癫痫与糖尿病的相关性研究进展_Journal of Epilepsy

Authors：

 陈成

扬州大学医学院（扬州 225000）;

Corresponding author：

陈成, Email: bainiandeshu@163.com

Keywords：

癫痫; 糖尿病; 共患病; 相关性

DOI：

10.7507/2096-0247.20210056

Video：

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Abstract Full text Figures/Tables Video References Cited by

随着糖尿病（Diabetes mellitus，DM）和癫痫患病率的不断增加，两者共病的现象已不少见，且大量流行病学调查显示，DM 和癫痫存在相关性。目前，国内外对于癫痫共病 DM 的认识仍不充分。本文就流行病学、基因层面、DM 促进癫痫发病的机制以及两者分别与相关疗法或药物之间的关系等方面对癫痫和 DM 的相关性展开综述，并总结文献对癫痫共病 DM 的治疗提出建议，为早期识别和防治提供依据。

Citation： 陈成. 癫痫与糖尿病的相关性研究进展. Journal of Epilepsy, 2021, 7(4): 343-349. doi: 10.7507/2096-0247.20210056 Copy

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1. Li Y, Teng D, Shi X, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ, 2020, 369: m997.
2. Fiest KM, Sauro KM, Wiebe S, et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology, 2017, 88(3): 296-303.
3. Keezer MR, Novy J, Sander JW. Type 1 diabetes mellitus in people with Pharmacoresistant epilepsy: Prevalence and clinical characteristics. Epilepsy Res, 2015, 115: 55-57.
4. TiamkaoS, Pratipanawatr T, Tiamkao S, et al. Seizures in nonketotic hyperglycaemia perglycaemia. Seizure, 2003, 12(6): 409-410.
5. Schober E, Otto K P, Dost A, et al. Association of epilepsy and type 1 diabetes mellitus in children and adolescents: Is there an increased risk for diabetic ketoacidosis? J Pediatr, 2012, 160(4): 662-666.
6. Dafoulas GE, Toulis KA, Mccorry D, et al. Type 1 diabetes mellitus and risk of incidentpilepsy: apopulation-based, open-cohort study. Diabetologia, 2016, 60(2): 258-261.
7. Chou IC, Wang CH, Lin WD, et al. Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study. Diabetologia, 2016, 59(6): 1196-1203.
8. Mastrangelo M, Tromba V, Silvestri F, et al. Epilepsy in children withtype 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks. Eur J Paediatr Neurol, 2019, 23(2): 240-247.
9. Yan D, Zhao E, Zhang H, et al. Associationbetween Type 1 diabetes mellitus and risk of epilepsy: A meta-analysis of observational studies. DrugDiscovTher, 2017, 11(3): 146-151.
10. Marcovecchio ML, Petrosino MI, Chiarelli F. Diabetes and epilepsy in children andadolescents. Curr Diab Rep, 2015, 15(4): 21.
11. Lu CL, Chang YH, Sun Y, et al. A population-based study of epilepsy incidence in association with type 2 diabetes and severe hypoglycaemia. Diabetes Research and Clinical Practice, 2018, 140: 97-106.
12. Mccorry D, Nicolson A, Smith D, et al. An association between type 1 diabetes and idiopathic generalized epilepsy. AnnNeurol, 2006, 59(1): 204-206.
13. Hamed SA. Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions. Epilepsy Res, 2007, 75(1): 1-9.
14. Doneray H, Houghton J, Tekgunduz KS, et al. Permanent neonatal diabetes mellitus caused by anovel mutation in the KCNJ11 gene. J Pediatr Endocrinol Metab, 2014, 27(3-4): 367-371.
15. Masia R, Koster JC, Tumini S, et al. An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes. Diabetes, 2007, 56(2): 328-336.
16. Poulton C, Schot R, Kia S, et al. Microcephaly with Simplified Gyration, Epilepsy, and Infantile Diabetes Linked to Inappropriate Apoptosis of NeuralProgenitors. AmJHumGenet, 2011, 89(2): 265-276.
17. Verrotti A, Scaparrotta A, Olivieri C, et al. Seizures and type 1 diabetes mellitus: current state of knowledge. Eur J Endocrinol, 2012, 167(6): 749-758.
18. Antony S, Kumar TP, Kuruvilla KP, et al. Decreased GABA receptor binding in the cerebral cortex of insulin induced Hypogly cemic and Streptozocin induced diabetes rats. Neurochem Res, 2010, 35(10): 1516-21.
19. Szeto V, Chen NH, Sun HS, et al. The role of KATP channels in cerebra ischemic stroke and diabetes. ActaPharmacolSin, 2018, 39(5): 683-694.
20. Herrmann W, Obeid R. Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med, 2011, 49(3): 435-41.
21. Gorgone G, Caccamo D, Pisani L R, et al. Hyperhomocysteinemia in patients with epilepsy: Does it play a role in the pathogenesis of brain atrophy? A preliminary report. Epilepsia, 2009, 50(1): 33-36.
22. Quan Y, Barszczyk A, Feng ZP, et al. Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders. Acta Pharmacol Sin, 2011, 32(6): 765-780.
23. Velísek L, Velísková J, Chudomel O, et al. Metabolic environment in substantia nigra reticulata is critical for the expression and controlof hypoglycemia-induced seizure. J Neurosci, 2008, 28(38): 9349-9362.
24. Lv RJ, He JS, Fu Y H, et al. ASIC1a polymorphism is associated with temporal lobe epilepsy. Epilepsy Res, 2011, 96(1-2): 74-80.
25. 魏东. 酸敏感离子通道 1a 的通道开放、药物调控及其在癫痫发生中的作用. 西安: 第四军医大学, 博士学位论文, 2015.
26. Wang YC, Li WZ, Wu Y, et al. Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons. J Neuroinflammation, 2015, 12: 246.
27. Ziemann AE, Schizler MK, Albert GW, et al. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci, 2008, 11(7): 816-822.
28. Cho JH, Askwith CC. Presynaptic ralease probability is increased inHippocampal neurons from ASIC1 knockout mice. J Neurophysiol, 2008, 99(2): 426-41.
29. Ievglevsky O, Isae D, Netsy O, et al. Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possibleImplications for epilepsy. Philos Trans R Soc Lond B Biol Sci, 2016, 371(1700): 20150431.
30. 郭为. 酸敏感离子通道 1a 在大脑皮质发育不良病理发生中的作用研究. 重庆: 第三军医大学, 博士学位论文, 2014.
31. 陈勇, 葛金芳, 陈飞虎. 酸敏感离子通道 1a 在自身免疫性疾病发病机制中的研究进展. 中国药理学通报, 2018, 34(1): 12-15.
32. 张海涛. 海马区神经元葡萄糖低代谢在癫痫发生中的作用及机制研究. 西安: 第四军医大学, 博士学位论文, 2017.
33. Moloney TC, Idris I, Waters P, et al. Autoantibodies to glutamic acid decarboxylase in patients with epilepsy and their relationship with type 1 diabetes: a pilot study. J Neurol Neurosurg Psychiatry, 2016, 87(6): 676-677.
34. Liimatainen S, Honnorat J, Pittock SJ, et al. GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies. Orphanet J Rare Dis, 2018, 13(1): 55.
35. kash SF, Johnson RS, Tecott LH, et al. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Nat1 Acad Sci USA, 1997: 94.
36. Mahmoud AA, Abdelmagid T, Alghofely M, et al. Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65. Neurosciences, 2020, 25(3): 200-204.
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