癫痫中环状RNA的研究现状_Journal of Epilepsy

Authors：

张舒雅 ^1,2 ,  孙洪英 ³

1. ;
2. ;
3. ;

Corresponding author：

孙洪英, Email: sunhongying2004@sina.com

Keywords：

环状RNA; 微小RNA; 癫痫

DOI：

10.7507/2096-0247.202111014

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

癫痫是一种神经系统慢性疾病，给家庭和社会带来沉重的经济及照护负担，其发病机制复杂，且约1/3的癫痫患者对药物治疗不敏感，发现一种可以诊断及治疗的分子标志物势在必行。近年来人们对环状RNA（circular RNA，circRNA）的研究越来越多，其作为非编码RNA的重要成员，可作为调控工具、生物标志物、治疗靶点，分别为癫痫的病理生理研究、诊断、治疗提供新的指导和方向。本综述结合国内外相关报道，旨在阐述circRNA相关功能、特性及其与癫痫相关性，为进一步研究circRNA与癫痫提供理论依据。

Citation： 张舒雅, 孙洪英. 癫痫中环状RNA的研究现状. Journal of Epilepsy, 2022, 8(2): 155-158. doi: 10.7507/2096-0247.202111014 Copy

1.	Thijs RD, Surges R, O'Brien TJ, et al. Epilepsy in adults. Lancet, 2019, 393(10172): 689-701.
2.	Chen F, Zheng H, Zhang W, et al. circ_0003170 aggravates human hippocampal neuron injuries by regulating the miR-421/CCL2 axis in cells models of epilepsy. Gen Physiol Biophys, 2021 , 40(2): 115-126.
3.	Hsiao KY, Sun HS, Tsai SJ. Circular RNA - New member of noncoding RNA with novel functions. Exp Biol Med (Maywood), 2017, 242(11): 1136-1141.
4.	Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol, 2020, 21(8): 475-490.
5.	Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol, 2014, 32(5): 453-461.
6.	Vo JN, Cieslik M, Zhang Y, et al. The landscape of Circular RNA in cancer. Cell, 2019, 176(4): 869-881.
7.	Aufiero S, Reckman YJ, Pinto YM, et al. Circular RNAs open a new chapter in cardiovascular biology. Nat Rev Cardiol, 2019, 16(8): 503-514.
8.	Mehta SL, Dempsey RJ, Vemuganti R. Role of circular RNAs in brain development and CNS diseases. Prog Neurobiol, 2020, 186: 101746.
9.	Zhou Z, Sun B, Huang S, et al. Roles of circular RNAs in immune regulation and autoimmune diseases. Cell Death Dis, 2019, 10(7): 503-507.
10.	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
11.	Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. Cell-type specific features of circular RNA expression. PLoS Genet, 2013, 9(9): e1003777.
12.	Schwanhäusser B, Busse D, Li N, et al. Global quantification of mammalian gene expression control. Nature, 2011, 473(7347): 337-342.
13.	Bahn JH, Zhang Q, Li F, et al. The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem, 2015, 61(1): 221-230.
14.	Park NJ, Li Y, Yu T, et al. Characterization of RNA in saliva. Clin Chem, 2006, 52(6): 988-94.
15.	Dong WW, Li HM, Qing XR, et al. Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Sci Rep, 2016 13(7), 6: 390-398.
16.	Kristensen LS, Andersen MS, Stagsted LVW, et al, The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet, 2019, 20(11): 675-691.
17.	Xia S, Feng J, Lei L, et al. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Brief Bioinform, 2017, 1,18(6): 984-992.
18.	Zhao Y, Alexandrov PN, Jaber V, et al. Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer's Disease (AD) is linked to deficits in a natural circular mirna-7 sponge (circRNA, ciRS-7). Genes (Basel), 2016, 7(12): 116-121.
19.	Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
20.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
21.	Granados-Riveron JT, Aquino-Jarquin G. The complexity of the translation ability of circRNAs. Biochim Biophys Acta, 2016, 1859(10): 1245-1251.
22.	Gu J, Tian X, Wang W, et al. Inhibition of Cgkii suppresses seizure activity and hippocampal excitation by regulating the postsynaptic delivery of glua1. Cell Physiol Biochem, 2018, 46(1): 160-177.
23.	Mazrooyisebdani M, Nair VA, Garcia-Ramos C, et al. Graph theory analysis of functional connectivity combined with machine learning approaches demonstrates widespread network differences and predicts clinical variables in temporal lobe epilepsy. Brain Connect, 2020, 10(1): 39-50.
24.	郎悦, 王小峰, 尹剑, 等. 离子通道与癫痫遗传学研究进展. 中华神经科杂志, 2018, 51(8): 642-648.
25.	Zhang Y, Du L, Bai Y, et al. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry, 2020, 25(6): 1175-1190.
26.	Zhou J, Xiong Q, Chen H, et al. Identification of the spinal expression profile of non-coding rnas involved in neuropathic pain following spared nerve injury by sequence analysis. Front Mol Neurosci, 2017, 3,10: 91.
27.	You X, Vlatkovic I, Babic A, et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 2015, 18(4): 603-610.
28.	Cavazos JE, Cross DJ. The role of synaptic reorganization in mesial temporal lobe epilepsy. Epilepsy Behav, 2006, 8(3): 483-493.
29.	Zhu Z, Wang S, Cao Q, et al. CircUBQLN1 promotes proliferation but inhibits apoptosis and oxidative stress of hippocampal neurons in epilepsy via the miR-155-Mediated SOX7 upregulation. J Mol Neurosci, 2021, 71(9): 1933-1943.
30.	Chen F, Zheng H, Zhang W, et al. circ_0003170 aggravates human hippocampal neuron injuries by regulating the miR-421/CCL2 axis in cells models of epilepsy. Gen Physiol Biophys, 2021, 40(2): 115-126.
31.	Lin Q, Chen J, Zheng X, et al. Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis. Neurochem Res, 2020, 45(12): 3034-3044.

