成人癫痫伴焦虑的研究进展_Journal of Epilepsy

Authors：

臧学革 ¹ , 乔慧 ¹ , 冯晓娜 ¹ , 陈艳艳 ² ,  王立波 ¹

1. ;
2. ;

Corresponding author：

王立波, Email: 935583975@qq.com

Keywords：

DOI：

10.7507/2096-0247.20200072

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大量流行病学研究表明焦虑性障碍（Anxiety disorder，AD）在癫痫患者中的患病率高于普通人群，AD 不仅能增加癫痫患者的自杀风险，还可导致疾病进一步恶化。目前，我国对于成人癫痫伴焦虑的研究仍不成熟，临床医生对于癫痫患者共患焦虑仍缺乏进一步的认识，使得临床上误诊率高，患者病情未能得到及时的治疗。文章结合国内外最新研究，对成人癫痫伴焦虑的危险因素、发病机制、分类、诊断、鉴别诊断、筛查、治疗等方面作一综述，为临床诊治提供参考。

Citation： 臧学革, 乔慧, 冯晓娜, 陈艳艳, 王立波. 成人癫痫伴焦虑的研究进展. Journal of Epilepsy, 2020, 6(5): 436-442. doi: 10.7507/2096-0247.20200072 Copy

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1. Hesdorffer DC, Ishihara L, Mynepalli L, <italic>et al</italic>. Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Ann Neurol, 2012, 72(2): 184-191.
2. Bourdon KH, Rae DS, Locke BZ, <italic>et al</italic>. Estimating the prevalence of mental disorders in US adults from the Epidemiologic Catchment Area Survey. Public Health Rep, Nov-Dec 1992, 107(6): 663-668.
3. Kessler RC, Petukhova M, Sampson NA, <italic>et al</italic>. Twelve‐month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res, 2012, 21(3): 169-184.
4. Alonso J, Lepine JP. Overview of key data from the European study of the epidemiology of mental disorders (ESEMeD). J Clin Psychiatry, 2007, 68(Suppl 2): 3-9.
5. Wittchen HU, Jacobi F. Size and burden of mental disorders in Europe–a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol, 2005, 15(4): 357-376.
6. Huang Y, Wang Y, Wang H, <italic>et al</italic>. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry, 2019, 6(3): 211-224.
7. Yang TW, Kim DH, Kim YS, <italic>et al</italic>. Anxiety disorders in outpatient clinics of epilepsy in tertiary care hospitals: A meta-analysis. Seizure, 2020, 75: 34-42.
8. Baxter AJ, Scott KM, Vos T, <italic>et al</italic>. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med, 2013, 43: 897-910.
9. Wittchen HU, Zhao S, Kessler RC, Eaton WW. DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Arch Gen Psychiatry, 1994, 51(5): 355-364.
10. Jansen C, Francomme L, Vignal JP, <italic>et al</italic>. Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy. Epilepsy Behav, 2019, 94: 288-296.
11. Gandy M, Sharpe L, Perry KN, <italic>et al</italic>. Rates of DSM-IV mood, anxiety disorders, and suicidality in Australian adult epilepsy outpatients: a comparison of well-controlled versus refractory epilepsy. Epilepsy Behav, 2013, 26: 29-35.
12. Rai D, Kerr MP, McManus S, <italic>et al</italic>. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia, 2012, 53(7): 1095-1103.
13. Scott AJ, Sharpe L, Hunt C, <italic>et al</italic>. Anxiety and depressive disorders in people with epilepsy: A meta-analysis. Epilepsia, 2017, 58(6): 973-982.
14. Tellez-Zenteno JF, Patten SB, Jetté N, <italic>et al</italic>. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia, 2007, 48(12): 2336-2344.
15. Jones JE, Hermann BP, Barry JJ, <italic>et al</italic>. Clinical assessment of axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci, 2005, 17(2): 172-179.
16. Brandt C, Mula M. Anxiety disorders in people with epilepsy. Epilepsy Behav, 2016, 59: 87-91.
17. Tang WK, Lu J, Ungvari GS, <italic>et al</italic>. Anxiety symptoms in patients with frontal lobe epilepsy versus generalized epilepsy. Seizure, 2012, 21(6): 457-460.
18. Jacoby A, Baker GA, Steen N, <italic>et al</italic>. The clinical course of epilepsy and its psychosocial correlates: findings from a U. K. Community study. Epilepsia, 1996, 37(2): 148-161.
19. Gaitatzis A, Trimble MR, Sander JW. The psychiatric comorbidity of epilepsy. Acta Neurol Scand, 2004, 110(4): 207-220.
20. Gaitatzis A, Carroll K, Majeed A, <italic>et al</italic>. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia, 2004, 45(12): 1613-1622.
21. Kobau R, Gilliam F, Thurman DJ. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 Health Styles Survey. Epilepsia, 2006, 47(11): 1915-1921.
22. Hingray C, McGonigal A, Kotwas I, <italic>et al</italic>. The relationship between epilepsy and anxiety disorders. Curr Psychiatry Rep, 2019, 21(6): 40.
23. Kanner AM. Anxiety disorders in epilepsy: the forgotten psychiat-ric comorbidity. Epilepsy Curr, 2011, 11(3): 90-91.
24. Kanner AM, Barry JJ, Gilliam F, <italic>et al</italic>. Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events? Epilepsia, 2012, 53(6): 1104-1108.
