The relationship between serum homocysteine and post-stroke epolepsy_Journal of Epilepsy

Authors：

ZHOU Xiaomin ,  ZHANG Zhongsheng

Department of Neurology, Qingyuan Hospital affiliated to Guangzhou Medical University, Qingyuan 511500, China;

Corresponding author：

ZHANG Zhongsheng, Email: zzsllokyy@sohu.com

Keywords：

Epilepsy; Homocysteine; Poststroke seizures; Antiseizure medications; Comorbidity

DOI：

10.7507/2096-0247.202402001

Video：

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Abstract Full text Figures/Tables Video References Cited by

Homocysteine is an intermediate product of methionine and cysteine metabolism, and plays a key role in methylation. Epilepsy is one of the common diseases of the nervous system, long-term repeated seizures will not only cause damage to the brain tissue, but also cause cognitive impairment. At present, the clinical treatment for epilepsy is still mainly to control symptoms, the fundamental etiology of epilepsy still needs to be improved, to explore the etiology of seizures, fundamentally control seizures, is still our long-term struggle direction. High homocysteine is associated with many diseases. Epidemiological studies have shown that the serum homocysteine level of 10% ~ 40% of epilepsy patients is higher than that of the normal population. By exploring the relationship between serum Hcy and epilepsy,We expect to provide help for the diagnosis and treatment of clinical epilepsy.

Citation： ZHOU Xiaomin, ZHANG Zhongsheng. The relationship between serum homocysteine and post-stroke epolepsy. Journal of Epilepsy, 2024, 10(3): 260-264. doi: 10.7507/2096-0247.202402001 Copy

