Effect of Glucosamine Hydrochloride Capsules and Calcitonin on Matrix Metalloproteinase-3 and Osteopontin Level in Patients with Postmenopausal Knee Osteoarthritis_West China Medical Journal

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Department of Orthopedics and Trauma, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hebei 430014, P. R. China;

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Keywords：

基质金属蛋白酶3; 骨桥蛋白; 骨关节炎，膝; 绝经后; 盐酸氨基葡萄糖; 降钙素

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目的　探讨盐酸氨基葡萄糖联合降钙素对绝经后膝骨关节炎基质金属蛋白酶3（MMP-3）和骨桥蛋白（OPN）表达的影响。方法　2012年1月－6月将120例绝经后膝骨关节炎妇女随机分为盐酸氨基葡萄糖组（A组）、盐酸氨基葡萄糖+依降钙素组（B组）、依降钙素组（C组），每组40例，采用酶联免疫吸附试验测定各组血清MMP-3、OPN、雌二醇、Ⅰ型胶原C端肽（CTX）和Ⅰ型胶原N端前肽（PINP）水平。结果　A组和B组在治疗后2周和6周其膝关节评分和视觉模拟评分明显优于C组（P＜0.05），A组在治疗后2周MMP-3的表达改善明显（P＜0.05），优于其他两组。治疗后6周，B组OPN表达水平改善明显（P＜0.05），优于其他两组。C组和B组CTX和PINP水平明显改善（P＜0.05），优于A组。结论　盐酸氨基葡萄糖联合降钙素能有效改善绝经后膝骨关节炎的症状，可能通过调节MMP-3和OPN的复合体表达，实现改善关节软骨功能的目的。

Citation： DAI Yi,YANG Huan,ZHANG Hanqing. Effect of Glucosamine Hydrochloride Capsules and Calcitonin on Matrix Metalloproteinase-3 and Osteopontin Level in Patients with Postmenopausal Knee Osteoarthritis. West China Medical Journal, 2012, 27(12): 1772-1775. doi: Copy

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11.	张汉庆, 戴燚, 李浩, 等. 绝经后妇女骨代谢过程中血清基质金属蛋白酶3和骨桥蛋白的变化[J]. 中国组织工程研究与临床康复, 2011, 15(41): 7783-7786.
12.	戴燚, 李浩, 王度, 等. MMP-3和OPN水平与绝经后骨质疏松症的相关性[J]. 中国民族民间医药, 2011, 20(21): 42-43.
13.	Fujikawa Y, Sabokbar A, Neale SD, et al. The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor) on human osteoclast formation from circulating cells[J]. Bone, 2001, 28(3): 261-267.
14.	Karsdal MA, Tanko LB, Riis BJ, et al. Calcitonin is involved in cartilage homeostasis:is calcitonin atreatment for OA? [J].Osteoarthritis Cartilage, 2006, 14(7): 617-624.
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16.	Papfioannou NA, Triantaflllopouios IK, Khaldik, et al. Effect of caicitonin in early and late stages of experimentally induced osteoarthritis[J]. Osteoarthritis Cartilage, 2011, 15(4): 386-395.
17.	周黎, 戴燚, 李浩, 等. 绝经后妇女基质金属蛋白酶-3和骨桥蛋白水平与骨密度和骨保护蛋白及其配体的相关性研究[J]. 湖北中医药大学学报, 2012, 14(2): 60-62.

1. 　Lidgren L. The bone and joint decade and the global economic and healthcare burden of musculoskeletal disease[J]. J Rheumatol Suppl, 2003, 67(67): 4-5.
2. 　Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur[J]. Acta Histochem Cytochem, 2007, 40(1): 27-34.
3. 　Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes[J]. Osteoarthritis Cartilage, 2007, 15(12): 1367-1377.
4. 　Sowers MR, Mcconnell D, Jannausch M, et al. Estradiol and its metabolites and their association with knee osteoarthritis[J]. Arthritis Rheum, 2006, 54(8): 2481-2487.
5. 　王亦璁. 膝关节外科的基础和临床[M]. 北京: 人民卫生出版社, 1999: 551-552.
6. 　赵延斌, 林伍伍. 盐酸氨基葡萄糖胶囊治疗膝骨关节炎疗效观察[J]. 中国药师, 2011, 14(9): 1314-1315.
7. 　李伟, 潘晓华. 雌激素受体与骨性关节炎相关性研究进展[J]. 广东医学, 2011, 32(19): 2601-2604.
8. 　Kusano K, Miyaura C, Inada M, et al. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption[J]. Endocrinology, 1998, 139(3): 1338-1345.
9. 　戴燚, 殷涛, 李浩, 等. 绝经后妇女基质金属蛋白酶3和抑制因子水平及其与骨密度和骨桥蛋白的关系[J]. 中国骨质疏松杂志, 2011, 17(8): 661-664, 673.
10. 　Behets C, Williams JM, Chappard D, et al. Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency[J]. J Bone Miner Res, 2004, 19(11): 1821-1826.
11. 　张汉庆, 戴燚, 李浩, 等. 绝经后妇女骨代谢过程中血清基质金属蛋白酶3和骨桥蛋白的变化[J]. 中国组织工程研究与临床康复, 2011, 15(41): 7783-7786.
12. 　戴燚, 李浩, 王度, 等. MMP-3和OPN水平与绝经后骨质疏松症的相关性[J]. 中国民族民间医药, 2011, 20(21): 42-43.
13. 　Fujikawa Y, Sabokbar A, Neale SD, et al. The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor) on human osteoclast formation from circulating cells[J]. Bone, 2001, 28(3): 261-267.
14. 　Karsdal MA, Tanko LB, Riis BJ, et al. Calcitonin is involved in cartilage homeostasis:is calcitonin atreatment for OA? [J].Osteoarthritis Cartilage, 2006, 14(7): 617-624.
15. 　Burr DB. Subchondral bone in the pathogenesis of osteoarthritis[M]. New York : oxford university press, 2003: 125-133.
16. 　Papfioannou NA, Triantaflllopouios IK, Khaldik, et al. Effect of caicitonin in early and late stages of experimentally induced osteoarthritis[J]. Osteoarthritis Cartilage, 2011, 15(4): 386-395.
17. 　周黎, 戴燚, 李浩, 等. 绝经后妇女基质金属蛋白酶-3和骨桥蛋白水平与骨密度和骨保护蛋白及其配体的相关性研究[J]. 湖北中医药大学学报, 2012, 14(2): 60-62.

West China Medical Journal

Effect of Glucosamine Hydrochloride Capsules and Calcitonin on Matrix Metalloproteinase-3 and Osteopontin Level in Patients with Postmenopausal Knee Osteoarthritis

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