Relationship between the Level of Serum Retinol-Binding Protein 4 and the Extent of Coronary Lesions in Coronary Heart Disease Accompanied with Type 2 Diabetes Mellitus_West China Medical Journal

Authors：

ZHANG Min ¹ , TANG Rongzhen ¹ , CAO Xiaohong ¹ , ZHANG Wei ¹ , GU Xiaohui ¹ , DONG Wei ²

1. Department of Cadre, 2. Central Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People′s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

2型糖尿病; 冠心病; Gensini评分; 血清视黄醇结合蛋白4; 胰岛素

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【摘要】　目的　研究合并2型糖尿病的冠心病患者冠状动脉病变程度与血清视黄醇结合蛋白4（retinol-binding protein 4，RBP4）水平的相关性。　方法　 2008年10月-2010年4月选择性冠状动脉造影确诊的冠心病患者共120例，分为单纯冠心病组（A组）60例和冠心病合并糖尿病组（B组）60例，检测血糖、血脂、胰岛素以及脂联素、RBP4水平；根据冠状动脉造影结果，以Gensini评分评判冠状动脉病变程度。　结果　 B组空腹血糖、胰岛素、RBP4均显著高于A组（P lt;0.05）；冠状动脉病变程度更重（P lt;0.05）。相关性分析显示RBP4水平与低密度脂蛋白胆固醇、胰岛素抵抗和冠状动脉病变积分呈正相关（r=0.312、0.322、0.314，P lt;0.05）。与脂联素水平呈负相关（r=-0.362，P lt;0.01）。　结论　冠心病合并2型糖尿病患者RBP4明显升高，且与冠状动脉狭窄程度呈正相关。
【Abstract】　Objective　 To explore the relationship between the level of serum retinol-binding protein 4 (RBP4) and the extent of coronary lesions in coronary heart disease (CHD) patients accompanied with type 2 diabetes mellitus (T2DM).　Methods　 A total of 120 patients with CHD diagnosed by coronary arteriongraphy between October 2008 and April 2010 were enrolled. The patients were divided into two groups: CHD group (60 patients); CHD accompanied with T2DM group (60 patients). The levels of serum insulin, adiponectin and RBP4 were measured. All the patients underwent coronary angiography and the extent of coronary lesions was assessed quantitatively based on the Gensini′s scoring system.　Results　 The levels of serum insulin, plasma RBP4 and the extent of coronary artery stenosis in CHD accompanied with T2DM group were significantly higher than those in CHD group (P lt;0.05). Correlation analysis showed that the level of RBP4 was positively correlated with LDL-C, insulin resistance index and the coronary artery narrow degree（r=0.312, 0.322, 0.314; P lt;0.05); and negatively correlated with adiponectin (r=-0.362, P lt;0.01).　Conclusion　 The significant elevated plasma RBP4 in CHD patients accompanied with T2DM is positively correlated with the extent of coronary artery lesion.

Citation： ZHANG Min,TANG Rongzhen,CAO Xiaohong,ZHANG Wei,GU Xiaohui,DONG Wei. Relationship between the Level of Serum Retinol-Binding Protein 4 and the Extent of Coronary Lesions in Coronary Heart Disease Accompanied with Type 2 Diabetes Mellitus. West China Medical Journal, 2011, 26(12): 1818-1821. doi: Copy