1.	Beghi E, D'Alessandro R, Beretta S, et al. Incidence and predictors of acute symptomatic seizures after stroke. Neurology, 2011, 77(20): 1785-1793.
2.	肖波, 周罗. 癫痫最新临床诊疗指南: 机遇与挑战并存. 协和医学杂志, 2017, 8(Z1): 122-126.
3.	李世绰. 述评: 国际抗癫痫事业最新进展(概述). 中风与神经疾病杂志, 2023, 40(6): 483-487.
4.	Yang B, Fan S, Zhi X, et al. Prevalence of hyperhomocysteinemia in China: a systematic review and meta-analysis. Nutrients, 2014, 7(1): 74-90.
5.	Zeng Y, Li FF, Yuan SQ, et al. Prevalence of hyperhomocysteinemia in China: an updated meta-analysis. Biology (Basel), 2021, 10(10): 12560.
6.	闫晗, 向瑞, 杨吉春, 等. 同型半胱氨酸代谢与疾病. 生理科学进展, 2023, 54(4): 290-296.
7.	孔娟. 高同型半胱氨酸血症诊疗专家共识. 肿瘤代谢与营养电子杂志, 2020, 7(3): 283-288.
8.	Gurda D, Handschuh L, Kotkowiak W, et al. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells. Amino Acids, 2015, 47(7): 1319-1339.
9.	王学峰. 癫痫研究新进展. 中国现代神经疾病杂志, 2022, 22(7): 543-548.
10.	梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
11.	沈新月, 石郑浩, 侯一玮, 等. 同型半胱氨酸与癫痫关系的研究进展. 滨州医学院学报, 2020, 43(2): 149-151.
12.	Swanger SA, Chen W, Wells G, et al. Mechanistic Insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains. Am J Hum Genet, 2016, 99(6): 1261-1280.
13.	Jakubowski H. Homocysteine Modification in protein structure/function and human disease. Physiol Rev, 2019, 99(1): 555-604.
14.	Hansen J, Åsberg S, Kumlien E, et al. Cause of death in patients with poststroke epilepsy: results from a nationwide cohort study. PLoS One, 2017, 12(4): e0174659.
15.	Merkler AE, Gialdini G, Lerario MP, et al. Population-based assessment of the long-term risk of seizures in survivors of stroke. Stroke, 2018, 49(6): 1319-1324.
16.	Xu MY. Poststroke seizure: optimising its management. Stroke Vasc Neurol, 2019, 4(1): 48-56.
17.	Johan Zelano, Martin Holtkamp, Nivedita Agarwal, et al. How to diagnose and treat post-stroke seizures and epilepsy. Epileptic Disord, 2020, 22(3): 252-263.
18.	侯宇婷, 石佳琦, 王洋, 等. 脑卒中后痫性发作与脑卒中后癫痫的研究进展. 中华神经医学杂志, 2018, 17(11): 1185-1188.
19.	Zhang T, Jiang Y, Zhang S, et al. The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis. Medicine (Baltimore), 2020, 99(12): e19467.
20.	王艾, 谭博, 张爱玲, 等. 同型半胱氨酸对脑梗死患者血管内皮细胞功能的影响. 检验医学与临床, 2015, 12(01): 121-123.
21.	陈杰莹, 黄江佼, 阳海金, 等. 高同型半胱氨酸与深静脉血栓形成的相关研究. 医学综述, 2010, 16(20): 3096-3098.
22.	Kumar A, Palfrey H A, Pathak R, et al. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond), 2017, 14(78.
23.	王浩, 聂谈, 朱杨. 脑卒中后癫痫发作的临床特点、脑电图表现及危险因素分析. 江西医药, 2019, 54(07): 769-771+813.
24.	刘盛佳, 郭马, 王周. 脑卒中患者血清Hcy及NSE水平与癫痫发作的相关性研究. 现代检验医学杂志, 2022, 37(1): 177-181.
25.	李承霞, 湛长青, 庞洪波. 148例脑卒中后癫痫发作患者的临床分析. 癫痫与神经电生理学杂志, 2019, 28(5): 288-292,296.
26.	史颖, 金鑫, 张新欣, 等. 补充叶酸、维生素B12治疗脑卒中后癫痫合并高同型半胱氨酸血症的临床疗效. 中西医结合心脑血管病杂志, 2021, 19(22): 3994-3997.
27.	Jakubus T, Michalska-Jakubus M, Lukawski K, et al. Atherosclerotic risk among children taking antiepileptic drugs. Pharmacol Rep, 2009, 61(3): 411-423.
28.	邹蓉, 戴永萍, 赵合庆. 抗癫痫药物对卒中后癫痫患者血清同型半胱氨酸、叶酸、B族维生素水平的影响. 临床神经病学杂志, 2017, 30(2): 93-97.
29.	Mahmoud AA, Aboelghar HM, Abdelmageed SM, et al. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatr Res, 2022, 92(6): 1606-1612.
30.	Hamed SA, Nabeshima T. The high atherosclerotic risk among epileptics: the atheroprotective role of multivitamins. J Pharmacol Sci, 2005, 98(4): 340-353.
31.	Tümer L, Serdaroğlu A, Hasanoğlu A, et al. Plasma homocysteine and lipoprotein (a) levels as risk factors for atherosclerotic vascular disease in epileptic children taking anticonvulsants. Acta Paediatr, 2002, 91(9): 923-926.
32.	郭亚培, 刘恒方, 张敏, 等. 血清同型半胱氨酸和血浆C反应蛋白、D-二聚体在癫痫患者中的表达水平及与服药种类的关系. 实用医学杂志, 2019, 35(5): 747-750.
33.	徐珊珊, 王小姗, 余传勇, 等. 不同抗癫痫药物对卒中后癫痫患者血Hcy影响及叶酸、维生素B_(12)的干预效果. 脑与神经疾病杂志, 2023, 31(5): 311-315.
34.	Emeksiz HC, Serdaroglu A, Biberoglu G, et al. Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. Seizure, 2013, 22(2): 124-127.
35.	Rasic-Markovic A, Hrncic D, Krstic D, et al. The effect of subchronic supplementation with folic acid and l-arginine on homocysteine-induced seizures. Can J Physiol Pharmacol, 2016, 94(10): 1083-1089.
36.	居春阳, 王琳晶, 朱雨岚. 高同型半胱氨酸血症在癫痫患者中的研究进展. 中华神经医学杂志, 2012, 11(4): 428-430.
37.	Ono H, Sakamoto A, Mizoguchi N, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants. Brain Dev, 2002, 24(4): 223-226.
38.	邹蓉, 赵合庆, 徐兴顺. 伴有同型半胱氨酸增高的老年癫痫患者维生素B补充治疗的临床价值. 中华神经科杂志, 2017, 50(4): 250-254.
39.	Chen K, Yang LN, Lai C, et al. Role of Grina/Nmdara1 in the central nervous system diseases. Curr Neuropharmacol, 2020, 18(9): 861-867.
40.	李娇健, 董岩, 郎朗, 等. 血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨. 河北医学, 2017, 23(1): 35-37.
41.	Sampson EL, Blanchard MR, Jones L, et al. Dementia in the acute hospital: prospective cohort study of prevalence and mortality. Br J Psychiatry, 2009, 195(1): 61-66.
42.	张爽. 血清同型半胱氨酸与癫痫患者认知功能损害的关系研究. 中国医学创新, 2019, 16(1): 152-155.
43.	Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol, 2003, 2(8): 473-481.
44.	邱小娥. 血浆同型半胱氨酸水平、脑萎缩与认知障碍的相关性研究. 实用预防医学, 2011, 18(4): 618-620.
45.	黄苑. 奥卡西平和丙戊酸钠对癫痫患者血浆同型半胱氨酸和不对称二甲基精氨酸水平的影响. 中国实用神经疾病杂志, 2016, 19(13): 70-71.

