迷走神经刺激治疗儿童药物难治性癫痫的中国专家共识_Journal of Epilepsy

Authors：

 中国医师协会神经调控专业委员会 , 中国抗癫痫协会神经调控专业委员会

执笔吴晔（北京大学第一医院），张凯（首都医科大学附属北京天坛医院），刘庆祝（北京大学第一医院），邵晓秋（首都医科大学附属北京天坛医院），栾国明（首都医科大学三博脑科医院），张建国（首都医科大学附属北京天坛医院）;

Corresponding author：

中国医师协会神经调控专业委员会, Email: zjguo73@126.com

Keywords：

DOI：

10.7507/2096-0247.202410013

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Citation： 中国医师协会神经调控专业委员会, 中国抗癫痫协会神经调控专业委员会. 迷走神经刺激治疗儿童药物难治性癫痫的中国专家共识. Journal of Epilepsy, 2025, 11(1): 1-11. doi: 10.7507/2096-0247.202410013 Copy

1.	Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia, 1998, 39(7): 677-686.
2.	中国医师协会神经内科分会癫(癎)专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
3.	中国抗癫痫协会神经调控专业委员会, 中国医师协会神经调控专业委员会, 中华医学会神经外科分会神经生理学组. 迷走神经刺激治疗药物难治性癫痫的中国专家共识. 癫痫杂志, 2021, 7(3): 191-196.
4.	McMillan SS, King M, Tully MP. How to use the nominal group and Delphi techniques. Int J Clin Pharm, 2016, 38(3): 655-662.
5.	Jain P, Arya R. Vagus nerve stimulation and seizure outcomes in pediatric refractory epilepsy: systematic review and meta-analysis. Neurology, 2021, 96(22): 1041-1051.
6.	Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: a European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
7.	Feygina AA, Koshelyaevskaya YN, Dibué M, et al. Efficacy and safety following two or more years of vagus nerve stimulation (VNS Therapy) in pediatric patients with drug-resistant epilepsy enrolled in a Russian VNS Registry. Brain & Behavior, 2023, 13(7): e3076.
8.	Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy & Behavior, 2020, 112: 107373.
9.	Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response: a review. JNS, 2011, 115(6): 1248-1255.
10.	Alexopoulos AV, Kotagal P, Loddenkemper T, et al. Long-term results with vagus nerve stimulation in children with pharmacoresistant epilepsy. Seizure, 2006, 15(7): 491-503.
11.	Benifla M, Rutka JT, Logan W, et al. Vagal nerve stimulation for refractory epilepsy in children: indications and experience at the hospital for sick children. Childs Nerv Syst, 2006, 22(8): 1018-1026.
12.	Murphy JV, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: The first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560.
13.	Helmers SL, Wheless JW, Frost M, et al. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective Study. J Child Neurol, 2001, 16(11): 843-848.
14.	Sauer V, Glaser M, Ellwardt E, et al. Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy. Epilepsy & Behavior, 2024, 150: 109562.
15.	Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: a 10–17 year follow-up study. Seizure, 2018, 59: 41-47.
16.	Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2018, 79(02): 152-158.
17.	Hilderink J, Tjepkema-Cloostermans MC, Geertsema A, et al. Predicting success of vagus nerve stimulation (VNS) from EEG symmetry. Seizure, 2017, 48: 69-73.
18.	Ching J, Khan S, White P, et al. Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients. British Journal of Neurosurgery, 2013, 27(2): 228-234.
19.	Scherrmann J, Hoppe C, Kral T, et al. Vagus nerve stimulation: clinical experience in a large patient series. Journal of Clinical Neurophysiology, 2001, 18(5): 408-414.
20.	Amar AP, DeGiorgio CM, Tarver WB, et al. Long-term multicenter experience with vagus nerve stimulation for intractable partial seizures. Stereotact Funct Neurosurg, 1999, 73(1-4): 104-108.
21.	Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
22.	Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
23.	Kostov KH, Kostov H, Larsson PG, et al. Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study. Epilepsia, 2022, 63(2): 414-425.
