Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma_Journal of Epilepsy

Authors：

LI Xingchao ^1,2 , ZHANG Jinling ^1,2,3 , LI Mingzhu ¹ , WANG Youfang ⁴ , ZHOU Liangjian ¹ , SUN Xiangjun ⁵ , LI Jinkui ⁶ , CUI Yuanyuan ³ ,  CHE Fengyuan ²

1. Office of Academic Research of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
2. Brain Tumor Functional Imaging Engineering Research Center of Academic Research of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
3. Oncology Department of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
4. Intensive Care Unit of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
5. General Surgery of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
6. Internal medicine of People's Hospital of Lanshan district, Linyi 276002, China;

Corresponding author：

CHE Fengyuan, Email: che1971@126.com

Keywords：

Glioma; Epilepsy; Lipid metabolism

DOI：

10.7507/2096-0247.20210051

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Objective To investigate the correlation between epileptic seizure and lipid metabolism and nutritional index in patients with glioma.Methods 380 patients with glioma admitted to Linyi People's Hospital Affiliated to Shandong University from January 2017 to December 2019 were selected. According to whether the first symptom is epilepsy or not, patients with glioma were divided into epileptic group (n=72) and control group (n=308). Combined with the basic demographic information, lipid metabolism and nutrition indicators in the medical records, the two groups of patients were analyzed retrospectively.Results The mean age of epileptic group was (39.38±13.40) years, and the sex ratio was 1.88∶1. The mean age of the control group was (46.25±15.97) years, and the sex ratio was 1.20∶1. Chi-square test results showed that there was a statistical correlation between gender, alcohol consumption, history of hypertension and seizures (χ²=0.813, P<0.05). The results of multiple logistic regression analysis showed that there were differences in age, weight, LDL-C and potassium between the epilepsy group and the control group (P<0.05).Conclusion Male, age, weight, LDL-C and abnormal potassium concentration are risk factors for epilepsy in patients with brain tumor, and effective prevention and treatment measures should be taken in time for patients with abnormal lipid metabolism and nutritional indicators.

Citation： LI Xingchao, ZHANG Jinling, LI Mingzhu, WANG Youfang, ZHOU Liangjian, SUN Xiangjun, LI Jinkui, CUI Yuanyuan, CHE Fengyuan. Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma. Journal of Epilepsy, 2021, 7(4): 318-322. doi: 10.7507/2096-0247.20210051 Copy

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2.	Giulioni M, Martinoni M, Marucci G. Challenges in epilepsyassociated tumors. J Neurooncol, 2016, 130(1): 239-240.
3.	梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
4.	章殷希, 丁美萍. 癫痫相关脑肿瘤的临床研究进展. 癫痫杂志, 2018, 4(1): 32-35.
5.	Ertürk Çetin Ö, Isler C, Uzan M, et al. Epilepsy-related brain tumors. Seizure, 2017, 44: 93-97.
6.	明文杰, 章殷希, 沈春红, 等. 胶质神经元肿瘤相关癫痫的临床特点及影响手术疗效的相关因素. 中华神经外科杂志, 2018, 34(12): 1202-1206.
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8.	王冰, 胡世颉, 李兵, 等. 脑肿瘤相关性癫痫发生的影响因素分析及对症处理. 中国肿瘤临床与康复, 2012, 19(6): 542-544.
9.	杨虎, 陈阳美. 脑肿瘤相关性癫痫的简介及目前研究进展. 癫痫与神经电生理学杂志, 2016, 253: 162-165.
10.	You G, Sha ZY, Yan W, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of lowgrade gliomas: a clinicopathological study. Neuro Oncol, 2012, 14(2): 230-241.
11.	郭毅. 酒精(乙醇)相关性癫痫发作的临床特点及预防. 国际神经病学神经外科学杂志, 2015, 42(6): 534-538.
12.	曾军, 洪震, 黄茂盛, 等. 人群癫痫危险因素及社会心理因素病例对照研究. 中华流行病学杂志, 2003, 24(2): 116-118.
13.	卢蕾, 王赞, 孟红梅, 等. 以抽搐发作为首发症状的234例老年癫痫的病因及临床特点分析. 中风与神经疾病杂志, 2010, 27(2): 164-166.
14.	谢清, 谷晓莉, 万久香, 等. 老年人脑血管病并发癫痫的临床特点. 中华老年医学杂志, 2020, 39(09): 1025-1028.
15.	Cowie CJ, Cunningham MO. Peritumoral epilepsy: relating form and function for surgical success. Epilepsy Behav, 2014, 38: 53-61.
16.	Giulioni M, Marucci G, Martinoni M, et al. Epilepsy associated tumors: review article. World J Clin Cases, 2014, 2(11): 623-641.
17.	严金柱, 庄小鹏, 季晓林, 等. 成人癫痫患者夜间睡眠事件的多导睡眠图分析. 福建医科大学学报, 2018, 52(3): 40-44.
18.	陈婷, 陈娅, 张海清, 等. 肠道微生态与癫痫的相关性研究进展. 中华神经医学杂志, 2019, 18(4): 413-416.
19.	陈润真, 刘臣, 周鹏, 等. 急性心肌梗死经皮冠状动脉介入治疗术后D-二聚体、高敏C反应蛋白及LDL-C水平与预后的关系. 中华心血管病杂志, 2020, 48(5): 359-366.
20.	汪云, 贾小芳, 苏畅, 等. 2015年中国15省(自治区、直辖市)60岁及以上居民膳食胆固醇摄入状况及与血清胆固醇水平的关联. 卫生研究, 2019, 13(1): 33-40.
21.	曾琦, 张月华. 良性癫痫与癫痫性脑病共享致病基因研究进展. 中华儿科杂志, 2019, 57(4): 309-312.
22.	吴靖, 常丽英, 续蕾. 194例成人症状性癫痫患者的病因分析. 卒中与神经疾病, 2018, 25(3): 78-79.