25. Velissaris SL, Wilson SJ, Newton MR, <italic>et al</italic>. Cognitive complaints after a first seizure in adulthood: Influence of psychological adjustment. Epilepsia, 2009, 50(5): 1012-1021.
26. Kanner AM, Byrne R, Chicharro A, <italic>et al</italic>. A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy. Neurology, 2009, 72(9): 793-799.
27. Petrovski S, Szoeke CE, Jones NC, <italic>et al</italic>. Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients. Neurology, 2010, 75(11): 1015-1021.
28. Hamilton KT, Anderson CT, Dahodwala N, <italic>et al</italic>. Utilization of care among drug resistant epilepsy patients with symptoms of anxiety and depression. Seizure, 2014, 23(3): 196-200.
29. Noble AJ, Goldstein LH, Seed P, <italic>et al</italic>. Characteristics of people with epilepsy who attend emergency departments: prospective study of metropolitan hospital attendees. Epilepsia, 2012, 53(10): 1820-1828.
30. Choi-Kwon S, Chung C, Kim H, <italic>et al</italic>. Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea. Acta Neurol Scand, 2003, 108(6): 428-434.
31. Pham T, Sauro KM, Patten SB, <italic>et al</italic>. The prevalence of anxiety and associated factors in persons with epilepsy. Epilepsia, 2017, 58(8): e107-e110.
32. Munger Clary HM, Snively BM, Hamberger MJ. Anxiety is common and independently associated with clinical features of epilepsy. Epilepsy Behav, 2018, 85: 64-71.
33. Wang HJ, Tan G, Deng Y, <italic>et al</italic>. Prevalence and risk factors of depression and anxiety among patients with convulsive epilepsy in rural West China. Acta Neurol Scand, 2018, 138(6): 541-547.
34. Bjørk MH, Veiby G, Reiter SC, <italic>et al</italic>. Depression and anxiety in women with epilepsy during pregnancy and after delivery: a prospective population-based cohort study on frequency, risk factors, medication, and prognosis. Epilepsia, 2015, 56(1): 28-39.
35. Stahl SM. Brainstorms: symptoms and circuits, part 2: anxiety disorders. J Clin Psychiatry, 2003, 64(12): 1408-1409.
36. Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. J Clin Psychopharmacol, 2007, 27(3): 263-272.
37. Shaw FZ, Chuang SH, Shieh KR, <italic>et al</italic>. Depression-and anxiety-like behaviors of a rat model with absence epileptic discharges. Neuroscience, 2009, 160(2): 382-393.
38. Duarte FS, Duzzioni M, Hoeller AA, <italic>et al</italic>. Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? Psychopharmacology (Berl), 2013, 227(2): 209-219.
39. Kanner AM, Schachter SC, Barry JJ, <italic>et al</italic>. Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy Behav, 2012, 24: 156-168.
40. Munger Clary HM, Salpekar JA. Should adult neurologists play a role in the management of the most common psychiatric comorbid-ities?. Practical considerations. Epilepsy Behav, 2019, 98(Pt B): 309-313.
41. de Toffol B, Hingray C, Biberon J, <italic>et al</italic>. Psychiatric comor-bidities in epilepsy. Presse Med, 2018, 47(3): 243-250.
42. Kanner AM. Ictal panic and interictal panic attacks: diagnostic and therapeutic principles. Neurol Clin, 2011, 29(1): 163-175.
43. American Psychiatric Association. Diagnostic and statistical manual for mental disorders-IV-TR. Arlington (VA): American Psychiatric Publishing, 1994: 1-915.
44. American Psychiatric Association. Diagnostic and statistical manual for mental disorders-5. Arlington (VA): American Psychiatric Publishing, 2013: 1-970.
45. Cleary RA, Baxendale SA, Thompson PJ, <italic>et al</italic>. Predicting and preventing psychopathology following temporal lobe epilepsy sur-gery. Epilepsy Behav, 2013, 26: 322-334.
46. Jones JE, Hermann BP, Barry JJ, <italic>et al</italic>. Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci, 2014, 17(2): 172-179.
47. Cohen JF, Korevaar DA, Altman DG, <italic>et al</italic>. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ Open, 2016, 6(11): e012799.
48. Brown TA, Campbell LA, Lehman CL, <italic>et al</italic>. Current and lifetime co-morbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. J Abnorm Psychol, 2001, 110(4): 585.
49. Bias AR. QUADAS 2. Am J Gastroenterol, 2012, 107: 1354-1360.
50. Wang Z, Luo Z, Li S, <italic>et al</italic>. Anxiety screening tools in people with epilepsy: A systematic review of validated tools. Epilepsy Behav, 2019, 99: 106392.
51. Sheehan DV, Lecrubier Y, Sheehan KH, <italic>et al</italic>. The va-lidity of the Mini International Neuropsychiatric Interview (MINI) according to the SCID-P and its reliability. Eur Psychiatry, 1997, 12(5): 232-241.
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