儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识（2022修订版）_Journal of Epilepsy

Authors：

 中国抗癫痫协会共患病专业委员会

执笔：周水珍（复旦大学附属儿科医院神经科）;

Corresponding author：

中国抗癫痫协会共患病专业委员会, Email: szzhou@shmu.edu.cn

Keywords：

DOI：

10.7507/2096-0247.202209016

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Citation： 中国抗癫痫协会共患病专业委员会. 儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识（2022修订版）. Journal of Epilepsy, 2022, 8(6): 481-487. doi: 10.7507/2096-0247.202209016 Copy

1.	Olusanya BO, Wright SM, Nair MKC, et al. Global burden of childhood epilepsy, intellectual disability, and sensory impairments. Pediatrics, 2020, 146(1): 120-125.
2.	Developmental disabilities among children younger than 5 years in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 . Lancet Glob Health, 2018, 6(10): e1100-e1121.
3.	Zhao X, Page TF, Altszuler AR, et al. Family burden of raising a child with ADHD. J Abnorm Child Psychol, 2019, 47(8): 1327-1338.
4.	中国抗癫痫协会. 临床诊疗指南: 癫痫病分册 . 北京: 人民卫士出版社, 2015.
5.	Chou IC, Chang YT, Chin ZN, et al. Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS One, 2013, 8(3): e57926.
6.	Bertelsen EN, Larsen JT, Petersen L, et al. Childhood epilepsy, febrile seizures, and subsequent risk of ADHD. Pediatrics, 2016, 138(2): 321-324.
7.	Wang M, Zhao Q, Kang H, et al. Attention deficit hyperactivity disorder (ADHD) in children with epilepsy. Ir J Med Sci, 2020, 189(1): 305-313.
8.	Zhao Q, Wang M, Kang H, et al. Behavior problems in children with epilepsy and attention-deficit hyperactivity disorder in Central China. Epilepsy Behav, 2018, 89: 79-83.
9.	Goker Z, Yilmaz A, Eraslan AN, et al. Seizures in children with epilepsy and attention-deficit/hyperactivity disorder. Pediatr Int, 2019, 61(10): 1043-1047.
10.	Sherman EM, Slick DJ, Connolly MB, et al. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia, 2007, 48(6): 1083-1091.
11.	Hermann B, Jones J, Dabbs K, et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy . Brain, 2007, 130(Pt 12): 3135-3148.
12.	Hesdorffer DC, Ludvigsson P, Olafsson E, et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry, 2004, 61(7): 731-736.
13.	Dunn DW, Austin JK, Harezlak J, et al. ADHD and epilepsy in childhood. Dev Med Child Neurol, 2003, 45(1): 50-54.
14.	Kim EH, Yum MS, Kim HW, et al. Attention-deficit/hyperactivity disorder and attention impairment in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2014, 37: 54-58.
15.	Choudhary A, Gulati S, Sagar R, et al. Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population. Sci Rep, 2018, 8(1): 2670.
16.	Barnes GN, Paolicchi JM. Neuropsychiatric comorbidities in childhood absence epilepsy. Nat Clin Pract Neurol, 2008, 4(12): 650-651.
17.	Williams AE, Giust JM, Kronenberger WG, et al. Epilepsy and attention-deficit hyperactivity disorder: links, risks, and challenges. Neuropsychiatr Dis Treat, 2016, 12: 287-296.
18.	Bechtel N, Weber P. Attention problems in children with epilepsy. How is the long-term outcome? Eur J Paediatr Neurol, 2015, 19(3): 383-385.
