Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus_Journal of Epilepsy

Authors：

CHEN Lilan ,  WANG Jianbiao , SUN Mingxia

Department of Neurology of Wuxi Children's Hospital, Wuxi 214000, China;

Corresponding author：

WANG Jianbiao, Email: wjb00883@sina.com

Keywords：

Hormone pulse; Epileptic electrical status; Children

DOI：

10.7507/2096-0247.20210081

Video：

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Objective To investigate the effect of high-dose hormone pulse therapy on children with epilepsy and sleep status epilepticus.Methods 60 children were randomly divided into control group (30 cases) and study group (30 cases) according to the admission sequence. The control group was treated with antiepileptic drugs (according to clinical electroencephalogram or syndrome), and the study group was treated with methylprednisolone sodium succinate [20 mg/(kg·d) × 3 days, once a month, for 6 months]. During the period, antiepileptic drugs were taken normally. After 6 months, the curative effect, abnormal EEG and side effects were compared.Results After 6 months of treatment, the clinical conditions of the two groups were significantly improved (effective rate: control group: 19/30 vs. study group: 26/30), and the clinical efficacy (26/30) and EEG improvement (26/30) of the study group were better than those of the control group (P<0.05), weight gain can be improved by diet control and reasonable exercise.Conclusion Hormone pulse therapy for children with epilepsy and sleep status epilepticus in the control of clinical seizures and improve the effect of abnormal EEG, recommended.

Citation： CHEN Lilan, WANG Jianbiao, SUN Mingxia. Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus. Journal of Epilepsy, 2021, 7(6): 497-499. doi: 10.7507/2096-0247.20210081 Copy

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2.	郑芳, 王华. 儿童睡眠中癫痫性电持续状态的分子遗传学研究进展. 国际科学杂志, 2021, 48(3): 182-185.
3.	Yilmaz S, Serdaroglu G, Akcay A, et al. Clinical characteristics and outcome of children with electrical status epilepticus during slow wave sleep. Journal of Pediatric Neurosciences, 2014, 9(2): 105-109.
4.	Nissenkorn A, Pappo A, Feldmann Y, et al. Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes. Eur J Paediatr Neurol, 2017, 21(6): 858-863.
5.	Veggiotti P, Peramc, Teutonico F, et al. Therapy of encepha1opathy with status epilepticus during sleep (ESES /CSWS syndrome): an update. Epileptic Disord, 2012, 14(1): 1-11.
6.	Anne T, Berg Samuel F, Berkovic Martin J, et al. 发作和癫痫分类框架术语及概念的修订: 国际抗癫痫联盟分类和术语委员会报告, 2005-2009. 中华神经科杂志, 2011, 44(3): 23-28.
7.	Değerliyurt A, Yalnizoğlu D, Bakar EE, et al. Electrical status epilepticus during sleep: A study of 22 patients. Brain and Development, 2015, 37(2): 250-264.
8.	杨志仙, 钱萍. 睡眠中癫痫性电持续状态的研究进展. 中华实用儿科临床杂志, 2017, 32(012): 881-886.
9.	Sanchez FI, Peters JM, Akhondiasl A, et al. Reduced thalamic volume in patients with electrical status epilepticus in sleep. Epilepsy research, 2017, 130(12): 74-80.
10.	Gencpinaar P, Dunadr NO, Tekgul H. Electricalstatus epilepticusin sleep (ESES)/ continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy & Behavior, 2016, 61(15): 107-111.
11.	陈静, 杨志仙, 刘晓燕, 等. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态的疗效. 中华儿科杂志, 2014, 52(9): 678-682.
12.	Kramer U, Sagi L, Goldberg-Stern H. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia, 2009, 50(6): 17-24.

1. 张赟, 郑辑英, 李光来, 等. 癫痫发病机制研究的进展与脑损伤机制. 中华临床医师杂志(电子版), 2016, 10(8): 116-119.
2. 郑芳, 王华. 儿童睡眠中癫痫性电持续状态的分子遗传学研究进展. 国际科学杂志, 2021, 48(3): 182-185.
3. Yilmaz S, Serdaroglu G, Akcay A, et al. Clinical characteristics and outcome of children with electrical status epilepticus during slow wave sleep. Journal of Pediatric Neurosciences, 2014, 9(2): 105-109.
4. Nissenkorn A, Pappo A, Feldmann Y, et al. Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes. Eur J Paediatr Neurol, 2017, 21(6): 858-863.
5. Veggiotti P, Peramc, Teutonico F, et al. Therapy of encepha1opathy with status epilepticus during sleep (ESES /CSWS syndrome): an update. Epileptic Disord, 2012, 14(1): 1-11.
6. Anne T, Berg Samuel F, Berkovic Martin J, et al. 发作和癫痫分类框架术语及概念的修订: 国际抗癫痫联盟分类和术语委员会报告, 2005-2009. 中华神经科杂志, 2011, 44(3): 23-28.
7. Değerliyurt A, Yalnizoğlu D, Bakar EE, et al. Electrical status epilepticus during sleep: A study of 22 patients. Brain and Development, 2015, 37(2): 250-264.
8. 杨志仙, 钱萍. 睡眠中癫痫性电持续状态的研究进展. 中华实用儿科临床杂志, 2017, 32(012): 881-886.
9. Sanchez FI, Peters JM, Akhondiasl A, et al. Reduced thalamic volume in patients with electrical status epilepticus in sleep. Epilepsy research, 2017, 130(12): 74-80.
10. Gencpinaar P, Dunadr NO, Tekgul H. Electricalstatus epilepticusin sleep (ESES)/ continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy & Behavior, 2016, 61(15): 107-111.
11. 陈静, 杨志仙, 刘晓燕, 等. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态的疗效. 中华儿科杂志, 2014, 52(9): 678-682.
12. Kramer U, Sagi L, Goldberg-Stern H. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia, 2009, 50(6): 17-24.

Journal of Epilepsy

Clinical study on the effect of hormone shock on children with epilepsy and sleep status epilepticus

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