迷走神经刺激治疗药物难治性癫痫的中国专家共识_Journal of Epilepsy

Authors：

 中国抗癫痫协会神经调控专业委员会 ,  中国医师协会神经调控专业委员会 ,  中华医学会神经外科分会神经生理学组

执笔（排名不分先后）吴晔（北京大学第一医院），周健（首都医科大学三博脑科医院），关宇光（首都医科大学三博脑科医院），孟凡刚（北京市神经外科研究所、首都医科大学附属天坛医院），季涛云（北京大学第一医院）;

Corresponding author：

中国抗癫痫协会神经调控专业委员会, Email: luangm3@163.com; 中国医师协会神经调控专业委员会, Email: jiangyuwu@bjmu.edu.cn; 中华医学会神经外科分会神经生理学组, Email: zjguo73@126.com

Keywords：

DOI：

10.7507/2096-0247.20210031

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Citation： 中国抗癫痫协会神经调控专业委员会, 中国医师协会神经调控专业委员会, 中华医学会神经外科分会神经生理学组. 迷走神经刺激治疗药物难治性癫痫的中国专家共识. Journal of Epilepsy, 2021, 7(3): 191-196. doi: 10.7507/2096-0247.20210031 Copy

1.	中华医学会编著临床诊疗指南·癫痫病分册(2015修订版). 北京: 人民卫生出版社, 2015.6.
2.	Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 2010, 51(6): 1069-77.
3.	Famm K, Litt B, Tracey KJ, et al. Drug discovery: a jump-start for electroceuticals. Nature, 2013, 496(7444): 159-161.
4.	Smalley E. The business of brain-computer interfaces. Nat Biotechnol, 2019, 37(9): 978-982.
5.	Hachem LD, Wong SM, Ibrahim GM. The vagus afferent network: emerging role in translational connectomics. Neurosurg Focus, 2018, 45(3): E2.
6.	Johnson RL, Wilson CG. A review of vagus nerve stimulation as a therapeutic intervention. J Inflamm Res, 2018, 11: 203-213.
7.	Spencer SS. Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia, 2002, 43(3): 219-227.
8.	Engineer ND, Riley JR, Seale JD, et al. Reversing pathological neural activity using targeted plasticity. Nature, 2011, 470(7332): 101-104.
9.	Cai PY, Bodhit A, Derequito, et al. Vagus nerve stimulation in ischemic stroke: old wine in a new bottle. Front Neurol, 2014, 5: 107.
10.	张建国, 张凯, 孟凡刚主编. 迷走神经刺激术, 北京: 人民卫生出版社, 2019, ISBN 978-7-117-28935-1.
11.	孟凡刚, 张凯, 邵晓秋, 等. 国产迷走神经刺激器治疗药物难治性癫痫的前瞻性多中心随机对照临床试验研究. 中华神经外科杂志, 2016, 32(9): 913-917.
12.	中国医师协会神经内科分会癫专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
13.	Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy Behav, 2020, 112: 107373.
14.	Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: A European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
15.	Liu H, Yang Z, Huang L, et al. Heart-rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug-resistant epilepsy. Epilepsia, 2017, 58(6): 1015-1022.
16.	Liu HY, Yang Z, Meng FG, et al. Preoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy. Sci Rep, 2018, 8(1): 3856.
17.	Mithani K, Mikhail M, Morgan BR, et al. Connectomic Profiling Identifies Responders to Vagus Nerve Stimulation. Ann Neurol, 2019, 86(5): 743-753.
18.	Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: A scopingreview. Epilepsia, 2020, 61(10): 2069-2085.
19.	李超, 马翔宇, 徐硕, 等. 颈部单切口在迷走神经刺激术中的应用. 中华神经外科杂志, 2017, 33(6): 640-641.
20.	Xie H, Ji T, Ma J, et al. Remote programming: A convenient and cost-effective measure of vagus nerve stimulation for children with epilepsy. Epilepsy Res, 2020, 159: 106246.
21.	Eggleston KS, Olin BD, Fisher RS. Ictal tachycardia: the head-heart connection. Seizure, 2014, 23(7): 496-505.
22.	姜玉武. 儿童癫痫治疗需重视顶层设计和适时合理使用多种治疗方法. 中华儿科杂志, 2020, 58(11): 867-870.
23.	González HFJ, Yengo-Kahn A, Englot DJ. Vagus Nerve Stimulation for the Treatment of Epilepsy. Neurosurg Clin N Am, 2019, 30(2): 219-230.
24.	Morris GL 3rd, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
