良性内侧颞叶癫痫的研究进展_Journal of Epilepsy

Authors：

黄小冬 ,  任惠

昆明医科大学第一附属医院老年神经内科（昆明 650032）;

Corresponding author：

任惠, Email: HuiRen2006@163.com

Keywords：

良性内侧颞叶癫痫; 海马硬化; 遗传学; 核磁共振成像

DOI：

10.7507/2096-0247.20190008

Video：

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颞叶癫痫（TLE）是指异常过度放电起源于一侧或双侧颞叶结构的癫痫，是最常见的成人局灶性癫痫，也是最常见的药物难治性癫痫。内侧（Mesial）TLE 是 TLE 的主要类型，手术切除致痫灶是有效治疗方法。然而，部分患者的症状则较轻，并且能够在服用或未服用抗癫痫药物治疗的情况下达到无限期的缓解期，被认为是良性（benign）MTLE，此类患者经常有发热发作和癫痫的家族史。目前研究者认为 MTLE 可能与海马硬化和遗传因素有关，文章就 bMTLE 的研究进展进行总结，以提高临床对其认识。

Citation： 黄小冬, 任惠. 良性内侧颞叶癫痫的研究进展. Journal of Epilepsy, 2019, 5(1): 38-40. doi: 10.7507/2096-0247.20190008 Copy

1.	Tatum WO 4th. Mesial temporal lobe epilepsy. J Clin Neurophysiol, 2012, 29(5): 356-365.
2.	于云莉, 蒋莎莎, 史梦婷, 等. 磁共振波谱联合视频脑电图对伴海马硬化的内侧颞叶癫痫的诊断价值. 贵州医科大学学报, 2017, 42(8): 946-951.
3.	Hosomi K, Kishima H, Oshino S, et al. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res, 2013, 103(2-3): 195-204.
4.	幸小亮, 沙龙泽, 张丹, 等. β-catenin 在内侧颞叶癫痫发病机制中的作用. 中国医学科学院学报, 2011, 33(6): 659-662.
5.	王丽琨, 洪震. 耐药性颞叶癫痫的研究进展. 癫痫与神经电生理学杂志, 2016, 25(2): 100-108.
6.	AlQassmi A, Burneo JG, McLachlan RS, et al. Benign mesial temporal lobe epilepsy: A clinical cohort and literature review. Epilepsy Behav, 2016, 65: 60-64.
7.	Labate A, Gambardella A, Andermann E, et al. Benign mesial temporal lobe epilepsy. Nat Rev Neurol, 2011, 7(4): 237-240.
8.	陈聪, 汪珊, 王爽. 良性颞叶癫痫研究进展. 中华神经科杂志, 2017, 50(12): 953-955.
9.	Spooner CG, Berkovic SF, Mitchell LA, et al. New-onset temporal lobe epilepsy in children: lesion on MRI predicts poor seizure outcome. Neurology, 2006, 67(12): 2147-2153.
10.	Hernandez-Ronquillo L, Buckley S, Ladino LD, et al. How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? Epileptic Disord, 2016, 18(2): 137-147.
11.	Yang K, Su J, Hu Z, et al. Triple pathology in patients with temporal lobe epilepsy: a case report and review of the literature. Exp Ther Med, 2013, 6(4): 925-928.
12.	Sequeira KM, Tabesh A, Sainju RK, et al. Perfusion network shift during seizures in medial temporal lobe epilepsy. PLoS One, 2013, 8(1): e53204.
13.	Abou-Khalil B. The relationship between febrile seizures and epilepsy. Epilepsia, 2010, 51(Suppl 1): 40-42.
14.	Liu C, Russin J, Heck C, et al. Dysregulation of PINCH signaling in mesial temporal epilepsy. J Clin Neurosci, 2017, 36: 43-52.
15.	Lewis DV, Shinnar S, Hesdorffer DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol, 2014, 75(2): 178-185.
16.	Sokol DK, Demyer WE, Edwards-Brown M, et al. From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizure. Seizure, 2003, 12(4): 237-240.
17.	黄诚衙, 梁春妍, 钟建东, 等. 颅脑损伤患者继发外伤性癫痫的危险因素分析. 临床神经外科杂志, 2017, 14(3): 182-185.
18.	Cohen I, Navarro V, Le Duigou C, et al. Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms? Biol Cell, 2003, 95(6): 329-333.
19.	Berkovic SF, McIntosh A, Howell RA, et al. familial temporal lobe epilepsy: a common disorder identified in twins. Ann Neurol, 1996, 40(2): 227-235.
20.	Gambardella A, Labate A, Giallonardo A, et al. Familial mesial temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 55-57.
21.	Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain, 2010, 133(11): 3221-3231.
22.	Hedera P, Blair MA, Andermann E, et al. familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology, 2007, 68(24): 2107-2112.
23.	Fanciulli M, Di Bonaventura C, Egeo G, et al. Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26. Epilepsy Res, 2014, 108(2): 232-240.
24.	陈薇, 岳建兰, 林志春. 颞叶癫痫大脑网络研究进展. 中华神经医学杂志, 2016, 15(9): 965-968.
25.	Kinjo ER, Rodriguez PXR, Dos Santos BA, et al. New insights on temporal lobe epilepsy based on plasticity-related network changes and high-order statistics. Mol Neurobiol, 2017, 55(5): 3990-3998.
26.	张丽云, 罗国刚. 颞叶癫痫患者的临床症状及脑电图分析. 吉林医学, 2014, 35(5): 975-976.
27.	Michelucci R, Pasini E, Nobile C. Lateral temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 52-54.
28.	Pittau F, Bisulli F, Mai R, et al. Prognostic factors in patients with mesial temporal lobe epilepsy. Epilepsia, 2009, 50(Suppl 1): 41-44.
29.	Labate A, Ventura P, Gambardella A, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Neurology, 2006, 66(4): 562-565.
30.	Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy. Braz J Med Biol Res, 2004, 37(6): 827-832.
31.	裴家生, 杨朋范. 高分辨率磁共振成像海马内部结构显影对内侧型颞叶癫痫的诊断价值. 癫痫与神经电生理学杂志, 2014, 23(6): 353-356, 373.
32.	Labate A, Aguglia U, Tripepi G, et al. Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. Neurology, 2016, 86(20): 1904-1910.

