The effect of the mode of continuous guidance with wechat group on the ketogenic diet retention rate in children with infantile spasms_Journal of Epilepsy

Authors：

ZHA Jian , CAO Fangfang , XIONG Ling , FANG Juhua , YI Zhaoshi , YANG Qianqian , CHEN Yong ,  ZHONG Jianmin

Department of Neurology, Jiangxi Provincial Children's Hospital(The Affiliated Children's Hospital of Nanchang University), Nanchang 330006, China;

Corresponding author：

ZHONG Jianmin, Email: zhongjm@126.com

Keywords：

Ketogenic diet; Infantile spasms; Wechat; Retention rate; Efficacy

DOI：

10.7507/2096-0247.20210020

Video：

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Objective To explore the impact on the retention and effective rate of the mode of continuous guidance with wechat group in children with infantile spasms (IS) treated by ketogenic diet (KD).Methods The clinical data of 40 children who received KD treatment in Jiangxi Children’s Hospital from January 2017 to June 2019 were retrospectively analyzed, including 23 males and 17 females, the average age was (19.90±13.10) months and the average course was (9.95±7.61) months. They were randomly divided into control group (20 cases) and observation group (wechat group continuity Guidance Group, 20 cases), and followed up one year to compare the retention rate and efficacy.Results There was no statistical difference between the general data of the observation group and the control group (P>0.05). After 9 and 12 months of KD treatment, the retention and effective rate of the observation group was significantly higher than the control group (P<0.05). And the seizure-free rate was higher than the control group (35% vs. 10%, 35% vs. 15%).Conclusion This model of continuous guidance with wechat group can increase the KD retention rate of IS children, And increase the effective rate.

Citation： ZHA Jian, CAO Fangfang, XIONG Ling, FANG Juhua, YI Zhaoshi, YANG Qianqian, CHEN Yong, ZHONG Jianmin. The effect of the mode of continuous guidance with wechat group on the ketogenic diet retention rate in children with infantile spasms. Journal of Epilepsy, 2021, 7(2): 122-126. doi: 10.7507/2096-0247.20210020 Copy

1.	甘靖, 屈艺, 罗蓉. 婴儿痉挛症治疗进展. 中华实用儿科临床杂志, 2014, 29(24): 1889-1892.
2.	Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
3.	Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
4.	Pires ME, Ilea A, Bourel E, et al. Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study. Epilepsy Research, 2013, 105(1-2): 189-194.
5.	Numis AL, Yellen MB, Chu-Shore CJ, et al. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Research, 2011, 96(1-2): 172-175.
6.	中国医师协会神经内科医师分会儿童神经专业委员会, 中华医学会儿科学分会神经学组. 生酮饮食治疗儿童癫痫性脑病循证指南. 中华实用儿科临床杂志, 2019, 34(12): 881-888.
7.	Hong AM, Turner Z, Hamdy RF, et al. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, 51(8): 1403-1407.
8.	查剑, 易招师, 钟建民, 等. 生酮饮食治疗儿童难治性癫痫的临床观察. 江西医药, 2015, (5): 461-464.
9.	吴革菲, 胡家胜, 吴舒华, 等. 生酮饮食治疗婴儿痉挛症的疗效和保留率. 中华实用儿科临床杂志, 2017, 32(10): 780-783.
10.	胡春辉, 王华. 生酮饮食治疗婴儿痉挛25例临床分析. 中华实用儿科临床杂志, 2015, 30(7): 532-534.
11.	石卉, 任翼, 石霖. 儿科微信公众平台的运行现状调研. 科技情报开发与经济, 2015, 25(20): 104-107.
12.	蒋凤宣, 郑帼. 生酮饮食治疗婴儿痉挛症 31 例临床分析. 南京医科大学学报(自然科学版), 2018, 38(2): 257-259.
13.	Kossoff EH, Hedderick EF, Turner Z, et al. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia, 2010, 49(9): 1504-1509.
14.	Eun SH, Kang HC, Kim DW, et al. Ketogenic diet for treatment of infantile spasms. Brain & Development, 2006, 28(9): 566-571.
15.	Kayyali HR, Gustafson M, Myers T, et al. Ketogenic Diet Efficacy in the Treatment of Intractable Epileptic Spasms. Pediatric Neurology, 2014, 50(3): 224-227.

1. 甘靖, 屈艺, 罗蓉. 婴儿痉挛症治疗进展. 中华实用儿科临床杂志, 2014, 29(24): 1889-1892.
2. Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
3. Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
4. Pires ME, Ilea A, Bourel E, et al. Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study. Epilepsy Research, 2013, 105(1-2): 189-194.
5. Numis AL, Yellen MB, Chu-Shore CJ, et al. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Research, 2011, 96(1-2): 172-175.
6. 中国医师协会神经内科医师分会儿童神经专业委员会, 中华医学会儿科学分会神经学组. 生酮饮食治疗儿童癫痫性脑病循证指南. 中华实用儿科临床杂志, 2019, 34(12): 881-888.
7. Hong AM, Turner Z, Hamdy RF, et al. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, 51(8): 1403-1407.
8. 查剑, 易招师, 钟建民, 等. 生酮饮食治疗儿童难治性癫痫的临床观察. 江西医药, 2015, (5): 461-464.
9. 吴革菲, 胡家胜, 吴舒华, 等. 生酮饮食治疗婴儿痉挛症的疗效和保留率. 中华实用儿科临床杂志, 2017, 32(10): 780-783.
10. 胡春辉, 王华. 生酮饮食治疗婴儿痉挛25例临床分析. 中华实用儿科临床杂志, 2015, 30(7): 532-534.
11. 石卉, 任翼, 石霖. 儿科微信公众平台的运行现状调研. 科技情报开发与经济, 2015, 25(20): 104-107.
12. 蒋凤宣, 郑帼. 生酮饮食治疗婴儿痉挛症 31 例临床分析. 南京医科大学学报(自然科学版), 2018, 38(2): 257-259.
13. Kossoff EH, Hedderick EF, Turner Z, et al. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia, 2010, 49(9): 1504-1509.
14. Eun SH, Kang HC, Kim DW, et al. Ketogenic diet for treatment of infantile spasms. Brain & Development, 2006, 28(9): 566-571.
15. Kayyali HR, Gustafson M, Myers T, et al. Ketogenic Diet Efficacy in the Treatment of Intractable Epileptic Spasms. Pediatric Neurology, 2014, 50(3): 224-227.

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