Rational Treatment of Carcinoma of Body and Tail of Pancreas_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

张太平 , 肖剑春 ,  赵玉沛

Corresponding author：

赵玉沛, Email: zhao8028@263.net

Keywords：

胰体尾癌; 规范化治疗; 根治性手术; 放疗; 化疗

Video：

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Citation： 张太平,肖剑春,赵玉沛. Rational Treatment of Carcinoma of Body and Tail of Pancreas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(1): 6-10. doi: Copy

1.	Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA Cancer J Clin, 2009, 59(4): 225249.
2.	Li D, Xie K, Wolff R, et al. Pancreatic cancer [J]. Lancet, 2004, 363（9414）: 10491057.
3.	Brennan MF, Moccia RD, Klimstra D. Management of adenocarinoma of the body and tail of the pancreas J]. Ann Surg, 1996, 233（5）: 506512.
4.	Bipat S, Phoa SS, van Delden OM, et al. Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a metaanalysis [J]. J Comput Assist Tomogr, 2005, 29(4): 438445.
5.	National Comprehensive Cancer Network (NCCN) Clinical Practice Guideline in Oncology for Pancreatic Adenocarcinoma. V.1. 2009[EB/OL]. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
6.	张太平, 肖剑春, 赵玉沛. NCCN胰腺外科治疗指南解读 [J]. 临床肝胆病杂志, 2010, 26（5）: 454458.
7.	中华医学会外科学分会胰腺外科学组. 胰腺癌诊治指南 [J]. 中国实用外科杂志, 2007, 27(9): 671673.
8.	Yeo CJ, Cameron JL, Sohn TA, et al. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and shortterm outcome [J]. Ann Surg, 1999, 229(5): 613622.
9.	Riall TS, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma-part 3: update on 5year survival [J]. J Gastrointest Surg, 2005, 9(9): 11911206.
10.	Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma [J]. Surgery, 2005, 138(4): 618630.
11.	Farnell MB, Aranha GV, Nimura Y, et al. The role of extended lymphadenectomy for adenocarcinoma of the head of the pancreas: strength of the evidence [J]. J Gastrointest Surg, 2008, 12(4): 651656.
12.	O’Morchoe CC. Lymphatic system of the pancreas [J]. Microsc Res Tech, 1997, 37（56）: 456477.
13.	Strasberg SM, Drebin JA, Linehan D. Radical antegrade modular pancreatosplenectomy [J]. Surgery, 2003, 133(5): 521527.
14.	Strasberg SM, Linehan DC, Hawkins WG. Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins [J]. J Am Coll Surg, 2007, 204(2): 244249.
15.	Shimada K, Sakamoto Y, Sano T, et al. Prognostic factors after distal pancreatectomy with extended lymphadenectomy for invasive pancreatic adenocarcinoma of the body and tail[J]. Surgery, 2006, 139(3): 288295.
16.	Appleby LH. The coeliac axis in the expansion of the operation for gastric carcinoma [J]. Cancer, 1953, 6（4）: 704707.
17.	Nimura Y, Hattori T, Miura K, et al. Experience of Appleby’s operation for advanced carcinoma of the pancreatic body and tail (in Japanese) [J]. Shujutsu, 1976, 30(7): 885889.
18.	Hishinuma S, Ogata Y, Matsui J, et al. Two cases of cancer of the pancreatic body undergoing gastric preservation with distal pancreatectomy combined with resection of the celial axis [J]. Jpn J Gastroenterol Surg, 1991, 24: 27822786.
19.	Hirai I, Kimura W, Kamiga M, et al. The significance of intraoperative Doppler ultrasonography in evaluating hepatic arterial flow when assessing the indications for the Appleby procedure for pancreatic body cancer [J]. J Hepatobiliary Pancreat Surg, 2005, 12(1): 5560.
20.	Kondo S, Katoh H, Shimizu T, et al. Preoperative embolization of the common hepatic artery in preparation for radical pancreatectomy for pancreas body cancer [J]. Hepatogastroenterology, 2000, 47(35): 14471449.
21.	Sperti C, Berselli M, Pedrazzoli S. Distal pancreatectomy for bodytail pancreatic cancer: Is there a role for celiac axis resection? [J]. Pancreatology, 2010, 10（4）: 491498.
22.	Hirano S, Kondo S, Hara T, et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: longterm results [J]. Ann Surg, 2007, 246(1): 4651.
23.	Hishinuma S, Ogata Y, Tomikawa M, et al. Patterns of recurrence after curative resection of pancreatic cancer, based on autopsy findings [J]. J Gastrointest Surg, 2006, 10(4): 511518.
24.	Tani M, Kawai M, Miyazawa M, et al. Liver metastasis as an initial recurrence has no impact on the survival of patients with resectable pancreatic adenocarcinoma [J]. Langenbecks Arch Surg, 2009, 394(2): 249253.
