维生素在癫痫发作中治疗作用的研究进展_Journal of Epilepsy

Authors：

高阳 ,  高飞

西安医学院第一附属医院神经内科（西安 710077）;

Corresponding author：

高飞, Email: gaofei0016@163.com

Keywords：

癫痫; 抗癫痫发作药物; 饮食; 维生素

DOI：

10.7507/2096-0247.202208001

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

癫痫是一种以癫痫发作为核心症状的常见神经系统疾病。虽然抗癫痫发作药物（Antiseizure medications，ASMs）是目前治疗癫痫的主要方式，且大多数癫痫患者的预后良好，但仍有30%的患者因其耐药性并未缓解，因此需要其他辅助治疗方案。维生素（Vitamin，Vit）在某些情况下可以辅助药物治疗，但目前指南仅明确推荐了生酮饮食，并未推荐其他的饮食治疗方案。本文探讨了维生素在癫痫发作中的治疗作用，旨在为我国临床医生、患者及家属提供参考，以便科学管理癫痫患者，并为相关研究提供临床依据。

Citation： 高阳, 高飞. 维生素在癫痫发作中治疗作用的研究进展. Journal of Epilepsy, 2022, 8(6): 539-543. doi: 10.7507/2096-0247.202208001 Copy

1.	Azevedo FR, Corrêa C, Muxfeld BM, et al. Anthropometric profile and nutritional intake in patients with epilepsy. Nutr Hosp, 2015, 32(2): 817-822.
2.	Soltani D, Ghaffar Pour M, Tafakhori A, et al. Nutritional aspects of treatment in epileptic patients. Iran J Child Neurol, 2016, 10(3): 1-12.
3.	Collins P, Patel V, Joestl S, et al. Grand challenges in global mental health. Nature, 2011, 475(7354): 27-30.
4.	DeGiorgio C, Miller P, Harper R, et al. Fish oil (n-3 fatty acids) in drug resistant epilepsy:a randomised placebo-controlled crossover study. J Neurol Neurosurg Psychiatry, 2015, 86(1): 65-70.
5.	Hagberg B, Hamfelt A, Hansson OJL, et al. Epileptic children with disturbed trytophan metabolism treated with vitamin B6. Lancet, 1964, 1(7325): 145.
6.	Holló A, Clemens Z, Kamondi A, et al. Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study. Epilepsy Behav, 2012, 24(1): 131-133.
7.	Mehvari J, Motlagh F, Najafi M, et al. Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients. Adv Biomed Res, 2016, 5: 36.
8.	Omrani S, Taheri M, Omrani M, et al. The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients:a triple blind randomized clinical trial. Clin Transl Med, 2019, 8(1): 3.
9.	Tombini M, Palermo A, Assenza G, et al. Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. Seizure, 2018, 58: 75-81.
10.	Gaby AR. Natural approaches to epilepsy. Altern Med Rev, 2007, 12(1): 9-24.
11.	Xiang J, Jiang Y. Regulation of Cu-Zn superoxide dismutase on SCN2A in SH-SY5Y cells as a potential therapy for temporal lobe epilepsy. Mol Med Rep, 2014, 9(1): 16-22.
12.	Crepin S, Godet B, Chassain B, et al. Malnutrition and epilepsy: a two-way relationship. Clin Nutr, 2009, 28(3): 219-225.
13.	Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: a meta-analysis of observational studies. Epilepsia Open, 2018, 3(1): 9-17.
14.	Winesett S, Bessone S, Kossoff E. The ketogenic diet in pharmacoresistant childhood epilepsy. Expert Rev Neurother, 2015, 15(6): 621-628.
15.	Falco-Walter J, Scheffer I, Fisher R. The new definition and classification of seizures and epilepsy. Epilepsy Res, 2018, 139: 73-79.
16.	Fisher R, Cross J, French J, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
17.	Fisher R, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(4): 470-472.
18.	Deng H, Xiu X, Song Z. The molecular biology of genetic-based epilepsies. Mol Neurobiol, 2014, 49(1): 352-367.
19.	Fisher R, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia, 2014, 55(4): 475-482.
20.	Shin E, Jeong J, Chung Y, et al. Role of oxidative stress in epileptic seizures. Neurochem Int, 2011, 59(2): 122-137.
