LU Qian 1,2 , ZHANG Qi 1,2 , WANG Qiuhong 1,2 , DUN Shuo 1,2 , WANG Jia 1,2 , ZOU Liping 1,2
  • 1. Medical School of Chinese PLA, Beijing 100853, China;
  • 2. Department of Pediatrics, the First Medical Center of PLA General Hospital, Beijing 100853, China;
ZOU Liping, Email: zouliping21@sina.com
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Epilepsy is a common neurological disease with complex etiology and various seizure forms. It can affect people of all ages. Although a variety of antiseizure medications are available, one-third of patients still have poor drug treatment. Therefore, better methods for the diagnosis and treatment of epilepsy are particularly important. Exosomes are extracellular vesicles with a diameter of 30 ~ 150 nm that have powerful intercellular information transmission functions and also play an important role in the central nervous system. Exosomes released by nerve cells in the local microenvironment can participate in nerve development and plasticity, regulate neuroinflammation, and reduce neuronal loss. Moreover, some proteins or micro ribonucleic acid (miRNA) in exosomes are highly correlated with epilepsy and are changed in epileptogenesis, so they play an important role in the prevention and early diagnosis of epilepsy. In addition, exosomes have better biocompatibility and lower immunogenicity. Its small size can effectively avoid the phagocytosis of mononuclear macrophages. Moreover, the proteins carried on its surface have a strong homing ability to target tissues or cells and can penetrate the blood-brain barrier to the intracranial, so exosomes have the advantage of natural drug delivery. Therefore, this study reviews the application of exosomes in epilepsy to improve the understanding of exosomes in scientific research and clinical workers.

Citation: LU Qian, ZHANG Qi, WANG Qiuhong, DUN Shuo, WANG Jia, ZOU Liping. Application of exosomes in the diagnosis and treatment of epilepsy. Journal of Epilepsy, 2023, 9(4): 306-309. doi: 10.7507/2096-0247.202304010 Copy

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