高频脑电振荡：临床研究综述_Journal of Epilepsy

Authors：

BirgitFrauscher ,  FabriceBartolomei , KatsuhiroKobayashi , 陆璐　译 , 张乐　慕洁　审

Corresponding author：

FabriceBartolomei, Email: brgit.frauscher@queensu.ca

Keywords：

头皮脑电图; 生物标记; 手术预后; 癫痫发作; 睡眠

DOI：

10.7507/2096-0247.20180086

Video：

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Abstract Full text Figures/Tables Video References Cited by

现代脑电图（EEG）技术的进步增强了对经典伯杰频段外，包含重要信息的脑电信号的识别。在癫痫领域，近十年的相关研究主要集中在发作间期>80 Hz 的高频振荡（High frequency oscillations, HFOs）。HFOs 大型临床应用始于癫痫手术术前的评估，近来也开始用于评估癫痫严重程度和监测抗癫痫疗效。该综述总结了 HFOs 在癫痫临床应用的证据，重点介绍了最新的进展。近期大量文献强调了 HFOs 与术后癫痫预后关系，一篇近期的 Meta 分析证实术后癫痫未发作患者 HFOs 切除率高于术后发作患者，利用术后 EEG 中的残留 HFOs 比术前 HFOs 率对癫痫手术预后预测更准确。文章深入讨论了区分生理性和癫痫性 HFOs 的尝试，这可能进一步加强 HFOs 的特异度。如睡眠结构分析表明，在痫灶内外对 HFOs 的偶联有差异。同时，越来越多的证据表明，HFOs 可用于对评估疾病活动度和利用非侵入性 EEG 和脑磁图（MEG）等检查中评估治疗效果。鉴于儿童 EEG 中 HFOs 比例高，这一技术在患儿中有良好的前景。在婴儿痉挛症中经促肾上腺皮质激素治疗后 HFOs 比例下降。在Rolandic区棘波时出现 HFOs 与发作频率相关。耗时的人工评估是过去 HFOs 临床应用的障碍，目前这一问题可由可靠的计算机算法解决。过去十年，HFOs 研究有了长足进展，利用非侵入性手段检测 HFOs 已在大量患者中得到应用。期待未来有多中心、大样本量研究获取长程监测资料，为这一领域提供更多信息。

Citation： BirgitFrauscher, FabriceBartolomei, KatsuhiroKobayashi, 陆璐　译, 张乐　慕洁　审. 高频脑电振荡：临床研究综述. Journal of Epilepsy, 2018, 4(6): 545-557. doi: 10.7507/2096-0247.20180086 Copy

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1. Jacobs J, Staba R, Asano E, et al. High-frequency oscillations (HFOs) in clinical epilepsy. Prog Neurobiol, 2012, 98(3): 302-315.
2. Bragin A, Engel J Jr, Wilson CL, et al. High-frequency oscillations in human brain. Hippocampus, 1999, 9: 137-142.
3. Zijlmans M, Worrell GA, Dümpelmann M. How to record high-frequency oscillations in epilepsy: a practical guideline. Epilepsia, 2017, 58(8): 1305-1315.
4. Allen PJ, Fish DR, Smith SJ. Very high-frequency rhythmic activity during SEEG suppression in frontal lobe epilepsy. Electroencephalogr Clin Neurophysiol, 1992, 82(2): 155-159.
5. Fisher RS, Webber WR, Lesser RP, et al. High-frequency EEG activity at the start of seizures. J Clin Neurophysiol, 1992, 9(3): 441-448.
6. Bragin A, Engel J Jr, Wilson CL, et al. Hippocampal and entorhinal cortex high-frequency oscillations (100-500 Hz) in human epileptic brain and in kainic acid-treated rats with chronic seizures. Epilepsia, 1999, 40(2): 127-137.
7. Bragin A, Engel J Jr, Wilson CL, et al. Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection. Epilepsia, 1999, 40(9): 1210-1221.
8. Bragin A, Wilson CL, Staba RJ, et al. Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex. Ann Neurol, 2002, 52(4): 407-415.
9. Staba RJ, Wilson CL, Bragin A, et al. High-frequency oscillations recorded in human medial temporal lobe during sleep. Ann Neurol, 2004, 56(1): 108-115.
10. Jirsch JD, Urrestarazu E, LeVan P, et al. High-frequency oscillations during human focal seizures. Brain, 2006, 129(Pt 6): 1593-1608.
11. Urrestarazu E, Jirsch JD, LeVan P, et al. High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes. Epilepsia, 2006, 47(9): 1465-1476.
12. Akiyama T, Otsubo H, Ochi A, et al. Focal cortical high-frequency oscillations trigger epileptic spasms: confirmation by digital video sub-dural EEG. Clin Neurophysiol, 2005, 116: 2819-2825.
13. Chátillon CÉ, Zelmann R, Bortel A, et al. Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model. Clin Neurophysiol, 2011, 122(9): 1701-1705.
14. Kobayashi K, Watanabe Y, Inoue T, et al. Scalp-recorded high-frequency oscillations in childhood sleep-induced electrical status epilepticus. Epilepsia, 2010, 51(10): 2190-2194.
15. Andrade-Valenca LP, Dubeau F, Mari F, et al. Interictal scalp fast oscillations as a marker of the seizure onset zone. Neurology, 2011, 77(6): 524-531.
16. Xiang J, Liu Y, Wang Y, et al. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord, 2009, 11(2): 113-125.
17. van Klink N, Hillebrand A, Zijlmans M. Identification of epileptic high frequency oscillations in the time domain by using MEG beamformer-based virtual sensors. Clin Neurophysiol, 2016, 127(1): 197-208.
18. von Ellenrieder N, Pellegrino G, Hedrich T, et al. Detection and magnetic source imaging of fast oscillations (40-160 Hz) recorded with magnetoencephalography in focal epilepsy patients. Brain Topogr, 2016, 29(2): 218-231.
19. Urrestarazu E, Chander R, Dubeau F, et al. Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients. Brain, 2007, 130(Pt 9): 2354-2366.
20. Jiruska, P, Alvarado-Rojas C, Schevon, C A, et al. Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders. Epilepsia, 2017, 58(8): 1330-1339.
21. Khosravani H, Mehrotra N, Rigby M, et al. Spatial localization and time-dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy. Epilepsia, 2009, 50(4): 605-616.
22. Zijlmans M, Jacobs J, Zelmann R, et al. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology, 2009, 72: 979-986.
23. Gotman J, Marciani MG. Electroencephalographic spiking activity, drug levels, and seizure occurrence in epileptic patients. Ann Neurol, 1985, 17(6): 597-603.
24. Goncharova II, Alkawadri R, Gaspard N, et al. The relationship between seizures, interictal spikes and antiepileptic drugs. Clin Neurophysiol, 2016, 127(9): 3180-3186.
25. Jacobs J, LeVan P, Chander R, et al. Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain. Epilepsia, 2008, 49(11): 1893-1907.
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