新生儿癫痫病因、临床表现及脑电图特点概述_Journal of Epilepsy

Authors：

李露莹 ,  陈锦

重庆医科大学附属儿童医院神经内科, 国家儿童健康与疾病临床医学研究中心, 儿童发育疾病研究教育部重点实验室, 儿科学重庆市重点实验室（重庆 400014）;

Corresponding author：

陈锦, Email: chenjinsuper@hotmail.com

Keywords：

新生儿癫痫; 病因; 临床表现; 脑电图

DOI：

10.7507/2096-0247.202211010

Video：

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新生儿癫痫被认为是新生儿期常见的神经系统急症，病因复杂，以急性脑损伤为主，但随着基因检测技术的开展，更多遗传相关的病因被发现。发作类型按照新的分类方法可分为电发作及电-临床发作，其中电-临床发作包括运动性发作和非运动性发作，均为局灶性发作。视频脑电图作为重要的监测手段能为诊断及预后判断方面带来极大帮助。除此，头颅超声（Cranial ultrasound，CUS）、头颅核磁共振（Magnetic resonance imaging，MRI）、核磁共振波谱也有各自优点。早期识别与确定病因对判断病情及改善预后有重要作用。

Citation： 李露莹, 陈锦. 新生儿癫痫病因、临床表现及脑电图特点概述. Journal of Epilepsy, 2023, 9(2): 156-159. doi: 10.7507/2096-0247.202211010 Copy

1.	吴静, 姜毅, 侯新琳, 等. 新生儿惊厥临床及视频脑电图特点分析. 中国新生儿科杂志, 2015, 30(6): 418-422.
2.	马思敏, 杨琳, 周文浩. 新生儿惊厥诊断和治疗进展. 中国循证儿科杂志, 2015, 10(02): 126-135.
3.	杨会阳, 束晓梅. 新生儿惊厥的遗传代谢性病因及预后. 中华实用儿科临床杂志, 2019, (14): 1109-1112.
4.	Glass HC, Shellhaas RA, Tsuchida TN, et al. Seizures in preterm neonates: a multicenter observational cohort study. Pediatr Neurol, 2017, 72: 19-24.
5.	Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
6.	Pressler RM, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 2021, 62(3): 615-628.
7.	刘晓燕. 临床脑电图学. 2 版. 北京:人民卫生出版社, 2017: 590-635.
8.	Donovan MD, Griffin BT, Kharoshankaya L, et al. Pharmacotherapy for neonatal seizures: current knowledge and future perspectives. Drugs, 2016, 76(6): 647-661.
9.	Pisani F, Spagnoli C, Falsaperla R, et al. Seizures in the neonate: a review of etiologies and outcomes. Seizure, 2021, 85: 48-56.
10.	Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.e1.
11.	Kaminiów K, Kozak S, Paprocka J. Neonatal seizures revisited. Children (Basel), 2021, 8(2): 155.
12.	Ramantani G, Schmitt B, Plecko B, et al. Neonatal seizures-are we there yet? Neuropediatrics, 2019, 50（5）: 280-293.
13.	Soul JS. Acute symptomatic seizures in term neonates: etiologies and treatments. Semin Fetal Neonatal Med, 2018, 23(3): 183-190.
14.	Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. Semin Neurol, 2020, 40(2): 246-256.
15.	Rafay MF, Cortez MA, de Veber GA, et al. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke, 2009, 40(7): 2402-2407.
16.	于灏婷. 新生儿惊厥预后相关因素的研究进展. 国际儿科学杂志, 2020, 24(3): 197-201.
17.	郑侠, 陈娇阳, 黑明燕, 等. 不明原因新生儿惊厥基因分析的临床研究. 中华新生儿科杂志, 2020, 35(5): 346-351.
18.	Massey SL, Jensen FE, Abend NS. Electroencephalographic monitoring for seizure identification and prognosis in term neonates. Semin Fetal Neonatal Med, 2018, 23(3): 168-174.
19.	Sansevere AJ, Kapur K, Peters JM, et al. Seizure prediction models in the neonatal intensive care unit. J Clin Neurophysiol, 2019, 36(3): 186-194.
20.	Shellhaas RA, Chang T, Tsuchida T, et al. The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-617.
21.	Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
22.	Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
23.	Shellhaas RA. Neonatal seizures reach the mainstream: The ILAE classification of seizures in the neonate. Epilepsia, 2021, 62(3): 629-631.
24.	Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022, 63(6): 1349-1397.
25.	Hirsch LJ, Fong MWK, Leitinger M, et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2021 version. J Clin Neurophysiol, 2021, 38(1): 1-29.
26.	韩烨, 符娜, 秦炯. 脑电图在新生儿惊厥诊断中的应用. 癫痫杂志, 2018, 4(3): 234-237.
27.	Nunes ML, Yozawitz EG, Zuberi S, et al. Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review. Epilepsia Open, 2019, 4(1): 10-29.
28.	陈新, 陆亚东, 周晓光, 等. 视频脑电图对新生儿惊厥的诊断价值及预后评估意义. 中华新生儿科杂志, 2019, 34(1): 24-28.
29.	马源培, 郝佳, 杨志仙, 等. 新生儿惊厥视频脑电图特点及其与临床表现和预后关系的研究. 中华新生儿科杂志, 2021, 36(1): 3-7.
30.	Fitzgerald MP, Massey SL, Fung FW, et al. High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy. Seizure, 2018, 61: 221-226.
31.	Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics, 2020, 145(6): e20193182.

