儿童良性癫痫伴中央颞区棘波药物治疗的研究进展_Journal of Epilepsy

Authors：

牛凯 ,  王小姗

南京医科大学附属脑科医院　神经内科（南京 210029）;

Corresponding author：

王小姗, Email: lidou2005@126.com

Keywords：

儿童良性癫痫伴中央颞区棘波; 抗癫痫药物; 脑电图; 认知功能; 功能磁共振

DOI：

10.7507/2096-0247.20210037

Video：

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儿童良性癫痫伴中央颞区棘波（Benign childhood epilepsy with centrotemporal spikes，BECT）是最常见的儿童局灶性癫痫综合征，可导致患儿神经心理功能的广泛受损。然而，BECT 的治疗一直存在颇多争议，抗癫痫药物的使用时机缺乏统一结论，药物治疗的具体风险和收益尚未明了。本文就 BECT 药物治疗的相关研究进展进行综述，着重从脑电图、神经心理功能、大脑功能活动等方面讨论药物治疗的影响，以供后续研究参考，进而为临床治疗提供意见。

Citation： 牛凯, 王小姗. 儿童良性癫痫伴中央颞区棘波药物治疗的研究进展. Journal of Epilepsy, 2021, 7(3): 241-245. doi: 10.7507/2096-0247.20210037 Copy

