Research progress on correlation between febrile seizure and trace elements in children_Journal of Epilepsy

Authors：

ZHONG Huiyong ¹ ,  ZHONG Jianmin ²

1. Department of Pediatrics, Jingdezhen First People’s Hospital, Jingdezhen 333000, China;
2. Department of Neurology, Jiangxi Children’s Hospital, Nanchang 330006, China;

Corresponding author：

ZHONG Jianmin, Email: zhongjm@163.com

Keywords：

Febrile seizure; Trace elements; Children; Research progress

DOI：

10.7507/2096-0247.202308015

Video：

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Abstract Full text Figures/Tables Video References Cited by

Febrile seizure is one of the most common emergencies in children, accounting for about 30% of all types of children, and the most common among children aged 6 months to 5 years. At the same time, children in this age group are at the peak of growth and development, and the content of various trace elements in the body is prone to abnormalities. At present, there are few related studies on febrile seizure and trace elements in children. This paper summarizes the related studies on febrile seizure and trace elements in order to provide theoretical guidance for the prevention and treatment of febrile seizure

Citation： ZHONG Huiyong, ZHONG Jianmin. Research progress on correlation between febrile seizure and trace elements in children. Journal of Epilepsy, 2023, 9(6): 503-508. doi: 10.7507/2096-0247.202308015 Copy