25.	Borad MJ, Saadati H, Lakshmipathy A, et al. Skeletal metastases in pancreatic cancer: a retrospective study and review of the literature [J]. Yale J Biol Med, 2009, 82(1): 16.
26.	Hafez H. Cutaneous pancreatic metastasis: a case report and review of literature [J]. Indian J Cancer, 2007, 44(3): 111114.
27.	Ausania F, Caricato M, Borzomati D, et al. Cerebellar metastasis from pancreatic adenocarcinoma: report of a clinical case [J]. Suppl Tumori, 2005, 4(3): S62.
28.	Kleeff J, Reiser C, Hinz U, et al. Surgery for recurrent pancreatic ductal adenocarcinoma [J]. Ann Surg, 2007, 245(4): 566572.
29.	Hernandez JM, Morton CA, AlSaadi S, et al. The natural history of resected pancreatic cancer without adjuvant chemotherapy [J]. Am Surg, 2010, 76(5): 480485.
30.	Hidalgo M. Pancreatic Cancer [J]. N Engl J Med, 2010, 362（17）: 16051617.
31.	Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer [J]. N Engl J Med, 2004, 350（12）: 12001210.
32.	Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curativeintent resection of pancreatic cancer: a randomized controlled trial [J]. JAMA, 2007, 297（3）: 267277.
33.	Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracilbased chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial [J]. JAMA, 2008, 299（9）: 10191026.
34.	Gillen S, Schuster T, Meyer Zum Büschenfelde C, et al. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and metaanalysis of response and resection percentages [J]. PLoS Med, 2010, 7(4): e1000267.
35.	McClaine RJ, Lowy AM, Sussman JJ, et al. Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer [J]. HPB (Oxford), 2010, 12(1): 7379.
36.	Landry J, Catalano PJ, Staley C, et al. Randomized phase Ⅱ study of gemcitabine plus radiotherapy versus gemcitabine, 5fluorouracil, and cisplatin followed by radiotherapy and 5fluorouracil for patients with locally advanced, potentially resectable pancreatic adenocarcinoma[J]. J Surg Oncol, 2010, 101(7): 587592.
37.	Abbott DE, Baker MS, Talamonti MS. Neoadjuvant therapy for pancreatic cancer: a current review[J]. J Surg Oncol, 2010, 101(4): 315320.
38.	Sultana A, Tudur Smith C, Cunningham D, et al. Systematic review, including metaanalyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy [J]. Br J Cancer, 2007, 96（8）: 11831190.
39.	张太平, 周斌, 赵玉沛. 胰腺癌综合治疗现状 [J]. 中国中西医结合外科杂志, 2010, 16（2）: 126129.
40.	Sultana A, Smith CT, Cunningham D, et al. Metaanalyses of chemotherapy for locally advanced and metastatic pancreatic cancer [J]. J Clin Oncol, 2007, 25（18）: 26072615.
41.	Heinemann V, Boeck S, Hinke A, et al. Metaanalysis of randomized trials: evaluation of benefit from gemcitabinebased combination chemotherapy applied in advanced pancreatic cancer [J]. BMC Cancer, 2008, 8: 82.
42.	Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase Ⅲ trial of the National Cancer Institute of Canada Clinical Trials Group [J]. J Clin Oncol, 2007, 25（15）: 19601966.
43.	Huguet F, Andre T, Hammel P, et al. Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase Ⅱ and Ⅲ studies [J]. J Clin Oncol, 2007, 25（3）: 326331.
44.	Chauffert B, Mornex F, Bonnetain F, et al. Phase Ⅲ trial comparing intensive induction chemoradiotherapy (60 Gy, infusion 5FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced pancreatic cancer. Definitive results of the 200001 FFCD/SFRO study[J]. Ann Oncol, 2008, 19（9）: 15921599.
45.	Loehrer PJ, Powell ME, Cardenes HR, et al. A randomized phase Ⅲ study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with localized, unresectable pancreatic cancer: E4201 [J]. J Clin Oncol, 2008, 26（Suppl 15）: Abstract 4506.
46.	Wieners G, Pech M, Rudzinska M, et al. CTguided interstitial brachytherapy in the local treatment of extrahepatic, extrapulmonary secondary malignancies[J]. Eur Radiol, 2006, 16(11): 25862593.
47.	Jin Z, Du Y, Li Z, et al. Endoscopic ultrasonographyguided interstitial implantation of iodine 125seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study [J]. Endoscopy, 2008, 40(4): 314320.
48.	Wang K, Jin Z, Du Y, et al. Evaluation of endoscopicultrasoundguided celiac ganglion irradiation with iodine125 seeds: a pilot study in a porcine model [J]. Endoscopy, 2009, 41(4): 346351.

