The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis_Journal of Epilepsy

Authors：

WU Yingying ¹ , CAO Li ² ,  ZHONG Ping ¹

1. Department of Neurology, Suzhou Hospital of Anhui Medical University, Suzhou 234000, China;
2. Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China;

Corresponding author：

ZHONG Ping, Email: Drzp1966@163.com

Keywords：

Sleep deprivation EEG; Epilepsy; Meta-analysis

DOI：

10.7507/2096-0247.20210067

Video：

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Objectives To review the value of sleep deprivation EEG methodology in the diagnosis of epilepsy.Methods Such databases as Pubmed, MEDLINE, The Cochrane Library, Wanfang, VIP and CNKI Data are searched electronically and comprehensively for literature on the diagnosis of epilepsy by sleep deprivation EEG from inception to January 2021. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, meta-analysis was performed using Stata software.Results A total of 14studies involving 1221 patients were included in total. The results of meta-analysis showed that: Duration of sleep deprivation and effect value of positive rate [ r=0.670, 95%CI (0.664, 0.696), P<0.001 ], duration of the awake period records and effect value of positive rate [ r=0.659, 95%CI (0.596, 0.722), P<0.001 ], duration of sleep period records and effect value of positive rate [ r=0.67, 95%CI(0.619, 0.721), P<0.001 ], with significant differences.Conclusions The duration of sleep deprivation, the awake period records, and the sleep period records of sleep deprivation EEG examination, sleep deprivation time between 16 h to 24 h, the awake recording time ≥30 min, and the sleep recording time ≥ 60 min (≤ 3 h) can obviously improve the positive rate of sleep deprivation EEG.

Citation： WU Yingying, CAO Li, ZHONG Ping. The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis. Journal of Epilepsy, 2021, 7(5): 411-416. doi: 10.7507/2096-0247.20210067 Copy

1.	RD Thijs, R Surges, TJ O'Brien, et al. Epilepsy in adults. Lancet (London, England), 2019, 393(10172): 689-701.
2.	桂华. 儿童癫痫自然睡眠与药物诱导睡眠的脑电图分析. 实用医技杂志, 2007, 14(7): 857-858.
3.	李荣. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床价值. 深圳中西医结合杂志, 2014, 24(03): 127-128.
4.	彭德强, 温世斌, 景兆德. 部分睡眠剥夺联合睡眠脑电图在癫痫诊断中的价值. 兰州医学院学报. 2003, 29(2): 56-58.
5.	王惠琪, 余秀兰, 魏亮. 自然睡眠与药物诱导睡眠对脑电图睡眠脑波的影响. 中国临床康复, 2005, 9(21): 46-48.
6.	王璐, 盛敏. 剥夺性睡眠后自然睡眠脑电图在癫痫诊断中的意义. 临床和实验医学杂志, 2004, 3(3): 136-137.
7.	杨春清, 杜亚丽, 张素芳等. 睡眠剥夺和药物诱导睡眠脑电图在癫痫诊断中的应用价值. 中国全科医学, 2010, 13(03): 305-306.
8.	杨丽. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床应用价值探析. 临床研究, 2018, 26(2): 85-87.
9.	朱艳. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床价值, 影像研究与医学应用, 2020, 4(10): 216-217.
10.	蔡少雅. 睡眠剥夺和药物诱导睡眠脑电图在癫痫诊断中的应用价值. 医药前沿, 2016, 22(06): 372-373.
11.	U Aguglia, A Gambardella, E Le Piane, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. Journal of neurology, 1994, 241(10): 605-610.
12.	R Degen, HE Degen. The diagnostic value of the sleep EEG with and without sleep deprivation in patients with atypical absences. Epilepsia, 1983, 24(5): 557-566.
13.	R Degen. A study of the diagnostic value of waking and sleep EEGs after sleep deprivation in epileptic patients on anticonvulsive therapy. Electroencephalography and clinical neurophysiology, 1980, 49(5-6): 577-584.
14.	R Degen, HE Degen, M Reker. Sleep EEG with or without sleep deprivation? Does sleep deprivation activate more epileptic activity in patients suffering from different types of epilepsy? European neurology, 1987, 26(1): 51-59.
15.	I Geut, S Weenink, ILH Knottnerus, et al. Detecting interictal discharges in first seizure patients: ambulatory EEG or EEG after sleep deprivation? Seizure, 2017, 51: 52-54.

1. RD Thijs, R Surges, TJ O'Brien, et al. Epilepsy in adults. Lancet (London, England), 2019, 393(10172): 689-701.
2. 桂华. 儿童癫痫自然睡眠与药物诱导睡眠的脑电图分析. 实用医技杂志, 2007, 14(7): 857-858.
3. 李荣. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床价值. 深圳中西医结合杂志, 2014, 24(03): 127-128.
4. 彭德强, 温世斌, 景兆德. 部分睡眠剥夺联合睡眠脑电图在癫痫诊断中的价值. 兰州医学院学报. 2003, 29(2): 56-58.
5. 王惠琪, 余秀兰, 魏亮. 自然睡眠与药物诱导睡眠对脑电图睡眠脑波的影响. 中国临床康复, 2005, 9(21): 46-48.
6. 王璐, 盛敏. 剥夺性睡眠后自然睡眠脑电图在癫痫诊断中的意义. 临床和实验医学杂志, 2004, 3(3): 136-137.
7. 杨春清, 杜亚丽, 张素芳等. 睡眠剥夺和药物诱导睡眠脑电图在癫痫诊断中的应用价值. 中国全科医学, 2010, 13(03): 305-306.
8. 杨丽. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床应用价值探析. 临床研究, 2018, 26(2): 85-87.
9. 朱艳. 癫痫诊断中睡眠剥夺和药物诱导睡眠脑电图的临床价值, 影像研究与医学应用, 2020, 4(10): 216-217.
10. 蔡少雅. 睡眠剥夺和药物诱导睡眠脑电图在癫痫诊断中的应用价值. 医药前沿, 2016, 22(06): 372-373.
11. U Aguglia, A Gambardella, E Le Piane, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. Journal of neurology, 1994, 241(10): 605-610.
12. R Degen, HE Degen. The diagnostic value of the sleep EEG with and without sleep deprivation in patients with atypical absences. Epilepsia, 1983, 24(5): 557-566.
13. R Degen. A study of the diagnostic value of waking and sleep EEGs after sleep deprivation in epileptic patients on anticonvulsive therapy. Electroencephalography and clinical neurophysiology, 1980, 49(5-6): 577-584.
14. R Degen, HE Degen, M Reker. Sleep EEG with or without sleep deprivation? Does sleep deprivation activate more epileptic activity in patients suffering from different types of epilepsy? European neurology, 1987, 26(1): 51-59.
15. I Geut, S Weenink, ILH Knottnerus, et al. Detecting interictal discharges in first seizure patients: ambulatory EEG or EEG after sleep deprivation? Seizure, 2017, 51: 52-54.

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Journal of Epilepsy

The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis

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