19.	Ashjazadeh N, Sahraeian A, Sabzgolin I, et al. Attention-deficit hyperactivity disorder in adults with epilepsy . Epilepsy Behav, 2019, 101(Pt A): 106543.
20.	奚晓隽, 汤继宏. 癫痫共患注意缺陷多动障碍发病机制的研究进展. 癫痫杂志, 2020, 6(4): 341-344.
21.	Kaufmann R, Goldberg-Stern H, Shuper A. Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol, 2009, 24(6): 727-733.
22.	Hamoda HM, Guild DJ, Gumlak S, et al. Association between attention-deficit/hyperactivity disorder and epilepsy in pediatric populations. Expert Rev Neurother, 2009, 9(12): 1747-1754.
23.	Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan. Lancet, 2012, 380(9848): 1180-1192.
24.	Austin JK, Harezlak J, Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics, 2001, 107(1): 115-122.
25.	郑毅. 中国注意缺陷多动障碍防治指南(第二版). 中华医学电子音像出版社, 2015.
26.	刘靖, 郑毅. 《中国注意缺陷多动障碍防治指南》第二版解读. 中华精神科杂志, 2016, 49: 132-135.
27.	冯晶, 徐通. 儿童癫痫共患注意缺陷多动障碍. 中国实用儿科志, 2014, 29(4): 315-318.
28.	Reilly CJ. Attention deficit hyperactivity disorder (ADHD) in childhood epilepsy. Res Dev Disabil, 2011, 32(3): 883-893.
29.	Schubert R. Attention deficit disorder and epilepsy. Pediatr Neurol, 2005, 32(1): 1-10.
30.	Bootsma HP, Ricker L, Hekster YA, et al. The impact of side effects on long-term retention in three new antiepileptic drugs. Seizure, 2009, 18(5): 327-331.
31.	Han SA, Yang EJ, Song MK, et al. Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients. Korean J Pediatr, 2017, 60(6): 189-195.
32.	Ijff DM, Aldenkamp AP. Cognitive side-effects of antiepileptic drugs in children. Handb Clin Neurol, 2013, 111: 707-718.
33.	Shinnar RC, Shinnar S, Cnaan A, et al. Childhood Absence Epilepsy Study Group. Pretreatment behavior and subsequent medication effects in childhood absence epilepsy. Neurology, 2017, 89(16): 1698-1706.
34.	Gul A, Mehreen S. Effectiveness of Lacosamide on everyday cognitive deficits, psychiatric symptoms and resilience in patients with epilepsy. J Pak Med Assoc, 2020, 70(9): 1611-1615.
35.	Meschede C, Witt JA, Rademacher M, et al. Evaluating the longer-term cognitive effects of adjunctive perampanel compared to lacosamide in a naturalistic outpatient setting. Seizure, 2018, 58: 141-146.
36.	Yakovleva YA, Yanaeva AN, Spikina AA, et al. Lacosamide in treatment of patients with focal epilepsy and comorbid mental disorders. Zh Nevrol Psikhiatr Im S S Korsakova, 2018, 118(10): 98-104.
37.	Dim IJ, Van Veenendaal TM, Majoie HJ, et al. Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy. Acta Neurol Scand, 2015, 131(6): 347-354.
38.	Kanemura H, Sano F, Tando T, et al. EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD. Epilepsy Behav, 2013, 27(3): 443-448.
39.	Wolraich M, Brown L, Brown RT, et al. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 2011, 128(5): 1007-1022.
40.	Montano CB, Young J. Discontinuity in the transition from pediatric to adult health care for patients with attention-deficit/hyperactivity disorder. Postgrad Med, 2012, 124(5): 23-32.