24.	Xie H, Ma J, Ji T, et al. Efficacy of vagus nerve stimulation in 95 children of drug-resistant epilepsy with structural etiology. Epilepsy & Behavior, 2023, 140: 109107.
25.	Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: a scoping review. Epilepsia, 2020, 61(10): 2069-2085.
26.	Zhang Y, Wang X, Tang C, et al. Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Journal of Neurosurgery, 2022, 136(3): 726-735.
27.	Ma J, Wang Z, Cheng T, et al. A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy. CNS Neurosci Ther, 2022, 28(11): 1838-1848.
28.	Geng G, Hu W, Meng Y, et al. Vagus nerve stimulation for treating developmental and epileptic encephalopathy in young children. Front Neurol, 2023, 14: 1191831.
29.	Klinkenberg S, Van Den Bosch CNCJ, Majoie HJM, et al. Behavioural and cognitive effects during vagus nerve stimulation in children with intractable epilepsy – a randomized controlled trial. European Journal of Paediatric Neurology, 2013, 17(1): 82-90.
30.	Morris GL, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
31.	Ostendorf AP, Ng YT. Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat, 2017, 13: 1131-1140.
32.	中国抗癫痫协会创新与转化专委会. Lennox-Gastaut综合征诊断治疗的中国专家共识. 癫痫杂志, 2022, 8(3): 187-195.
33.	Dibué M, Greco T, Spoor JKH, et al. Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: a meta-analysis. Acta Neurol Scand, 2021, 143(5): 497-508.
34.	Cersósimo RO, Bartuluchi M, Fortini S, et al. Vagus nerve stimulation: effectiveness and tolerability in 64 paediatric patients with refractory epilepsies. Epileptic Disorders, 2011, 13(4): 382-388.
35.	Abdelmoity SA, Abdelmoity AA, Riordan SM, et al. The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome. Seizure, 2021, 86: 168-174.
36.	Dravet C. Les epilepsies graves de l’enfant. VIE MED. 1978;59(8): 543-548.
37.	中国抗癫痫协会创新与转化专业委员会 , 中华医学会儿科学分会罕见病学组 , 中华医学会儿科学分会神经学组. Dravet综合征诊断与治疗的中国专家共识. 癫痫杂志, 2024, 10(1): 1-11.
38.	Dibué-Adjei M, Fischer I, Steiger HJ, et al. Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: a meta-analysis of 68 patients. Seizure, 2017, 50: 147-152.
39.	Hajtovic S, LoPresti MA, Zhang L, et al. The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis. Journal of Neurosurgery: Pediatrics, 2022, 29(6): 667-680.
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1. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia, 1998, 39(7): 677-686.
2. 中国医师协会神经内科分会癫(癎)专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
3. 中国抗癫痫协会神经调控专业委员会, 中国医师协会神经调控专业委员会, 中华医学会神经外科分会神经生理学组. 迷走神经刺激治疗药物难治性癫痫的中国专家共识. 癫痫杂志, 2021, 7(3): 191-196.
4. McMillan SS, King M, Tully MP. How to use the nominal group and Delphi techniques. Int J Clin Pharm, 2016, 38(3): 655-662.
5. Jain P, Arya R. Vagus nerve stimulation and seizure outcomes in pediatric refractory epilepsy: systematic review and meta-analysis. Neurology, 2021, 96(22): 1041-1051.
6. Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: a European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
7. Feygina AA, Koshelyaevskaya YN, Dibué M, et al. Efficacy and safety following two or more years of vagus nerve stimulation (VNS Therapy) in pediatric patients with drug-resistant epilepsy enrolled in a Russian VNS Registry. Brain & Behavior, 2023, 13(7): e3076.
8. Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy & Behavior, 2020, 112: 107373.
9. Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response: a review. JNS, 2011, 115(6): 1248-1255.
10. Alexopoulos AV, Kotagal P, Loddenkemper T, et al. Long-term results with vagus nerve stimulation in children with pharmacoresistant epilepsy. Seizure, 2006, 15(7): 491-503.
