Survivin Expression in Medulloblastoma and its Clinical Significance_West China Medical Journal

Authors：

1.Department of Neurology，Central Hospital of Suining City，Suining Sichuan 629000;2.Department of Neurology，West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

髓母细胞瘤; 凋亡; survivin; 免疫组化

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目的:通过检测髓母细胞瘤（Medulloblastoma）中凋亡抑制蛋白（survivin）的表达情况，探讨它的临床意义，为髓母细胞瘤的治疗寻求新的思路。方法:对50例髓母细胞瘤及10例正常脑组织石蜡切片行免疫组化检测，通过对survivin蛋白在髓母细胞瘤患者与正常脑组织中的表达差异，并运用相关统计分析方法分析它在不同性别、年龄段、肿瘤大小、病理类型、临床分期的表达差异及其与预后的相关性。结果:（1）髓母细胞瘤中survivin蛋白阳性表达率为72%，明显高于正常脑组织的阳性表达率0%，二者表达差异明显（P lt;0.01）；亚组分析发现在survivin蛋白阳性组（n=36）和阴性组（n=14）病例中，性别分布、肿瘤部位、肿瘤大小、病理分型等因素在两者间无明显差别（P gt;0.05），而年龄及TM临床分期在两组间差异显著（P分别为0.044和0.027）。（2）survivin阳性患者预后与和阴性组相比差异显著（P=0.001）。结论:survivin可能参与了对髓母细胞瘤细胞凋亡的调控，并对髓母细胞瘤的发生发展可能起着重要作用。由于survivin蛋白表达与髓母细胞瘤患者年龄、临床分期及预后等也密切相关，可作为判断病情和评价预后的指标。

Citation： WANG Duobin,JIANG Yongming,NU Mingxue,et al.. Survivin Expression in Medulloblastoma and its Clinical Significance. West China Medical Journal, 2009, 24(1): 1-4. doi: Copy

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1. Bailey P，Cushing HW.Medulloblastoma cerebell:a common type of midcerebellar glioma of childhood[J].Arch Neurol Psychiatry，1925，14:192-223..
2. 王忠诚.神经外科学[M].第1版，湖北科学技术出版社，2002..
3. Walker RW，Rosenblum MK.Childhood medulloblastoma[M].Rev Neurol（Paris），1992：148-149..
4. Giangaspero F，Cenacchi G，Roncaroli F，et al.Medulloblastoma （lipidized medulloblastoma）.A cerebellar neoplasm of adults with favorable prognosis[J].Am J Surg Pathol，1996，20(6):656-664..
5. 赵继宗.颅脑肿瘤外科学[M].第1版.北京:人民卫生出版社，2004..
6. Palmer SL，Goloubeva O，Reddick WE，et al.Patterns of intellectual development among survivors of pediatric medulloblastoma:A longitudinal analysis[J].J Clin Oncol，2001，19:23022308..
7. MacDonald TJ， Rood BR， Santi MR，et al.Advances in the diagnosis， molecular genetics， and treatment of pediatric embryonal CNS tumors[J]. Oncologist，2003，8（2）:174186..
8. Michiels EM，Oussoren E，Van Groenigen M，et al.Genes differentially expressed in medulloblastoma and fetal brain[J].Physiol Genomics，1999，1:83-91..
9. Sasaki T，Lopes MB，Hankins GR，et al.Expression of survivin， an inhibitor of apoptosis protein， in tumors of the nervous system[J].Acta Neuropathol，2002，104（1）:105-109 .
10. Caputy AJ，Mccullorgh DC，Manz HJ，et al.A review of the factors influencing the prognosis of medulloblastoma，the importance of cell differentiation[J].J Neurosurg，1987，66:80..
11. Packer RJ，Sutton LN，Rorke LB，et al.Prognostic of cellular differentiation in medulloblastoma of childhood[J].J Nurosurg，1984，61:296..
12. David KM， Casey AT， Hayward RD，et al.Medulloblastoma: is the 5year survival rate improving? A review of 80 cases from a single institution[J].J Neurosurg，1997，86（1）:1321..
13. Giangasero F，Chieco P，Ceccarelli C，et al.“Desmoplastic”versus“classic” medulloblastoma，comparison of DAN content[J].Virchow Arch Pathol，1991，418:207-16..

West China Medical Journal

Survivin Expression in Medulloblastoma and its Clinical Significance

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