1.	王双, 朱兰, 李峻, 等. 罗格列酮在2型糖尿病治疗中的循证证据[J]. 华西医学, 2003, 18(1): 1-2.
2.	Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes[J]. Nature, 2005, 436(7049): 356-362.
3.	Cho YM, Youn BS, Lee H, et al. Plasma retinol　binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type2 diabetes[J]. Diabetes Care, 2006, 29(11): 2457-2461.
4.	Qi Q, Yu Z, Ye X, et al. Elevated retinol2binding p rotein 4 levels are associated with metabolic syndrome in chinese people[J]. J Clin Endocrinol Metab, 2007, 92(12): 4827-4834.
5.	von Eynatten M, Lepper PM, Liu D, et al. Retinol binding protein 4 is associated with components of the metabolic syndrome, but notwith insulin resistance, in men with type 2 diabetes or coronary artery disease[J].Diabetologia, 2007, 50(9): 1930-1937.
6.	Cabré A, Lázaro I, Girona J, et al. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes[J].J Intern Med, 2007, 262(4): 496-503.
7.	刘更夫, 左华泽, 骆明波, 等. 血清视黄醇结合蛋白4水平与动脉粥样硬化危险因素的相关性分析[J]. 微循环学杂志, 2009, 19(3): 62-63.
8.	蒋伏松, 成兴波, 李慧娟, 等. 血清视黄醇结合蛋白4与2型糖尿病颈动脉粥样硬化的关系[J]. 苏州大学学报(医学版), 2009, 29(3): 508-510.
9.	Lee JW, Im JA, Lee HR, et al. Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women[J]. Obesity(Silver Spring), 2007, 15(9): 2225-2232.
10.	Yao-Borengasser A, Varma V, Bodles AM, et al. Retinol binding protein 4 expression in humans:relationship to insulin resistance, inflammation, and response to pioglitazone[J]. J Clin Endocrinol Metab, 2007, 92(7): 2590-2597.
11.	徐良成, 高大胜. 肿瘤坏死因子β基因多态性与冠心病[J]. 华西医学, 2009, 24(9): 2487-2489.
12.	Perseghin G, Lattuada G, De Cobelli F, et al. Serum retinol-binding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation[J]. J Clin Endocrinol Metab, 2007, 92(12): 4883-4888.

1. 　王双, 朱兰, 李峻, 等. 罗格列酮在2型糖尿病治疗中的循证证据[J]. 华西医学, 2003, 18(1): 1-2.
2. 　Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes[J]. Nature, 2005, 436(7049): 356-362.
3. 　Cho YM, Youn BS, Lee H, et al. Plasma retinol　binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type2 diabetes[J]. Diabetes Care, 2006, 29(11): 2457-2461.
4. 　Qi Q, Yu Z, Ye X, et al. Elevated retinol2binding p rotein 4 levels are associated with metabolic syndrome in chinese people[J]. J Clin Endocrinol Metab, 2007, 92(12): 4827-4834.
5. 　von Eynatten M, Lepper PM, Liu D, et al. Retinol binding protein 4 is associated with components of the metabolic syndrome, but notwith insulin resistance, in men with type 2 diabetes or coronary artery disease[J].Diabetologia, 2007, 50(9): 1930-1937.
6. 　Cabré A, Lázaro I, Girona J, et al. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes[J].J Intern Med, 2007, 262(4): 496-503.
7. 　刘更夫, 左华泽, 骆明波, 等. 血清视黄醇结合蛋白4水平与动脉粥样硬化危险因素的相关性分析[J]. 微循环学杂志, 2009, 19(3): 62-63.
8. 　蒋伏松, 成兴波, 李慧娟, 等. 血清视黄醇结合蛋白4与2型糖尿病颈动脉粥样硬化的关系[J]. 苏州大学学报(医学版), 2009, 29(3): 508-510.
9. 　Lee JW, Im JA, Lee HR, et al. Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women[J]. Obesity(Silver Spring), 2007, 15(9): 2225-2232.
10. 　Yao-Borengasser A, Varma V, Bodles AM, et al. Retinol binding protein 4 expression in humans:relationship to insulin resistance, inflammation, and response to pioglitazone[J]. J Clin Endocrinol Metab, 2007, 92(7): 2590-2597.
11. 　徐良成, 高大胜. 肿瘤坏死因子β基因多态性与冠心病[J]. 华西医学, 2009, 24(9): 2487-2489.
12. 　Perseghin G, Lattuada G, De Cobelli F, et al. Serum retinol-binding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation[J]. J Clin Endocrinol Metab, 2007, 92(12): 4883-4888.

West China Medical Journal

Relationship between the Level of Serum Retinol-Binding Protein 4 and the Extent of Coronary Lesions in Coronary Heart Disease Accompanied with Type 2 Diabetes Mellitus

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