Clinical efficacy analysis of Semen ziziphi spinosae decoction combined Sodium valproate sustained-release tablets on treating post-traumatic epilepsy_Journal of Epilepsy

Authors：

LU Wei , WANG Wehua , XU Min , JIN Xuegang , WANG Jian ,  CHEN Long

Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Jiangsu Province Kunshan Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Kunshan 215300, China;

Corresponding author：

CHEN Long, Email: 13776118488@qq.com

Keywords：

Post-traumatic epilepsy; Semen ziziphi spinosae; Jujuboside A

DOI：

10.7507/2096-0247.20200019

Video：

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Objective Determine the effect of Semen ziziphi spinosae decoction combined Sodium valproate (VPA) sustained-release tablets on treating patients with Post-traumatic epilepsy (PTE).Methods 30 patients are chosen among the patients who were hospitalised in Epilepsy Department of Kunshan Traditional Chinese Medicine Hospital from Jan 2017 to Jan 2019. The age ranges from 31 to 75, averaging at (42.5±13.5) years old, and composed of 16 male samples and 14 female, randomly divided into experimental group (Semen ziziphi spinosae decoction combined VPA, n=15) and control group (VPA, n=15). In general, imaging data and EEG data are collected. Regular follow-up is also carried out for these 30 patients. The results are analysed to determine the effect of treatment.Results After 9-months treatment of Semen ziziphi spinosae decoction combined VPA, morbidity of experiment group is significantly lower than that of the control group. It is also found that the differenes of imaging data and EEG data of patients were of no statistical significance.Conclusion It is demonstrated that Semen ziziphi spinosae decoction combined VPA has superior performance in treating patients with PTE. The efficiency of Semen ziziphi spinosae decoction combined VPS in treating PTE is 93.3%, higher than the 80% of VPA. It can serve as reference for clinical diagnosis and treatment.

Citation： LU Wei, WANG Wehua, XU Min, JIN Xuegang, WANG Jian, CHEN Long. Clinical efficacy analysis of Semen ziziphi spinosae decoction combined Sodium valproate sustained-release tablets on treating post-traumatic epilepsy. Journal of Epilepsy, 2020, 6(2): 108-112. doi: 10.7507/2096-0247.20200019 Copy

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1. Kharatishvili I, Pitknen A. Posttraumatic epilepsy. Curr OpinNeurol, 2010, 23(2): 183-188.
2. 黄胜英, 谢世荣, 黄彩云, 等. 酸枣仁皂甙的镇静作用研究. 大连大学学报, 2002, 23(4): 90-92.
3. 封洲燕, 郭殿武, 苏松, 等. 酸枣仁皂甙A 镇静和抗惊厥作用试验. 浙江大学学报(医学版), 2002, 31(2): 103-106.
4. Wang C, You ZL, Xia Q, et al. Upregulation of mark3 and rpgrip1 mRNA expression byjujuboside a in mouse hippocampus. Acta Pharmacol Sin, 2007, 28(3): 334-338.
5. Cotter D, Kelso A, Neligan A. Genetic biomarkers of post traumatic epilepsy: a systematic review. Seizure, 2017, 9(46): 53-58.
6. Mecozzi M, Sturchio E, Boccia P, et al. Molecular and structural changes induced by essential oil treatments in Vicia faba roots detected by FTIR and FTNIR spectroscopy. Environ Sci Pollut Res Int, 2017, 24(6): 5305-5315.
7. 游宇, 徐如祥. 创伤性癫痫发病机制研究新进展. 中华神经医学杂志, 2015, 14(1): 94-97.
8. Mcdonald JW, Johnston MV. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Research Reviews, 1990, 15(1): 41-70.
9. Sommer B, Seeburg PH. Glutamate receptor channels: novel properties and new clones. Trends in Pharmacological Sciences, 1992, 13(7): 291-296.
10. Hattori H, Wasterlain CG. Excitatory amino acids in the developing brain: ontogeny, plasticity, and excitotoxicity. Pediatric neurology, 1990, 6(4): 219-228.
11. 荣春蕾, 代永霞, 崔瑛. 酸枣仁对阴虚小鼠焦虑行为的影响. 中药材, 2008, 31(11): 1703-1705.
12. 邓伟, 唐其柱, 李欣, 等. 酸枣仁皂苷A对大鼠心室肌细胞L-型钙通道的影响. 武汉大学学报(医学版), 2009, 30(3): 299-302.
13. 王超. 酸枣仁中有效成分的提取及在大鼠体内的吸收研究. 天津商业大学, 硕士研究生学位论文, 2011: 1-88.
14. 王平, 王晨, 楼一层. 冰片、川芎对复方舒郁健脑方剂透过血脑屏障的作用研究. 湖北中医药大学学报, 2011, 13(5): 21-23.

Journal of Epilepsy

Clinical efficacy analysis of Semen ziziphi spinosae decoction combined Sodium valproate sustained-release tablets on treating post-traumatic epilepsy

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