• 1.Department of General Suregery, The First People,s Hospital of Baiyin City, Baiyin 730900, Gansu Province, China;;
  • 2.Department of General Surgery, Lanzhou General Hospital Attached to Military Region, PLA, Lanzhou 730050, Gansu Province, China;
WANG Yun, Email: wangyun19680109@163.com
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Objective  To discuss the pathogenesis,clinical manifestations,diagnoses and preventive methods on subsequent Wernicke encephalopathy cases of old gastric cancer patients during perioperation.
Methods  Collected the data of 237 old gastric cancer patients in perioperation from October 1990 to December 2009 hospitalized in the Department of General Surgery,Lanzhou General Hospital Attached to Military Region,PLA.And then retrospectively analysed 7 patents of them who complicated with Wernicke encephalopathy to summarize the clinical manifestation, accessory examination,diagnosis,prevention, and therapy of the Wernicke encephalopathy,and associated factors with its incidence.
Results  The clinical manifestations of 7 patients included nystagmus (7 cases),ataxia(4 cases),brain disorder(6 cases).Auxiliary examination:4 cases with anemia,7 cases with unusual blood biochemical examination, 5 cases with urinary ketone bodies positive,2 cases with decreasing blood vitamin B1,1 case with unusual skull MRI examination.Five patients were diagnosed before treatment and 2 case were diagnosed by experimental treatment.Finally,4 patents were cured,1 case obviously improved,1 case improved, and 1 case died.And The patients complicated with preoperative hypoproteinemia or pyloric obstruction and postoperative fistula of intestine or gastroplegia syndrome had statistical higher incidence rates of the Wernicke encephalopathy than those without these complications (P<0.05).
Conclusions  The clinical manifestation of the Wernicke encephalopathy have no specificity, it is hard to diagnose,so clinicians should pay attention to it,and combine different ways to diagnose.Improving or preventing complications during perioperative period,and supplementing enough vitamin B are important preventive and therapeutic measures.

Citation: WANG Yun,YANG Wenju. Analysis on Seven Cases Subsequent Wernicke Encephalopathy During Perioperation in Elderly Patients with Gastric Caner. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(1): 77-81. doi: Copy