1. Olusanya BO, Wright SM, Nair MKC, et al. Global burden of childhood epilepsy, intellectual disability, and sensory impairments. Pediatrics, 2020, 146(1): 120-125.
2. Developmental disabilities among children younger than 5 years in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 . Lancet Glob Health, 2018, 6(10): e1100-e1121.
3. Zhao X, Page TF, Altszuler AR, et al. Family burden of raising a child with ADHD. J Abnorm Child Psychol, 2019, 47(8): 1327-1338.
4. 中国抗癫痫协会. 临床诊疗指南: 癫痫病分册 . 北京: 人民卫士出版社, 2015.
5. Chou IC, Chang YT, Chin ZN, et al. Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS One, 2013, 8(3): e57926.
6. Bertelsen EN, Larsen JT, Petersen L, et al. Childhood epilepsy, febrile seizures, and subsequent risk of ADHD. Pediatrics, 2016, 138(2): 321-324.
7. Wang M, Zhao Q, Kang H, et al. Attention deficit hyperactivity disorder (ADHD) in children with epilepsy. Ir J Med Sci, 2020, 189(1): 305-313.
8. Zhao Q, Wang M, Kang H, et al. Behavior problems in children with epilepsy and attention-deficit hyperactivity disorder in Central China. Epilepsy Behav, 2018, 89: 79-83.
9. Goker Z, Yilmaz A, Eraslan AN, et al. Seizures in children with epilepsy and attention-deficit/hyperactivity disorder. Pediatr Int, 2019, 61(10): 1043-1047.
10. Sherman EM, Slick DJ, Connolly MB, et al. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia, 2007, 48(6): 1083-1091.
11. Hermann B, Jones J, Dabbs K, et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy . Brain, 2007, 130(Pt 12): 3135-3148.
12. Hesdorffer DC, Ludvigsson P, Olafsson E, et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry, 2004, 61(7): 731-736.
13. Dunn DW, Austin JK, Harezlak J, et al. ADHD and epilepsy in childhood. Dev Med Child Neurol, 2003, 45(1): 50-54.
14. Kim EH, Yum MS, Kim HW, et al. Attention-deficit/hyperactivity disorder and attention impairment in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2014, 37: 54-58.
15. Choudhary A, Gulati S, Sagar R, et al. Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population. Sci Rep, 2018, 8(1): 2670.
16. Barnes GN, Paolicchi JM. Neuropsychiatric comorbidities in childhood absence epilepsy. Nat Clin Pract Neurol, 2008, 4(12): 650-651.
17. Williams AE, Giust JM, Kronenberger WG, et al. Epilepsy and attention-deficit hyperactivity disorder: links, risks, and challenges. Neuropsychiatr Dis Treat, 2016, 12: 287-296.
18. Bechtel N, Weber P. Attention problems in children with epilepsy. How is the long-term outcome? Eur J Paediatr Neurol, 2015, 19(3): 383-385.
19. Ashjazadeh N, Sahraeian A, Sabzgolin I, et al. Attention-deficit hyperactivity disorder in adults with epilepsy . Epilepsy Behav, 2019, 101(Pt A): 106543.
20. 奚晓隽, 汤继宏. 癫痫共患注意缺陷多动障碍发病机制的研究进展. 癫痫杂志, 2020, 6(4): 341-344.
21. Kaufmann R, Goldberg-Stern H, Shuper A. Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol, 2009, 24(6): 727-733.
22. Hamoda HM, Guild DJ, Gumlak S, et al. Association between attention-deficit/hyperactivity disorder and epilepsy in pediatric populations. Expert Rev Neurother, 2009, 9(12): 1747-1754.
23. Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan. Lancet, 2012, 380(9848): 1180-1192.
24. Austin JK, Harezlak J, Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics, 2001, 107(1): 115-122.
25. 郑毅. 中国注意缺陷多动障碍防治指南(第二版). 中华医学电子音像出版社, 2015.
26. 刘靖, 郑毅. 《中国注意缺陷多动障碍防治指南》第二版解读. 中华精神科杂志, 2016, 49: 132-135.
27. 冯晶, 徐通. 儿童癫痫共患注意缺陷多动障碍. 中国实用儿科志, 2014, 29(4): 315-318.
28. Reilly CJ. Attention deficit hyperactivity disorder (ADHD) in childhood epilepsy. Res Dev Disabil, 2011, 32(3): 883-893.
29. Schubert R. Attention deficit disorder and epilepsy. Pediatr Neurol, 2005, 32(1): 1-10.
30. Bootsma HP, Ricker L, Hekster YA, et al. The impact of side effects on long-term retention in three new antiepileptic drugs. Seizure, 2009, 18(5): 327-331.
31. Han SA, Yang EJ, Song MK, et al. Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients. Korean J Pediatr, 2017, 60(6): 189-195.
32. Ijff DM, Aldenkamp AP. Cognitive side-effects of antiepileptic drugs in children. Handb Clin Neurol, 2013, 111: 707-718.
33. Shinnar RC, Shinnar S, Cnaan A, et al. Childhood Absence Epilepsy Study Group. Pretreatment behavior and subsequent medication effects in childhood absence epilepsy. Neurology, 2017, 89(16): 1698-1706.
34. Gul A, Mehreen S. Effectiveness of Lacosamide on everyday cognitive deficits, psychiatric symptoms and resilience in patients with epilepsy. J Pak Med Assoc, 2020, 70(9): 1611-1615.
35. Meschede C, Witt JA, Rademacher M, et al. Evaluating the longer-term cognitive effects of adjunctive perampanel compared to lacosamide in a naturalistic outpatient setting. Seizure, 2018, 58: 141-146.
36. Yakovleva YA, Yanaeva AN, Spikina AA, et al. Lacosamide in treatment of patients with focal epilepsy and comorbid mental disorders. Zh Nevrol Psikhiatr Im S S Korsakova, 2018, 118(10): 98-104.
37. Dim IJ, Van Veenendaal TM, Majoie HJ, et al. Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy. Acta Neurol Scand, 2015, 131(6): 347-354.
38. Kanemura H, Sano F, Tando T, et al. EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD. Epilepsy Behav, 2013, 27(3): 443-448.
39. Wolraich M, Brown L, Brown RT, et al. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 2011, 128(5): 1007-1022.
40. Montano CB, Young J. Discontinuity in the transition from pediatric to adult health care for patients with attention-deficit/hyperactivity disorder. Postgrad Med, 2012, 124(5): 23-32.

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Journal of Epilepsy

儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识（2022修订版）

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