21.	Wei F, Yan L, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
22.	Wolfart J, Laker D. Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential. Front Physiol, 2015, 6: 168.
23.	Frantseva M, Velazquez J, Hwang P, et al. Free radical production correlates with cell death in an in vitro model of epilepsy. Eur J Neurosci, 2000, 12(4): 1431-1439.
24.	Moretti M, Marchioni CF. An overview of erdosteine antioxidant activity in experimental research. Pharmacol Res, 2007, 55(4): 249-254.
25.	Pearson-Smith J, Patel M. Metabolic dysfunction and oxidative stress in epilepsy. Int J Mol Sci, 2017, 18(11).
26.	Devinsky O, Vezzani A, Najjar S, et al. Glia and epilepsy: excitability and inflammation. Trends Neurosci, 2013, 36(3): 174-184.
27.	Stadtman ER. Protein oxidation in aging and age-related diseases. Ann NY Acad Sci, 2001, 928: 22-38.
28.	Webster K, Sun M, Crack P, et al. Inflammation in epileptogenesis after traumatic brain injury. J Neuroinflammation, 2017, 14(1): 10.
29.	Wong-Ekkabut J, Xu Z, Triampo W, et al. Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. Biophys J, 2007, 93(12): 4225-4236.
30.	Steriade C, Titulaer M, Vezzani A, et al. The association between systemic autoimmune disorders and epilepsy and its clinical implications. Brain, 2021, 144(2): 372-390.
31.	Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol, 2013, 34(1): 47-64.
32.	Rössler A, Launay J, Venault P, et al. Changes in benzodiazepine binding in a subkindling situation. Epilepsia, 2000, 41(6): 651-654.
33.	Teagarden DL, Meador KJ, Loring DW. Low vitamin D levels are common in patients with epilepsy. Epilepsy Res, 2014, 108(8): 1352-1356.
34.	Abdel-Wahab A, Afify M, Mahfouz A, et al. Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats. Brain Res, 2017, 1673: 78-85.
35.	Kalueff A, Minasyan A, Tuohimaa P. Anticonvulsant effects of 1, 25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Res Bull, 2005, 67: 156-160.
36.	Kalueff A, Minasyan A, Keisala T, et al. Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. Neurosci Lett, 2006, 394(1): 69-73.
37.	Brewer L, Thibault V, Chen K, et al. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci, 2001, 21(1): 98-108.
38.	Lefebvre d'Hellencourt C, Montero-Menei C, Bernard R, et al. Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. J Neurosci Res, 2003, 71(4): 575-582.
39.	Bartels L, Jørgensen S, Agnholt J, et al. 1, 25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. Int Immunopharmacol, 2007, 7(13): 1755-1764.
40.	Kozan R, Ayyildiz M, Yildirim M, et al. The effects of ethanol intake and withdrawal on penicillin-induced epileptiform activity in rats. Acta Neurobiol Exp (Wars), 2006, 71: 111-115.
41.	Dursun E, Gezen-Ak D, Yilmazer S. The influence of Vitamin D treatment on the Inducible Nitric Oxide Synthase (INOS) expression in primary hippocampal neurons. Noro psikiyatri arsivi, 2014, 51(2): 163-168.
42.	Friedman M. Chemistry, nutrition, and health-promoting properties of hericium erinaceus (Lion's Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J Agric Food Chem, 2015, 63(32): 7108-7123.
43.	Jang H, Kim J, Jeong K, et al. Hericium erinaceusthe neuroprotective effect of extracts in mouse hippocampus after pilocarpine-induced status epilepticus. Int J Mol Sci, 2019, 20(4).