25.	Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: A 10-17 year follow-up study. Seizure, 2018, 59: 41-47.
26.	Kuba R, Brázdil M, Kalina M, et al. Vagus nerve stimulation: longitudinal follow-up of patients treated for 5 years. Seizure, 2009, 18(4): 269-274.
27.	Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
28.	Kossoff EH, Shields WD. Nonpharmacologic care for patients with Lennox-Gastaut syndrome: ketogenic diets and vagus nerve stimulation. Epilepsia, 2014, 55(Suppl 4): 29-33.
29.	Dibué-Adjei M, Fischer I, Steiger HJ, et al. Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: A meta-analysis of 68 patients. Seizure, 2017, 50: 147-152.
30.	Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg, 2011, 115(6): 1248-1255.
31.	Fan PC, Peng SSF, Yen RF, et al. Neuroimaging and electroencephalographic changes after vagus nerve stimulation in a boy with medically intractable myoclonic astatic epilepsy. J Formos Med Assoc, 2014, 113(4): 258-263.
32.	Wilfong AA, Schultz RJ. Vagus nerve stimulation for treatment of epilepsy in Rett syndrome. Dev Med Child Neurol, 2006, 48(8): 683-686.
33.	Welch WP, Sitwat B, Sogawa Y. Use of Vagus Nerve Stimulator on children with primary generalized epilepsy. J Child Neurol, 2018, 33(7): 449-452.
34.	Dibué-Adjei M, Brigo F, Yamamoto T. Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review. Brain Stimul, 2019, 12(5): 1101-1110.
35.	Toffa DH, Touma L, El Meskine T, et al. Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: A critical review. Seizure, 2020, 83: 104-123.
36.	Wheless JW, Gienapp AJ, Ryvlin P. Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav, 2018, 88(Suppl): 2-10.
37.	Spindler P, Bohlmann K, Straub HB, et al. Effects of vagus nerve stimulation on symptoms of depression in patients with difficult-to-treat epilepsy. Seizure, 2019, 69: 77-79.
38.	Annegers JF, Coan SP, Hauser WA, et al. Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality, and sudden, unexpected, unexplained death. Epilepsia, 2000, 41(5): 549-553.
39.	Englot DJ, Hassnain KH, Rolston JD, et al. Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data. Epilepsy Behav, 2017, 66: 4-9.
40.	Levy ML, Levy KM, Hoff D, et al. Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. J NeurosurgPediatr, 2010, 5(6): 595-602.
41.	Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav, 2011, 20(1): 57-63.
42.	Révész D, Rydenhag B, Ben-Menachem E. Complications and safety of vagus nerve stimulation: 25 years of experience at a single center. J NeurosurgPediatr, 2016, 18(1): 97-104.
43.	Ohemeng KK, Parham K. Vagal nerve stimulation: indications, implantation, and outcomes. Otolaryngol Clin North Am, 2020, 53(1): 127-143.
44.	Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 1998, 51(1): 48-55.
45.	Liporace J, Hucko D, Morrow R, et al. Vagal nerve stimulation: adjustments to reduce painful side effects. Neurology, 2001, 57(5): 885-886.
46.	Frei MG, Osorio I. Left vagus nerve stimulation with the neurocybernetic prosthesis has complex effects on heart rate and on its variability in humans. Epilepsia, 2001, 42(8): 1007-1116.
47.	Binks AP, Paydarfar D, Schachter SC, et al. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respir Physiol, 2001, 127(2-3): 125-133.