1.	Lee SH, Byeon JH, Kim GH, et al. Epilepsy in children with a history of febrile seizures. Korean J Pediatr, 2016, 59 (2): 74-79.
2.	Smith DK, Sadler KP, Benedum M. Febrile Seizures: risks, evaluation, and prognosis. Am Fam Physician, 2019, 99 (7): 445-450.
3.	Laino D, Mencaroni E, Esposito S. Management of pediatric febrile seizures. Int J Environ Res Public Health, 2018, 15 (10): 2232.
4.	钟建民. 热性惊厥的临床诊治策略. 实用儿科临床杂志, 2012, 27 (24): 1856-1859.
5.	Chung S. Febrile seizures. Korean J Pediatr, 2014, 57 (9): 384-395.
6.	Boillot M, Morin-Brureau M, Picard F, et al.Novel GABRG2 mutations cause familial febrile seizures. Neurol Genet, 2015, 1 (4): e35.
7.	华欣洋, 江震, 王志锋, 等. 贵州省农村地区儿童微量元素补充现状、影响因素及对生长发育迟缓效果预测研究. 中国儿童保健杂志, 2014, 22 (8): 791-794.
8.	Namakin K, Zardast M, Sharifzadeh G, et al. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol, 2016, 10 (3): 57-60.
9.	Shiva S, Barzegar M, Zokaie N, et al. Dose supplemental zinc prevents recurrence of febrile seizures? Iran J Child Neurol, 2011, 5 (4): 11-14.
10.	Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ, 1996, 313 (7053): 343.
11.	Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol, 1995, 10 (2): 105-109.
12.	Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr, 2010, 47 (5): 437-439.
13.	Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr, 2019, 19 (1): 309.
14.	Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta-analysis. Seizure, 2017, 52: 27-34.
15.	Sulviani R, Kamarullah W, Dermawan S, et al. Anemia and poor iron indices are associated with susceptibility to febrile seizures in children: a systematic review and meta-analysis. J Child Neurol, 2023, 38 (3-4): 186-197.
16.	李琴娜. 儿童热性惊厥与血清离子及微量元素的相关性分析. 内蒙古医科大学, 2019, 硕士学位论文.
17.	张前明. 儿童热性惊厥与常见微量元素关系探讨. 中外医疗, 2013, 32 (9): 47-49.
18.	Burhanoğlu M, Tütüncüoğlu S, Coker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr, 1996, 155 (6): 498-501.
19.	Salehiomran MR, Mahzari M. Zinc status in febrile seizure: a case-control study. Iran J Child Neurol, 2013, 7 (4): 20-23.
20.	Hosseini F, Nikkhah A, Afkhami Goli M. Serum zinc level in children with febrile seizure. Iran J Child Neurol, 2020, 14 (1): 43-47.
21.	Çığrı E, İnan FÇ. Comparison of serum selenium, homocysteine, zinc, and vitamin d levels in febrile children with and without febrile seizures: a prospective single-center Study. Children (Basel), 2023, 10 (3): 528.
22.	张才军. 热性惊厥患儿的血清及脑脊液锌水平的Meta分析. 重庆医科大学, 2018, 硕士学位论文.
23.	Kannachamkandy L, Kamath SP, Mithra P, et al. Association between serum micronutrient levels and febrile seizures among febrile children in southern india: a case control study. Clinical Epidemiology and Global Health, 2020, 8 (4): 1366-1370.
24.	Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev, 2015, 73 (11): 760-779.
25.	Prasad R, Singh A, Das B K, et al. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. Journal of Clinical and Diagnostic Research, 2009, 3 (6): 1841-1846.
26.	Salah ON, Abdelraouf ER, Abdelhameed MH, et al. Assessment of the level of GABA and some trace elements in blood in children who suffer from familial febrile convulsions. Open Access Maced J Med Sci, 2014, 2 (1): 68-73.
