中国癫痫诊断治疗现状_Journal of Epilepsy

Authors：

唐颖莹 , 陆璐 ,  周东

四川大学华西医院神经内科（成都 610041）;

Corresponding author：

周东, Email: zhoudong66@yahoo.de

Keywords：

癫痫; 诊治; 中国; 现状

DOI：

10.7507/2096-0247.20190028

Video：

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随着认识的深入和研究的进展，近年来国际癫痫学科领域先后对癫痫的定义、分类及诊断治疗进行了重要更新，国内癫痫学科团队不仅在诊疗实践中紧跟国际步伐，力争使我国癫痫医疗可及性及质量位居世界前列，还在抗癫痫药物的规范使用、添加治疗、微创手术及共病防治等多方面为世界癫痫诊疗的进步做出了众多贡献。目前，我国癫痫诊疗面临的最大问题是癫痫医疗资源的发展不平衡，治疗缺口仍大，进一步推行和完善中国癫痫医疗质量指标体系建设，或将成为解决我国癫痫诊治全面规范化及同质化的重要策略。

Citation： 唐颖莹, 陆璐, 周东. 中国癫痫诊断治疗现状. Journal of Epilepsy, 2019, 5(3): 161-164. doi: 10.7507/2096-0247.20190028 Copy

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2.	Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
3.	GBD 2016 Healthcare Access and Quality Collaborators. Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. Lancet, 2018, 391(10136): 2236-2271.
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5.	Kanner AM, Ashman E, Gloss D, et al. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2018, 91(2): 74-81.
6.	中国抗癫痫协会. 临床诊疗指南: 癫痫病分册. 北京: 人民卫生出版社, 2015.
7.	中国抗癫痫协会共患病专业委员会. 癫痫伴焦虑诊断治疗的中国专家共识. 癫痫杂志, 2018, 4(3): 185-191.
8.	中国抗癫痫协会共患病专业委员会. 儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识. 癫痫杂志, 2018, 4(4): 281-289.
9.	中国抗癫痫协会共患病专业委员会. 儿童癫痫共患孤独症谱系障碍诊断治疗的中国专家共识. 癫痫杂志, 2019, 5(1): 3-10.
10.	Yu P, Zhou D, Liao W, et al. An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China. Epilepsy Behav, 2017, 69: 126-132.
11.	Hao X, Chen Z, Yan B, et al. Impact of drug manipulation on seizure freedom in adults with uncontrolled epilepsy: a prospective controlled study in rural China. CNS Drugs, 2017, 31(3): 237-243.
12.	Chi X, Li R, Hao X, et al. Response to treatment schedules after the first antiepileptic drug failed. Epilepsia, 2018, 59(11): 2118-2124.
13.	Wu XT, Hu FY, An DM, et al. Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B^*1502 allele among patients in central China. Epilepsy Behav, 2010, 19(3): 405-408.
14.	Cheung YK, Cheng SH, Chan EJ, et al. HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia, 2013, 54(7): 1307-1314.
15.	Shi YW, Min FL, Zhou D, et al. HLA-A^*24: 02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions. Neurology, 2017, 88(23): 2183-2191.
16.	Guo J, Guo J, Li J, et al. Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, 85(8): 701-707.
17.	Trinka E, Kwan P, Lee B, et al. Epilepsy in Asia: Disease burden, management barriers, and challenges. Epilepsia, 2019, 60(Suppl 1): 7-21.
18.	Wei PH, An Y, Fan XT, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartomas: preliminary evidence. World Neurosurg, 2018, 114: e1073-1078.
19.	Yu T, Wang X, Li Y, et al. High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans. Brain, 2018, 141(9): 2631-2643.
20.	Mu J, Liu L, Zhang Q, et al. Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology, 2011, 77(2): 132-137.
21.	Ge Y, Ding D, Zhang Q, et al. Incidence of sudden unexpected death in epilepsy in community-based cohort in China. Epilepsy Behav, 2017, 76: 76-83.
22.	Si Y, Chen D, Tian L, et al. Update on causes of premature death in people with convulsive epilepsy in rural West China. Epilepsia, 2016, 57(6): e117-120.
23.	Tong X, An D, Lan L, et al. Validation of the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E) in West China. Epilepsy Behav, 2015, 47: 6-10.
24.	Tong X, An D, Mcgonigal A, et al. Validation of the Generalized Anxiety Disorder-7(GAD-7) among Chinese people with epilepsy. Epilepsy Res, 2016, 120: 31-36.
25.	Chen S, Wu X, Lui S, et al. Resting-state fMRI study of treatment-naive temporal lobe epilepsy patients with depressive symptoms. Neuro Image, 2012, 60(1): 299-304.
26.	Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
27.	Wu XQ, Zhao YN, Ding J, et al. Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A[(18) F] VAT positron emission tomography brain imaging study. Epilepsia, 2018, 59(9): 1655-1666.
28.	Jiang Y, Han CL, Liu HG, et al. Abnormal hippocampal functional network and related memory impairment in pilocarpine-treated rats. Epilepsia, 2018, 59(9): 1785-1795.
29.	Hu J, Si Y, Zhou D, et al. Prevalence and treatment gap of active convulsive epilepsy: a large community-based survey in rural West China. Seizure, 2014, 23(5): 333-337.
30.	Zhao Y, Zhang Q, Tsering T, et al. Prevalence of convulsive epilepsy and health-related quality of life of the population with convulsive epilepsy in rural areas of Tibet Autonomous Region in China: an initial survey. Epilepsy Behav, 2008, 12(3): 373-381.
31.	Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology, 2003, 60(9): 1544-1545.
32.	Yu J, Luo N, Wang Z, et al. Current status of epilepsy treatment and efficacy of standard Phenobarbital therapy in rural areas of Northern China. Int J Neurosci, 2017, 127(8): 659-666.
33.	Li J, Si Y, Hu J, et al. Enhancing medical compliance of patients with convulsive epilepsy in rural community: a randomized intervention trial. Epilepsia, 2013, 54(11): 1988-1996.
34.	国家神经内科医疗质量控制中心. 2017 神经内科医疗质量报告. 北京: 人民卫生出版社, 2018: 68-101.

1. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
2. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
3. GBD 2016 Healthcare Access and Quality Collaborators. Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. Lancet, 2018, 391(10136): 2236-2271.
4. Kanner AM, Ashman E, Gloss D, et al. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2018, 91(2): 82-90.
5. Kanner AM, Ashman E, Gloss D, et al. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2018, 91(2): 74-81.
6. 中国抗癫痫协会. 临床诊疗指南: 癫痫病分册. 北京: 人民卫生出版社, 2015.
7. 中国抗癫痫协会共患病专业委员会. 癫痫伴焦虑诊断治疗的中国专家共识. 癫痫杂志, 2018, 4(3): 185-191.
8. 中国抗癫痫协会共患病专业委员会. 儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识. 癫痫杂志, 2018, 4(4): 281-289.
9. 中国抗癫痫协会共患病专业委员会. 儿童癫痫共患孤独症谱系障碍诊断治疗的中国专家共识. 癫痫杂志, 2019, 5(1): 3-10.
10. Yu P, Zhou D, Liao W, et al. An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China. Epilepsy Behav, 2017, 69: 126-132.
11. Hao X, Chen Z, Yan B, et al. Impact of drug manipulation on seizure freedom in adults with uncontrolled epilepsy: a prospective controlled study in rural China. CNS Drugs, 2017, 31(3): 237-243.
12. Chi X, Li R, Hao X, et al. Response to treatment schedules after the first antiepileptic drug failed. Epilepsia, 2018, 59(11): 2118-2124.
13. Wu XT, Hu FY, An DM, et al. Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B^*1502 allele among patients in central China. Epilepsy Behav, 2010, 19(3): 405-408.
14. Cheung YK, Cheng SH, Chan EJ, et al. HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia, 2013, 54(7): 1307-1314.
15. Shi YW, Min FL, Zhou D, et al. HLA-A^*24: 02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions. Neurology, 2017, 88(23): 2183-2191.
16. Guo J, Guo J, Li J, et al. Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, 85(8): 701-707.
17. Trinka E, Kwan P, Lee B, et al. Epilepsy in Asia: Disease burden, management barriers, and challenges. Epilepsia, 2019, 60(Suppl 1): 7-21.
18. Wei PH, An Y, Fan XT, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartomas: preliminary evidence. World Neurosurg, 2018, 114: e1073-1078.
19. Yu T, Wang X, Li Y, et al. High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans. Brain, 2018, 141(9): 2631-2643.
20. Mu J, Liu L, Zhang Q, et al. Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology, 2011, 77(2): 132-137.
21. Ge Y, Ding D, Zhang Q, et al. Incidence of sudden unexpected death in epilepsy in community-based cohort in China. Epilepsy Behav, 2017, 76: 76-83.
22. Si Y, Chen D, Tian L, et al. Update on causes of premature death in people with convulsive epilepsy in rural West China. Epilepsia, 2016, 57(6): e117-120.
23. Tong X, An D, Lan L, et al. Validation of the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E) in West China. Epilepsy Behav, 2015, 47: 6-10.
24. Tong X, An D, Mcgonigal A, et al. Validation of the Generalized Anxiety Disorder-7(GAD-7) among Chinese people with epilepsy. Epilepsy Res, 2016, 120: 31-36.
25. Chen S, Wu X, Lui S, et al. Resting-state fMRI study of treatment-naive temporal lobe epilepsy patients with depressive symptoms. Neuro Image, 2012, 60(1): 299-304.
26. Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
27. Wu XQ, Zhao YN, Ding J, et al. Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A[(18) F] VAT positron emission tomography brain imaging study. Epilepsia, 2018, 59(9): 1655-1666.
28. Jiang Y, Han CL, Liu HG, et al. Abnormal hippocampal functional network and related memory impairment in pilocarpine-treated rats. Epilepsia, 2018, 59(9): 1785-1795.
29. Hu J, Si Y, Zhou D, et al. Prevalence and treatment gap of active convulsive epilepsy: a large community-based survey in rural West China. Seizure, 2014, 23(5): 333-337.
30. Zhao Y, Zhang Q, Tsering T, et al. Prevalence of convulsive epilepsy and health-related quality of life of the population with convulsive epilepsy in rural areas of Tibet Autonomous Region in China: an initial survey. Epilepsy Behav, 2008, 12(3): 373-381.
31. Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology, 2003, 60(9): 1544-1545.
32. Yu J, Luo N, Wang Z, et al. Current status of epilepsy treatment and efficacy of standard Phenobarbital therapy in rural areas of Northern China. Int J Neurosci, 2017, 127(8): 659-666.
33. Li J, Si Y, Hu J, et al. Enhancing medical compliance of patients with convulsive epilepsy in rural community: a randomized intervention trial. Epilepsia, 2013, 54(11): 1988-1996.
34. 国家神经内科医疗质量控制中心. 2017 神经内科医疗质量报告. 北京: 人民卫生出版社, 2018: 68-101.

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中国癫痫诊断治疗现状

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