1. Thijs RD, Surges R, O'Brien TJ, et al. Epilepsy in adults. Lancet, 2019, 393(10172): 689-701.
2. Chen F, Zheng H, Zhang W, et al. circ_0003170 aggravates human hippocampal neuron injuries by regulating the miR-421/CCL2 axis in cells models of epilepsy. Gen Physiol Biophys, 2021 , 40(2): 115-126.
3. Hsiao KY, Sun HS, Tsai SJ. Circular RNA - New member of noncoding RNA with novel functions. Exp Biol Med (Maywood), 2017, 242(11): 1136-1141.
4. Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol, 2020, 21(8): 475-490.
5. Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol, 2014, 32(5): 453-461.
6. Vo JN, Cieslik M, Zhang Y, et al. The landscape of Circular RNA in cancer. Cell, 2019, 176(4): 869-881.
7. Aufiero S, Reckman YJ, Pinto YM, et al. Circular RNAs open a new chapter in cardiovascular biology. Nat Rev Cardiol, 2019, 16(8): 503-514.
8. Mehta SL, Dempsey RJ, Vemuganti R. Role of circular RNAs in brain development and CNS diseases. Prog Neurobiol, 2020, 186: 101746.
9. Zhou Z, Sun B, Huang S, et al. Roles of circular RNAs in immune regulation and autoimmune diseases. Cell Death Dis, 2019, 10(7): 503-507.
10. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
11. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. Cell-type specific features of circular RNA expression. PLoS Genet, 2013, 9(9): e1003777.
12. Schwanhäusser B, Busse D, Li N, et al. Global quantification of mammalian gene expression control. Nature, 2011, 473(7347): 337-342.
13. Bahn JH, Zhang Q, Li F, et al. The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem, 2015, 61(1): 221-230.
14. Park NJ, Li Y, Yu T, et al. Characterization of RNA in saliva. Clin Chem, 2006, 52(6): 988-94.
15. Dong WW, Li HM, Qing XR, et al. Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Sci Rep, 2016 13(7), 6: 390-398.
16. Kristensen LS, Andersen MS, Stagsted LVW, et al, The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet, 2019, 20(11): 675-691.
17. Xia S, Feng J, Lei L, et al. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Brief Bioinform, 2017, 1,18(6): 984-992.
18. Zhao Y, Alexandrov PN, Jaber V, et al. Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer's Disease (AD) is linked to deficits in a natural circular mirna-7 sponge (circRNA, ciRS-7). Genes (Basel), 2016, 7(12): 116-121.
19. Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
20. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
21. Granados-Riveron JT, Aquino-Jarquin G. The complexity of the translation ability of circRNAs. Biochim Biophys Acta, 2016, 1859(10): 1245-1251.
22. Gu J, Tian X, Wang W, et al. Inhibition of Cgkii suppresses seizure activity and hippocampal excitation by regulating the postsynaptic delivery of glua1. Cell Physiol Biochem, 2018, 46(1): 160-177.
23. Mazrooyisebdani M, Nair VA, Garcia-Ramos C, et al. Graph theory analysis of functional connectivity combined with machine learning approaches demonstrates widespread network differences and predicts clinical variables in temporal lobe epilepsy. Brain Connect, 2020, 10(1): 39-50.
24. 郎悦, 王小峰, 尹剑, 等. 离子通道与癫痫遗传学研究进展. 中华神经科杂志, 2018, 51(8): 642-648.
25. Zhang Y, Du L, Bai Y, et al. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry, 2020, 25(6): 1175-1190.
26. Zhou J, Xiong Q, Chen H, et al. Identification of the spinal expression profile of non-coding rnas involved in neuropathic pain following spared nerve injury by sequence analysis. Front Mol Neurosci, 2017, 3,10: 91.
27. You X, Vlatkovic I, Babic A, et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 2015, 18(4): 603-610.
28. Cavazos JE, Cross DJ. The role of synaptic reorganization in mesial temporal lobe epilepsy. Epilepsy Behav, 2006, 8(3): 483-493.
29. Zhu Z, Wang S, Cao Q, et al. CircUBQLN1 promotes proliferation but inhibits apoptosis and oxidative stress of hippocampal neurons in epilepsy via the miR-155-Mediated SOX7 upregulation. J Mol Neurosci, 2021, 71(9): 1933-1943.
30. Chen F, Zheng H, Zhang W, et al. circ_0003170 aggravates human hippocampal neuron injuries by regulating the miR-421/CCL2 axis in cells models of epilepsy. Gen Physiol Biophys, 2021, 40(2): 115-126.
31. Lin Q, Chen J, Zheng X, et al. Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis. Neurochem Res, 2020, 45(12): 3034-3044.

Previous Article
SCN8A基因相关癫痫研究进展
Next Article
认知行为疗法改善癫痫患者心理痛苦研究进展

Journal of Epilepsy

癫痫中环状RNA的研究现状

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content