1. 中华医学会编著临床诊疗指南·癫痫病分册(2015修订版). 北京: 人民卫生出版社, 2015.6.
2. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 2010, 51(6): 1069-77.
3. Famm K, Litt B, Tracey KJ, et al. Drug discovery: a jump-start for electroceuticals. Nature, 2013, 496(7444): 159-161.
4. Smalley E. The business of brain-computer interfaces. Nat Biotechnol, 2019, 37(9): 978-982.
5. Hachem LD, Wong SM, Ibrahim GM. The vagus afferent network: emerging role in translational connectomics. Neurosurg Focus, 2018, 45(3): E2.
6. Johnson RL, Wilson CG. A review of vagus nerve stimulation as a therapeutic intervention. J Inflamm Res, 2018, 11: 203-213.
7. Spencer SS. Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia, 2002, 43(3): 219-227.
8. Engineer ND, Riley JR, Seale JD, et al. Reversing pathological neural activity using targeted plasticity. Nature, 2011, 470(7332): 101-104.
9. Cai PY, Bodhit A, Derequito, et al. Vagus nerve stimulation in ischemic stroke: old wine in a new bottle. Front Neurol, 2014, 5: 107.
10. 张建国, 张凯, 孟凡刚主编. 迷走神经刺激术, 北京: 人民卫生出版社, 2019, ISBN 978-7-117-28935-1.
11. 孟凡刚, 张凯, 邵晓秋, 等. 国产迷走神经刺激器治疗药物难治性癫痫的前瞻性多中心随机对照临床试验研究. 中华神经外科杂志, 2016, 32(9): 913-917.
12. 中国医师协会神经内科分会癫专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
13. Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy Behav, 2020, 112: 107373.
14. Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: A European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
15. Liu H, Yang Z, Huang L, et al. Heart-rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug-resistant epilepsy. Epilepsia, 2017, 58(6): 1015-1022.
16. Liu HY, Yang Z, Meng FG, et al. Preoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy. Sci Rep, 2018, 8(1): 3856.
17. Mithani K, Mikhail M, Morgan BR, et al. Connectomic Profiling Identifies Responders to Vagus Nerve Stimulation. Ann Neurol, 2019, 86(5): 743-753.
18. Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: A scopingreview. Epilepsia, 2020, 61(10): 2069-2085.
19. 李超, 马翔宇, 徐硕, 等. 颈部单切口在迷走神经刺激术中的应用. 中华神经外科杂志, 2017, 33(6): 640-641.
20. Xie H, Ji T, Ma J, et al. Remote programming: A convenient and cost-effective measure of vagus nerve stimulation for children with epilepsy. Epilepsy Res, 2020, 159: 106246.
21. Eggleston KS, Olin BD, Fisher RS. Ictal tachycardia: the head-heart connection. Seizure, 2014, 23(7): 496-505.
22. 姜玉武. 儿童癫痫治疗需重视顶层设计和适时合理使用多种治疗方法. 中华儿科杂志, 2020, 58(11): 867-870.
23. González HFJ, Yengo-Kahn A, Englot DJ. Vagus Nerve Stimulation for the Treatment of Epilepsy. Neurosurg Clin N Am, 2019, 30(2): 219-230.
24. Morris GL 3rd, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
25. Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: A 10-17 year follow-up study. Seizure, 2018, 59: 41-47.
26. Kuba R, Brázdil M, Kalina M, et al. Vagus nerve stimulation: longitudinal follow-up of patients treated for 5 years. Seizure, 2009, 18(4): 269-274.
27. Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
28. Kossoff EH, Shields WD. Nonpharmacologic care for patients with Lennox-Gastaut syndrome: ketogenic diets and vagus nerve stimulation. Epilepsia, 2014, 55(Suppl 4): 29-33.
29. Dibué-Adjei M, Fischer I, Steiger HJ, et al. Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: A meta-analysis of 68 patients. Seizure, 2017, 50: 147-152.
30. Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg, 2011, 115(6): 1248-1255.
31. Fan PC, Peng SSF, Yen RF, et al. Neuroimaging and electroencephalographic changes after vagus nerve stimulation in a boy with medically intractable myoclonic astatic epilepsy. J Formos Med Assoc, 2014, 113(4): 258-263.
32. Wilfong AA, Schultz RJ. Vagus nerve stimulation for treatment of epilepsy in Rett syndrome. Dev Med Child Neurol, 2006, 48(8): 683-686.
33. Welch WP, Sitwat B, Sogawa Y. Use of Vagus Nerve Stimulator on children with primary generalized epilepsy. J Child Neurol, 2018, 33(7): 449-452.
34. Dibué-Adjei M, Brigo F, Yamamoto T. Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review. Brain Stimul, 2019, 12(5): 1101-1110.
35. Toffa DH, Touma L, El Meskine T, et al. Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: A critical review. Seizure, 2020, 83: 104-123.
36. Wheless JW, Gienapp AJ, Ryvlin P. Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav, 2018, 88(Suppl): 2-10.
37. Spindler P, Bohlmann K, Straub HB, et al. Effects of vagus nerve stimulation on symptoms of depression in patients with difficult-to-treat epilepsy. Seizure, 2019, 69: 77-79.
38. Annegers JF, Coan SP, Hauser WA, et al. Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality, and sudden, unexpected, unexplained death. Epilepsia, 2000, 41(5): 549-553.
39. Englot DJ, Hassnain KH, Rolston JD, et al. Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data. Epilepsy Behav, 2017, 66: 4-9.
40. Levy ML, Levy KM, Hoff D, et al. Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. J NeurosurgPediatr, 2010, 5(6): 595-602.
41. Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav, 2011, 20(1): 57-63.
42. Révész D, Rydenhag B, Ben-Menachem E. Complications and safety of vagus nerve stimulation: 25 years of experience at a single center. J NeurosurgPediatr, 2016, 18(1): 97-104.
43. Ohemeng KK, Parham K. Vagal nerve stimulation: indications, implantation, and outcomes. Otolaryngol Clin North Am, 2020, 53(1): 127-143.
44. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 1998, 51(1): 48-55.
45. Liporace J, Hucko D, Morrow R, et al. Vagal nerve stimulation: adjustments to reduce painful side effects. Neurology, 2001, 57(5): 885-886.
46. Frei MG, Osorio I. Left vagus nerve stimulation with the neurocybernetic prosthesis has complex effects on heart rate and on its variability in humans. Epilepsia, 2001, 42(8): 1007-1116.
47. Binks AP, Paydarfar D, Schachter SC, et al. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respir Physiol, 2001, 127(2-3): 125-133.

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迷走神经刺激治疗药物难治性癫痫的中国专家共识

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