癫痫与昼夜节律_Journal of Epilepsy

Authors：

张亚男 , 孙晴晴 , 林卫红 , 魏春会 , 王传蕾 ,  王赞

吉林大学第一医院神经内科（长春 130021）;

Corresponding author：

王赞, Email: wangzanprof@163.com

Keywords：

癫痫; 昼夜节律; 机制; 诊断; 治疗

DOI：

10.7507/2096-0247.20190007

Video：

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癫痫是常见的神经系统疾病，由不同病因引起脑部神经元高度同步化异常放电所致，其发病率高，临床表现复杂，具有不可预测性。昼夜节律是调节机体行为、生理、生物化学的 24 h 模式。随着对癫痫研究的不断深入，癫痫与昼夜节律的关系越来越受到关注。癫痫发作具有昼夜节律，同一类型的癫痫在不同时间、不同状态发作的频率不同。癫痫发作可能会影响昼夜节律，包括睡眠与睡眠觉醒周期、核心体温、心血管参数、内分泌系统等。同时，昼夜节律变化可能导致癫痫发生，二者相互作用形成恶性循环，严重影响癫痫患者的工作、生活和学习。内源性昼夜节律系统可能是癫痫发作的独立危险因素。各种癫痫发作类型可能具有不同的昼夜节律分布，并且这些节律分布特点可能提供癫痫诊断线索和依据。明确癫痫发作的昼夜节律，根据其发作节律进行干预及治疗，既可以减少药物不良反应，还能有效控制癫痫发作。文章就癫痫与昼夜节律的相互关系进行综述。

Citation： 张亚男, 孙晴晴, 林卫红, 魏春会, 王传蕾, 王赞. 癫痫与昼夜节律. Journal of Epilepsy, 2019, 5(1): 34-37. doi: 10.7507/2096-0247.20190007 Copy