11. Benifla M, Rutka JT, Logan W, et al. Vagal nerve stimulation for refractory epilepsy in children: indications and experience at the hospital for sick children. Childs Nerv Syst, 2006, 22(8): 1018-1026.
12. Murphy JV, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: The first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560.
13. Helmers SL, Wheless JW, Frost M, et al. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective Study. J Child Neurol, 2001, 16(11): 843-848.
14. Sauer V, Glaser M, Ellwardt E, et al. Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy. Epilepsy & Behavior, 2024, 150: 109562.
15. Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: a 10–17 year follow-up study. Seizure, 2018, 59: 41-47.
16. Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2018, 79(02): 152-158.
17. Hilderink J, Tjepkema-Cloostermans MC, Geertsema A, et al. Predicting success of vagus nerve stimulation (VNS) from EEG symmetry. Seizure, 2017, 48: 69-73.
18. Ching J, Khan S, White P, et al. Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients. British Journal of Neurosurgery, 2013, 27(2): 228-234.
19. Scherrmann J, Hoppe C, Kral T, et al. Vagus nerve stimulation: clinical experience in a large patient series. Journal of Clinical Neurophysiology, 2001, 18(5): 408-414.
20. Amar AP, DeGiorgio CM, Tarver WB, et al. Long-term multicenter experience with vagus nerve stimulation for intractable partial seizures. Stereotact Funct Neurosurg, 1999, 73(1-4): 104-108.
21. Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
22. Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
23. Kostov KH, Kostov H, Larsson PG, et al. Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study. Epilepsia, 2022, 63(2): 414-425.
24. Xie H, Ma J, Ji T, et al. Efficacy of vagus nerve stimulation in 95 children of drug-resistant epilepsy with structural etiology. Epilepsy & Behavior, 2023, 140: 109107.
25. Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: a scoping review. Epilepsia, 2020, 61(10): 2069-2085.
26. Zhang Y, Wang X, Tang C, et al. Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Journal of Neurosurgery, 2022, 136(3): 726-735.
27. Ma J, Wang Z, Cheng T, et al. A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy. CNS Neurosci Ther, 2022, 28(11): 1838-1848.
28. Geng G, Hu W, Meng Y, et al. Vagus nerve stimulation for treating developmental and epileptic encephalopathy in young children. Front Neurol, 2023, 14: 1191831.
29. Klinkenberg S, Van Den Bosch CNCJ, Majoie HJM, et al. Behavioural and cognitive effects during vagus nerve stimulation in children with intractable epilepsy – a randomized controlled trial. European Journal of Paediatric Neurology, 2013, 17(1): 82-90.
30. Morris GL, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
31. Ostendorf AP, Ng YT. Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat, 2017, 13: 1131-1140.
32. 中国抗癫痫协会创新与转化专委会. Lennox-Gastaut综合征诊断治疗的中国专家共识. 癫痫杂志, 2022, 8(3): 187-195.
33. Dibué M, Greco T, Spoor JKH, et al. Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: a meta-analysis. Acta Neurol Scand, 2021, 143(5): 497-508.
34. Cersósimo RO, Bartuluchi M, Fortini S, et al. Vagus nerve stimulation: effectiveness and tolerability in 64 paediatric patients with refractory epilepsies. Epileptic Disorders, 2011, 13(4): 382-388.
35. Abdelmoity SA, Abdelmoity AA, Riordan SM, et al. The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome. Seizure, 2021, 86: 168-174.
36. Dravet C. Les epilepsies graves de l’enfant. VIE MED. 1978;59(8): 543-548.
37. 中国抗癫痫协会创新与转化专业委员会 , 中华医学会儿科学分会罕见病学组 , 中华医学会儿科学分会神经学组. Dravet综合征诊断与治疗的中国专家共识. 癫痫杂志, 2024, 10(1): 1-11.
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