedeken P. Cost effectiveness of lacosamide in the adjunctive treatment of patients with refractory focal epilepsy in Belgium. CNS Drugs, 2012, 26(4): 337-350.
25. Knoester PD, Boendermaker AJ, Egberts AC, et al. Cost-effectiveness of add-on lamotrigine therapy in clinical practice. Epilepsy Res, 2005, 67(3): 143-151.
26. Vera-Llonch M, Brandenburg NA, Oster G. Cost-effectiveness of addon therapy with pregabalin in patients with refractory partial epilepsy. Epilepsia, 2008, 49(3): 431-437.
27. Maltoni S, Messori A. Lifetime cost-utility analysis of patients with refractory epilepsy treated with adjunctive topiramate therapy: costeffectiveness in refractory epilepsy. Clin Drug Investig, 2003, 23(4): 225-232.
28. Remak E, Hutton J, Selai CE, et al. A cost-utility analysis of adjunctive treatment with newer antiepileptic drugs in the UK. J Med Econ, 2004, 7: 29-40.
29. Hawkins N, Epstein D, Drummond M, et al. Assessing the costeffectiveness of new pharmaceuticals in epilepsy in adults: the results of a probabilistic decision model. Med Decis Making, 2005, 25(5): 493-510.
30. Spackman DE, Yeates A, Rentz AM, et al. The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy. J Med Econ, 2007, 10(4): 455-473.
31. Kristian B, Wachtmeister K, Stefan F, et al. Retigabine as add-on treatment of refractory epilepsy: a cost-utility study in a Swedish setting. Acta Neurol Scand, 2013, 127(6): 419-426.
32. Craig D, Rice S, Paton F, et al. Retigabine for the adjunctive treatment of adults with partial-onset seizures in epilepsy with and without secondary generalization: a NICE single technology appraisal. Pharmacoeconomics, 2013, 301(2): 101-110.
33. Frew EJ, Sandercock J, Whitehouse WP, et al. The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies. Seizure, 2007, 16(2): 99-112.
34. Gharibnaseri Z, Kebriaeezadeh A, Nikfar S, et al. Cost-effectiveness of adding-on new antiepileptic drugs to conventional regimens in controlling intractable seizures in children. Daru, 2012, 20(1): 17.
35. Benedict A, Verdian L, Maclaine G. The cost effectiveness of rufinamide in the treatment of Lennox-Gastaut syndrome in the UK. Pharmacoeconomics, 2010, 28(3): 185-199.
36. Blais L, Sheehy O, St-Hilaire JM, et al. Economic evaluation of levetiracetam as an add-on therapy in patients with refractory epilepsy. Pharmacoeconomics, 2005, 23(5): 493-503.
37. Suh GH, Lee SK. Economic evaluation of add-on levetiracetam for the treatment of refractory partial epilepsy in korea. Psychiatry Investig, 2009, 6(3): 185-193.
38. Verdian L, Yi Y. Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with lennox-gastaut syndrome in the United Kingdom. Seizure, 2010, 19(1): 1-11.
39. Clements KM, Skornicki M, O’Sullivan AK. Cost-effectiveness analysis of antiepileptic drugs in the treatment of lennox-gastaut syndrome. Epilepsy Behav, 2013, 29(1): 184-189.
40. Bowen JM, Snead OC, Chandra K, et al. Epilepsy care in ontario: an economic analysis of increasing access to epilepsy surgery. Ont Health Technol Assess Ser, 2012, 12(18): 1-41.
41. Widjaja E, Li B, Schinkel CD, et al. Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy. Epilepsy Res, 2011, 94(1-2): 61-68.
42. Oldham MS, Horn PS, Tsevat J, et al. Costs and clinical outcomes of epilepsy surgery in children with drug-resistant epilepsy. Pediatr Neurol, 2015, 53(3): 216-220.
43. de Kinderen RJ, Lambrechts DA, Wijnen BF, et al. An economic evaluation of the ketogenic diet versus care as usual in children and adolescents with intractable epilepsy: an interim analysis. Epilepsia, 2016, 57(1): 41-50.
44. De Kinderen RJ, Postulart D, Aldenkamp AP, et al. Cost-effectiveness of the ketogenic diet and vagus nerve stimulation for the treatment of children with intractable epilepsy. Epilepsy Res, 2015, 110: 119-131.
45. Helmers SL, Duh MS, Guerin A, et al. Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy. Eur J Paediatr Neurol, 2012, 16(5): 449-458.
