• Department of Pediatrics, Guizhou Provincial People's Hospital, Guiyang 550002, China;
ZHOU Hao, Email: haoye320@163.com
Export PDF Favorites Scan Get Citation

CDKL5 deficiency disorder (CDD), also known as developmental epileptic encephalopathy, is a rare X-linked dominant disease of the nervous system. Its main clinical manifestations include: uncontrollable seizures, cognitive impairment, motor retardation, visual impairment, sleep disorders, gastrointestinal impairment, autonomic nervous dysfunction, and autistic like manifestations. Its high disability rate and heavy disease burden bring heavy burden to society and family. However, the current domestic and foreign studies on this disease mainly focus on the clinical phenotype and pathogenesis, and there are few studies involving the standard clinical management of various systems. Therefore, a core committee composed of CDD experts from the United States, Europe, and the United Kingdom conducted a six-month investigation (August 2020—January 2021) and developed the international consensus: recommendations for the assessment and management of CDKL5 deficiency patients (hereafter referred to as the Consensus) based on the Durfel research methodology. This consensus invites multidisciplinary experts to put forward diagnosis and treatment suggestions for the diagnosis and treatment of CDD as well as the clinical management of various systemic systems, which will provide evidence-based basis for regulating the diagnosis and treatment behaviors of clinicians for CDD. In this paper, the consensus was interpreted to facilitate the long-term management of the disease.

Citation: ZHOU Fang, CUI Yuxia, WANG Xike, LIU Kaiyu, ZHOU Hao. Interpretation of international consensus: recommendations for the assessment and management of individuals with CDKL5 defificiency disorder. Journal of Epilepsy, 2023, 9(3): 248-254. doi: 10.7507/2096-0247.202302006 Copy

  • Previous Article

    Advances in the p38 Mitogen-activated protein kinase signalling pathway in epilepsy
  • Next Article

    一例儿童亚急性硬化性全脑炎的脑电演变及临床特点