肠道菌群与癫痫相关性研究进展_Journal of Epilepsy

Authors：

宋成艳 ¹ ,  李亚军 ²

1. ;
2. ;

Corresponding author：

李亚军, Email: liyajun9@hotmail.com

Keywords：

肠道菌群; 癫痫; 自身免疫性癫痫; 治疗

DOI：

10.7507/2096-0247.20210027

Video：

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癫痫为高度异质性的慢性脑部疾病，长期反复发作可遗留严重的神经功能残障，给患者及其家庭、社会带来沉重的疾病负担。自身免疫性癫痫是免疫介导的伴有不同发作形式的特殊类型癫痫，此类患者脑脊液/血液中可检测到特异性神经元抗体。限于癫痫发作复杂的病因学基础、发病及复发机制，癫痫的诊疗一直面临挑战。最近的研究表明，癫痫特别是自身免疫性癫痫患者肠道菌群存在异常改变，自身免疫性癫痫发作可能与肠道菌群改变及炎症细胞因子的释放有着因果关系。益生菌补充剂、粪便菌群移植等重建正常肠道菌群疗法能很大程度改善患者病情和预后，免疫联合微生物疗法可能是未来治疗自身免疫性癫痫的关键策略。

Citation： 宋成艳, 李亚军. 肠道菌群与癫痫相关性研究进展. Journal of Epilepsy, 2021, 7(2): 159-161. doi: 10.7507/2096-0247.20210027 Copy

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17.	Bien C G, Holtkamp M. “Autoimmune Epilepsy”: Encephalitis With Autoantibodies for Epileptologists. Epilepsy Curr, 2017, 17(3): 134-141.
18.	Yeshokumar AK, Pardo CA. Autoimmune epilepsies. Seminars in Pediatric Neurology, 2017, 24(3): 161-167.
19.	Bauer J, Becker AJ, Elyaman W, et al. Innate and adaptive immunity in human epilepsies. Epilepsia, 2017, 58(Suppl 3): 57-68.
20.	Belkaid Y, Harrison O J. Homeostatic immunity and the microbiota. Immunity, 2017, 46(4): 562-576.
21.	Divyanshu Dubey, Sean J Pittock, Andrew McKeon. Antibody prevalence in epilepsy and encephalopathy score: Increased specificity and applicability. Epilepsia, 2019, 60(2): 367-369.
22.	Dunphy-Doherty F, O'Mahony S M, Peterson V L, et al. Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain Behav Immun, 2018, 68: 261-273.
23.	Rothhammer V, Borucki D M, Tjon E C, et al. Microglial control of astrocytes in response to microbial metabolites. Nature, 2018, 557(7707): 724-728.
24.	M Gómez-Eguílaz, J L Ramón-Trapero, L Pérez-Martínez, et al. The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study. Beneficial microbes, 2018, 9(6): 875-881.
25.	Stephenson J, Nutma E, Valk P, et al. Inflammation in CNS neurodegenerative diseases. Immunology, 2018, 154(2): 204-219.
26.	Evrensel A, Ceylan ME. Fecal microbiota transplantation and its usage in neuropsychiatric disorders. Clin Psychopharmacol Neurosci, 2016, 14(3): 231-237.
27.	Zhi He, Bo-Ta Cui, Ting Zhang, et al. Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report. World J Gastroenterol, 2017, 23(19): 3565-3568.
28.	曾畅, 王冕, 张晨, 等. 自身免疫性癫痫入院诊断与免疫治疗转归的相关性. 中南大学学报(医学版), 2019, 44(8): 885-891.
29.	BP Kelley, SC Patel, HL Marin, et al. Autoimmune encephalitis: pathophysiology and imaging review of an overlooked diagnosis. American journal of neuroradiology, 2017, 38(6): 1070-1078.

