儿童良性癫痫伴中央颞区棘波的研究进展_Journal of Epilepsy

Authors：

束明珠 , 石祺 ,  王小姗

南京医科大学附属脑科医院神经内科（南京 210029）;

Corresponding author：

王小姗, Email: lidou2005@126.com

Keywords：

儿童良性癫痫伴中央颞区棘波; 病因; 诊断; 治疗

DOI：

10.7507/2096-0247.20210054

Video：

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Abstract Full text Figures/Tables Video References Cited by

儿童良性癫痫伴中央颞区棘波（Benign childhood epilepsy with centrotemporal spikes，BECTS）是一种儿童时期发病的癫痫综合征，属于特发性局灶性癫痫，在所有儿童癫痫中约占 8%～23%。其临床特征为局灶性发作，发作间期脑电图显示特征性的中央颞区棘波。目前关于儿童良性癫痫伴中央颞区棘波的病因及最佳诊疗方案尚未达成明确共识，本文对近年来该病相关研究作一综述，以期对该疾病的基础及临床研究提供一定参考。

Citation： 束明珠, 石祺, 王小姗. 儿童良性癫痫伴中央颞区棘波的研究进展. Journal of Epilepsy, 2021, 7(4): 335-339. doi: 10.7507/2096-0247.20210054 Copy

1.	Loiseau P, Beaussart M. The seizures of benign childhood epilepsy with Rolandic paroxysmal discharges. Epilepsia, 1973, 14(4): 381-389.
2.	Guerrini R. Epilepsy in children. Lancet, 2006, 367(9509): 499-524.
3.	Engel J, Jr. International League Against E. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia, 2001, 42(6): 796-803.
4.	Panayiotopoulos CP, Michael M, Sanders S, et al. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain, 2008, 131(Pt 9): 2264-2286.
5.	Dryzalowski P, Jozwiak S, Franckiewicz M, et al. Benign epilepsy with centrotemporal spikes - Current concepts of diagnosis and treatment. Neurol Neurochir Pol, 2018, 52(6): 677-689.
6.	Vears DF, Tsai MH, Sadleir LG, et al. Clinical genetic studies in benign childhoodepilepsy with centrotemporal spikes. Epilepsia, 2012, 53(2): 319-324.
7.	Bali B, Kull LL, Strug LJ, et al. Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families. Epilepsia, 2007, 48(12): 2266-2272.
8.	Lee YJ, Hwang SK, Kwon S. The clinical spectrum of benign epilepsy with centro-temporal spikes: a challenge in categorization and predictability. J Epilepsy Res, 2017, 7(1): 1-6.
9.	Xiong W, Zhou D. Progress in unraveling the genetic etiology of rolandic epilepsy. Seizure, 2017, 47: 99-104.
10.	Addis L, Virdee JK, Vidler LR, et al. Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue. Sci Rep, 2017, 7(1): 66.
11.	Lesca G, Moller RS, Rudolf G, et al. Update on the genetics of the epilepsy-aphasia spectrum and role of GRIN2A mutations. Epileptic Disord, 2019, 21(S1): 41-47.
12.	Lemke JR, Lal D, Reinthaler EM, et al. Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet, 2013, 45(9): 1067-1072.
13.	Panjwani N, Wilson MD, Addis L, et al. A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy. Ann Clin Transl Neurol, 2016, 3(7): 512-522.
14.	Fejerman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children: are they predictable? Epilepsia, 2000, 41(4): 380-390.
15.	Cerminara C, Montanaro ML, Curatolo P, et al. Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy. Neurology, 2004, 63(2): 373-375.
16.	Parmeggiani L, Seri S, Bonanni P, et al. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol, 2004, 115(1): 50-58.
17.	Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
18.	Okubo Y, Matsuura M, Asai T, et al. Epileptiform EEG discharges in healthy children: prevalence, emotional and behavioral correlates, and genetic influences. Epilepsia, 1994, 35(4): 832-841.
19.	Liu MJ, Su XJ, Md XS, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
20.	Kim EH, Yum MS, Shim WH, et al. Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS). Seizure, 2015, 27: 40-46.
21.	Thorn EL, Ostrowski LM, Chinappen DM, et al. Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes. Epilepsia, 2020, 61(11): 2500-2508.
22.	Overvliet GM, Aldenkamp AP, Klinkenberg S, et al. Correlation between language impairment and problems in motor development in children with rolandic epilepsy. Epilepsy Behav, 2011, 22(3): 527-531.
23.	Shields WD, Snead OC, 3rd. Benign epilepsy with centrotemporal spikes. Epilepsia, 2009, 50 Suppl 8: 10-15.
24.	Basnec A, Skarpa D, Barisic N, et al. The risk of second seizure in children with benign childhood epilepsy with centrotemporal spikes without treatment--a prospective study. Acta Med Croatica, 2005, 59(1): 59-62.
25.	Arts WF, Geerts AT. When to start drug treatment for childhood epilepsy: the clinical-epidemiological evidence. Eur J Paediatr Neurol, 2009, 13(2): 93-101.
26.	Glauser T, Ben-Menachem E, Bourgeois B, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2013, 54(3): 551-563.
27.	Asadi-Pooya AA, Forouzesh M, Eidi H, et al. Levetiracetam versus carbamazepine in treatment of rolandic epilepsy. Epilepsy Behav, 2019, 94: 1-8.
28.	Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
29.	Camfield CS, Camfield PR. Rolandic epilepsy has little effect on adult life 30 years later: a population-based study. Neurology, 2014, 82(13): 1162-1166.
30.	Xie W, Ross EE, Kramer MA, et al. Timing matters: Impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes. Epilepsia Open, 2018, 3(3): 409-417.
31.	Varesio C, Zanaboni MP, Salmin EC, et al. Childhood epilepsy with centrotemporal spikes: clinical and neuropsychological outcomes 5 years after remission. Diagnostics (Basel), 2020, 10(11).
32.	Li Z, Zhang J, Wang F, et al. Surface-based morphometry study of the brain in benign childhood epilepsy with centrotemporal spikes. Ann Transl Med, 2020, 8(18): 1150.
33.	Kramer U. Atypical presentations of benign childhood epilepsy with centrotemporal spikes: a review. J Child Neurol, 2008, 23(7): 785-790.