1.	Heijbel J, Blom S, Bergfors PG. Benign epilepsy of children with centrotemporal EEG foci. A study of incidence rate in outpatient care. Epilepsia, 1975, 16(5): 657-664.
2.	Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia, 2015, 56(10): 1615-1622.
3.	Kirby A, Williams N, Koelewijn L, et al. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder. Epilepsy Behav, 2017, 72: 122-126.
4.	Jiang S, Luo C, Huang Y, et al. Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci, 2020, 14: 361.
5.	Jiang Y, Song L, Li X, et al. Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes. Hum Brain Mapp, 2019, 40(10): 3113-3124.
6.	von Stülpnagel C, Kluger G, Leiz S, et al. Levetiracetam as add-on therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood. Epilepsy Behav, 2010, 17(2): 193-198.
7.	Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS): to treat or not to treat, that is the question. Epilepsy Behav, 2010, 19(3): 197-203.
8.	Mellish LC, Dunkley C, Ferrie CD, et al. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility. Arch Dis Child, 2015, 100(1): 62-67.
9.	Liu MJ, Su XJ, Shi XY, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
10.	Gu W, Chen J, Tian W, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study. Seizure, 2020, 82: 105-108.
11.	Gkampeta A, Fidani L, Zafeiriou D, et al. Benign epilepsy with centrotemporal spikes: Relationship between type of seizures and response to medication in a Greek population. J Neurosci Rural Pract, 2015, 6(4): 545-548.
12.	Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsia, 1988, 29(3): 229-235.
13.	Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
14.	Samaitienė R, Norkūnienė J, Jurkevičienė G, et al. Behavioral problems in children with benign childhood epilepsy with centrotemporal spikes treated and untreated with antiepileptic drugs. Medicina (Kaunas), 2012, 48(7): 338-344.
15.	Xiao F, An D, Deng H, et al. Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). Seizure, 2014, 23(9): 756-761.
16.	王卫星, 付淑芳, 陈凤仪, 等. 不同类型抗癫痫药物对伴中央颞区棘波儿童良性癫痫注意网络损害及脑电图痫样放电的影响. 疑难病杂志, 2019, 18(9): 904-909.
17.	Grosso S, Balestri M, Di Bartolo RM, et al. Oxcarbazepine and atypical evolution of benign idiopathic focal epilepsy of childhood. Eur J Neurol, 2006, 13(10): 1142-1145.
18.	Verrotti A, D'Egidio C, Mohn A, et al. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia, 2011, 52(2): 199-211.
19.	McNally MA, Kossoff EH. Incidental rolandic spikes: long-term outcomes and impact of treatment. Epilepsy Behav, 2015, 43: 135-138.
20.	Operto FF, Pastorino GMG, Mazza R, et al. Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up. Epilepsy Behav, 2019, 97: 187-191.
21.	Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
22.	Lee EH, You SJ. Factors associated with electroencephalographic and clinical remission of benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2019, 41(2): 158-162.
23.	Kim H, Kim SY, Lim BC, et al. Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain Dev, 2018, 40(8): 693-698.
24.	Han JY, Choi SA, Chung YG, et al. Change of centrotemporal spikes from onset to remission in self-limited epilepsy with centrotemporal spikes (SLECTS). Brain Dev, 2020, 42(3): 270-276.
25.	Tacke M, Borggraefe I, Gerstl L, et al. Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial. Seizure, 2018, 56: 115-120.
26.	Tenney JR, Glauser T, Altaye M, et al. Longitudinal stability of interictal spikes in benign epilepsy with centrotemporal spikes. Epilepsia, 2016, 57(5): 805-811.
27.	Kanemura H, Sano F, Ohyama T, et al. Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy. Seizure, 2018, 62: 79-83.
28.	van Klink NE, van 't Klooster MA, Leijten FS, et al. Ripples on rolandic spikes: A marker of epilepsy severity. Epilepsia, 2016, 57(7): 1179-1189.
29.	Liu X, Han Q. Depression and anxiety in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). BMC Pediatr, 2016, 16(1): 128.
30.	张静, 陈芳, 靳梅, 等. 伴中央颞区棘波的儿童良性癫(痫)治疗前后脑电图与认知功能的对比分析. 国际儿科学杂志, 2016, 43(4): 329-332.
31.	Tacke M, Gerstl L, Heinen F, et al. Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS. Eur J Paediatr Neurol, 2016, 20(6): 874-879.
32.	Han MJ, Kim SJ. Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes. J Clin Neurol, 2018, 14(4): 523-529.
33.	Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
34.	孙贵玉. 左乙拉西坦与丙戊酸钠治疗 BECTS 的疗效及对患儿认知功能影响的临床对比研究. 临床和实验医学杂志, 2015, (14): 1189-1193.
35.	Wang X, Zhang Y, Long Z, et al. Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. J Psychiatr Res, 2017, 95: 68-75.
36.	Gohel SR, Biswal BB. Functional integration between brain regions at rest occurs in multiple-frequency bands. Brain Connect, 2015, 5(1): 23-34.
37.	Xu Q, Hu Z, Yang F, et al. Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy. Brain Res Bull, 2020, 162: 125-131.
38.	Zhang Q, Yang F, Hu Z, et al. Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy. Front Neurosci, 2018, 12: 796.

