Relation Between Using Time of Prophylactic Antibiotics and Surgical Site Infection in Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Shijun ,  WANG Yongqiang.

Department of Anal-Colorectal Surgery, The First People’s Hospital, Chengdu 610000, China;

Corresponding author：

WANG Yongqiang., Email: wangbom@163.com

Keywords：

Colorectal cancer; Antibiotic; Surgical site; Infection

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Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the relationship between antibiotic prophylaxis and surgical site infection (SSI) in colorectal cancer.
Methods A survey of 880 patients with colorectal cancer from Jan. 1998 to Dec. 2008 were studied. Patients were divided into two groups by antibiotic duration: ≥24 h group (n=401) and lt;24 h group (n=479). To compare the differences of surgical site infection between two groups.
Results For SSI patients, operation time obviously prolonged (P=0.04), or with more blood loss (P=0.03) and longer time use of antibiotics (P=0.04). In colon cancer patients with SSI operation time was significantly different from the cases of colon cancer without SSI （P=0.01）, while there was no difference between SSI and operation time, blood loss and duration of antibiotics （P gt;0.05）.
Conclusion Longer operation time, more blood loss and longer bleeding time are the risk factors of surgical site infection. Moreover prolonged antibiotic prophylaxis can not decrease the incidence of SSI.

Citation： CHEN Shijun,WANG Yongqiang.. Relation Between Using Time of Prophylactic Antibiotics and Surgical Site Infection in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(1): 73-76. doi: Copy

1.	刘宗荣, 朱易凡, 马淙, 等. 结直肠癌手术后感染并发症的调查和分析 [J]. 中国普通外科杂志, 2008; 17(1): 104106.
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9.	石喜之, 王济峰, 周涌, 等. 手术后切口感染与抗生素合理应用的评价 [J]. 第四军医大学学报, 2002; 23(7): 602.
10.	Baker RJ, Fischer JE. 临床外科学 [M]. 天津：天津科技翻译出版公司, 2002： 18701965.
11.	Suehiro T, Hirashita T, Araki S, et al. Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery [J]. Hepatogastroenterology, 2008; 55(8687): 16361639.
12.	Bratzler DW, Houck PM, Richards C, et al. Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project [J]. Arch Surg, 2005; 140(2): 174182.
13.	唐伟松, 李小毅, 杨志英, 等. 预防性抗生素在普通外科手术中的应用 [J]. 中华普通外科杂志, 2001; 16(7): 445.
14.	Chodak GW, Plaut ME. Use of systemic antibiotics for in prophylaxis surgery: A critical review [J]. Arch Surg, 1977; 112: 326334.
15.	Gul YA, Lian LH, Jabar FM, et al. Antibiotic prophylaxis in elective colorectal surgery [J]. ANZ J Surg, 2002; 72(4): 275278.
16.	黎沾良. 合理使用抗生素预防手术部位感染 [J]. 中国普外基础与临床杂志, 2003; 10(1): 1415.
17.	Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee [J]. Infect Control Hosp Epidemiol, 1999; 20(4): 250280.
18.	Hartmann B, Sucke J, Brammen D, et al. Impact of inadequate surgical antibiotic prophylaxis on perioperative outcome and length of stay on ICU in general and trauma surgery. Analysis using automated data collection [J]. Int J Antimicrob Agents, 2005; 25(3): 231236.
19.	Gorecki P, Schein M, Rucinski JC, et al. Antibiotic administration in patients undergoing common surgical procedures in a community teaching hospital: the chaos continues [J]. World J Surg, 1999; 23(5): 429432.
20.	《应用抗菌药物防治外科感染的指导意见》撰写协作组. 应用抗菌药物防治外科感染的指导意见(草案)Ⅱ [J]. 中华外科杂志, 2003; 41(7): 552554.
21.	王鲜平, 王发强, 曹力. 外科清洁手术预防性抗生素应用探讨 [J]. 中华医院感染学杂志, 2000; 10(1): 6667.
22.	李龙, 王忠荣, 王亮. 预防小儿腹部Ⅲ类切口感染247例体会 [J]. 中国普外基础与临床杂志, 2007; 14(1): 38.