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA Cancer J Clin, 2009, 59(4): 225249.
2. Li D, Xie K, Wolff R, et al. Pancreatic cancer [J]. Lancet, 2004, 363（9414）: 10491057.
3. Brennan MF, Moccia RD, Klimstra D. Management of adenocarinoma of the body and tail of the pancreas J]. Ann Surg, 1996, 233（5）: 506512.
4. Bipat S, Phoa SS, van Delden OM, et al. Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a metaanalysis [J]. J Comput Assist Tomogr, 2005, 29(4): 438445.
5. National Comprehensive Cancer Network (NCCN) Clinical Practice Guideline in Oncology for Pancreatic Adenocarcinoma. V.1. 2009[EB/OL]. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
6. 张太平, 肖剑春, 赵玉沛. NCCN胰腺外科治疗指南解读 [J]. 临床肝胆病杂志, 2010, 26（5）: 454458.
7. 中华医学会外科学分会胰腺外科学组. 胰腺癌诊治指南 [J]. 中国实用外科杂志, 2007, 27(9): 671673.
8. Yeo CJ, Cameron JL, Sohn TA, et al. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and shortterm outcome [J]. Ann Surg, 1999, 229(5): 613622.
9. Riall TS, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma-part 3: update on 5year survival [J]. J Gastrointest Surg, 2005, 9(9): 11911206.
10. Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma [J]. Surgery, 2005, 138(4): 618630.
11. Farnell MB, Aranha GV, Nimura Y, et al. The role of extended lymphadenectomy for adenocarcinoma of the head of the pancreas: strength of the evidence [J]. J Gastrointest Surg, 2008, 12(4): 651656.
12. O’Morchoe CC. Lymphatic system of the pancreas [J]. Microsc Res Tech, 1997, 37（56）: 456477.
13. Strasberg SM, Drebin JA, Linehan D. Radical antegrade modular pancreatosplenectomy [J]. Surgery, 2003, 133(5): 521527.
14. Strasberg SM, Linehan DC, Hawkins WG. Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins [J]. J Am Coll Surg, 2007, 204(2): 244249.
15. Shimada K, Sakamoto Y, Sano T, et al. Prognostic factors after distal pancreatectomy with extended lymphadenectomy for invasive pancreatic adenocarcinoma of the body and tail[J]. Surgery, 2006, 139(3): 288295.
16. Appleby LH. The coeliac axis in the expansion of the operation for gastric carcinoma [J]. Cancer, 1953, 6（4）: 704707.
17. Nimura Y, Hattori T, Miura K, et al. Experience of Appleby’s operation for advanced carcinoma of the pancreatic body and tail (in Japanese) [J]. Shujutsu, 1976, 30(7): 885889.
18. Hishinuma S, Ogata Y, Matsui J, et al. Two cases of cancer of the pancreatic body undergoing gastric preservation with distal pancreatectomy combined with resection of the celial axis [J]. Jpn J Gastroenterol Surg, 1991, 24: 27822786.
19. Hirai I, Kimura W, Kamiga M, et al. The significance of intraoperative Doppler ultrasonography in evaluating hepatic arterial flow when assessing the indications for the Appleby procedure for pancreatic body cancer [J]. J Hepatobiliary Pancreat Surg, 2005, 12(1): 5560.
20. Kondo S, Katoh H, Shimizu T, et al. Preoperative embolization of the common hepatic artery in preparation for radical pancreatectomy for pancreas body cancer [J]. Hepatogastroenterology, 2000, 47(35): 14471449.
21. Sperti C, Berselli M, Pedrazzoli S. Distal pancreatectomy for bodytail pancreatic cancer: Is there a role for celiac axis resection? [J]. Pancreatology, 2010, 10（4）: 491498.
22. Hirano S, Kondo S, Hara T, et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: longterm results [J]. Ann Surg, 2007, 246(1): 4651.
23. Hishinuma S, Ogata Y, Tomikawa M, et al. Patterns of recurrence after curative resection of pancreatic cancer, based on autopsy findings [J]. J Gastrointest Surg, 2006, 10(4): 511518.
24. Tani M, Kawai M, Miyazawa M, et al. Liver metastasis as an initial recurrence has no impact on the survival of patients with resectable pancreatic adenocarcinoma [J]. Langenbecks Arch Surg, 2009, 394(2): 249253.
25. Borad MJ, Saadati H, Lakshmipathy A, et al. Skeletal metastases in pancreatic cancer: a retrospective study and review of the literature [J]. Yale J Biol Med, 2009, 82(1): 16.
26. Hafez H. Cutaneous pancreatic metastasis: a case report and review of literature [J]. Indian J Cancer, 2007, 44(3): 111114.
