围发作期打哈欠在癫痫中的应用价值_Journal of Epilepsy

Authors：

杜晓萍 ¹ , 姚一 ² , 孙美珍 ¹ ,  郭军红 ¹

1. ;
2. ;

Corresponding author：

郭军红, Email: neuroguo@163.com

Keywords：

打哈欠; 病理性打哈欠; 癫痫; 围发作期

DOI：

10.7507/2096-0247.202301007

Video：

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打哈欠是哺乳动物、鸟类、爬行动物常见的一种生理性动作，与警觉性降低有关。病理情况下也可以出现打哈欠，称之为病理性打哈欠，意义和价值尚未明确。癫痫围发作期打哈欠罕见，多为病例报道，仅有一项颞叶癫痫的系统性回顾。癫痫类型方面，近半数患者类型不明或者未提及，提及的患者中以颞叶癫痫最常见，其次可见于额叶癫痫、特发性癫痫、婴儿痉挛症等。病因方面，以肿瘤和皮质发育不良常见。脑电图方面，发作间期和发作期脑电图提示颞叶最常受累，发作期脑电图模式以慢波活动多见。围发作期打哈欠在颞叶癫痫中可能具有定侧价值，定侧价值不统一，非优势半球的可能性大。发病机制上，人类电刺激壳核产生了打哈欠动作，动物实验方面证实杏仁核中央核和下丘脑室旁核神经元在打哈欠动作完成上发挥了作用。我们推测，癫痫患者出现围发作期打哈欠的机制，可能与边缘系统受累有关。癫痫围发作期打哈欠罕见，特点尚未完全认识。未来还需要更多的病例进行系统性研究，也期望更多的同行能够关注癫痫围发作期打哈欠。

Citation： 杜晓萍, 姚一, 孙美珍, 郭军红. 围发作期打哈欠在癫痫中的应用价值. Journal of Epilepsy, 2023, 9(2): 142-146. doi: 10.7507/2096-0247.202301007 Copy

