Association of TGF-β1 Gene Polymorphism with IgA Nephropathy_West China Medical Journal

Authors：

1Division of Nephrology,2Division of Rheumatology,West China Hospital,Sichuan University,Chengdu 610041,China;

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Keywords：

IgA肾病; TGF-β1; 基因多态性

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目的：对TGF-β1的G-800A，C-509T，T869C和G915C多态性位点与IgA肾病及其临床表现之间的相关性进行了分析。方法：纳入119例经肾活检证实为IgA肾病的患者和116例健康正常成人作为对照组。采用多聚酶链式反应-限制片段长度多态性分析和多聚酶链式反应-扩增受阻突变体系方法测定TGF-β1的G-800A，C-509T，T869C和G915C多态性位点的基因型，分析其与IgA肾病发病以及临床表现的相关性。结果：研究对象中G-800A和G+915C这两个位点没有多态性。IgAN患者C-509T位点的等位基因型分布与正常对照具有显著性差异（Ｐ＜0.05），且IgAN患者TT纯合子的频率显著高于对照组（33% vs 20%,Ｐ=0.02）。C869T位点等位基因的分布无显著性差异。C-509T和C869T位点等位基因分布和患者临床表现无明显的相关性。结论：TGF-β1基因C-509T位点的T等位基因携带可能与IgA肾病的发病易感性具有相关性。

Citation： QIN Wei,ZHANG Yingjuan,TAN Chunyu,et al.. Association of TGF-β1 Gene Polymorphism with IgA Nephropathy. West China Medical Journal, 2008, 23(1): 61-63. doi: Copy

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1. Barratt,J.and J.Feehally.IgA nephropathy[J].J Am Soc Nephrol,2005,16(7):2088-97.
2. 秦伟,李学旺,秦岩,等.传递不平衡检测IL-1β基因多态性和IgA肾病的相关性[J].华西医学,2007,22(2):305-307.
3. Fan J,M,Y Y Ng,P A Hill,et al.Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro[J].Kidney Int,1999,56(4):1455-67.
4. 沈莲莉,邓跃毅.转化生长因子-β1与IgA肾病[J].中国中西医结合肾病杂志,2006,7(3):180-181.
5. K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification[J].Am J Kidney Dis,2002,39(2 Suppl 1):S1-266.
6. Perrey C,S J Turner,V Pravica,et al.ARMS-PCR methodologies to determine IL-10,TNF-alpha,TNF-beta and TGF-beta 1 gene polymorphisms [J].Transpl Immunol,1999,7(2):p.127-8.
7. 王文新,张青霞,刘宏伟,等.TGF-β1在IgA肾病患者肾组织中的表达[J].基础医学与临床,2002,22(1):43-44.
8. Grainger D J,K Heathcote,M Chiano,et al.Genetic control of the circulating concentration of transforming growth factor type beta1[J].Hum Mol Genet,1999,8(1)93-7.
9. Yokota M,S.Ichihara,T L Lin,et al.Association of a T29--＞C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese[J].Circulation,2000,101(24):2783-7.
10. Lim C S,Y S Kim,D W Chae,et al.Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with susceptibility to and progression of IgA nephropathy[J].Clin Nephrol,2005,63(2):61-7.
11. 薛超,李幼姬,李彩霞,等.基于家庭的TGF-β1-509C/T多态性和IgA肾病相关性研究 [J].中国病理生理杂志,2005,21(3):422-426.
12. Sato F,I Narita,S Goto,et al.Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy[J].Tissue Antigens,2004,64(1):35-42.

West China Medical Journal

Association of TGF-β1 Gene Polymorphism with IgA Nephropathy

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