Study of correlation and status of compliance with ketogenic diet in children with refractory epilepsy_Journal of Epilepsy

Authors：

AI Lili ¹ ,  YU Lifei ¹ , GU Ying ² , Zhou Shuizhen ¹ , WANG Shuangyu ¹ , WU Min ¹

1. Department of Neurology, Children’s Hospital of Fudan University, Shanghai 201102, China;
2. Nursing Department , Children’s Hospital of Fudan University, Shanghai 201102, China;

Corresponding author：

YU Lifei, Email: yulifei7711@163.com

Keywords：

Refractory epilepsy; Ketogenic diet; Compliance

DOI：

10.7507/2096-0247.202211006

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Objective To investigate the compliance of ketogenic diet in children with refractory epilepsy and its correlation with the curative effect, and to provide support and basis for the implementation and improvement of the long-term management of ketogenic diet in this patient population. Methods A total of 106 children and their families who were followed up on ketogenic diet in the Department of Pediatrics of Fudan University from March 2019 to January 2022 in the Department of Ketogenic Multidisciplinary Treatment (MDT) were selected by convenience sampling method. General data questionnaire and ketogenic compliance questionnaire were used for investigation and follow-up. Results The mean compliance of ketogenic diet in refractory epilepsy children was (13.27±3.68). The compliance scores of ketogenic children with different therapeutic effects and cognitive functions were significantly different. The compliance score was significantly correlated with the therapeutic effect and cognitive level, that is, the higher the therapeutic effect of ketogenic diet in children with higher compliance score, the better the cognitive improvement. Conclusion The compliance of ketogenic diet in children with refractory epilepsy needs to be further improved. Improving the compliance of ketogenic diet is of great significance for the efficacy of ketogenic diet. Medical staff should actively develop the corresponding intervention program and follow-up management mode to further improve the treatment compliance of children's families, improve the treatment effect and improve the quality of life of children's families.

Citation： AI Lili, YU Lifei, GU Ying, Zhou Shuizhen, WANG Shuangyu, WU Min. Study of correlation and status of compliance with ketogenic diet in children with refractory epilepsy. Journal of Epilepsy, 2023, 9(1): 16-21. doi: 10.7507/2096-0247.202211006 Copy

1.	武洁, 王荃, 钱素云, 等. 氯胺酮治疗儿童难治性和超级难治性癫痫持续状态的效果分析. 中华儿科杂志, 2020, (4): 295-300.
2.	Zupec-Kania BA, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract, 2008, 23(6): 589-596.
3.	Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 2010, 51(6): 1069-1077.
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5.	童丽丽, 吕明. 电话随访对生酮饮食治疗难治性癫痫患儿的疗效及依从性的影响. 齐鲁护理杂志, 2016, 22(5): 116-118.
6.	乔红丽, 刘晓鸣, 李玮玮. 全程个性化干预对难治性癫癎患儿生酮饮食治疗依从性的改善效果. 中国医药, 2019, 14(6): 883-886.
7.	王娟, 郭艺, 程敏, 等. 两种血酮仪对癫痫生酮饮食患儿的检测结果对比分析. 癫痫杂志, 2018, 4(1): 6-9.
8.	van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
9.	黎振声, 高曲文, 王伟, 等. 颞叶内侧癫痫智力损害与发作间期痫样放电扩散区域的相关性. 中国神经精神疾病杂志, 2018, 44(1): 6-10.
10.	Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
11.	Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
12.	梁丽丽, 贾珊珊, 李霞, 等. 生酮饮食添加治疗儿童难治性癫痫的临床效果. 临床医学研究与实践, 郑州大学, 2014, 硕士学位论文.

1. 武洁, 王荃, 钱素云, 等. 氯胺酮治疗儿童难治性和超级难治性癫痫持续状态的效果分析. 中华儿科杂志, 2020, (4): 295-300.
2. Zupec-Kania BA, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract, 2008, 23(6): 589-596.
3. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 2010, 51(6): 1069-1077.
4. 王纪文, 张娜娜. 生酮饮食疗法的安全性. 中华实用儿科临床杂志, 2013, 28(12): 886-887.
5. 童丽丽, 吕明. 电话随访对生酮饮食治疗难治性癫痫患儿的疗效及依从性的影响. 齐鲁护理杂志, 2016, 22(5): 116-118.
6. 乔红丽, 刘晓鸣, 李玮玮. 全程个性化干预对难治性癫癎患儿生酮饮食治疗依从性的改善效果. 中国医药, 2019, 14(6): 883-886.
7. 王娟, 郭艺, 程敏, 等. 两种血酮仪对癫痫生酮饮食患儿的检测结果对比分析. 癫痫杂志, 2018, 4(1): 6-9.
8. van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
9. 黎振声, 高曲文, 王伟, 等. 颞叶内侧癫痫智力损害与发作间期痫样放电扩散区域的相关性. 中国神经精神疾病杂志, 2018, 44(1): 6-10.
10. Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
11. Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
12. 梁丽丽, 贾珊珊, 李霞, 等. 生酮饮食添加治疗儿童难治性癫痫的临床效果. 临床医学研究与实践, 郑州大学, 2014, 硕士学位论文.

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