1. Nowell M, Miserocchi A, McEvoy AW. Tumors in epilepsy. Semin Neurol, 2015, 35(3): 209-217.
2. Giulioni M, Martinoni M, Marucci G. Challenges in epilepsyassociated tumors. J Neurooncol, 2016, 130(1): 239-240.
3. 梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
4. 章殷希, 丁美萍. 癫痫相关脑肿瘤的临床研究进展. 癫痫杂志, 2018, 4(1): 32-35.
5. Ertürk Çetin Ö, Isler C, Uzan M, et al. Epilepsy-related brain tumors. Seizure, 2017, 44: 93-97.
6. 明文杰, 章殷希, 沈春红, 等. 胶质神经元肿瘤相关癫痫的临床特点及影响手术疗效的相关因素. 中华神经外科杂志, 2018, 34(12): 1202-1206.
7. Blümcke I, Aronica E, Becker A, et al. Low-grade epilepsy associated neuroepithelial tumours - the 2016 WHO classification. Nat Rev Neurol, 2016, 12(12): 732-740.
8. 王冰, 胡世颉, 李兵, 等. 脑肿瘤相关性癫痫发生的影响因素分析及对症处理. 中国肿瘤临床与康复, 2012, 19(6): 542-544.
9. 杨虎, 陈阳美. 脑肿瘤相关性癫痫的简介及目前研究进展. 癫痫与神经电生理学杂志, 2016, 253: 162-165.
10. You G, Sha ZY, Yan W, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of lowgrade gliomas: a clinicopathological study. Neuro Oncol, 2012, 14(2): 230-241.
11. 郭毅. 酒精(乙醇)相关性癫痫发作的临床特点及预防. 国际神经病学神经外科学杂志, 2015, 42(6): 534-538.
12. 曾军, 洪震, 黄茂盛, 等. 人群癫痫危险因素及社会心理因素病例对照研究. 中华流行病学杂志, 2003, 24(2): 116-118.
13. 卢蕾, 王赞, 孟红梅, 等. 以抽搐发作为首发症状的234例老年癫痫的病因及临床特点分析. 中风与神经疾病杂志, 2010, 27(2): 164-166.
14. 谢清, 谷晓莉, 万久香, 等. 老年人脑血管病并发癫痫的临床特点. 中华老年医学杂志, 2020, 39(09): 1025-1028.
15. Cowie CJ, Cunningham MO. Peritumoral epilepsy: relating form and function for surgical success. Epilepsy Behav, 2014, 38: 53-61.
16. Giulioni M, Marucci G, Martinoni M, et al. Epilepsy associated tumors: review article. World J Clin Cases, 2014, 2(11): 623-641.
17. 严金柱, 庄小鹏, 季晓林, 等. 成人癫痫患者夜间睡眠事件的多导睡眠图分析. 福建医科大学学报, 2018, 52(3): 40-44.
18. 陈婷, 陈娅, 张海清, 等. 肠道微生态与癫痫的相关性研究进展. 中华神经医学杂志, 2019, 18(4): 413-416.
19. 陈润真, 刘臣, 周鹏, 等. 急性心肌梗死经皮冠状动脉介入治疗术后D-二聚体、高敏C反应蛋白及LDL-C水平与预后的关系. 中华心血管病杂志, 2020, 48(5): 359-366.
20. 汪云, 贾小芳, 苏畅, 等. 2015年中国15省(自治区、直辖市)60岁及以上居民膳食胆固醇摄入状况及与血清胆固醇水平的关联. 卫生研究, 2019, 13(1): 33-40.
21. 曾琦, 张月华. 良性癫痫与癫痫性脑病共享致病基因研究进展. 中华儿科杂志, 2019, 57(4): 309-312.
22. 吴靖, 常丽英, 续蕾. 194例成人症状性癫痫患者的病因分析. 卒中与神经疾病, 2018, 25(3): 78-79.

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Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma

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