44.	Ambrogini P, Albertini M, Betti M, et al. Neurobiological correlates of alpha-tocopherol antiepileptogenic effects and microRNA expression modulation in a rat model of kainate-induced seizures. Mol Neurobiol, 2018, 55(10): 7822-7838.
45.	Ribeiro M, de Avila D, Schneider C, et al. Alpha-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions. Epilepsy Res, 2005, 66: 185-194.
46.	Pott-Junior H, Nascimento C, Costa-Guarisco L, et al. Vitamin D deficient older adults are more prone to have metabolic syndrome, but not to a greater number of metabolic syndrome parameters. Nutrients, 2020, 12(3): 1-9.
47.	Lee A, Wong R, Chuang S, et al. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol, 2002, 88(4): 1625-1633.
48.	Betti M, Minelli A, Ambrogini P, et al. Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus. Free Radic Res, 2011, 45(10): 1136-1142.
49.	Tomé AR, Feng D, Freitas RM. The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. Neurochem Res, 2010, 35(4): 580-587.
50.	Zakharova I, Sokolova T, Vlasova Y, et al. α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress. Int J Mol Sci, 2017, 18(1).
51.	Simeone K, Matthews S, Samson K, et al. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Exp Neurol, 2014, 251: 84-90.
52.	Liu R, Wu S, Guo C, et al. Ibuprofen exerts antiepileptic and neuroprotective effects in the rat model of pentylenetetrazol-induced epilepsy via the COX-2/NLRP3/IL-18 pathway. Neurochem Res, 2020, 45(10): 2516-2526.
53.	Bowling FJSic, biology d. Pyridoxine supply in human development. Semin Cell Dev Biol, 2011, 22(6): 611-618.
54.	Kuhara T, Akiyama T, Ohse M, et al. Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics. Anal Biochem, 2020, 604: 113739.
55.	Mastrangelo M, Cesario S. Update on the treatment of vitamin B6 dependent epilepsies. Expert Rev Neurother, 2019, 19(11): 1135-1147.
56.	Stracke H, Hammes H, Werkmann D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes, 2001, 109(6): 330-336.
57.	Woldeamanuel Y, Girma B. Contributing towards the betterment of translational epilepsy research in Africa: needs, challenges, resources, and opportunities. Curr Neurol Neurosci Rep, 2014, 14(8): 480.
58.	Jain K, Singh J, Jain A, et al. A case report of nonalcoholic gayet-wernicke encephalopathy: don't miss thiamine. A A Pract, 2020, 14(8): e01230.
59.	Botez M, Botez T, Ross-Chouinard A, et al. Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale. Epilepsy Res, 1993, 16(2): 157-163.
60.	Tomé AR, Ferreira P, Freitas R. Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats. Arq Neuropsiquiatr, 2010, 68(3): 355-361.
61.	Harrison F, May J. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med, 2009, 46(6): 719-730.
62.	Santos I, Tomé AR, Saldanha G, et al. Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid. Oxid Med Cell Longev, 2009, 2(4): 214-221.
63.	González-Ramírez M, Razo-Juárez L, Sauer-Ramírez J, et al. Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats. Pharmacol Biochem Behav, 2010, 97(2): 267-272.
64.	Das A, Sarwar M, Hossain M, et al. Elevated serum lipid peroxidation and reduced vitamin C and trace element concentrations are correlated with epilepsy. Clin EEG Neurosci, 2019, 50(1): 63-72.