46. Majoie HJ, Berfelo MW, Aldenkamp AP, et al. Vagus nerve stimulation in children with therapy-resistant epilepsy diagnosed as lennox-gastaut syndrome: clinical results, neuropsychological effects, and cost-effectiveness. J Clin Neurophysiol, 2001, 18(5): 419-428.
47. Beretta S, Beghi E, Messina P, et al. Comprehensive educational plan for patients with epilepsy and comorbidity (EDU-COM): a pragmatic randomised trial. J Neurol Neurosurg Psychiatry, 2014, 85(8): 889-894.
48. Noble AJ, McCrone P, Seed PT, et al. Clinical-and cost-effectiveness of a nurse led self-management intervention to reduce emergency visits by people with epilepsy. PLoS ONE, 2014, 9(6): e90789.
49. Plumpton CO, Brown I, Reuber M, et al. Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence. Epilepsy Behav, 2015, 45: 180-186.
50. Rane CT, Dalvi SS, Gogtay NJ, et al. A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adult patients with generalized tonic-clonic epilepsy. Br J Clin Pharmacol, 2001, 52(2): 193-195.
51. Lee D, Gladwell D, Batty AJ, et al. The cost effectiveness of licensed oromucosal midazolam (Buccolam) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited. Paediatr Drugs, 2013, 15(2): 151-162.
52. Lee DC, Gladwell D, Hatswell AJ, et al. A comparison of the costeffectiveness of treatment of prolonged acute convulsive epileptic seizures in children across europe. Health Econ Rev, 2014, 4: 6.
53. Zorg RvdVe. Zinnige en duurzame zorg. Zoetermeer, 2006.
54. Wilby J, Kainth A, Hawkins N, et al. Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health Technol Assess, 2005, 9(15): 172.
55. van Steenbergen-Weijenburg KM, van der Feltz-Cornelis CM, Horn EK, et al. Cost-effectiveness of collaborative care for the treatment of major depressive disorder in primary care. A systematic review. Bmc Health Serv Res, 2010, 10: 19.
56. Udsen FW, Hejlesen O, Ehlers LH. A systematic review of the cost and cost-effectiveness of telehealth for patients suffering from chronic obstructive pulmonary disease. J Telemed Telecare, 2014, 20(4): 212-220.
57. Claxton K, Sculpher M, Drummond M. A rational framework for decision making by the National Institute for Clinical Excellence (NICE). Lancet, 2002, 360: 711-715.
58. Hiligsmann M, Cooper C, Guillemin F, et al. A reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Amsterdam: Elsevier, 2014, 44(3): 271-282.
59. Hiligsmann M, Cooper C, Arden N, et al. Health economics in the field of osteoarthritis: an expert’s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Amsterdam: Elsevier, 2013, 43(3): 303-313.
60. Bolin K, Forsgren L. The cost effectiveness of newer epilepsy treatments: a review of the literature on partial-onset seizures. Pharmacoeconomics, 2012, 30(10): 903-923.
61. Knies S, Ament AJ, Evers SM, et al. The transferability of economic evaluations: testing the model of welte. Value Health, 2009, 12(5): 730-738.
62. Kralj-Hans I, Goldstein LH, Noble AJ, et al. Self-management education for adults with poorly controlled epILEpsy (SMILE (UK)): a randomised controlled trial protocol. BMC Neurol, 2014, 14: 69.
63. Leenen LA, Wijnen BF, de Kinderen RJ, et al. (Cost)-effectiveness of a multi-component intervention for adults with epilepsy: study protocol of a Dutch randomized controlled trial (ZMILE study. BMC Neurol, 2014, 14: 255.
64. de Kinderen RJ, Lambrechts DA, Postulart D, et al. Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial. BMC Neurol, 2011, 11: 1-10.
65. de Kinderen RJ, Wijnen BF, van Breukelen G, et al. From clinically relevant outcome measures to quality of life in epilepsy: a time tradeoff study. Epilepsy Res, 2016, 125: 24-31.
66. Jentink J, Boersma C, de Jong-van den Berg LT, et al. Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. J Med Econ, 2012, 15(5): 862-868.

Previous Article
癫痫的 ILAE 分类：ILAE 委员会关于分类和术语的意见书
Next Article
高频脑电振荡：临床研究综述

Journal of Epilepsy

癫痫患者治疗经济评价的系统回顾

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content