1. Loiseau P, Beaussart M. The seizures of benign childhood epilepsy with Rolandic paroxysmal discharges. Epilepsia, 1973, 14(4): 381-389.
2. Guerrini R. Epilepsy in children. Lancet, 2006, 367(9509): 499-524.
3. Engel J, Jr. International League Against E. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia, 2001, 42(6): 796-803.
4. Panayiotopoulos CP, Michael M, Sanders S, et al. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain, 2008, 131(Pt 9): 2264-2286.
5. Dryzalowski P, Jozwiak S, Franckiewicz M, et al. Benign epilepsy with centrotemporal spikes - Current concepts of diagnosis and treatment. Neurol Neurochir Pol, 2018, 52(6): 677-689.
6. Vears DF, Tsai MH, Sadleir LG, et al. Clinical genetic studies in benign childhoodepilepsy with centrotemporal spikes. Epilepsia, 2012, 53(2): 319-324.
7. Bali B, Kull LL, Strug LJ, et al. Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families. Epilepsia, 2007, 48(12): 2266-2272.
8. Lee YJ, Hwang SK, Kwon S. The clinical spectrum of benign epilepsy with centro-temporal spikes: a challenge in categorization and predictability. J Epilepsy Res, 2017, 7(1): 1-6.
9. Xiong W, Zhou D. Progress in unraveling the genetic etiology of rolandic epilepsy. Seizure, 2017, 47: 99-104.
10. Addis L, Virdee JK, Vidler LR, et al. Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue. Sci Rep, 2017, 7(1): 66.
11. Lesca G, Moller RS, Rudolf G, et al. Update on the genetics of the epilepsy-aphasia spectrum and role of GRIN2A mutations. Epileptic Disord, 2019, 21(S1): 41-47.
12. Lemke JR, Lal D, Reinthaler EM, et al. Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet, 2013, 45(9): 1067-1072.
13. Panjwani N, Wilson MD, Addis L, et al. A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy. Ann Clin Transl Neurol, 2016, 3(7): 512-522.
14. Fejerman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children: are they predictable? Epilepsia, 2000, 41(4): 380-390.
15. Cerminara C, Montanaro ML, Curatolo P, et al. Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy. Neurology, 2004, 63(2): 373-375.
16. Parmeggiani L, Seri S, Bonanni P, et al. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol, 2004, 115(1): 50-58.
17. Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
18. Okubo Y, Matsuura M, Asai T, et al. Epileptiform EEG discharges in healthy children: prevalence, emotional and behavioral correlates, and genetic influences. Epilepsia, 1994, 35(4): 832-841.
19. Liu MJ, Su XJ, Md XS, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
20. Kim EH, Yum MS, Shim WH, et al. Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS). Seizure, 2015, 27: 40-46.
21. Thorn EL, Ostrowski LM, Chinappen DM, et al. Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes. Epilepsia, 2020, 61(11): 2500-2508.
22. Overvliet GM, Aldenkamp AP, Klinkenberg S, et al. Correlation between language impairment and problems in motor development in children with rolandic epilepsy. Epilepsy Behav, 2011, 22(3): 527-531.
23. Shields WD, Snead OC, 3rd. Benign epilepsy with centrotemporal spikes. Epilepsia, 2009, 50 Suppl 8: 10-15.
24. Basnec A, Skarpa D, Barisic N, et al. The risk of second seizure in children with benign childhood epilepsy with centrotemporal spikes without treatment--a prospective study. Acta Med Croatica, 2005, 59(1): 59-62.
25. Arts WF, Geerts AT. When to start drug treatment for childhood epilepsy: the clinical-epidemiological evidence. Eur J Paediatr Neurol, 2009, 13(2): 93-101.
26. Glauser T, Ben-Menachem E, Bourgeois B, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 2013, 54(3): 551-563.
27. Asadi-Pooya AA, Forouzesh M, Eidi H, et al. Levetiracetam versus carbamazepine in treatment of rolandic epilepsy. Epilepsy Behav, 2019, 94: 1-8.
28. Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
29. Camfield CS, Camfield PR. Rolandic epilepsy has little effect on adult life 30 years later: a population-based study. Neurology, 2014, 82(13): 1162-1166.
30. Xie W, Ross EE, Kramer MA, et al. Timing matters: Impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes. Epilepsia Open, 2018, 3(3): 409-417.
31. Varesio C, Zanaboni MP, Salmin EC, et al. Childhood epilepsy with centrotemporal spikes: clinical and neuropsychological outcomes 5 years after remission. Diagnostics (Basel), 2020, 10(11).
32. Li Z, Zhang J, Wang F, et al. Surface-based morphometry study of the brain in benign childhood epilepsy with centrotemporal spikes. Ann Transl Med, 2020, 8(18): 1150.
33. Kramer U. Atypical presentations of benign childhood epilepsy with centrotemporal spikes: a review. J Child Neurol, 2008, 23(7): 785-790.

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