1.	Karoly PJ, Ung H, Grayden DB, et al. The circadian profile of epilepsy improves seizure forecasting. Brain, 2017, 140(8): 2169-2182.
2.	Baud MO, Kleen JK, Mirro EA, et al. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun, 2018, 9(1): 1-10.
3.	Morin LP. Neuroanatomy of the extended circadian rhythm system. Exp Neurol, 2013, 243(5): 4-20.
4.	Reppert SM, WeaverDR, Ebisawa T. Cloning andcharacterization ofa mammalian melatonin receptor thatmediates reproductive and circadian responses. Neuron, 1994, 13(5): 1177-1185.
5.	Gowers W. Epilepsy and other chronicconvulsivediseases: their causes, symptoms andtreatment. New York: WilliamWood, 1885: 157-164.
6.	Van Campen JS, Valentijn FA, Jansen FE, et al. Seizure occurrence and the circadian rhythm ofcortisol: a systematic review. Epilepsy Behav, 2015, 47: 132-137.
7.	Ramgopal S, Powell C, Zarowski M, et al. Predicting diurnal and sleep/wake seizure patterns in paediatric patients of different ages. Epileptic Disord, 2014, 16(1): 56-66.
8.	Gurkas E, Serdaroglu A, Hirfanoglu T, et al. Sleep-wake distribution and circadian patterns of epileptic seizures in children. Eur J Paediatr Neurol, 2016, 20(4): 549-554.
9.	Tinuper P, Bisulli F, Cross JH, et al. Definition and diagnostic criteria of sleep-related hypermotor epilepsy. Neurology, 2016, 86(19): 1834-1842.
10.	Quigg M, Clayburn H, Straume M, et al. Hypothalamicneuronal loss and altered circadian rhythm of temperature in a rat model ofmesial temporal lobe epilepsy. Epilepsia, 1999, 40(12): 1688-1696.
11.	Quigg M, Straume M, Smith T, et al. Seizures induce phaseshifts of rat circadian rhythms. Brain Res, 2001, 913(2): 165-169.
12.	Quigg M, Clayburn H, Straume M, et al. Effects ofcircadian regulation and rest-activity state on spontaneous seizures in a ratmodel of limbic epilepsy. Epilepsia, 2000, 41(5): 502-509.
13.	Persson H, Kumlien E, Ericson M, et al. Circadian variation in heart-ratevariability in localization-related epilepsy. Epilepsia, 2007, 48(5): 917-922.
14.	Jenwitheesuk A, Nopparat C, Mukda S, et al. Melatonin regulates aging andneurodegeneration through energy metabolism, epigenetics, autophagy and circadianrhythm pathways. Int J Mol Sci, 2014, 15(9): 16848-16884.
15.	Peled N, Shorer Z, Peled E, et al. Melatonin effect on seizures in children with severe neurologic deficit disorder. Epilepsia, 2001, 42(9): 1208-1210.
16.	Sarabdjitsingh RA, Jezequel J, Pasricha N, et al. Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity. Proc Natl Acad Sci USA, 2014, 111(39): 14265-14270.
17.	Bauer J. Epilepsy and prolactin in adults: a clinical review. Epilepsy Res, 1996, 24(1): 1-7.
18.	Kasting N, Veale W, Cooper K, et al. Vasopressin may mediate febrile convulsions. Brain Res, 1981, 213(2): 327-333.
19.	Albertson TE, Peterson SL, Stark LG, et al. The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology, 1981, 20(1): 61-66.
20.	Fauteck JD, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol SignRecep, 1999, 8(1-2): 105-110.
21.	Ehlers CL, Henriksen SJ, Wang M, et al. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res, 1983, 278(1-2): 332-336.
22.	Baram TZ, Schultz L. Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat. Brain Res, 1991, 61(1): 97-101.
23.	Gray TS, Bingaman EW. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit Rev Neurobiol, 1996, 10(2): 155-168.
24.	BaramTZ, Mitchell WG, Tournay A, et al. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics, 1996, 97(3): 375-379.
25.	Pranzatelli M. On the molecular mechanism of adrenocorticotropin hormone in the CNS: transmitters and receptors. Exp Neurol, 1994, 125: 142-161.
26.	Laakso ML, Leinonen L, Hatonen T, et al. Melatonin, cortisol and body temperaturerhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. J Neurol, 1993, 240(7): 410-416.
27.	Schmutz M, Baud J, Glatt A, et al. Chronopharmacological investigations on tonic–clonic seizures on rats and their suppression by carbamazepine, oxcarbazepine, and diazepam. In: Dreifuss F, MeinardiH, Stefan H (Eds.), Chronopharmacology in Therapy of the Epilepsies. Raven Press, New York, 1993: 145-154.
28.	Loddenkemper T, Lockley SW, Kaleyias J, et al. Chronobiology of epilepsy: diagnostic and therapeutic. J Clin Neurophysiol, 2011, 28(2): 146-153.