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2.	Krestel H, Bassetti CL, Walusinski O. Yawning-Its anatomy, chemistry, role, and pathological considerations. Prog Neurobiol, 2018, 161: 61-78.
3.	Walusinski O. Pathological yawning, laughing and crying. Front Neurol Neurosci, 2018, 41: 40-49.
4.	Singer OC, Humpich MC, Lanfermann H, et al. Yawning in acute anterior circulation stroke. J Neurol Neurosurg Psychiatry, 2007, 78(11): 1253-1254.
5.	Cattaneo L, Cucurachi L, Chierici E, et al. Pathological yawning as a presenting symptom of brain stem ischaemia in two patients. 2006, 77 (1): 98-100.
6.	Goessler UR, Hein G, Sadick H, et al. Physiology, role and neuropharmacology of yawning. Laryngorhinootologie, 2005, 84(5): 345-351.
7.	Sato-Suzuki I, Kita I, Oguri M, et al. Stereotyped yawning responses induced by electrical and chemical stimulation of paraventricular nucleus of the rat. J Neurophysiol, 1998, 80(5): 2765-2775.
8.	Argiolas A, Melis MR. The neuropharmacology of yawning. Eur J Pharmacol, 1998, 5; 343(1): 1-16.
9.	Collins GT, Eguibar JR. Neurophamacology of yawning. Front Neurol Neurosci, 2010, 28: 90-106.
10.	Melis MR, Argiolas A, Gessa GL. Oxytocin-induced penile erection and yawning: site of action in the brain. Brain Res, 1986, 398(2): 259-265.
11.	Kubota N, Amemiya S, Yanagita S, et al. Central nucleus of the amygdala is involved in induction of yawning response in rats. Behav Brain Res, 2019, 371: 111974.
12.	Kubota N, Amemiya S, Yanagita S, et al. Neural pathways from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus are involved in induction of yawning behavior due to emotional stress in rats. Behav Brain Res, 2023, 436: 114091.
13.	Penfield W, Jasper H. Epilepsy and the functional anatomy of the human brain. Boston:Little, Brown, 1954: 416-418.
14.	Kuba R, Musilová K, Brázdil M, et al. Peri-ictal yawning lateralizes the seizure onset zone to the nondominant hemisphere in patients with temporal lobe epilepsy. Epilepsy Behav, 2010, 19(3): 311-314.
15.	谢鹏飞, 沈祥骏. 哈欠性癫痫一例报告. 临床神经病学杂志, 1992, 12(4): 234.
16.	Yankovsky AE, Andermann F, Dubeau F. Post-ictal forceful yawning in a patient with nondominant hemisphere epilepsy. Epileptic Disord, 2006, 8(1): 65-69.
17.	Wasade VS, Balki I, Bowyer SM, et al. Controllable yawning expressed as focal seizures of frontal lobe epilepsy. Epilepsy Behav Case Rep, 2016, 26(6): 61-63.
18.	Specchio N, Carotenuto A, Trivisano M, et al. Ictal yawning in a patient with drug-resistant focal epilepsy: video/EEG documentation and review of literature reports. Epilepsy Behav, 2011, 22(3): 602-605.
19.	Goldie L, Green JM. Yawning and epilepsy. J Psychosom Res, 1961, 5: 263-268.
20.	Donat JF, Wright FS. Unusual variant of infantile spasms. J Child Neurol, 1991, 6(4): 313-318.
21.	Kutty RK, Alapatt JP, Govindan A. Intractable yawning as a predominant symptom of temporal lobe ganglioglioma: case report and review of literature. Asian J Neurosurg, 2018, 13(1): 102-104.
22.	Casciato S, Di Bonaventura C, Lapenta L, et al. Recurrent partial seizures with ictal yawning as atypical presentation of Hashimoto's encephalopathy (steroid-responsive encephalopathy associated with autoimmune thyroiditis). Epilepsy Behav, 2011, 22(4): 799-803.
23.	Akbar A, Ahmad S. New-onset seizures as an acute presentation with atypical EEG findings in a previously healthy child with asymptomatic COVID-19 infection. Cureus, 2022, 14(3): e22899.
24.	Muchnik S, Finkielman S, Semeniuk G, et al. Yawning and temporal lobe epilepsy. Medicina (B Aires), 2003, 63(2): 137-139.
25.	Medrano V, Selles-Galiana MF, Fernández-Izquierdo S, et al. Yawning and temporal lobe epilepsy. Rev Neurol, 2005, 41(1): 63-64.
26.	Nicotra A, Khalil NM, Owbridge P, et al. Pathological yawning as an ictal seizure manifestation in the elderly BMJ Case Rep, 2012, 12: bcr0120125618.
27.	Joshi S, Bayat A, Gagnon L, et al. Yawning induced by focal electrical stimulation in the human brain. Epilepsy Behav, 2017, 66: 1-3.