1. Bliss ES, Whiteside E. The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol, 2018, 9: 900.
2. 王春敏, 李丽秋. 人体肠道正常菌群的研究进展. 中国微生态学杂志, 2010, 22(8): 760-762.
3. Qianquan M, Changsheng X, Wenyong L, et al. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. Journal of neuroinflammation, 2016, 16(1): 53.
4. Rodrigues-Amorim D, Rivera-Baltanas T, Regueiro B, et al. The role of the gut microbiota in schizophrenia: Current and future perspectives. World J Biol Psychiatry, 2018, 19(8): 571-585.
5. Sherwin E, Dinan TG, Cryan JF. Recent developments in understanding the role of the gut microbiota in brain health and disease. Ann N Y Acad Sci, 2018, 1420(1): 5-25.
6. Olga L Rojas, Anne-Katrin Pröbstel, Elisa A Porfilio, et al. Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10. Cell, 2019, 176(3): 610-624.
7. Lum GR, Olson CA, Hsiao EY. Emerging roles for the intestinal microbiome in epilepsy. Neurobiol Dis, 2019: 104576.
8. Patterson V. Managing epilepsy by telemedicine in resource-poor settings. Front Public Health, 2019, 7: 321.
9. Rothschild D, Weissbrod O, Barkan E, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature, 2018, 555(7695): 210-215.
10. Bagheri S, Heydari A, Alinaghipour A, et al. Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling. Epilepsy Behav, 2019, 95(1): 43-50.
11. Liang L, Yuan J, Zhang S, et al. Effects of gut microbiota disturbance induced in early life on the expression of extrasynaptic GABA-A receptor Î±5 and Î´ subunits in the hippocampus of adult rat. Brain Research Bulletin, 2017, 135(1): 113.
12. Peng A, Qiu X, Lai W, et al. Altered composition of the gut microbiome in patients with drug-resistant epilepsy. Epilepsy Research, 2018, 147(1): 102-107.
13. Marie L, Alexander E, Hamid D, et al. The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy. NPJ biofilms and microbiomes, 2019, 5(1): 5.
14. Xie G, Zhou Q, Qiu C, et al. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J Gastroenterol, 2017, 23(33): 6164-6171.
15. Vuong HE, Yano JM, Fung TC, et al. The Microbiome and Host Behavior. Annual review of neuroscience, 2017, 40: 21-49.
16. Medel-Matus J S, Shin D, Dorfman E, et al. Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome. Epilepsia Open, 2018, 3(2): 290-294.
17. Bien C G, Holtkamp M. “Autoimmune Epilepsy”: Encephalitis With Autoantibodies for Epileptologists. Epilepsy Curr, 2017, 17(3): 134-141.
18. Yeshokumar AK, Pardo CA. Autoimmune epilepsies. Seminars in Pediatric Neurology, 2017, 24(3): 161-167.
19. Bauer J, Becker AJ, Elyaman W, et al. Innate and adaptive immunity in human epilepsies. Epilepsia, 2017, 58(Suppl 3): 57-68.
20. Belkaid Y, Harrison O J. Homeostatic immunity and the microbiota. Immunity, 2017, 46(4): 562-576.
21. Divyanshu Dubey, Sean J Pittock, Andrew McKeon. Antibody prevalence in epilepsy and encephalopathy score: Increased specificity and applicability. Epilepsia, 2019, 60(2): 367-369.
22. Dunphy-Doherty F, O'Mahony S M, Peterson V L, et al. Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain Behav Immun, 2018, 68: 261-273.
23. Rothhammer V, Borucki D M, Tjon E C, et al. Microglial control of astrocytes in response to microbial metabolites. Nature, 2018, 557(7707): 724-728.
24. M Gómez-Eguílaz, J L Ramón-Trapero, L Pérez-Martínez, et al. The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study. Beneficial microbes, 2018, 9(6): 875-881.
25. Stephenson J, Nutma E, Valk P, et al. Inflammation in CNS neurodegenerative diseases. Immunology, 2018, 154(2): 204-219.
26. Evrensel A, Ceylan ME. Fecal microbiota transplantation and its usage in neuropsychiatric disorders. Clin Psychopharmacol Neurosci, 2016, 14(3): 231-237.
27. Zhi He, Bo-Ta Cui, Ting Zhang, et al. Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report. World J Gastroenterol, 2017, 23(19): 3565-3568.
28. 曾畅, 王冕, 张晨, 等. 自身免疫性癫痫入院诊断与免疫治疗转归的相关性. 中南大学学报(医学版), 2019, 44(8): 885-891.
29. BP Kelley, SC Patel, HL Marin, et al. Autoimmune encephalitis: pathophysiology and imaging review of an overlooked diagnosis. American journal of neuroradiology, 2017, 38(6): 1070-1078.

Journal of Epilepsy

肠道菌群与癫痫相关性研究进展

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