Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee_West China Medical Journal

Authors：

LIU Juncai ,  LI Zhong , ZUO Yinlong , WU Shaojun , CHEN Ge , YIN Yiran

Department of Bone and Joint Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LI Zhong, Email: ljc125520@163.com

Keywords：

骨关节炎，膝; 关节镜; 盐酸氨基葡萄糖

Video：

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目的　探讨关节镜手术联合口服盐酸氨基葡萄糖治疗膝骨关节炎（KOA）的近期临床疗效。方法　选取2011年1月－12月具有关节镜手术指征的KOA患者86例，按手术顺序单双号分成两组，试验组（单号）行关节镜手术联合口服盐酸氨基葡萄糖治疗，对照组（双号）行关节镜手术治疗。采用Lequesne指数对两组患膝术前，术后第4、6周进行评分及疗效分析。结果　两组患膝术前与术后第4、6周Lequesne指数得分比较，差异有统计学意义（P＜0.05）；两组术后近期疗效比较，差异有统计学意义（P＜0.05）。结论　关节镜手术联合口服盐酸氨基葡萄糖治疗KOA具有良好的近期疗效，优于单用关节镜手术治疗者。

Citation： LIU Juncai,LI Zhong,ZUO Yinlong,WU Shaojun,CHEN Ge,YIN Yiran. Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee. West China Medical Journal, 2012, 27(12): 1768-1771. doi: Copy

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1. 　刘俊才, 李忠, 王治, 等. 关节镜手术与康复训练联合治疗膝关节骨关节炎的疗效分析[J]. 中国康复医学杂志, 2012, 27(1): 66-68.
2. 　罗娟, 胡永善, 吴毅, 等. 盐酸氨基葡萄糖改善膝骨性关节炎症状的效果评估[J]. 中国临床康复, 2005, 9(38): 70-72.
3. 　Altman R, Asch E, Bloch D, et al. Development of criteria for theclassification and reporting of osteoarthritis. Classification of osteoarthritisof the knee[J]. Arthritis Rheum, 1986, 29(8): 1039-1049.
4. 　Outerbridge RE. The etiology of chondromalacia patellae[J]. J Bone Joint Surg Br, 1961, 43-B: 752-757.
5. 　Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis[J]. Ann Rheum Dis, 1957, 16(4): 494-502.
6. 　Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatoi Suppl, 1991, 27(1): 16-18.
7. 　Sassi N, Laadhar L, Driss M, et al. The role of the Notch pathway in healthy and osteoarthritic articular cartilage:from experimental models to ex vivo studies. Arthritis Res Ther, 2011, 13(2): 208.
8. 　Ivanovska N, Dimitrova P. Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine[J]. Arthritis Res Ther, 2011, 13(2): R44.
9. 　陈德生, 张志刚, 曹靖, 等. 盐酸氨基葡萄糖对兔膝骨性关节炎的影响[J]. 中国修复重建外科杂志, 2010, 24(3): 287-291.
10. 　康明, 胡建中, 郭汉明, 等. 关节镜下清理术联合透明质酸钠注射对膝骨关节炎的疗效分析[J].中国内镜杂志, 2009, 15(7): 719-722.
11. 　孙捷, 吴阳. 关节镜治疗中老年膝关节骨关节炎[J]. 中国微创外科杂志, 2009, 9(8): 733-734.
12. 　李军, 马广文, 周盛智, 等. 关节镜诊治膝关节骨关节炎临床探讨[J]. 安徽医学, 2010, 31(8): 924-926.

West China Medical Journal

Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee

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