1. Azevedo FR, Corrêa C, Muxfeld BM, et al. Anthropometric profile and nutritional intake in patients with epilepsy. Nutr Hosp, 2015, 32(2): 817-822.
2. Soltani D, Ghaffar Pour M, Tafakhori A, et al. Nutritional aspects of treatment in epileptic patients. Iran J Child Neurol, 2016, 10(3): 1-12.
3. Collins P, Patel V, Joestl S, et al. Grand challenges in global mental health. Nature, 2011, 475(7354): 27-30.
4. DeGiorgio C, Miller P, Harper R, et al. Fish oil (n-3 fatty acids) in drug resistant epilepsy:a randomised placebo-controlled crossover study. J Neurol Neurosurg Psychiatry, 2015, 86(1): 65-70.
5. Hagberg B, Hamfelt A, Hansson OJL, et al. Epileptic children with disturbed trytophan metabolism treated with vitamin B6. Lancet, 1964, 1(7325): 145.
6. Holló A, Clemens Z, Kamondi A, et al. Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study. Epilepsy Behav, 2012, 24(1): 131-133.
7. Mehvari J, Motlagh F, Najafi M, et al. Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients. Adv Biomed Res, 2016, 5: 36.
8. Omrani S, Taheri M, Omrani M, et al. The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients:a triple blind randomized clinical trial. Clin Transl Med, 2019, 8(1): 3.
9. Tombini M, Palermo A, Assenza G, et al. Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. Seizure, 2018, 58: 75-81.
10. Gaby AR. Natural approaches to epilepsy. Altern Med Rev, 2007, 12(1): 9-24.
11. Xiang J, Jiang Y. Regulation of Cu-Zn superoxide dismutase on SCN2A in SH-SY5Y cells as a potential therapy for temporal lobe epilepsy. Mol Med Rep, 2014, 9(1): 16-22.
12. Crepin S, Godet B, Chassain B, et al. Malnutrition and epilepsy: a two-way relationship. Clin Nutr, 2009, 28(3): 219-225.
13. Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: a meta-analysis of observational studies. Epilepsia Open, 2018, 3(1): 9-17.
14. Winesett S, Bessone S, Kossoff E. The ketogenic diet in pharmacoresistant childhood epilepsy. Expert Rev Neurother, 2015, 15(6): 621-628.
15. Falco-Walter J, Scheffer I, Fisher R. The new definition and classification of seizures and epilepsy. Epilepsy Res, 2018, 139: 73-79.
16. Fisher R, Cross J, French J, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
17. Fisher R, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(4): 470-472.
18. Deng H, Xiu X, Song Z. The molecular biology of genetic-based epilepsies. Mol Neurobiol, 2014, 49(1): 352-367.
19. Fisher R, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia, 2014, 55(4): 475-482.
20. Shin E, Jeong J, Chung Y, et al. Role of oxidative stress in epileptic seizures. Neurochem Int, 2011, 59(2): 122-137.
21. Wei F, Yan L, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
22. Wolfart J, Laker D. Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential. Front Physiol, 2015, 6: 168.
23. Frantseva M, Velazquez J, Hwang P, et al. Free radical production correlates with cell death in an in vitro model of epilepsy. Eur J Neurosci, 2000, 12(4): 1431-1439.
24. Moretti M, Marchioni CF. An overview of erdosteine antioxidant activity in experimental research. Pharmacol Res, 2007, 55(4): 249-254.
25. Pearson-Smith J, Patel M. Metabolic dysfunction and oxidative stress in epilepsy. Int J Mol Sci, 2017, 18(11).
26. Devinsky O, Vezzani A, Najjar S, et al. Glia and epilepsy: excitability and inflammation. Trends Neurosci, 2013, 36(3): 174-184.
27. Stadtman ER. Protein oxidation in aging and age-related diseases. Ann NY Acad Sci, 2001, 928: 22-38.
28. Webster K, Sun M, Crack P, et al. Inflammation in epileptogenesis after traumatic brain injury. J Neuroinflammation, 2017, 14(1): 10.
29. Wong-Ekkabut J, Xu Z, Triampo W, et al. Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. Biophys J, 2007, 93(12): 4225-4236.
30. Steriade C, Titulaer M, Vezzani A, et al. The association between systemic autoimmune disorders and epilepsy and its clinical implications. Brain, 2021, 144(2): 372-390.
31. Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol, 2013, 34(1): 47-64.
32. Rössler A, Launay J, Venault P, et al. Changes in benzodiazepine binding in a subkindling situation. Epilepsia, 2000, 41(6): 651-654.
33. Teagarden DL, Meador KJ, Loring DW. Low vitamin D levels are common in patients with epilepsy. Epilepsy Res, 2014, 108(8): 1352-1356.
34. Abdel-Wahab A, Afify M, Mahfouz A, et al. Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats. Brain Res, 2017, 1673: 78-85.
35. Kalueff A, Minasyan A, Tuohimaa P. Anticonvulsant effects of 1, 25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Res Bull, 2005, 67: 156-160.
36. Kalueff A, Minasyan A, Keisala T, et al. Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. Neurosci Lett, 2006, 394(1): 69-73.
