Clinical Study on Glucosamine Hydrochloride and Etofenamate Gel in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

LU Weizhong , HU Zhifen , ZHOU Jie

Department of Orthopedics, Traditional Chinese Medical Hospital of Chongqing, Chongqing 400021, P. R. China;

Corresponding author：

Keywords：

骨关节炎，膝; 临床试验; 盐酸氨基葡萄糖; 依托芬那酯凝胶

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　临床观察盐酸氨基葡萄糖和依托芬那酯凝胶治疗膝骨关节炎（KOA）的疗效。方法　2010年6月－2012年2月，将354例KOA患者随机分为盐酸氨基葡萄糖组（A组）、依托芬那酯凝胶组（B组）和盐酸氨基葡萄糖+依托芬那酯凝胶组（C组）。A组为口服盐酸氨基葡萄糖，750 mg/次，2次/d，疗程6周；B组为依托芬那酯凝胶外用，2次/d，6周为1个疗程；C组为在A组的基础上同时加用B组的方法。结果　C组在改善行走疼痛、夜间静息痛、晨僵方面优于A、B组，A组优于B组，差异有统计学意义（P＜0.05）。总有效率A组为79.65%，B组67.28%，C组89.38%，差异有统计学意义（P＜0.05）。出现不良反应A组3例，B组3例，C组4例，均较轻微，无严重不良事件发生。结论　盐酸氨基葡萄糖和依托芬那酯凝胶治疗KOA均安全、有效，联合应用时，疗效进一步增强。

Citation： LU Weizhong,HU Zhifen,ZHOU Jie. Clinical Study on Glucosamine Hydrochloride and Etofenamate Gel in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2012, 27(12): 1800-1804. doi: Copy

1.	戴海霞, 张晓燕, 徐开俊, 等. 非甾体抗炎药研究的最新进展[J]. 药物生物技术, 2012, 19(1): 90-94.
2.	Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50): 4405-4409.
3.	缪定国, 舒彬, 杨志金, 等. 依托芬那酯超声透入治疗网球肘疗效观察[J]. 中国康复, 2011, 26(1): 73.
4.	杨光, 严世贵, 冯建钜, 等. 膝骨性关节炎的影像学表现与关节镜术后疗效的相关性研究[J]. 中国骨伤, 2010, 23(12): 899-902.
5.	Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
6.	Gatti JC. Glucosamine treatment for osteoarthritis[J]. Am Fam Physician, 2006, 73(6): 1189-1191.
7.	Fox BA, Schmitz ED, Wallace R, et al. Glucosamine and chondroitin for osteoarthritis[J]. Am Fam Physsician, 2006, 73(5): 1245-1246.
8.	Pavelka K, Gatterova J, Marta O, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis[J]. Arch Intern Med, 2002, 162(8): 2113-2123.
9.	Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis[J]. N Engl J Med, 2006, 354(8): 795-808.
10.	范步新, 王志义, 张立平. 四种药物对兔骨关节炎模型关节液中IL-1β、TNFα水平的影响[J]. 中国骨肿瘤骨病, 2007(1): 29-31.
11.	陆艳红, 石晓兵. 膝骨关节炎国内外流行病学研究现状及进展[J]. 中国中医骨伤科杂志, 2012, 20(6): 81-84.

1. 　戴海霞, 张晓燕, 徐开俊, 等. 非甾体抗炎药研究的最新进展[J]. 药物生物技术, 2012, 19(1): 90-94.
2. 　Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50): 4405-4409.
3. 　缪定国, 舒彬, 杨志金, 等. 依托芬那酯超声透入治疗网球肘疗效观察[J]. 中国康复, 2011, 26(1): 73.
4. 　杨光, 严世贵, 冯建钜, 等. 膝骨性关节炎的影像学表现与关节镜术后疗效的相关性研究[J]. 中国骨伤, 2010, 23(12): 899-902.
5. 　Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
6. 　Gatti JC. Glucosamine treatment for osteoarthritis[J]. Am Fam Physician, 2006, 73(6): 1189-1191.
7. 　Fox BA, Schmitz ED, Wallace R, et al. Glucosamine and chondroitin for osteoarthritis[J]. Am Fam Physsician, 2006, 73(5): 1245-1246.
8. 　Pavelka K, Gatterova J, Marta O, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis[J]. Arch Intern Med, 2002, 162(8): 2113-2123.
9. 　Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis[J]. N Engl J Med, 2006, 354(8): 795-808.
10. 　范步新, 王志义, 张立平. 四种药物对兔骨关节炎模型关节液中IL-1β、TNFα水平的影响[J]. 中国骨肿瘤骨病, 2007(1): 29-31.
11. 　陆艳红, 石晓兵. 膝骨关节炎国内外流行病学研究现状及进展[J]. 中国中医骨伤科杂志, 2012, 20(6): 81-84.

West China Medical Journal

Clinical Study on Glucosamine Hydrochloride and Etofenamate Gel in the Treatment of Knee Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Format

Content