1. Tatum WO 4th. Mesial temporal lobe epilepsy. J Clin Neurophysiol, 2012, 29(5): 356-365.
2. 于云莉, 蒋莎莎, 史梦婷, 等. 磁共振波谱联合视频脑电图对伴海马硬化的内侧颞叶癫痫的诊断价值. 贵州医科大学学报, 2017, 42(8): 946-951.
3. Hosomi K, Kishima H, Oshino S, et al. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res, 2013, 103(2-3): 195-204.
4. 幸小亮, 沙龙泽, 张丹, 等. β-catenin 在内侧颞叶癫痫发病机制中的作用. 中国医学科学院学报, 2011, 33(6): 659-662.
5. 王丽琨, 洪震. 耐药性颞叶癫痫的研究进展. 癫痫与神经电生理学杂志, 2016, 25(2): 100-108.
6. AlQassmi A, Burneo JG, McLachlan RS, et al. Benign mesial temporal lobe epilepsy: A clinical cohort and literature review. Epilepsy Behav, 2016, 65: 60-64.
7. Labate A, Gambardella A, Andermann E, et al. Benign mesial temporal lobe epilepsy. Nat Rev Neurol, 2011, 7(4): 237-240.
8. 陈聪, 汪珊, 王爽. 良性颞叶癫痫研究进展. 中华神经科杂志, 2017, 50(12): 953-955.
9. Spooner CG, Berkovic SF, Mitchell LA, et al. New-onset temporal lobe epilepsy in children: lesion on MRI predicts poor seizure outcome. Neurology, 2006, 67(12): 2147-2153.
10. Hernandez-Ronquillo L, Buckley S, Ladino LD, et al. How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? Epileptic Disord, 2016, 18(2): 137-147.
11. Yang K, Su J, Hu Z, et al. Triple pathology in patients with temporal lobe epilepsy: a case report and review of the literature. Exp Ther Med, 2013, 6(4): 925-928.
12. Sequeira KM, Tabesh A, Sainju RK, et al. Perfusion network shift during seizures in medial temporal lobe epilepsy. PLoS One, 2013, 8(1): e53204.
13. Abou-Khalil B. The relationship between febrile seizures and epilepsy. Epilepsia, 2010, 51(Suppl 1): 40-42.
14. Liu C, Russin J, Heck C, et al. Dysregulation of PINCH signaling in mesial temporal epilepsy. J Clin Neurosci, 2017, 36: 43-52.
15. Lewis DV, Shinnar S, Hesdorffer DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol, 2014, 75(2): 178-185.
16. Sokol DK, Demyer WE, Edwards-Brown M, et al. From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizure. Seizure, 2003, 12(4): 237-240.
17. 黄诚衙, 梁春妍, 钟建东, 等. 颅脑损伤患者继发外伤性癫痫的危险因素分析. 临床神经外科杂志, 2017, 14(3): 182-185.
18. Cohen I, Navarro V, Le Duigou C, et al. Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms? Biol Cell, 2003, 95(6): 329-333.
19. Berkovic SF, McIntosh A, Howell RA, et al. familial temporal lobe epilepsy: a common disorder identified in twins. Ann Neurol, 1996, 40(2): 227-235.
20. Gambardella A, Labate A, Giallonardo A, et al. Familial mesial temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 55-57.
21. Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain, 2010, 133(11): 3221-3231.
22. Hedera P, Blair MA, Andermann E, et al. familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology, 2007, 68(24): 2107-2112.
23. Fanciulli M, Di Bonaventura C, Egeo G, et al. Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26. Epilepsy Res, 2014, 108(2): 232-240.
24. 陈薇, 岳建兰, 林志春. 颞叶癫痫大脑网络研究进展. 中华神经医学杂志, 2016, 15(9): 965-968.
25. Kinjo ER, Rodriguez PXR, Dos Santos BA, et al. New insights on temporal lobe epilepsy based on plasticity-related network changes and high-order statistics. Mol Neurobiol, 2017, 55(5): 3990-3998.
26. 张丽云, 罗国刚. 颞叶癫痫患者的临床症状及脑电图分析. 吉林医学, 2014, 35(5): 975-976.
27. Michelucci R, Pasini E, Nobile C. Lateral temporal lobe epilepsies: clinical and genetic features. Epilepsia, 2009, 50(Suppl 5): 52-54.
28. Pittau F, Bisulli F, Mai R, et al. Prognostic factors in patients with mesial temporal lobe epilepsy. Epilepsia, 2009, 50(Suppl 1): 41-44.
29. Labate A, Ventura P, Gambardella A, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Neurology, 2006, 66(4): 562-565.
30. Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy. Braz J Med Biol Res, 2004, 37(6): 827-832.
31. 裴家生, 杨朋范. 高分辨率磁共振成像海马内部结构显影对内侧型颞叶癫痫的诊断价值. 癫痫与神经电生理学杂志, 2014, 23(6): 353-356, 373.
32. Labate A, Aguglia U, Tripepi G, et al. Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. Neurology, 2016, 86(20): 1904-1910.

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