37. Brewer L, Thibault V, Chen K, et al. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci, 2001, 21(1): 98-108.
38. Lefebvre d'Hellencourt C, Montero-Menei C, Bernard R, et al. Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. J Neurosci Res, 2003, 71(4): 575-582.
39. Bartels L, Jørgensen S, Agnholt J, et al. 1, 25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. Int Immunopharmacol, 2007, 7(13): 1755-1764.
40. Kozan R, Ayyildiz M, Yildirim M, et al. The effects of ethanol intake and withdrawal on penicillin-induced epileptiform activity in rats. Acta Neurobiol Exp (Wars), 2006, 71: 111-115.
41. Dursun E, Gezen-Ak D, Yilmazer S. The influence of Vitamin D treatment on the Inducible Nitric Oxide Synthase (INOS) expression in primary hippocampal neurons. Noro psikiyatri arsivi, 2014, 51(2): 163-168.
42. Friedman M. Chemistry, nutrition, and health-promoting properties of hericium erinaceus (Lion's Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J Agric Food Chem, 2015, 63(32): 7108-7123.
43. Jang H, Kim J, Jeong K, et al. Hericium erinaceusthe neuroprotective effect of extracts in mouse hippocampus after pilocarpine-induced status epilepticus. Int J Mol Sci, 2019, 20(4).
44. Ambrogini P, Albertini M, Betti M, et al. Neurobiological correlates of alpha-tocopherol antiepileptogenic effects and microRNA expression modulation in a rat model of kainate-induced seizures. Mol Neurobiol, 2018, 55(10): 7822-7838.
45. Ribeiro M, de Avila D, Schneider C, et al. Alpha-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions. Epilepsy Res, 2005, 66: 185-194.
46. Pott-Junior H, Nascimento C, Costa-Guarisco L, et al. Vitamin D deficient older adults are more prone to have metabolic syndrome, but not to a greater number of metabolic syndrome parameters. Nutrients, 2020, 12(3): 1-9.
47. Lee A, Wong R, Chuang S, et al. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol, 2002, 88(4): 1625-1633.
48. Betti M, Minelli A, Ambrogini P, et al. Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus. Free Radic Res, 2011, 45(10): 1136-1142.
49. Tomé AR, Feng D, Freitas RM. The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. Neurochem Res, 2010, 35(4): 580-587.
50. Zakharova I, Sokolova T, Vlasova Y, et al. α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress. Int J Mol Sci, 2017, 18(1).
51. Simeone K, Matthews S, Samson K, et al. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Exp Neurol, 2014, 251: 84-90.
52. Liu R, Wu S, Guo C, et al. Ibuprofen exerts antiepileptic and neuroprotective effects in the rat model of pentylenetetrazol-induced epilepsy via the COX-2/NLRP3/IL-18 pathway. Neurochem Res, 2020, 45(10): 2516-2526.
53. Bowling FJSic, biology d. Pyridoxine supply in human development. Semin Cell Dev Biol, 2011, 22(6): 611-618.
54. Kuhara T, Akiyama T, Ohse M, et al. Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics. Anal Biochem, 2020, 604: 113739.
55. Mastrangelo M, Cesario S. Update on the treatment of vitamin B6 dependent epilepsies. Expert Rev Neurother, 2019, 19(11): 1135-1147.
56. Stracke H, Hammes H, Werkmann D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes, 2001, 109(6): 330-336.
57. Woldeamanuel Y, Girma B. Contributing towards the betterment of translational epilepsy research in Africa: needs, challenges, resources, and opportunities. Curr Neurol Neurosci Rep, 2014, 14(8): 480.
58. Jain K, Singh J, Jain A, et al. A case report of nonalcoholic gayet-wernicke encephalopathy: don't miss thiamine. A A Pract, 2020, 14(8): e01230.
59. Botez M, Botez T, Ross-Chouinard A, et al. Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale. Epilepsy Res, 1993, 16(2): 157-163.
60. Tomé AR, Ferreira P, Freitas R. Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats. Arq Neuropsiquiatr, 2010, 68(3): 355-361.
61. Harrison F, May J. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med, 2009, 46(6): 719-730.
62. Santos I, Tomé AR, Saldanha G, et al. Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid. Oxid Med Cell Longev, 2009, 2(4): 214-221.
63. González-Ramírez M, Razo-Juárez L, Sauer-Ramírez J, et al. Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats. Pharmacol Biochem Behav, 2010, 97(2): 267-272.
64. Das A, Sarwar M, Hossain M, et al. Elevated serum lipid peroxidation and reduced vitamin C and trace element concentrations are correlated with epilepsy. Clin EEG Neurosci, 2019, 50(1): 63-72.

Previous Article
拉考沙胺在成人及儿童不同类型癫痫中的研究进展
Next Article
芬氟拉明治疗难治性癫痫的研究进展

Journal of Epilepsy

维生素在癫痫发作中治疗作用的研究进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content