The Expression of EphA2 in Cervical Cancer and the Relationship of Prognostic for Patients_West China Medical Journal

Authors：

FAN Bo ¹ , YAO ZhenWei ²

1Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000;2Affiliated First Hospital of Chongqing Medical University,Chongqing 400016,China;

Corresponding author：

Keywords：

EphA2; 宫颈癌; 免疫组化

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探讨宫颈癌中EphA2的表达及其临床意义。方法:应用免疫组织化学方法检测10例慢性宫颈炎、25例宫颈上皮内瘤样变（CIN）、50例宫颈癌（鳞癌41例、腺癌9例）中EphA2的蛋白表达。并对50例宫颈癌患者进行8～46月随访，分析EphA2在宫颈癌中的表达与患者预后的关系。结果:慢性宫颈炎、CIN、宫颈癌组织中EphA2蛋白阳性表达的差异有统计学意义（P＜0.05）。EphA2蛋白在宫颈癌中的表达与患者年龄、FIGO分期、病理类型无关，与病理分级、有无淋巴结转移有密切相关性，且EphA2蛋白表达越强，患者生存率越低。结论：EphA2与宫颈癌的侵袭、转移密切相关，可望作为判断宫颈癌患者预后的参考指标。

Citation： FAN Bo,YAO ZhenWei. The Expression of EphA2 in Cervical Cancer and the Relationship of Prognostic for Patients. West China Medical Journal, 2008, 23(1): 78-79. doi: Copy

1.	Davis S,Gale NW,Aldrich TH,et al.Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity[J].Science,1994,266(5186):816 819．.
2.	Kataoka H,Igarashi H,Kanamori M,et al.Correlation of EPHA2 overexpression with high microvessel count in human primary coloreetal cancer.Cancer Sci,2004,95(2):136-141．.
3.	Walker-Daniels J,Hess AR,Hendrix MJ,et al.Differential regulation of EphA2 in normal and malignant cells[J].Am J Pathol,2003,162(4):1037-1042．.
4.	Iantek ND,Walker-Daniels J,Stewart J,et al.MCF-10A-NeoST:a new cell system for studing cell-ECM and cell-cell interactions in breast cancer[J].Clin Cancer Res,2001,7(11):3640-3648．.
5.	Kinch MS,Carles-Kinch K.Overexpression and functional alterations of the EphA2 tyrosine kinase in canaer[J].Clin Exp Metastasis,2003,20(1)．.
6.	Wu D，Suo Z．Kristensen GB，et a1．Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma10[J]．Gyneeol Oncol,2004，94(2)：312-319．.

1. Davis S,Gale NW,Aldrich TH,et al.Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity[J].Science,1994,266(5186):816 819．.
2. Kataoka H,Igarashi H,Kanamori M,et al.Correlation of EPHA2 overexpression with high microvessel count in human primary coloreetal cancer.Cancer Sci,2004,95(2):136-141．.
3. Walker-Daniels J,Hess AR,Hendrix MJ,et al.Differential regulation of EphA2 in normal and malignant cells[J].Am J Pathol,2003,162(4):1037-1042．.
4. Iantek ND,Walker-Daniels J,Stewart J,et al.MCF-10A-NeoST:a new cell system for studing cell-ECM and cell-cell interactions in breast cancer[J].Clin Cancer Res,2001,7(11):3640-3648．.
5. Kinch MS,Carles-Kinch K.Overexpression and functional alterations of the EphA2 tyrosine kinase in canaer[J].Clin Exp Metastasis,2003,20(1)．.
6. Wu D，Suo Z．Kristensen GB，et a1．Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma10[J]．Gyneeol Oncol,2004，94(2)：312-319．.

West China Medical Journal

The Expression of EphA2 in Cervical Cancer and the Relationship of Prognostic for Patients

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