1. Beghi E, D'Alessandro R, Beretta S, et al. Incidence and predictors of acute symptomatic seizures after stroke. Neurology, 2011, 77(20): 1785-1793.
2. 肖波, 周罗. 癫痫最新临床诊疗指南: 机遇与挑战并存. 协和医学杂志, 2017, 8(Z1): 122-126.
3. 李世绰. 述评: 国际抗癫痫事业最新进展(概述). 中风与神经疾病杂志, 2023, 40(6): 483-487.
4. Yang B, Fan S, Zhi X, et al. Prevalence of hyperhomocysteinemia in China: a systematic review and meta-analysis. Nutrients, 2014, 7(1): 74-90.
5. Zeng Y, Li FF, Yuan SQ, et al. Prevalence of hyperhomocysteinemia in China: an updated meta-analysis. Biology (Basel), 2021, 10(10): 12560.
6. 闫晗, 向瑞, 杨吉春, 等. 同型半胱氨酸代谢与疾病. 生理科学进展, 2023, 54(4): 290-296.
7. 孔娟. 高同型半胱氨酸血症诊疗专家共识. 肿瘤代谢与营养电子杂志, 2020, 7(3): 283-288.
8. Gurda D, Handschuh L, Kotkowiak W, et al. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells. Amino Acids, 2015, 47(7): 1319-1339.
9. 王学峰. 癫痫研究新进展. 中国现代神经疾病杂志, 2022, 22(7): 543-548.
10. 梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
11. 沈新月, 石郑浩, 侯一玮, 等. 同型半胱氨酸与癫痫关系的研究进展. 滨州医学院学报, 2020, 43(2): 149-151.
12. Swanger SA, Chen W, Wells G, et al. Mechanistic Insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains. Am J Hum Genet, 2016, 99(6): 1261-1280.
13. Jakubowski H. Homocysteine Modification in protein structure/function and human disease. Physiol Rev, 2019, 99(1): 555-604.
14. Hansen J, Åsberg S, Kumlien E, et al. Cause of death in patients with poststroke epilepsy: results from a nationwide cohort study. PLoS One, 2017, 12(4): e0174659.
15. Merkler AE, Gialdini G, Lerario MP, et al. Population-based assessment of the long-term risk of seizures in survivors of stroke. Stroke, 2018, 49(6): 1319-1324.
16. Xu MY. Poststroke seizure: optimising its management. Stroke Vasc Neurol, 2019, 4(1): 48-56.
17. Johan Zelano, Martin Holtkamp, Nivedita Agarwal, et al. How to diagnose and treat post-stroke seizures and epilepsy. Epileptic Disord, 2020, 22(3): 252-263.
18. 侯宇婷, 石佳琦, 王洋, 等. 脑卒中后痫性发作与脑卒中后癫痫的研究进展. 中华神经医学杂志, 2018, 17(11): 1185-1188.
19. Zhang T, Jiang Y, Zhang S, et al. The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis. Medicine (Baltimore), 2020, 99(12): e19467.
20. 王艾, 谭博, 张爱玲, 等. 同型半胱氨酸对脑梗死患者血管内皮细胞功能的影响. 检验医学与临床, 2015, 12(01): 121-123.
21. 陈杰莹, 黄江佼, 阳海金, 等. 高同型半胱氨酸与深静脉血栓形成的相关研究. 医学综述, 2010, 16(20): 3096-3098.
22. Kumar A, Palfrey H A, Pathak R, et al. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond), 2017, 14(78.
23. 王浩, 聂谈, 朱杨. 脑卒中后癫痫发作的临床特点、脑电图表现及危险因素分析. 江西医药, 2019, 54(07): 769-771+813.
24. 刘盛佳, 郭马, 王周. 脑卒中患者血清Hcy及NSE水平与癫痫发作的相关性研究. 现代检验医学杂志, 2022, 37(1): 177-181.
25. 李承霞, 湛长青, 庞洪波. 148例脑卒中后癫痫发作患者的临床分析. 癫痫与神经电生理学杂志, 2019, 28(5): 288-292,296.
