Features of Normal Pancrease Perfusion with First-pass Technique with 64-MDCT_West China Medical Journal

Authors：

YAO Jin ,  YANG Zhigang

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041,P.R.China;

Corresponding author：

YANG Zhigang, Email: yangzg1117@yahoo.ocm.cn

Keywords：

胰腺; 体层摄影术，X线计算机; 灌注

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【摘要】　目的　利用首过时间技术进行全胰腺CT灌注扫描，了解正常胰腺CT灌注的特点。　方法　 2006年6月-2007年3月， 64例正常胰腺患者行64排螺旋CT灌注扫描，测量胰头、胰体及胰尾的灌注值、强化峰值、达峰时间和血容量。分别按患者的性别、年龄及胰腺测量的部位分组，将灌注参数进行统计分析。　结果　 ①男性胰腺的血容量高于女性（P lt;0.05），其余灌注参数在两性间差异无统计学意义（P gt;0.05）。②41~60岁组的灌注值低于 lt;40岁组和 gt;60岁组； gt;60岁组的强化峰值高于41~60岁组；41~60岁组的达峰时间长于 lt;40岁组； gt;60岁组的血容量高于41~60岁组（P lt;0.05）。③胰体和胰尾的灌注值高于胰头（P lt;0.05），其余灌注参数在胰腺不同部位差异无统计学意义。　结论　正常胰腺血流状况在不同性别、不同年龄段及不同部位存在差异，首过时间技术应用于正常胰腺能反映这些特征。
【Abstract】　Objective　 To investigate the CT perfusion features of normal pancreas with first-pass technique with 64-MDCT.　Methods　 Perfusion CT was performed on 64 patients with normal pancreas from June 2006 to March 2007. Four perfusion parameters, including perfusion, peak enhancement, time to peak, and blood volume, were obtained at the head, body and tail of the pancreas. Perfusion parameters were compared between different sexes, among different age groups and among different sites.　Results　 ① Blood volume of male was significantly higher than that of female (P lt;0.05). ② The perfusion value in the age group of 41-60 was significantly lower than that in the age group of lt;40 and gt;60 (P lt;0.05). The peak enhancement in the age group of gt;60 was significantly higher than that in the age group of 41-60 (P lt;0.05). The time to peak in the age group of 41-60 was significantly longer than that in the age group of lt;40 (P lt;0.05). The blood volume in the age group of gt;60 was significantly higher than that in the age group of 41-60 (P lt;0.05). ③The perfusion values of the body and the tail were significantly higher than that of the head (P lt;0.05).　Conclusion　 There are significant differences in the perfusion parameters between different sexes and among several age groups and sites. The first-pass technique of perfusion applied in normal pancreas can reflect these features.

Citation： YAO Jin,YANG Zhigang. Features of Normal Pancrease Perfusion with First-pass Technique with 64-MDCT. West China Medical Journal, 2010, 25(12): 2191-2194. doi: Copy

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5.	Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅳ. The anterior inferior and posterior pancreaticoduodenal aa, and minor sources of blood supply for the head of the pancreas. An anatomical review and radiologic study [J]. Surg Radiol Anat, 1997, 19(4): 203-212.
6.	Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. V. The dorsal pancreatic artery. An anatomic review and a radiologic study [J]. Surg Radiol Anat, 1998, 20(6): 445-452.
7.	王芳军, 陈卫昌, 郭亮, 等. 正常胰腺64 层螺旋CT灌注成像的特征研究[J]. CT理论与应用研究, 2009, 18(2): 83-91.
8.	夏进东, 周翔平. 正常胰腺组织的多层螺旋 CT血流灌注研究[J]. 临床放射学杂志, 2009, 28(1): 58-62.
9.	Tsushima Y, Kusano S. Age-dependent decline in parenchymal perfusion in the normal human pancreas: measurement by dynamic computedtomography [J]. Pancreas, 1998, 17 (2): 148-152.
10.	赵心明, 周纯武, 吴宁, 等. 胰腺多层螺旋CT灌注研究[J]. 中华放射学杂志, 2003, 37 (9): 845-849.
11.	Kandel S, Kloeters C, Meyer H, et al. Whole-organ perfusion of the pancreas using dynamic volume CT in patients with primary pancreas carcinoma: acquisition technique, post-processing and initial results [J]. Eur Radiol, 2009, 19(11): 2641-2646.
12.	Bali MA, Metens T, Denolin V, et al. Pancreatic perfusion: noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers--initial results [J]. Radiology, 2008, 247(1): 115-121.
13.	Xu J, Liang Z, Hao S, et al. Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging [J]. Abdom Imaging, 2009, 34(6): 759-766.
14.	林晓珠, 陈克敏. CT灌注成像测量正常胰腺组织血流灌注[J]. 中国CT 和MRI杂志, 2004, 2(1): 29-32.

1. 　Miles KA. Ideal contrast medium bolus for perfusion measurement in dynamic lung CT[J]. Radiology, 1998, 209(2): 584-585.
2. 　Bertelli E, Di gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review I. The superior pancreati-coduodenal and the anterior superior pancreaticoduodenal arteries. An anatomical and radiological study [J]. Surg Radiol Anat, 1995, 17(2): 97-106.
3. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅱ. The posterior superior pancreaticoduodenal artery: an anatomical and radiological study[J]. Surg Radiol Anat, 1996, 18(1): 1-9.
4. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅲ. The inferior pancreaticoduodenal artery. An anatomical review and a radiological study [J]. Surg Radiol Anat, 1996, 18(2): 67-74.
5. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅳ. The anterior inferior and posterior pancreaticoduodenal aa, and minor sources of blood supply for the head of the pancreas. An anatomical review and radiologic study [J]. Surg Radiol Anat, 1997, 19(4): 203-212.
6. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. V. The dorsal pancreatic artery. An anatomic review and a radiologic study [J]. Surg Radiol Anat, 1998, 20(6): 445-452.
7. 　王芳军, 陈卫昌, 郭亮, 等. 正常胰腺64 层螺旋CT灌注成像的特征研究[J]. CT理论与应用研究, 2009, 18(2): 83-91.
8. 　夏进东, 周翔平. 正常胰腺组织的多层螺旋 CT血流灌注研究[J]. 临床放射学杂志, 2009, 28(1): 58-62.
9. 　Tsushima Y, Kusano S. Age-dependent decline in parenchymal perfusion in the normal human pancreas: measurement by dynamic computedtomography [J]. Pancreas, 1998, 17 (2): 148-152.
10. 　赵心明, 周纯武, 吴宁, 等. 胰腺多层螺旋CT灌注研究[J]. 中华放射学杂志, 2003, 37 (9): 845-849.
11. 　Kandel S, Kloeters C, Meyer H, et al. Whole-organ perfusion of the pancreas using dynamic volume CT in patients with primary pancreas carcinoma: acquisition technique, post-processing and initial results [J]. Eur Radiol, 2009, 19(11): 2641-2646.
12. 　Bali MA, Metens T, Denolin V, et al. Pancreatic perfusion: noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers--initial results [J]. Radiology, 2008, 247(1): 115-121.
13. 　Xu J, Liang Z, Hao S, et al. Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging [J]. Abdom Imaging, 2009, 34(6): 759-766.
14. 　林晓珠, 陈克敏. CT灌注成像测量正常胰腺组织血流灌注[J]. 中国CT 和MRI杂志, 2004, 2(1): 29-32.

West China Medical Journal

Features of Normal Pancrease Perfusion with First-pass Technique with 64-MDCT

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