肠外营养液中的铝污染_West China Medical Journal

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樊新星 , 徐珽 , 金朝辉 , 唐尧

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【摘要】　目的　介绍肠外营养液中的铝污染。方法　本文根据国内外文献，对肠外营养液中的铝污染进行了综述。结果　肠外营养液中的铝污染研究仍处于探索阶段，但已找到了两个主要来源，给予了一些解决措施。结论　重视肠外营养液中的铝污染，加强肠外营养液的安全使用。

Citation： 樊新星,徐珽,金朝辉,唐尧. 肠外营养液中的铝污染. West China Medical Journal, 2008, 23(1): 203-204. doi: Copy

1.	Leung FY. Trace elements in parenteral micronutrition[J]. Clin Biochem, 1995, 28(6): 561-566.
2.	Leung FY, Grace DM, Alfieri MA, et al. Abnormal trace elements in a patient on total parenteral nutrition with normal renal function[J]. Clin Biochem, 1995, 28(3): 297-302.
3.	Hewitt CD, Savory J, Wills MR. Aspects of aluminum toxicity[J]. Clin Lab Med, 1990, 10(2): 403-422.
4.	Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition. Fed Regist, 2000, 65(17): 4103-4111.
5.	Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
6.	Koo WW, Kaplan LA, Horn J, et al. Aluminum in parenteral nutrition solution--sources and possible alternatives[J]. JPEN J Parenter Enteral Nutr, 1986, 10(6): 591-595.
7.	Recknagel S, Bratter P, Chrissafidou A, et al. Parenteralaluminum loading in critical care medicine. Part 1: aluminum content of infusion solutions and solutions for parenteral nutrition. Infusionsther Transfusionsmed, 1994, 21: 266-273.
8.	Smith BS, Kothari H, Hayes BD, et al. Effect of additive selection on calculated aluminum content of parenteral nutrient solutions[J]. Am J Health Syst Pharm, 2007, 64(7): 730-739.
9.	Mouser JF, Wu AH, Herson VC. Aluminum contamination of neonatal parenteral nutrient solutions and additives[J]. Am J Health Syst Pharm, 1998, 55(10): 1071-1072. Comment on: Am J Health Syst Pharm, 1998, 55(2): 150-154.
10.	Pluhator-Murton MM, Fedorak RN, Audette RJ, et al. Traceelement contamination of total parenteral nutrition. 1. Contribution of componentsolutions[J]. JPEN J Parenter Enteral Nutr, 1999, 23(4): 222-227. [11]　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
11.	Frey OR, Maier L. Polyethylene vials of calcium gluconate reduce aluminum contamination of TPN[J]. Ann Pharmacother, 2000, 34(6): 811-812.
12.	马森. 铝的生物毒性作用及食品卫生[J]. 南平师专学报, 2004, 23(4): 9-12.
13.	盛明纯. 铝对人体健康影响的研究进展综述[J]. 安徽预防医学杂志, 2006, 12(1): 46-48.
14.	Driscoll M, Driscoll DF. Calculating aluminum content in total parenteral nutrition admixtures[J]. Am J Health Syst Pharm, 2005, 62(3): 312-315.
15.	[No authors listed]. Parenteral drug products containing aluminum as an ingredient or a contaminant: response to Food and Drug Administration notice of intent and request for information. ASCN/A. S. P. E. N. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions[J]. JPEN J Parenter Enteral Nutr, 1991, 15(2): 194-198. Comment in: JPEN J Parenter Enteral Nutr, 1992, 16(1): 92-95.
16.	Young D. FDA aluminum rule poses challengesfor industry, pharmacists[J]. Am J Health Syst Pharm, 2004, 61(8): 742, 744. [18]　Canada TW. Aluminum exposure through parenteral nutrition formulations: mathematical versus clinical relevance[J]. Am J Health Syst Pharm, 2005, 62(3): 315-318. Erratum in: Am J Health Syst Pharm, 2005, 62(7): 679.

1. 　Leung FY. Trace elements in parenteral micronutrition[J]. Clin Biochem, 1995, 28(6): 561-566.
2. 　Leung FY, Grace DM, Alfieri MA, et al. Abnormal trace elements in a patient on total parenteral nutrition with normal renal function[J]. Clin Biochem, 1995, 28(3): 297-302.
3. 　Hewitt CD, Savory J, Wills MR. Aspects of aluminum toxicity[J]. Clin Lab Med, 1990, 10(2): 403-422.
4. 　Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition. Fed Regist, 2000, 65(17): 4103-4111.
5. 　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
6. 　Koo WW, Kaplan LA, Horn J, et al. Aluminum in parenteral nutrition solution--sources and possible alternatives[J]. JPEN J Parenter Enteral Nutr, 1986, 10(6): 591-595.
7. 　Recknagel S, Bratter P, Chrissafidou A, et al. Parenteralaluminum loading in critical care medicine. Part 1: aluminum content of infusion solutions and solutions for parenteral nutrition. Infusionsther Transfusionsmed, 1994, 21: 266-273.
8. 　Smith BS, Kothari H, Hayes BD, et al. Effect of additive selection on calculated aluminum content of parenteral nutrient solutions[J]. Am J Health Syst Pharm, 2007, 64(7): 730-739.
9. 　Mouser JF, Wu AH, Herson VC. Aluminum contamination of neonatal parenteral nutrient solutions and additives[J]. Am J Health Syst Pharm, 1998, 55(10): 1071-1072. Comment on: Am J Health Syst Pharm, 1998, 55(2): 150-154.
10. 　Pluhator-Murton MM, Fedorak RN, Audette RJ, et al. Traceelement contamination of total parenteral nutrition. 1. Contribution of componentsolutions[J]. JPEN J Parenter Enteral Nutr, 1999, 23(4): 222-227. [11]　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
11. 　Frey OR, Maier L. Polyethylene vials of calcium gluconate reduce aluminum contamination of TPN[J]. Ann Pharmacother, 2000, 34(6): 811-812.
12. 　马森. 铝的生物毒性作用及食品卫生[J]. 南平师专学报, 2004, 23(4): 9-12.
13. 　盛明纯. 铝对人体健康影响的研究进展综述[J]. 安徽预防医学杂志, 2006, 12(1): 46-48.
14. 　Driscoll M, Driscoll DF. Calculating aluminum content in total parenteral nutrition admixtures[J]. Am J Health Syst Pharm, 2005, 62(3): 312-315.
15. 　[No authors listed]. Parenteral drug products containing aluminum as an ingredient or a contaminant: response to Food and Drug Administration notice of intent and request for information. ASCN/A. S. P. E. N. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions[J]. JPEN J Parenter Enteral Nutr, 1991, 15(2): 194-198. Comment in: JPEN J Parenter Enteral Nutr, 1992, 16(1): 92-95.
16. 　Young D. FDA aluminum rule poses challengesfor industry, pharmacists[J]. Am J Health Syst Pharm, 2004, 61(8): 742, 744. [18]　Canada TW. Aluminum exposure through parenteral nutrition formulations: mathematical versus clinical relevance[J]. Am J Health Syst Pharm, 2005, 62(3): 315-318. Erratum in: Am J Health Syst Pharm, 2005, 62(7): 679.

West China Medical Journal

肠外营养液中的铝污染

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