27. Ausania F, Caricato M, Borzomati D, et al. Cerebellar metastasis from pancreatic adenocarcinoma: report of a clinical case [J]. Suppl Tumori, 2005, 4(3): S62.
28. Kleeff J, Reiser C, Hinz U, et al. Surgery for recurrent pancreatic ductal adenocarcinoma [J]. Ann Surg, 2007, 245(4): 566572.
29. Hernandez JM, Morton CA, AlSaadi S, et al. The natural history of resected pancreatic cancer without adjuvant chemotherapy [J]. Am Surg, 2010, 76(5): 480485.
30. Hidalgo M. Pancreatic Cancer [J]. N Engl J Med, 2010, 362（17）: 16051617.
31. Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer [J]. N Engl J Med, 2004, 350（12）: 12001210.
32. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curativeintent resection of pancreatic cancer: a randomized controlled trial [J]. JAMA, 2007, 297（3）: 267277.
33. Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracilbased chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial [J]. JAMA, 2008, 299（9）: 10191026.
34. Gillen S, Schuster T, Meyer Zum Büschenfelde C, et al. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and metaanalysis of response and resection percentages [J]. PLoS Med, 2010, 7(4): e1000267.
35. McClaine RJ, Lowy AM, Sussman JJ, et al. Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer [J]. HPB (Oxford), 2010, 12(1): 7379.
36. Landry J, Catalano PJ, Staley C, et al. Randomized phase Ⅱ study of gemcitabine plus radiotherapy versus gemcitabine, 5fluorouracil, and cisplatin followed by radiotherapy and 5fluorouracil for patients with locally advanced, potentially resectable pancreatic adenocarcinoma[J]. J Surg Oncol, 2010, 101(7): 587592.
37. Abbott DE, Baker MS, Talamonti MS. Neoadjuvant therapy for pancreatic cancer: a current review[J]. J Surg Oncol, 2010, 101(4): 315320.
38. Sultana A, Tudur Smith C, Cunningham D, et al. Systematic review, including metaanalyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy [J]. Br J Cancer, 2007, 96（8）: 11831190.
39. 张太平, 周斌, 赵玉沛. 胰腺癌综合治疗现状 [J]. 中国中西医结合外科杂志, 2010, 16（2）: 126129.
40. Sultana A, Smith CT, Cunningham D, et al. Metaanalyses of chemotherapy for locally advanced and metastatic pancreatic cancer [J]. J Clin Oncol, 2007, 25（18）: 26072615.
41. Heinemann V, Boeck S, Hinke A, et al. Metaanalysis of randomized trials: evaluation of benefit from gemcitabinebased combination chemotherapy applied in advanced pancreatic cancer [J]. BMC Cancer, 2008, 8: 82.
42. Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase Ⅲ trial of the National Cancer Institute of Canada Clinical Trials Group [J]. J Clin Oncol, 2007, 25（15）: 19601966.
43. Huguet F, Andre T, Hammel P, et al. Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase Ⅱ and Ⅲ studies [J]. J Clin Oncol, 2007, 25（3）: 326331.
44. Chauffert B, Mornex F, Bonnetain F, et al. Phase Ⅲ trial comparing intensive induction chemoradiotherapy (60 Gy, infusion 5FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced pancreatic cancer. Definitive results of the 200001 FFCD/SFRO study[J]. Ann Oncol, 2008, 19（9）: 15921599.
45. Loehrer PJ, Powell ME, Cardenes HR, et al. A randomized phase Ⅲ study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with localized, unresectable pancreatic cancer: E4201 [J]. J Clin Oncol, 2008, 26（Suppl 15）: Abstract 4506.
46. Wieners G, Pech M, Rudzinska M, et al. CTguided interstitial brachytherapy in the local treatment of extrahepatic, extrapulmonary secondary malignancies[J]. Eur Radiol, 2006, 16(11): 25862593.
47. Jin Z, Du Y, Li Z, et al. Endoscopic ultrasonographyguided interstitial implantation of iodine 125seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study [J]. Endoscopy, 2008, 40(4): 314320.
48. Wang K, Jin Z, Du Y, et al. Evaluation of endoscopicultrasoundguided celiac ganglion irradiation with iodine125 seeds: a pilot study in a porcine model [J]. Endoscopy, 2009, 41(4): 346351.

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Rational Treatment of Carcinoma of Body and Tail of Pancreas

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