Prediction of Depth of Sedation by ENI(tm) Monitor during Target-controlledInfusion of Propofol:A Comparison with BISTM Monitor_West China Medical Journal

Authors：

1Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610041，China; 2Department of Ob/Gyn,West China Second University Hospital,Sichuan University,Chengdu 610041,China);

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Keywords：

麻醉深度; 脑电非线性指数; 脑电双频指数; 近似熵

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目的：本研究旨在比较一种新的脑电参数-脑电非线性指数（ENI）与BIS在丙泊酚靶控输注时预测镇静深度的能力。方法:选择30例18～60岁，ASA Ⅰ～Ⅱ级，拟行择期普外科手术患者。每一患者同时监测ENI和BIS。麻醉诱导给予丙泊酚靶控输注，直至患者意识消失后给予芬太尼和罗库溴铵行气管插管。麻醉诱导过程中每30秒进行一次镇静评分（采用改良OAA/S评分），并记录ENI和BIS值以及平均动脉压（MAP）和心率（HR）。结果:ENI和BIS与镇静评分的相关性比MAP和HR高（r=0.90、0.93 vs r=0.77、0.27）。镇静过程（改良OAA/S评分）中ENI和BIS有很好的相关性(R2=0.828)。ENI和BIS预测镇静深度的能力优于MAP和HR。结论：ENI可提供与BIS相似的反映镇静深度的信息，能准确预测不同的镇静深度。

Citation： YU Hai,YANG Xiaoyun,LI Qian,et al.. Prediction of Depth of Sedation by ENI(tm) Monitor during Target-controlledInfusion of Propofol:A Comparison with BISTM Monitor. West China Medical Journal, 2008, 23(1): 25-26. doi: Copy

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6.	Drummond JC.Mornitoring depth of anesthesia:With emphasis on the application of the Bispectral Index and the middle latency auditory evoked response to the prevention of recal.Anesthesiology,2000,93:876-82.
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1. Smith WD,Dutton RC,Smith NT.Measuring the performance of anesthetic depth indicators[J].Anesthesiology,1996,84:38-51.
2. Gan TJ,Glass PS,Windsor A,et al.Bispectral index monitoring allows faster emergence and improved recovery from propofol,alfentanil,and nitrous oxide anesthesia[J].Anesthesiology,1997,87:808-15.
3. Struys MM,Jensen EW,Smith W,et al.Performance of the ARX-derived auditory evoked potential index as an indicator of anesthetic depth:A comparison with bispectral index andhemodynamic measures during propofol administration[J].Anesthesiology,2002,96:803-16.
4. Chernik DA,Gillings D,Laine H,et al.Validity and reliability of the observer’s assessment of alertness/sedation scale:study with intravenous midazolam[J].J Clin Psychopharmacol 1990,10:244-5.[5]Liu J,Harbhej S,White PF.Electroencephalographic bispectral index correlates with intraoperative recall and depth of propofol-induced sedation[J].Anesth Analg,1997,84:185-9.
5. Bauerle K,Greim CA,Schroth M,et al.Prediction of depth of sedation and anesthesia by the NarcotrendＴＭ EEG monitor[J].Br J Anaesth,2004,92:841-5.
6. Drummond JC.Mornitoring depth of anesthesia:With emphasis on the application of the Bispectral Index and the middle latency auditory evoked response to the prevention of recal.Anesthesiology,2000,93:876-82.
7. Sleigh JW,Donovan J.Comparison of BIS,95 spectral edge frequency and approximate entropy of EEG,with change in heart variability during induction of general anaesthesia[J].Br J Anaesth,1999,82:666-71.
8. Bruhn J,Bouillon TW,Shafer SL.Onset of propofol-induced burst suppression may be correctly detected as deepening of anesthesia by approximate entropy but not by bispectral index[J].Br J Anaesth,2001,87:505-7.

West China Medical Journal

Prediction of Depth of Sedation by ENI(tm) Monitor during Target-controlledInfusion of Propofol:A Comparison with BISTM Monitor

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