1. Karoly PJ, Ung H, Grayden DB, et al. The circadian profile of epilepsy improves seizure forecasting. Brain, 2017, 140(8): 2169-2182.
2. Baud MO, Kleen JK, Mirro EA, et al. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun, 2018, 9(1): 1-10.
3. Morin LP. Neuroanatomy of the extended circadian rhythm system. Exp Neurol, 2013, 243(5): 4-20.
4. Reppert SM, WeaverDR, Ebisawa T. Cloning andcharacterization ofa mammalian melatonin receptor thatmediates reproductive and circadian responses. Neuron, 1994, 13(5): 1177-1185.
5. Gowers W. Epilepsy and other chronicconvulsivediseases: their causes, symptoms andtreatment. New York: WilliamWood, 1885: 157-164.
6. Van Campen JS, Valentijn FA, Jansen FE, et al. Seizure occurrence and the circadian rhythm ofcortisol: a systematic review. Epilepsy Behav, 2015, 47: 132-137.
7. Ramgopal S, Powell C, Zarowski M, et al. Predicting diurnal and sleep/wake seizure patterns in paediatric patients of different ages. Epileptic Disord, 2014, 16(1): 56-66.
8. Gurkas E, Serdaroglu A, Hirfanoglu T, et al. Sleep-wake distribution and circadian patterns of epileptic seizures in children. Eur J Paediatr Neurol, 2016, 20(4): 549-554.
9. Tinuper P, Bisulli F, Cross JH, et al. Definition and diagnostic criteria of sleep-related hypermotor epilepsy. Neurology, 2016, 86(19): 1834-1842.
10. Quigg M, Clayburn H, Straume M, et al. Hypothalamicneuronal loss and altered circadian rhythm of temperature in a rat model ofmesial temporal lobe epilepsy. Epilepsia, 1999, 40(12): 1688-1696.
11. Quigg M, Straume M, Smith T, et al. Seizures induce phaseshifts of rat circadian rhythms. Brain Res, 2001, 913(2): 165-169.
12. Quigg M, Clayburn H, Straume M, et al. Effects ofcircadian regulation and rest-activity state on spontaneous seizures in a ratmodel of limbic epilepsy. Epilepsia, 2000, 41(5): 502-509.
13. Persson H, Kumlien E, Ericson M, et al. Circadian variation in heart-ratevariability in localization-related epilepsy. Epilepsia, 2007, 48(5): 917-922.
14. Jenwitheesuk A, Nopparat C, Mukda S, et al. Melatonin regulates aging andneurodegeneration through energy metabolism, epigenetics, autophagy and circadianrhythm pathways. Int J Mol Sci, 2014, 15(9): 16848-16884.
15. Peled N, Shorer Z, Peled E, et al. Melatonin effect on seizures in children with severe neurologic deficit disorder. Epilepsia, 2001, 42(9): 1208-1210.
16. Sarabdjitsingh RA, Jezequel J, Pasricha N, et al. Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity. Proc Natl Acad Sci USA, 2014, 111(39): 14265-14270.
17. Bauer J. Epilepsy and prolactin in adults: a clinical review. Epilepsy Res, 1996, 24(1): 1-7.
18. Kasting N, Veale W, Cooper K, et al. Vasopressin may mediate febrile convulsions. Brain Res, 1981, 213(2): 327-333.
19. Albertson TE, Peterson SL, Stark LG, et al. The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology, 1981, 20(1): 61-66.
20. Fauteck JD, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol SignRecep, 1999, 8(1-2): 105-110.
21. Ehlers CL, Henriksen SJ, Wang M, et al. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res, 1983, 278(1-2): 332-336.
22. Baram TZ, Schultz L. Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat. Brain Res, 1991, 61(1): 97-101.
23. Gray TS, Bingaman EW. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit Rev Neurobiol, 1996, 10(2): 155-168.
24. BaramTZ, Mitchell WG, Tournay A, et al. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics, 1996, 97(3): 375-379.
25. Pranzatelli M. On the molecular mechanism of adrenocorticotropin hormone in the CNS: transmitters and receptors. Exp Neurol, 1994, 125: 142-161.
26. Laakso ML, Leinonen L, Hatonen T, et al. Melatonin, cortisol and body temperaturerhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. J Neurol, 1993, 240(7): 410-416.
27. Schmutz M, Baud J, Glatt A, et al. Chronopharmacological investigations on tonic–clonic seizures on rats and their suppression by carbamazepine, oxcarbazepine, and diazepam. In: Dreifuss F, MeinardiH, Stefan H (Eds.), Chronopharmacology in Therapy of the Epilepsies. Raven Press, New York, 1993: 145-154.
28. Loddenkemper T, Lockley SW, Kaleyias J, et al. Chronobiology of epilepsy: diagnostic and therapeutic. J Clin Neurophysiol, 2011, 28(2): 146-153.

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