26. 史颖, 金鑫, 张新欣, 等. 补充叶酸、维生素B12治疗脑卒中后癫痫合并高同型半胱氨酸血症的临床疗效. 中西医结合心脑血管病杂志, 2021, 19(22): 3994-3997.
27. Jakubus T, Michalska-Jakubus M, Lukawski K, et al. Atherosclerotic risk among children taking antiepileptic drugs. Pharmacol Rep, 2009, 61(3): 411-423.
28. 邹蓉, 戴永萍, 赵合庆. 抗癫痫药物对卒中后癫痫患者血清同型半胱氨酸、叶酸、B族维生素水平的影响. 临床神经病学杂志, 2017, 30(2): 93-97.
29. Mahmoud AA, Aboelghar HM, Abdelmageed SM, et al. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatr Res, 2022, 92(6): 1606-1612.
30. Hamed SA, Nabeshima T. The high atherosclerotic risk among epileptics: the atheroprotective role of multivitamins. J Pharmacol Sci, 2005, 98(4): 340-353.
31. Tümer L, Serdaroğlu A, Hasanoğlu A, et al. Plasma homocysteine and lipoprotein (a) levels as risk factors for atherosclerotic vascular disease in epileptic children taking anticonvulsants. Acta Paediatr, 2002, 91(9): 923-926.
32. 郭亚培, 刘恒方, 张敏, 等. 血清同型半胱氨酸和血浆C反应蛋白、D-二聚体在癫痫患者中的表达水平及与服药种类的关系. 实用医学杂志, 2019, 35(5): 747-750.
33. 徐珊珊, 王小姗, 余传勇, 等. 不同抗癫痫药物对卒中后癫痫患者血Hcy影响及叶酸、维生素B_(12)的干预效果. 脑与神经疾病杂志, 2023, 31(5): 311-315.
34. Emeksiz HC, Serdaroglu A, Biberoglu G, et al. Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. Seizure, 2013, 22(2): 124-127.
35. Rasic-Markovic A, Hrncic D, Krstic D, et al. The effect of subchronic supplementation with folic acid and l-arginine on homocysteine-induced seizures. Can J Physiol Pharmacol, 2016, 94(10): 1083-1089.
36. 居春阳, 王琳晶, 朱雨岚. 高同型半胱氨酸血症在癫痫患者中的研究进展. 中华神经医学杂志, 2012, 11(4): 428-430.
37. Ono H, Sakamoto A, Mizoguchi N, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants. Brain Dev, 2002, 24(4): 223-226.
38. 邹蓉, 赵合庆, 徐兴顺. 伴有同型半胱氨酸增高的老年癫痫患者维生素B补充治疗的临床价值. 中华神经科杂志, 2017, 50(4): 250-254.
39. Chen K, Yang LN, Lai C, et al. Role of Grina/Nmdara1 in the central nervous system diseases. Curr Neuropharmacol, 2020, 18(9): 861-867.
40. 李娇健, 董岩, 郎朗, 等. 血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨. 河北医学, 2017, 23(1): 35-37.
41. Sampson EL, Blanchard MR, Jones L, et al. Dementia in the acute hospital: prospective cohort study of prevalence and mortality. Br J Psychiatry, 2009, 195(1): 61-66.
42. 张爽. 血清同型半胱氨酸与癫痫患者认知功能损害的关系研究. 中国医学创新, 2019, 16(1): 152-155.
43. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol, 2003, 2(8): 473-481.
44. 邱小娥. 血浆同型半胱氨酸水平、脑萎缩与认知障碍的相关性研究. 实用预防医学, 2011, 18(4): 618-620.
45. 黄苑. 奥卡西平和丙戊酸钠对癫痫患者血浆同型半胱氨酸和不对称二甲基精氨酸水平的影响. 中国实用神经疾病杂志, 2016, 19(13): 70-71.

Journal of Epilepsy

The relationship between serum homocysteine and post-stroke epolepsy

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