27.	Mahyar A, Ayazi P, Dalirani R, et al. A case- control study of the association between serum copper level and febrile seizures in children. Iran J Child Neurol, 2012, 6 (1): 23-28.
28.	Aly IA, Kmal HM, Soliman DR, et al. Iron profile parameters and serum zinc & copper levels in children with febrile convulsions in Banha. J Am Sci, 2014, 10 (7): 320-327.
29.	赵凯, 唐卫珍, 陈迎春. 儿童热性惊厥与常见微量元素关系探讨. 中国急救医学, 2007, 27 (2): 121-123.
30.	孙运梅. 小儿热性惊厥与常见微量元素锌铁铜的相关性探讨. 中国现代药物应用, 2017, 11 (6): 62-64.
31.	Mahyar A, Ayazi P, Fallahi M, et al. Correlation between serum selenium level and febrile seizures. Pediatr Neurol, 2010, 43 (5): 331-334.
32.	Amiri M, Farzin L, Moassesi ME, et al. Serum trace element levels in febrile convulsion. Biol Trace Elem Res, 2010, 135: 38-44.
33.	Bakhtiari E, Heydarian F, Khalesi M, et al. A comparison between serum selenium level in febrile children with or without seizure. Biol Trace Elem Res, 2022, 200 (7): 3103-3106.
34.	廖培成. 热性惊厥患儿血清11种矿物质水平变化分析. 沈阳医学院, 2021, 硕士学位论文.
35.	郑柔, 祈乐, 白凤芝, 等. 高热惊厥患儿血钠、钾、钙、铅、糖变化的临床意义. 中国实验诊学, 2008, 12 (3): 407-408.
36.	江志雄, 吴旅平, 邢旺兴. 儿童脑性疾病血清痕量元素变化及其临床意义. 杭州医学高等专科学校学报, 2002, 23 (5): 209-210.
37.	Fallah R, Sabbaghzadegan S, Karbasi SA, et al. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial. Nutrition, 2015, 31 (11-12): 1358-1361.
38.	Kumar M, Swarnim S, Khanam S. Zinc supplementation for prevention of febrile seizures recurrences in children: a systematic review and meta-analysis. Indian Pediatr, 2021, 58 (9): 857-860.
39.	Sharawat IK, Panda PK, Kumar V, et al. Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: a prospective study with comparison with historical controls. J Neurosci Rural Pract, 2022, 13 (4): 718-724.
40.	章静静, 钟建民. 热性惊厥发病机制的研究进展. 实用临床医学, 2019, 20 (09): 102-104+106.
41.	Daoud AS, Batieha A, Abu-Ekteish F, et al. Iron status: a possible risk factor for the first febrile seizure. Epilepsia, 2002, 43 (7): 740-743.
42.	Li Z, Liu Y, Wei R, et al. The important role of zinc in neurological diseases. biomolecules, 2022, 13 (1): 28.
43.	Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res, 2004, 102 (1-3): 1-10.
44.	Evens A, Hryhorczuk D, Lanphear BP, et al. The impact of low-level lead toxicity on school performance among children in the Chicago Public Schools: a population-based retrospective cohort study. Environ Health, 2015, 14: 21.
45.	黄跃海, 黄之抗. 复杂性高热惊厥患儿血清锌、铅的测定及意义探讨. 岭南急诊医学杂志, 2008 (3): 197-198.
46.	Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients, 2018, 10 (9): 1203.
47.	Schweizer U, Schomburg L, Savaskan NE. The neurobiology of selenium: lessons from transgenic mice. J Nutr, 2004, 134 (4): 707-710.
48.	Turkdogan D, Toplan S, Karakoc Y. Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy. J Child Neurol, 2002, 17 (9): 673-676.
49.	El-Masry HMA, Sadek AA, Hassan MH, et al. Metabolic profile of oxidative stress and trace elements in febrile seizures among children. Metab Brain Dis, 2018, 33 (5): 1509-1515.
50.	Balachandran RC, Mukhopadhyay S, McBride D, et al. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem, 2020, 295 (19): 6312-6329.
51.	张建裕, 龚华. 2094例儿童微量元素铅、镉、铜含量分析. 中国妇幼保健, 2012, 27 (1): 69-70.
52.	Malara P, Kwapuliński J, Drugacz J. Lead and cadmium occurrence in deciduous teeth of children exposed to cigarette smoke in apartments. Przegl Lek, 2004, 61 (10): 1122-1125.

