The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long_West China Medical Journal

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羟甲戊二酰辅酶A还原酶抑制剂; 辛伐他汀; 慢性肾功能不全

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目的：研究羟甲戊二酰辅酶A还原酶抑制剂辛伐他汀治疗慢性肾功能不全的临床疗效。方法：选择慢性肾功能衰竭患者共40例，随机分成两组，在原有基础治疗上治疗组20例患者予以辛伐他汀治疗，对照组20例单纯以基础治疗，在24周时监测TC、TG、24 h尿蛋白、Scr、BUN、C-反应蛋白的值。结果：与治疗前相比，两组TC、TG、24 h尿蛋白、Scr、BUN、C-反应蛋白均明显下降，与对照组相比，治疗组血脂有显著下降（P＜0.01）而且24h尿蛋白、Scr、BUN、C-反应蛋白均明显下降(P＜0.05)。结论：辛伐他汀能降低蛋白尿，延缓慢性肾功能不全的进展

Citation： MOU Hong,CHEN Tong,HE Long. The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long. West China Medical Journal, 2008, 23(1): 130-130. doi: Copy

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1. [１]Nakamura T，Ushiyama C，Hirokawa K，et a1．Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomlo nephritis[J].Nephrol Dial Transplant，2002,17(5)：798－802．.
2. 李航，李学旺，段琳，等，洛伐他汀对系膜细胞核因子-kB活性及炎性细胞因子表达的影响[Ｊ]．中华肾脏病杂志，2001，17（4）；242-245．.
3. 陈楠，李娅，王伟铭，等，辛伐他汀对大鼠肾间质成纤维细胞的影响[Ｊ]．肾脏病与透析肾移植杂志，2000，9（5）：411-415．.
4. Danesh FR,Sadeghi M M,Amro N,et a1.3 Hydroxy-3-methyl-glutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase／p21 signaling pathway:Implications for diabetic nephropathy[J].Proc Natl Acad Sci,2002,11,99:8301-8305..
5. Yokota N，O Donnell M，DanM s F，ct a1．Protective effect of HMG～CoA reductase inhibitor on experimental renal ischemia－reperfusion injury[J]．Am J Nephrol，2003，23：13－17．.
6. Fehr T，Kahlert C，Fierz W，et a1．Statin induced immunomodulatory effects on human T cells in vivo[J]．Atherosclerosis，2004，175:83－90．.

West China Medical Journal

The Effect of Simvastatin in Patient with Chronic Renal Insufficiency MOU Hong,CHEN Tong,HE Long

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