目的：探讨高血压合并阻塞性睡眠呼吸暂停综合征（OSAS）患者血浆5-羟色胺（5-HT）水平的变化。方法：应用放射免疫法测定45例高血压合并阻塞性睡眠呼吸暂停综合征患者血清5-HT浓度。结果：高血压合并阻塞性睡眠呼吸暂停综合症患者与单纯高血压不合并OSAS的患者相比，血压控制较差，而血浆5-HT水平明显增高（P＜0.05），轻、中、重度阻塞性睡眠呼吸暂停综合征患者血浆5-HT水平之间相比较有差异（P＜0.05）。结论：5-HT水平可能与血压控制和阻塞性睡眠呼吸暂停综合征的发病有关。
Citation：
ZHANG Yanling,LEI Fei,YANG Zhonghua. The Correlation of Plasma 5-hytroxytryptamine andHypertension Associated with Obstructive Sleep Apnea Syndrome. West China Medical Journal, 2008, 23(1): 43-44. doi:
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- 2. Foley D,Ancoli-Iarael S,Britz P,Walsh J.Sleep disturbances and chronic diseases in older adults:Results of the 2003 National Sleep Foundation Sleep in America Survey[J].J Psychosom Res,2004,56:497-502.
- 3. 李明娴，王莹，雷虹，等.阻塞性睡眠呼吸暂停综合征与高血压的相关性分析[J].中华老年心脑血管病杂志，2005，7（5）：295-297.
- 4. Bokinsky G,Miller M,Ault K,et al.Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure[J].Chest,1995,108:625-630.
- 5. Carley DW,Radulovacki M.Mirtazapine,a mixed profile serotonin agonist/antagonist,suppresses sleep apnea in rhe rat[J].Am J Respir Crit Care,1999,160:1824-1829.
- 6. Kraiczi,H,Hedner,J,Dahlof,P et al.Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea[J].Sleep,1999,22:61.
- 7. Berry,RB,Yamaura,EM,Gill,K,Reist,C.Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea[J].Sleep,1999,22:1087.