1. Teive HAG, Munhoz RP, Camargo CHF, et al. Yawning in neurology: a review. Arq Neuropsiquiatr, 2018, 76(7): 473-480.
2. Krestel H, Bassetti CL, Walusinski O. Yawning-Its anatomy, chemistry, role, and pathological considerations. Prog Neurobiol, 2018, 161: 61-78.
3. Walusinski O. Pathological yawning, laughing and crying. Front Neurol Neurosci, 2018, 41: 40-49.
4. Singer OC, Humpich MC, Lanfermann H, et al. Yawning in acute anterior circulation stroke. J Neurol Neurosurg Psychiatry, 2007, 78(11): 1253-1254.
5. Cattaneo L, Cucurachi L, Chierici E, et al. Pathological yawning as a presenting symptom of brain stem ischaemia in two patients. 2006, 77 (1): 98-100.
6. Goessler UR, Hein G, Sadick H, et al. Physiology, role and neuropharmacology of yawning. Laryngorhinootologie, 2005, 84(5): 345-351.
7. Sato-Suzuki I, Kita I, Oguri M, et al. Stereotyped yawning responses induced by electrical and chemical stimulation of paraventricular nucleus of the rat. J Neurophysiol, 1998, 80(5): 2765-2775.
8. Argiolas A, Melis MR. The neuropharmacology of yawning. Eur J Pharmacol, 1998, 5; 343(1): 1-16.
9. Collins GT, Eguibar JR. Neurophamacology of yawning. Front Neurol Neurosci, 2010, 28: 90-106.
10. Melis MR, Argiolas A, Gessa GL. Oxytocin-induced penile erection and yawning: site of action in the brain. Brain Res, 1986, 398(2): 259-265.
11. Kubota N, Amemiya S, Yanagita S, et al. Central nucleus of the amygdala is involved in induction of yawning response in rats. Behav Brain Res, 2019, 371: 111974.
12. Kubota N, Amemiya S, Yanagita S, et al. Neural pathways from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus are involved in induction of yawning behavior due to emotional stress in rats. Behav Brain Res, 2023, 436: 114091.
13. Penfield W, Jasper H. Epilepsy and the functional anatomy of the human brain. Boston:Little, Brown, 1954: 416-418.
14. Kuba R, Musilová K, Brázdil M, et al. Peri-ictal yawning lateralizes the seizure onset zone to the nondominant hemisphere in patients with temporal lobe epilepsy. Epilepsy Behav, 2010, 19(3): 311-314.
15. 谢鹏飞, 沈祥骏. 哈欠性癫痫一例报告. 临床神经病学杂志, 1992, 12(4): 234.
16. Yankovsky AE, Andermann F, Dubeau F. Post-ictal forceful yawning in a patient with nondominant hemisphere epilepsy. Epileptic Disord, 2006, 8(1): 65-69.
17. Wasade VS, Balki I, Bowyer SM, et al. Controllable yawning expressed as focal seizures of frontal lobe epilepsy. Epilepsy Behav Case Rep, 2016, 26(6): 61-63.
18. Specchio N, Carotenuto A, Trivisano M, et al. Ictal yawning in a patient with drug-resistant focal epilepsy: video/EEG documentation and review of literature reports. Epilepsy Behav, 2011, 22(3): 602-605.
19. Goldie L, Green JM. Yawning and epilepsy. J Psychosom Res, 1961, 5: 263-268.
20. Donat JF, Wright FS. Unusual variant of infantile spasms. J Child Neurol, 1991, 6(4): 313-318.
21. Kutty RK, Alapatt JP, Govindan A. Intractable yawning as a predominant symptom of temporal lobe ganglioglioma: case report and review of literature. Asian J Neurosurg, 2018, 13(1): 102-104.
22. Casciato S, Di Bonaventura C, Lapenta L, et al. Recurrent partial seizures with ictal yawning as atypical presentation of Hashimoto's encephalopathy (steroid-responsive encephalopathy associated with autoimmune thyroiditis). Epilepsy Behav, 2011, 22(4): 799-803.
23. Akbar A, Ahmad S. New-onset seizures as an acute presentation with atypical EEG findings in a previously healthy child with asymptomatic COVID-19 infection. Cureus, 2022, 14(3): e22899.
24. Muchnik S, Finkielman S, Semeniuk G, et al. Yawning and temporal lobe epilepsy. Medicina (B Aires), 2003, 63(2): 137-139.
25. Medrano V, Selles-Galiana MF, Fernández-Izquierdo S, et al. Yawning and temporal lobe epilepsy. Rev Neurol, 2005, 41(1): 63-64.
26. Nicotra A, Khalil NM, Owbridge P, et al. Pathological yawning as an ictal seizure manifestation in the elderly BMJ Case Rep, 2012, 12: bcr0120125618.
27. Joshi S, Bayat A, Gagnon L, et al. Yawning induced by focal electrical stimulation in the human brain. Epilepsy Behav, 2017, 66: 1-3.

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