1. Heijbel J, Blom S, Bergfors PG. Benign epilepsy of children with centrotemporal EEG foci. A study of incidence rate in outpatient care. Epilepsia, 1975, 16(5): 657-664.
2. Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia, 2015, 56(10): 1615-1622.
3. Kirby A, Williams N, Koelewijn L, et al. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder. Epilepsy Behav, 2017, 72: 122-126.
4. Jiang S, Luo C, Huang Y, et al. Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci, 2020, 14: 361.
5. Jiang Y, Song L, Li X, et al. Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes. Hum Brain Mapp, 2019, 40(10): 3113-3124.
6. von Stülpnagel C, Kluger G, Leiz S, et al. Levetiracetam as add-on therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood. Epilepsy Behav, 2010, 17(2): 193-198.
7. Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS): to treat or not to treat, that is the question. Epilepsy Behav, 2010, 19(3): 197-203.
8. Mellish LC, Dunkley C, Ferrie CD, et al. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility. Arch Dis Child, 2015, 100(1): 62-67.
9. Liu MJ, Su XJ, Shi XY, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
10. Gu W, Chen J, Tian W, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study. Seizure, 2020, 82: 105-108.
11. Gkampeta A, Fidani L, Zafeiriou D, et al. Benign epilepsy with centrotemporal spikes: Relationship between type of seizures and response to medication in a Greek population. J Neurosci Rural Pract, 2015, 6(4): 545-548.
12. Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsia, 1988, 29(3): 229-235.
13. Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
14. Samaitienė R, Norkūnienė J, Jurkevičienė G, et al. Behavioral problems in children with benign childhood epilepsy with centrotemporal spikes treated and untreated with antiepileptic drugs. Medicina (Kaunas), 2012, 48(7): 338-344.
15. Xiao F, An D, Deng H, et al. Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). Seizure, 2014, 23(9): 756-761.
16. 王卫星, 付淑芳, 陈凤仪, 等. 不同类型抗癫痫药物对伴中央颞区棘波儿童良性癫痫注意网络损害及脑电图痫样放电的影响. 疑难病杂志, 2019, 18(9): 904-909.
17. Grosso S, Balestri M, Di Bartolo RM, et al. Oxcarbazepine and atypical evolution of benign idiopathic focal epilepsy of childhood. Eur J Neurol, 2006, 13(10): 1142-1145.
18. Verrotti A, D'Egidio C, Mohn A, et al. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia, 2011, 52(2): 199-211.
19. McNally MA, Kossoff EH. Incidental rolandic spikes: long-term outcomes and impact of treatment. Epilepsy Behav, 2015, 43: 135-138.
20. Operto FF, Pastorino GMG, Mazza R, et al. Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up. Epilepsy Behav, 2019, 97: 187-191.
21. Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
22. Lee EH, You SJ. Factors associated with electroencephalographic and clinical remission of benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2019, 41(2): 158-162.
23. Kim H, Kim SY, Lim BC, et al. Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain Dev, 2018, 40(8): 693-698.
24. Han JY, Choi SA, Chung YG, et al. Change of centrotemporal spikes from onset to remission in self-limited epilepsy with centrotemporal spikes (SLECTS). Brain Dev, 2020, 42(3): 270-276.
25. Tacke M, Borggraefe I, Gerstl L, et al. Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial. Seizure, 2018, 56: 115-120.
26. Tenney JR, Glauser T, Altaye M, et al. Longitudinal stability of interictal spikes in benign epilepsy with centrotemporal spikes. Epilepsia, 2016, 57(5): 805-811.
27. Kanemura H, Sano F, Ohyama T, et al. Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy. Seizure, 2018, 62: 79-83.
28. van Klink NE, van 't Klooster MA, Leijten FS, et al. Ripples on rolandic spikes: A marker of epilepsy severity. Epilepsia, 2016, 57(7): 1179-1189.
29. Liu X, Han Q. Depression and anxiety in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). BMC Pediatr, 2016, 16(1): 128.
30. 张静, 陈芳, 靳梅, 等. 伴中央颞区棘波的儿童良性癫(痫)治疗前后脑电图与认知功能的对比分析. 国际儿科学杂志, 2016, 43(4): 329-332.
31. Tacke M, Gerstl L, Heinen F, et al. Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS. Eur J Paediatr Neurol, 2016, 20(6): 874-879.
32. Han MJ, Kim SJ. Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes. J Clin Neurol, 2018, 14(4): 523-529.
33. Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
34. 孙贵玉. 左乙拉西坦与丙戊酸钠治疗 BECTS 的疗效及对患儿认知功能影响的临床对比研究. 临床和实验医学杂志, 2015, (14): 1189-1193.
35. Wang X, Zhang Y, Long Z, et al. Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. J Psychiatr Res, 2017, 95: 68-75.
36. Gohel SR, Biswal BB. Functional integration between brain regions at rest occurs in multiple-frequency bands. Brain Connect, 2015, 5(1): 23-34.
37. Xu Q, Hu Z, Yang F, et al. Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy. Brain Res Bull, 2020, 162: 125-131.
38. Zhang Q, Yang F, Hu Z, et al. Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy. Front Neurosci, 2018, 12: 796.

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