1. 刘宗荣, 朱易凡, 马淙, 等. 结直肠癌手术后感染并发症的调查和分析 [J]. 中国普通外科杂志, 2008; 17(1): 104106.
2. Tweed C. Prevention of surgical wound infection: prophylactic antibiotics in colorectal surgery [J]. J Wound Care, 2005; 14(5): 202205.
3. 周惠平. 医院感染－临床医学面临的一个严峻问题 [J]. 中华医学杂志, 2001; 81(5): 257258.
4. 唐伟松. 外科预防性抗生素的应用 [J]. 中国普外基础与临床杂志, 2002; 9(1): 67.
5. Greene FL, Compton CC, Fritz AG, et al. AJCC Cancer Staging Atlas [M]. New York: Springer, 2006: 107112.
6. Rahman GA, Mungadi IA. Surgical trainees’ understanding of Dukes’ staging in rectal cancer [J]. Niger J Med, 2009; 18(1): 7578.
7. Solomkin JS, Mazuski JE, Baron EJ, et al. Guidelines for the selection of antiinfective agents for complicated intraabdominal infections [J]. Clin Infect Dis, 2003; 37(8): 997 1005.
8. 卫生部医政司医院内感染监控协调小组. 医院内感染的诊断标准 [J]. 中华医院管理杂志, 1991; 7(1): 211.
9. 石喜之, 王济峰, 周涌, 等. 手术后切口感染与抗生素合理应用的评价 [J]. 第四军医大学学报, 2002; 23(7): 602.
10. Baker RJ, Fischer JE. 临床外科学 [M]. 天津：天津科技翻译出版公司, 2002： 18701965.
11. Suehiro T, Hirashita T, Araki S, et al. Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery [J]. Hepatogastroenterology, 2008; 55(8687): 16361639.
12. Bratzler DW, Houck PM, Richards C, et al. Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project [J]. Arch Surg, 2005; 140(2): 174182.
13. 唐伟松, 李小毅, 杨志英, 等. 预防性抗生素在普通外科手术中的应用 [J]. 中华普通外科杂志, 2001; 16(7): 445.
14. Chodak GW, Plaut ME. Use of systemic antibiotics for in prophylaxis surgery: A critical review [J]. Arch Surg, 1977; 112: 326334.
15. Gul YA, Lian LH, Jabar FM, et al. Antibiotic prophylaxis in elective colorectal surgery [J]. ANZ J Surg, 2002; 72(4): 275278.
16. 黎沾良. 合理使用抗生素预防手术部位感染 [J]. 中国普外基础与临床杂志, 2003; 10(1): 1415.
17. Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee [J]. Infect Control Hosp Epidemiol, 1999; 20(4): 250280.
18. Hartmann B, Sucke J, Brammen D, et al. Impact of inadequate surgical antibiotic prophylaxis on perioperative outcome and length of stay on ICU in general and trauma surgery. Analysis using automated data collection [J]. Int J Antimicrob Agents, 2005; 25(3): 231236.
19. Gorecki P, Schein M, Rucinski JC, et al. Antibiotic administration in patients undergoing common surgical procedures in a community teaching hospital: the chaos continues [J]. World J Surg, 1999; 23(5): 429432.
20. 《应用抗菌药物防治外科感染的指导意见》撰写协作组. 应用抗菌药物防治外科感染的指导意见(草案)Ⅱ [J]. 中华外科杂志, 2003; 41(7): 552554.
21. 王鲜平, 王发强, 曹力. 外科清洁手术预防性抗生素应用探讨 [J]. 中华医院感染学杂志, 2000; 10(1): 6667.
22. 李龙, 王忠荣, 王亮. 预防小儿腹部Ⅲ类切口感染247例体会 [J]. 中国普外基础与临床杂志, 2007; 14(1): 38.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relation Between Using Time of Prophylactic Antibiotics and Surgical Site Infection in Colorectal Cancer

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