1. 吴静, 姜毅, 侯新琳, 等. 新生儿惊厥临床及视频脑电图特点分析. 中国新生儿科杂志, 2015, 30(6): 418-422.
2. 马思敏, 杨琳, 周文浩. 新生儿惊厥诊断和治疗进展. 中国循证儿科杂志, 2015, 10(02): 126-135.
3. 杨会阳, 束晓梅. 新生儿惊厥的遗传代谢性病因及预后. 中华实用儿科临床杂志, 2019, (14): 1109-1112.
4. Glass HC, Shellhaas RA, Tsuchida TN, et al. Seizures in preterm neonates: a multicenter observational cohort study. Pediatr Neurol, 2017, 72: 19-24.
5. Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
6. Pressler RM, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 2021, 62(3): 615-628.
7. 刘晓燕. 临床脑电图学. 2 版. 北京:人民卫生出版社, 2017: 590-635.
8. Donovan MD, Griffin BT, Kharoshankaya L, et al. Pharmacotherapy for neonatal seizures: current knowledge and future perspectives. Drugs, 2016, 76(6): 647-661.
9. Pisani F, Spagnoli C, Falsaperla R, et al. Seizures in the neonate: a review of etiologies and outcomes. Seizure, 2021, 85: 48-56.
10. Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.e1.
11. Kaminiów K, Kozak S, Paprocka J. Neonatal seizures revisited. Children (Basel), 2021, 8(2): 155.
12. Ramantani G, Schmitt B, Plecko B, et al. Neonatal seizures-are we there yet? Neuropediatrics, 2019, 50（5）: 280-293.
13. Soul JS. Acute symptomatic seizures in term neonates: etiologies and treatments. Semin Fetal Neonatal Med, 2018, 23(3): 183-190.
14. Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. Semin Neurol, 2020, 40(2): 246-256.
15. Rafay MF, Cortez MA, de Veber GA, et al. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke, 2009, 40(7): 2402-2407.
16. 于灏婷. 新生儿惊厥预后相关因素的研究进展. 国际儿科学杂志, 2020, 24(3): 197-201.
17. 郑侠, 陈娇阳, 黑明燕, 等. 不明原因新生儿惊厥基因分析的临床研究. 中华新生儿科杂志, 2020, 35(5): 346-351.
18. Massey SL, Jensen FE, Abend NS. Electroencephalographic monitoring for seizure identification and prognosis in term neonates. Semin Fetal Neonatal Med, 2018, 23(3): 168-174.
19. Sansevere AJ, Kapur K, Peters JM, et al. Seizure prediction models in the neonatal intensive care unit. J Clin Neurophysiol, 2019, 36(3): 186-194.
20. Shellhaas RA, Chang T, Tsuchida T, et al. The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-617.
21. Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
22. Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
23. Shellhaas RA. Neonatal seizures reach the mainstream: The ILAE classification of seizures in the neonate. Epilepsia, 2021, 62(3): 629-631.
24. Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022, 63(6): 1349-1397.
25. Hirsch LJ, Fong MWK, Leitinger M, et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2021 version. J Clin Neurophysiol, 2021, 38(1): 1-29.
26. 韩烨, 符娜, 秦炯. 脑电图在新生儿惊厥诊断中的应用. 癫痫杂志, 2018, 4(3): 234-237.
27. Nunes ML, Yozawitz EG, Zuberi S, et al. Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review. Epilepsia Open, 2019, 4(1): 10-29.
28. 陈新, 陆亚东, 周晓光, 等. 视频脑电图对新生儿惊厥的诊断价值及预后评估意义. 中华新生儿科杂志, 2019, 34(1): 24-28.
29. 马源培, 郝佳, 杨志仙, 等. 新生儿惊厥视频脑电图特点及其与临床表现和预后关系的研究. 中华新生儿科杂志, 2021, 36(1): 3-7.
30. Fitzgerald MP, Massey SL, Fung FW, et al. High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy. Seizure, 2018, 61: 221-226.
31. Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics, 2020, 145(6): e20193182.

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新生儿癫痫病因、临床表现及脑电图特点概述

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