1. Lee SH, Byeon JH, Kim GH, et al. Epilepsy in children with a history of febrile seizures. Korean J Pediatr, 2016, 59 (2): 74-79.
2. Smith DK, Sadler KP, Benedum M. Febrile Seizures: risks, evaluation, and prognosis. Am Fam Physician, 2019, 99 (7): 445-450.
3. Laino D, Mencaroni E, Esposito S. Management of pediatric febrile seizures. Int J Environ Res Public Health, 2018, 15 (10): 2232.
4. 钟建民. 热性惊厥的临床诊治策略. 实用儿科临床杂志, 2012, 27 (24): 1856-1859.
5. Chung S. Febrile seizures. Korean J Pediatr, 2014, 57 (9): 384-395.
6. Boillot M, Morin-Brureau M, Picard F, et al.Novel GABRG2 mutations cause familial febrile seizures. Neurol Genet, 2015, 1 (4): e35.
7. 华欣洋, 江震, 王志锋, 等. 贵州省农村地区儿童微量元素补充现状、影响因素及对生长发育迟缓效果预测研究. 中国儿童保健杂志, 2014, 22 (8): 791-794.
8. Namakin K, Zardast M, Sharifzadeh G, et al. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol, 2016, 10 (3): 57-60.
9. Shiva S, Barzegar M, Zokaie N, et al. Dose supplemental zinc prevents recurrence of febrile seizures? Iran J Child Neurol, 2011, 5 (4): 11-14.
10. Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ, 1996, 313 (7053): 343.
11. Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol, 1995, 10 (2): 105-109.
12. Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr, 2010, 47 (5): 437-439.
13. Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr, 2019, 19 (1): 309.
14. Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta-analysis. Seizure, 2017, 52: 27-34.
15. Sulviani R, Kamarullah W, Dermawan S, et al. Anemia and poor iron indices are associated with susceptibility to febrile seizures in children: a systematic review and meta-analysis. J Child Neurol, 2023, 38 (3-4): 186-197.
16. 李琴娜. 儿童热性惊厥与血清离子及微量元素的相关性分析. 内蒙古医科大学, 2019, 硕士学位论文.
17. 张前明. 儿童热性惊厥与常见微量元素关系探讨. 中外医疗, 2013, 32 (9): 47-49.
18. Burhanoğlu M, Tütüncüoğlu S, Coker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr, 1996, 155 (6): 498-501.
19. Salehiomran MR, Mahzari M. Zinc status in febrile seizure: a case-control study. Iran J Child Neurol, 2013, 7 (4): 20-23.
20. Hosseini F, Nikkhah A, Afkhami Goli M. Serum zinc level in children with febrile seizure. Iran J Child Neurol, 2020, 14 (1): 43-47.
21. Çığrı E, İnan FÇ. Comparison of serum selenium, homocysteine, zinc, and vitamin d levels in febrile children with and without febrile seizures: a prospective single-center Study. Children (Basel), 2023, 10 (3): 528.
22. 张才军. 热性惊厥患儿的血清及脑脊液锌水平的Meta分析. 重庆医科大学, 2018, 硕士学位论文.
23. Kannachamkandy L, Kamath SP, Mithra P, et al. Association between serum micronutrient levels and febrile seizures among febrile children in southern india: a case control study. Clinical Epidemiology and Global Health, 2020, 8 (4): 1366-1370.
24. Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev, 2015, 73 (11): 760-779.
25. Prasad R, Singh A, Das B K, et al. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. Journal of Clinical and Diagnostic Research, 2009, 3 (6): 1841-1846.
26. Salah ON, Abdelraouf ER, Abdelhameed MH, et al. Assessment of the level of GABA and some trace elements in blood in children who suffer from familial febrile convulsions. Open Access Maced J Med Sci, 2014, 2 (1): 68-73.
27. Mahyar A, Ayazi P, Dalirani R, et al. A case- control study of the association between serum copper level and febrile seizures in children. Iran J Child Neurol, 2012, 6 (1): 23-28.
28. Aly IA, Kmal HM, Soliman DR, et al. Iron profile parameters and serum zinc & copper levels in children with febrile convulsions in Banha. J Am Sci, 2014, 10 (7): 320-327.
29. 赵凯, 唐卫珍, 陈迎春. 儿童热性惊厥与常见微量元素关系探讨. 中国急救医学, 2007, 27 (2): 121-123.
30. 孙运梅. 小儿热性惊厥与常见微量元素锌铁铜的相关性探讨. 中国现代药物应用, 2017, 11 (6): 62-64.
31. Mahyar A, Ayazi P, Fallahi M, et al. Correlation between serum selenium level and febrile seizures. Pediatr Neurol, 2010, 43 (5): 331-334.
32. Amiri M, Farzin L, Moassesi ME, et al. Serum trace element levels in febrile convulsion. Biol Trace Elem Res, 2010, 135: 38-44.
33. Bakhtiari E, Heydarian F, Khalesi M, et al. A comparison between serum selenium level in febrile children with or without seizure. Biol Trace Elem Res, 2022, 200 (7): 3103-3106.
34. 廖培成. 热性惊厥患儿血清11种矿物质水平变化分析. 沈阳医学院, 2021, 硕士学位论文.
35. 郑柔, 祈乐, 白凤芝, 等. 高热惊厥患儿血钠、钾、钙、铅、糖变化的临床意义. 中国实验诊学, 2008, 12 (3): 407-408.
36. 江志雄, 吴旅平, 邢旺兴. 儿童脑性疾病血清痕量元素变化及其临床意义. 杭州医学高等专科学校学报, 2002, 23 (5): 209-210.
37. Fallah R, Sabbaghzadegan S, Karbasi SA, et al. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial. Nutrition, 2015, 31 (11-12): 1358-1361.
38. Kumar M, Swarnim S, Khanam S. Zinc supplementation for prevention of febrile seizures recurrences in children: a systematic review and meta-analysis. Indian Pediatr, 2021, 58 (9): 857-860.
39. Sharawat IK, Panda PK, Kumar V, et al. Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: a prospective study with comparison with historical controls. J Neurosci Rural Pract, 2022, 13 (4): 718-724.
40. 章静静, 钟建民. 热性惊厥发病机制的研究进展. 实用临床医学, 2019, 20 (09): 102-104+106.
41. Daoud AS, Batieha A, Abu-Ekteish F, et al. Iron status: a possible risk factor for the first febrile seizure. Epilepsia, 2002, 43 (7): 740-743.
42. Li Z, Liu Y, Wei R, et al. The important role of zinc in neurological diseases. biomolecules, 2022, 13 (1): 28.
43. Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res, 2004, 102 (1-3): 1-10.
44. Evens A, Hryhorczuk D, Lanphear BP, et al. The impact of low-level lead toxicity on school performance among children in the Chicago Public Schools: a population-based retrospective cohort study. Environ Health, 2015, 14: 21.
45. 黄跃海, 黄之抗. 复杂性高热惊厥患儿血清锌、铅的测定及意义探讨. 岭南急诊医学杂志, 2008 (3): 197-198.
46. Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients, 2018, 10 (9): 1203.
47. Schweizer U, Schomburg L, Savaskan NE. The neurobiology of selenium: lessons from transgenic mice. J Nutr, 2004, 134 (4): 707-710.
48. Turkdogan D, Toplan S, Karakoc Y. Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy. J Child Neurol, 2002, 17 (9): 673-676.
49. El-Masry HMA, Sadek AA, Hassan MH, et al. Metabolic profile of oxidative stress and trace elements in febrile seizures among children. Metab Brain Dis, 2018, 33 (5): 1509-1515.
50. Balachandran RC, Mukhopadhyay S, McBride D, et al. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem, 2020, 295 (19): 6312-6329.
51. 张建裕, 龚华. 2094例儿童微量元素铅、镉、铜含量分析. 中国妇幼保健, 2012, 27 (1): 69-70.
52. Malara P, Kwapuliński J, Drugacz J. Lead and cadmium occurrence in deciduous teeth of children exposed to cigarette smoke in apartments. Przegl Lek, 2004, 61 (10): 1122-1125.

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